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[Urethral stenosis in the young girl, myth or reality? Comparison of clinical, radiological, instrumental and urodynamic data (author's transl)].

In 240 girls aged between three and fifteen years with mictional problems or urological infectious complications, 58 had radiological appearances of urethral stenosis. A complete clinical, urographic, urodynamic, endoscopic and instrumental study was performed in these 58 children. The majority of these young girls suffered from frequency with urgency, enuresis, pyuria and radiological and endoscopic appearances of trabeculated bladder. Thirteen showed signs of vesico-ureteric reflux. A basic fact: only two of the children had meatal stenosis. All the others had a urethral calibre larger than normal. Almost all the children had an unstable bladder, but with the exception of the two girls with a tight meatal stenosis, none had urodynamic data compatible with poor stream or vesico-sphincter dysinergism. The author concluded in the existence and the exceptional nature of true stenosis of the terminal urethra in the young girl. Most often, in the absence of true stenosis, there is nevertheless a functional stenosis related to contraction of the striate sphincter intended to overcome contraction of the unstable bladder. Such non-inhibited bladders are the site of marked disinhibition contractions without any element of outlet obstruction no increase in urethral resistance and no increase in micturation pressures. Disturbances of day and night continence are essential. Vesical trabeculations are a logical consequence, easy to understand, but the episodes of recurrent infection and the development of vesico-ureteric reflux (present in 13 of the girls) are rather more complicated to explain. This pathological state is most often reversible as the bladder matures. Nevertheless, bladder education, pharmacological treatment, dilatations and urethrotomy may help such children. Such treatment has given favourable results in 50% of cases.

Adolescent↗

[Rhabdomyosarcoma of the bladder in a 2-year-old boy].

A case of rarely occurring rhabdomyosarcoma of the urinary bladder in a boy of 2 is presented. The period from the first clinical manifestations (pyuria, macrohematuria) to death was 4 months. Urological examinations were done at the period of manifest clinical signs of disuria. A tumour of the urinary bladder almost completely filling the lumen was found in the form of numerous papillary-polyplike formations, with uropassage disorders. On the materials of operation biopsy the histological conclusion of urinary bladder rhabdomyosarcoma was reached. The death occurred with urogenic infection and manifestations of drug agranulocytosis (cytostatic therapy). The tumour outgrew into the posterior wall, no metastases were found. Histologically the tumour was characterized by random arrangement of mono- and multinuclear polymorphic cells with oxiphilic cytoplasm. The granularity and fibrous pattern of the cytoplasm were discernible. Typically, an argirophilic framework was observed. By its histological structure the tumour belongs to the embryonal type.

Biopsy↗

The spectrum of urinary tract infections in family practice.

Urinary tract infections are among the most frequently encountered health problems in patients of family physicians. The diagnosis requires the demonstration of more than 100,000 bacterial colonies per milliliter in a freshly voided urine specimen. Dysuria, proteinuria, and pyuria are unreliable diagnostic criteria. The pathogenesis is uncertain although vaginal colonization with enteric bacteria, voluntary avoidance of urination, and sexual intercourse are contributing causes. Vesicoureteral reflux is related to recurrent infection but a causal relationship has not been established. Urinary tract infection in children is related to decreased renal growth and kidney scars, but therapy of the infections does not prevent kidney damage. Infections disappear spontaneously in up to 40 percent of adult women. Bacteriuria in pregnancy, however, is related to low birth weight in infants and increased perinatal mortality. Asymptomatic bacteriuria need not be diagnosed or treated except in pregnant women. For symptomatic infections, short-term antibiotic therapy is as effective as long-term therapy. Prophylactic antibiotics and therapy by modification of behavior using a multifaceted regimen can reduce the frequency of recurrent infection.

Adult↗

Experience with a new intraurethral stent for high-risk patients with benign prostatic hypertrophy.

Eight patients with benign prostatic hypertrophy (BPH), considered as a high risk for an operation because of severe accompanying disease, were treated with a self-retaining intraurethral catheter set. Two patients were judged unfit for operation (one because of severe cardiac failure, the other because of severe respiratory failure) and 1 patient rejected an operation. The BPH surgery was postponed in the others because of recent operations for such diseases as gastric cancer or because of severe gastric ulcer. All patients voided freely after stent placement and were continent. The device was left in place for 1 to 16 weeks. The chief complaint was frequency of voiding, with intervals of 1 to 2 hours. Some micturition discomforts such as urgency were recognized in 2 patients, but disappeared within 1 to 2 days. Pyuria observed before treatment disappeared in all but 1 patient. Average residual urine volume calculated on ultrasonograms was 54 ml. Stone formation was demonstrated in 1 patient 9 weeks after placement. We concluded that the intraurethral stent is an effective device for high-risk patients with BPH. However, a longer follow-up study will be needed to exclude late side effects.

Aged↗

[Interstitial nephropathy due to chronic bacterial pyelonephritis].

Chronic renal infection (Chronic bacterial pyelonephritis) is a cause of tubulo-interstitial nephropathy (nephritis); TIN. The disorder causes end-stage renal failure in about 2% of the patients who are treated by dialysis. However, Chronic bacterial pyelonephritis is a relatively benign condition that seldom leads to renal function loss. The affected kidney shows non-specific histological pictures similar to that seen with other diseases producing TIN. Clinical symptoms are of ten vague. Obstructive uropathy (eg, stones, benign prostatic hyperplasia) is frequently present. The affected kidney, which is almost unilateral, shows atrophy and scarring of variable degree. Significant pyuria and bacteriuria may or may not be found. Depending on the stage of the disease, the serum creatinine and blood urea nitrogen may be normal or elevated. Contributing obstructive uropathy should be corrected. The patients must be followed closely, urinary tract infection must be controlled and complications (eg, hypertension, azotemia) must be identified promptly and treated adequately.

Bacterial Infections↗

[Atypical course of Kawasaki syndrome in a 3-month old infant].

The authors report on the case history of a three-month-old infant with Kawasaki-syndrome. The course of the disease was atypical, the various symptoms (antibiotic resistant high fever, urticariform rash, meningitis serosa, steril pyuria, coronaria aneurysma, thrombocytosis, high sedimentation rate) developed slowly during a period of several weeks. The authors intend to point out that Kawasaki-syndrome may appear in early infