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PubMed2003

Serum sex hormones and breast cancer risk factors in postmenopausal women.

Postmenopausal women with elevated serum estrogens and androgens are at an increased risk of breast cancer. We evaluated associations of serum estrogen and androgen levels with age, anthropometry, and reproductive history to assess whether these characteristics could potentially modify breast cancer risk through hormonal mechanisms. A cross-sectional study was conducted among 133 postmenopausal women who donated blood to the serum bank (Columbia, MO) and served as controls in a previous prospective nested case control study of serum hormones and breast cancer risk. Standard regression methods were used to calculate adjusted means and test for trends in relationships of serum hormone concentrations with breast cancer risk factors. All analyses were performed on the log(e) scale, and all models included assay batch, date, and time of blood collection. Serum levels of estradiol, non-sex hormone binding globulin bound estradiol, estrone, estrone sulfate, and testosterone increased significantly with increasing body mass index (BMI), whereas sex hormone binding globulin levels decreased. After adjusting for BMI, nulliparous women tended to have higher testosterone levels compared with parous women (P = 0.05), but there was no evidence of a trend of decreasing testosterone with increasing parity. Dehydroepiandrosterone, its sulfate, and androstenediol decreased significantly with increasing age. Although BMI and parity could potentially modify breast cancer risk through hormonal mechanisms, age-related increases in breast cancer incidence do not appear to be mediated through changes in serum levels of the hormones evaluated.

Aged↗
PubMed2003

Potential role of reactive oxygen species on testicular pathology associated with infertility.

AIM: To investigate the level of malondialdehyde (MDA), a direct indicator of lipid peroxidation-induced injury by reactive oxygen species (ROS), in testicular biopsy specimens from infertile patients. METHODS: Levels of MDA were measured in testicular biopsy specimens from 29 consequent-randomized infertile men, aged 29.58+/-4.76 (21 to approximately 45) years. All patients were evaluated by a complete medical and reproductive history, physical examination, semen analysis (at least two), serum follicle-stimulating hormone and free testosterone levels, testicular biopsy and contact imprint. Scrotal colour Doppler ultrasonography was used to confirm suspected varicocele. The testicular MDA level was measured using the thiobarbituric acid test and the results were expressed per unit tissue weight. RESULTS: As a causal factor in infertility, varicocele was identified in 17 (58.6 %) patients, and idiopathic infertility, testicular failure and obstruction in 4 (13.8 %) patients each. The testicular MDA level was 13.56 (6.01), 49.56 (24.04), 58.53 (48.07), and 32.64 (21.51), 32.72 (13.61), 23.07 (7.82), 42,12 (34.76) pmol/mg tissue in the normal spermatogenesis (control), late maturation arrest, Sertoli cell only (SCO) and hypospermatogenesis (mild, moderate, severe) groups, respectively. The elevation of MDA levels was significant in the testicular tissue from SCO and maturation arrest groups compared with the controls (P<0.05). In addition, the elevation in testicular MDA levels between the SCO and the moderate hypospermatogenesis, and the moderate hypospermatogenesis and the maturation arrest groups was significant (P<0.05). CONCLUSION: Severe pathologic changes in the testicular tissue are associated with a high level of lipid peroxidation. These findings suggest that overproduction of ROS may play a role in the mechanism of testicular degeneration associated with infertility.

Adult↗
PubMed2003

Population and parity levels of Aedes aegypti collected in Tucson.

Oviposition traps were used to follow changes in the population of Aedes aegypti (L.) (Diptera:Culicidae) in a seven-block area in midtown region of Tucson, Arizona. About 20,000 eggs were collected over a period from 1 June to 14 October 2000. Peak mosquito populations were correlated with the late summer rains. Mosquitoes seeking a blood meal were collected and dissected to determine if they had previously fed, i.e. if they were parous. Of the 241 females examined, 44% were parous, with a range from 0% to 80%. Females that had blood in their guts were collected and the source of blood was identified using an ELISA. Preliminary results suggest that 80% of them had fed on humans. These data suggest that the reproductive history of Tucson populations of Ae. aegypti could be conducive for transmission of dengue viruses.

Aedes↗
PubMedDate not supplied

Characteristics of women by smoking status in the San Francisco Bay Area.

To better understand why smokers are more likely to develop cervical cancer than nonsmokers, we investigated laboratory and demographic differences between the two groups. Women between the ages of 18 and 49 who attended eleven community clinics in the San Francisco Bay Area were studied to investigate differences between smokers and nonsmokers. The 332 smokers and 365 nonsmokers were queried about smoking habits, sexual and reproductive history, and recent diet. Cervical mucus specimens were cultured for yeast, lactobacillus, and other microorganisms. Results showed that white Hispanic women were less likely to smoke than white non-Hispanic women. Smokers, when compared to nonsmokers, consumed larger quantities of coffee, soft drinks, liquor, and beer in the 24 h prior to the interview. Women who smoked were more likely than those who did not smoke to have had first sexual intercourse before age 16, had a greater number of lifetime sexual partners, and were more likely than nonsmokers to have been pregnant. After controlling for number of sexual partners, smokers reported a history of chlamydia, gonorrhea, and/or pelvic inflammatory disease more often than did nonsmokers, and cervical mucus of smokers was more likely than that from nonsmokers to contain greater than 8500 microorganisms/ml.

Adolescent↗
PubMed1992

Maternal uniparental isodisomy of chromosome 14: association with autosomal recessive rod monochromacy.

Rod monochromacy (complete congenital achromatopsia) is inherited as an autosomal recessive trait of unknown genetic location. The disorder is characterized by total absence of color discrimination because retinal cone photoreceptors do not develop; systemic features do not occur. A 20-year-old white female with rod monochromacy presented with short stature (less than 5th percentile), mild developmental delay, premature puberty, small hands and feet (length less than 5th percentile), minimal dysmorphism, and a reproductive history of three consecutive first-trimester miscarriages. Cytogenetic analysis showed 45,XX,rob(14;14) in all 30 cells examined. Southern analysis of DNA from the patient and her phenotypically normal mother and two brothers (her father is deceased) ascertained the parental origin of the 14;14 Robertsonian translocation. Analysis of RFLPs associated with nine VNTR probes and two dinucleotide repeat polymorphisms from chromosome 14 demonstrated that the patient had inherited two copies of a single allele, each of which was maternally derived. A fully informative RFLP analysis of three probes from chromosome 14 enabled reconstruction of the paternal haplotype and showed the lack of any paternal contribution to the subject. These data are consistent with maternal isodisomy for all portions of chromosome 14 tested by these markers. This finding suggests that rod monochromacy maps to chromosome 14, and it emphasizes the importance of uniparental isodisomy to provide a putative chromosomal assignment of a gene for a rare autosomal recessive disorder.

Chromosome Mapping↗
PubMedDate not supplied

[Infantile colic incidence and associated risk factors: a cohort study].

OBJECTIVE: To assess the incidence of infantile colic and its determinants. METHODS: Between May and July 1999, the research team performed daily visits to the three main maternities of Pelotas. All women were interviewed after the delivery and their infants were targeted for follow-up at three months. Colic was defined according to Wessel. The following risk factors were evaluated: social class, mother's educational level, parents' age, parents' divorce, changes in the parents' relationship during pregnancy, type of delivery, reproductive history, quality of prenatal care, previous abortion, previous stillbirths, previous newborn with health problems, gender, and infant's feeding pattern. Chi-square test was used to compare proportions and conditional logistic regression was applied in the multivariate model. RESULTS: We managed to follow 1,086 of the 1,195 infants. At the three months visit, 80.1% of the mothers reported that their infants had had colic. On the other hand, only 16.3% was considered as having colic according to Wessel criteria. Mother's educational level, father's age, type of delivery and breast-feeding duration remained in the multivariate model. Even after controlling for possible-confounding factors, the chances of having colic was 1.86 times higher among non-breastfed infants than among breastfed infants. CONCLUSIONS: Most mothers misclassify the occurrence of colic. Breastfeeding is the main protective factor.

Adult↗
PubMed2004

Alcohol, wine, and risk of epithelial ovarian cancer.

Moderate alcohol intake can influence sex hormone levels and affect ovarian function as well as increasing breast cancer risk. This suggests that alcohol might also influence ovarian cancer risk. We have evaluated this among 696 Australian women with histologically confirmed epithelial ovarian cancer and 786 cancer-free control women, selected at random from the electoral roll. Sociodemographic information and a detailed reproductive history were collected in a face-to-face interview, and information about diet and alcohol consumption was obtained from a food frequency questionnaire. Logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Overall, 59% of women drank <1 standard drink/week and only 5% of cases and 8% of controls drank an average of > or =2 standard drinks/day. Compared with nondrinkers, the OR for women who drank an average of > or =2 standard drinks/day was 0.49 (95% CI = 0.30-0.81). This effect did not vary for the different subtypes but was restricted to wine (OR = 0.56, 95% CI = 0.33-0.93 for > or =1 glass/day versus nondrinkers) with no effect for beer (OR = 1.26, 95% CI = 0.65-2.46) or sherry/spirits (OR = 1.07, 95% CI = 0.59-1.95). Combining our results with the six previous population-based studies gave a pooled OR of 0.72 (95% CI = 0.54-0.97) for the highest alcohol intake group versus nondrinkers. These data suggest that alcohol does not increase risk of ovarian cancer. In this Australian population, the inverse association with alcohol was due solely to wine consumption and so may be a consequence of antioxidants and/or phytoestrogens in wine rather than the alcohol itself.

Adolescent↗
PubMed1992

Sperm creatine phosphokinase M-isoform ratios and fertilizing potential of men: a blinded study of 84 couples treated with in vitro fertilization.

OBJECTIVE: To examine the value of sperm creatine phosphokinase M-isoform (CK-MM) measurements toward predicting fertilizing potential of men. DESIGN: In 84 in vitro fertilization (IVF) couples without knowing the semen parameters, reproductive history or the outcome of the IVF cycles, we determined the sperm CK-MM ratios (the proportion of sperm CK-MM versus CK-MM+CK-BB). Husbands with less than 10% or greater than or equal to 10% CK-MM ratios were classified as "low likelihood for fertilization" (CKMM-Infertile, n = 22) or "high likelihood for fertilization" (CKMM-Fertile, n = 62), respectively. RESULTS: Both the CKMM-Infertile and CKMM-Fertile groups (CK-MM ratios: 4.9% +/- 0.6% versus 31.1% +/- 1.8%) were in the normospermic range (31.5 +/- 6.9 versus 78.4 +/- 5.9 x 10(6) sperm/mL and 45.6% +/- 5.0% versus 54.0% +/- 2.0% motility). The fertilization rates (6.2 versus 4.9 oocytes inseminated) were 14.2% versus 53.4%, and 72.7% versus 25.8% of the couples failed to achieve any oocyte fertilization. All 14 pregnancies (16.7% rate) occurred in the CKMM-Fertile group. The pregnancy rate in the 62 CKMM-Fertile couples was 22.6%, and considering only the 46 CKMM-Fertile women in whom oocyte fertilization occurred, it was 30.4%. Among the 22 CKMM-Infertile men, 9 were normospermic and 9 of the 62 CKMM-Fertile men were oligospermic. Within the CKMM-Fertile group, 12 and 2 of the 14 pregnancies occurred by the 53 normospermic and 9 oligospermic men (22.6% versus 22.2% rate). CONCLUSIONS: Sperm CK-MM ratios, a measure of normal sperm development, predict fertilizing potential independently from sperm concentrations. Sperm CK-MM ratios also detect unexplained male infertility (infertile men with normospermic semen), a diagnosis that until now could not be substantiated.

Biomarkers↗
PubMed1992

A comparison of unbooked mothers delivering at Port Moresby General Hospital with mothers seen antenatally: socioeconomic and reproductive characteristics.

It is well known that antenatal care improves perinatal and maternal outcomes. This is especially true for deprived communities and for the developing world, where women commonly have risk factors. At the Port Moresby General Hospital mothers who did not attend an antenatal clinic in the index pregnancy (unbooked mothers) form about 6% of all mothers delivered. These unbooked mothers have a perinatal death rate which is four times that of those who attended antenatal clinics before their delivery. A case-control survey was conducted of 136 unbooked mothers delivered at the Port Moresby General Hospital and 136 parity-matched control mothers who had been seen antenatally at least three times during their pregnancy. The purpose of the study was to find out if the cases and controls differed in their socioeconomic characteristics and in some selected aspects of their reproductive history. There was no significant difference between the groups in the following: marital status, and distance between present residence and nearest antenatal clinic. The groups were very significantly different in the following characteristics: age less than 20 years, social class, husband's education, and previous antenatal attendance in the penultimate pregnancy. The difference in patient's education was only just significant.

Adult↗
PubMed2004

Risk factors for HIV infection among special treatment clinic attendees in Ibadan, Nigeria.

Control of sexually transmitted infections (STIs) is an important factor in the prevention of sexual transmission of HIV infection. Despite a close link between the two disease entities, not enough data are however available on risk factors for HIV infection among STI clinic patients in Nigeria. This information is important for planning preventive measures. All consenting patients that attended special treatment clinic (STC), University College Hospital (UCH), Ibadan from March to November 2001 were enrolled into the study. Using a structured interview assisted questionnaire, information on socio-demographic characteristics, sexual and reproductive history and other potential risk factors for HIV infection were obtained. Urethral swab, endocervical swab and high vaginal swab were also obtained and processed by standard laboratory methods. HIV tests were carried out by double ELISA tests. Of the 210 subjects, 180 (85.7%) were diagnosed as having STI while 46 (21.9%) screened positive for HIV. Co-infection was found in 41(19.5%) of all subjects. The risk of HIV was higher in subjects with STIs. Multivariate logistic regression analysis indicated that subjects who were not infected with gonorrhoea (OR = 0.685, 95% CI = 0.47- 0.99, p = 0.045) and those with negative history of blood transfusion (OR= 0.1,95% CI = 0.02-0.5, p=0.009) were less at risk of HIV infection while those with lower occupation had a higher risk (OR = 1.126,95% CI = 0.32-3.9, p = 0.085). The results of this study emphasize the need for adequate management of STIs and the importance of upgrading blood transfusion services in order to curtail the spread of HIV infection.

Adolescent↗
PubMed2004

Bacterial vaginosis and vaginal anaerobes in preterm labour.

Maternal genital infections, particularly bacterial vaginosis has been implicated as a cause for preterm labour and adverse pregnancy outcomes. This prospective study aimed to study the association of bacterial vaginosis with preterm labour. The prevalence of bacterial vaginosis was studied in 60 women in preterm labour who had no recognisable cause for prematurity and in 60 term labour controls. Demographic factors, pregnancy outcome and reproductive history were also studied. Vaginal specimens for Gram-stain and culture were collected from posterior vaginal fomix and bacterial vaginosis was defined by evaluation of Gram-stained smear by Spiegel criteria. Bacterial vaginosis was diagnosed in 31.6% of women in preterm labour and in 15% of term labour controls ( p<0.05). In preterm labour group, preterm delivery occurred in 48 women (80%) out of which 18 women had bacterial vaginosis and term delivery occurred in only one woman with the condition. Anaerobes were significantly associated with bacterial vaginosis ( p<0.01) and were more common in women with preterm labour ( b>0.05). The results indicates that bacterial vaginosis has a significant association with preterm labour and adverse pregnancy outcome.

Adult↗
PubMed2005

[Environmental risk factors and outdoor formaldehyde and risk of congenital heart malformations].

UNLABELLED: The aim of the study was to assess the relationships between environmental risk factors and the risk of congenital heart malformations. METHODS AND MATERIALS: An epidemiological case-control study was conducted. We investigated the effect of 43 potential risk factors for congenital heart malformations and calculated their crude and adjusted odds ratios. RESULTS: The analysis revealed that maternal age at delivery (< 19 or > or = 35 years), marital status, chronic diseases, reproductive history, maternal and paternal smoking, occupational and residential hazards were associated with increased risk of congenital heart malformations. Residential exposure to ambient formaldehyde (>2.42 microg/m3) tended to increase the risk of congenital heart malformations by 24% (OR=1.24; 95% CI 0.81-2.07). CONCLUSION: Stratified analysis of effects of exposure to occupational and residential hazards together showed that the risk of congenital heart malformations has increased significantly.

Abortion, Threatened↗
PubMedDate not supplied

Early experience of sexual intercourse--a risk factor for cervical cancer requiring specific intervention for teenagers.

There is consensus that the main risk factor for cervical cancer development is persistent infection with high-risk group human papilloma viruses (HPVs), together with smoking, and reproductive history. Since sexual behaviour determines exposure to HPVs and the adolescent period may be particularly important in this regard it is of interest to consider behavioural determinants of teenagers. In one survey conducted in Khon Kaen, Thailand, some 62% percent of male and 19.3 % of female respondents aged 13-15 years reported having experienced sexual desire, and 19.1% of male and 4.7 % of female respondents admitted to sexual intercourse. The possibility that this might impact on HPV infection rates, with added risk due to the physical trauma associated with pregnancy and illegal abortions, indicates that more attention needs to education of early teens, not only for avoidance of HIV and AIDS, but also for prevention of cervical cancer.

Adolescent↗
PubMed1991

[A clinical study on 268 patients with cervical carcinoma].

Cancer is the leading cause of death in Taiwan with cervical carcinoma having the highest incidence rate (29.65 per 100,000) of all cancers among women. In the present study, we collected 268 consecutive cases of cervical carcinoma, seen in Tri-Service General Hospital from January 1983 to December 1984. The evaluation included a review of the case data including demographic features, symptoms, stage of cancer, reproductive history, pathology, and survival time (product limit method for survival). Results showed that in situ cervical carcinoma was diagnosed in 31 (11.5%) patients with a mean age of 47.7 years. Two hundred and thirty-seven patients (88.5%) with a mean age of 55.6 years were noted to have invasive carcinoma, showing stage I 22.4%, stage II 46.6%, stage III 10.1% and stage IV 9.3%. The ratio of invasive carcinoma to carcinoma in situ was 7.7:1. Ninety-two percent of patients were symptomatic on admission with vaginal bleeding (78%), vaginal discharge (16%) and abdominal pain (16%) being the most common, and the majority of these patients were symptomatic before cervical carcinoma was pathologically proved. Survival analysis showed five-year survival rates of 100%, 84.6%, 63.2%, 54.1% and 13.2% for stages O, I, II, III and IV, respectively. Low cervical carcinoma survival rates seemed clearly related to progression of the disease the presence of more extensive disease. The average age at the time of diagnosis was older and the clinical stage of disease was more advanced when compared with most developed countries.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion].

An association between thrombophilic genes and obstetric conditions with early pregnancy termination has been previously proposed. In the present study we attempted to evaluate the possible association between thrombophilic genetic polymorphisms and habitual abortion (HA). Samples from two groups of volunteers were analyzed. The experimental group (n>100) was conformed by women attending the Centro Medico de Occidente, IMSS and their male couples, with a reproductive history ofat least three miscarriages. The reference group (n > 200) was composed by male and female healthy adults living in the state of Jalisco, Mexico. DNA was extracted from peripheral blood, and polymorphisms FII G20210A , FVG1691A, MTHFR C677T, ECA IID y TNF G-308A were typed by PCR-RFLP or -SSP. Genotype proportions in the reference group were in agreement with the HardyWeinberg expectations. Allele, genotype, and phenotype proportion inter-group comparisons did not show statistically significant differences. The present results could not demonstrate that thrombophilic polymorphisms constitute risk factors for HA in Jalisco.

Abortion, Habitual↗
PubMed2006

Czech Teratology Information Service: comparison of treatments by psychotropic and antiepileptic drugs.

OBJECTIVES: Care, treatment and follow-up in psychiatric and epileptic pregnant women were compared with women inquiring Czech Teratology Information Service (CZTIS) due to other exposure to drugs during pregnancy. METHODS: Data were collected by CZTIS, member of European Network of Teratology Information Services from 1996. Exposed groups were compared with pregnant women exposed to drugs which were not classified as major teratogens or hyperthermia. Groups do not vary in age, reproductive history and other parameters. RESULTS: We observed higher frequency of miscarriage and voluntary termination of pregnancy in the group of psychiatric patients. The number of malformation in prospective follow-up cases was lower than in control group. CONCLUSIONS: Chronic diseases as epilepsy or psychiatric disorders have to be treated during pregnancy. Women should obtain accurate information about possible risk before pregnancy. Co-operation is needed in these cases. Physicians should keep in mind that appropriate information is to be given to the patient according to her disease, education and comprehension of the problem. If there is any doubt they should organize help for their patients.

Anticonvulsants↗
PubMed2006

[Pregnancy outcomes of 194 couples with balanced translocations].

OBJECTIVE: To investigate the pregnancy outcomes of couples with either maternal or paternal balanced translocations. METHODS: One hundred and ninety-four couples were divided into three groups based on the kind of translocations: 135 with reciprocal translocation, 52 with nonhomologous Robertsonian translocations, and 7 with homologous Robertsonian translocations. Past reproductive histories were surveyed. For those who wanted to have their own babies by natural conceptions after knowing their karyotypes as well as the risks of abnormal offsprings, subsequent pregnancy outcomes were recorded. Total pregnancy outcomes were compared between three groups. RESULTS: (1) 503 previous and subsequent pregnancies were recorded in detail. The pregnancy outcomes are as follows: spontaneous abortions 81.7% (411/503); induced terminations because of fetal abnormalities 3.2% (16/503); birth defects 7.2% (36/503); normal/balanced offsprings 8.0% (40/503). In reciprocal translocations, nonhomologous Robertsonian translocations and homologous Robertsonian translocations, the birth defects rates were 5.7% (20/350), 10.9% (14/128) and 8.0% (2/25), respectively (P < 0.05). The rates of normal/balanced offsprings in each group were 6.6% (23/350), 13.28% (17/128) and 0, respectively (P < 0.05). The rates of spontaneous abortions as well as the rates of induced terminations among three groups had no statistical differences. (2) Among the 52 congenital defects, induced terminations accounted for 30.8% (16/52), and liveborn 69% (36/52). Cytogenetic analyses were performed for 27 congenital defects and Down's syndrome occupied 59% (16/27). (3) 39 couples with reciprocal or nonhomologous Robertsonian translocations gave birth to 40 normal/balanced offsprings, of which 26 were karyotyped: normal karyotypes were 6 (23%) and balanced translocations 20 (77%). Couples with homologous Robertsonian translocations had no normal/balanced offspring. CONCLUSIONS: Balanced translocation carriers suffer from poor pregnancy prognosis. Couples with homologous Robertsonian translocations have little chance to give birth to normal/balanced offsprings.

Abortion, Habitual↗
PubMed1991

Uterine clearance of non-antigenic markers (51Cr) in response to a bacterial challenge in mares potentially susceptible and resistant to chronic uterine infections.

The purpose of this study was to investigate the physical ability of the mare's uterus to eliminate non-antigenic 51Cr microspheres during an infectious challenge. Mares both potentially susceptible and resistant to chronic uterine infections were used in this study. The procedure described serves as a model of the uterine capacity to clear physically infectious agents and inflammatory products during the acute phase of an infection. Based on the results from intra-uterine bacterial challenges, reproductive history, examination per rectum and endometrial biopsies, mares were classified as potentially susceptible (n = 6) or resistant (n = 5) to chronic uterine infections. On the third day of oestrus the mares were infused with Streptococcus zooepidemicus followed immediately by an inoculation of 51Cr labelled microspheres into the uterus. At 24 h post infection the uterus was lavaged to recover remaining microspheres. The procedure was repeated during the next 2 cycles to determine the retention of microspheres at 48 and 96 h post infection. Mares classified as potentially susceptible to chronic uterine infections demonstrated a significant delay in physical clearance of microspheres from the uterus compared to the resistant mares (P less than 0.0001). Uterine retention of microspheres in mares classified as potentially resistant was insignificant 24 h post inoculation. In contrast, mares classified as potentially susceptible to chronic uterine infections failed to clear microspheres from the uterus before 96 h post inoculation. It is concluded from this study that the physical ability of the uterus to clear infectious agents and inflammatory products may be a critical factor as a first line of defence against uterine infections.

Animals↗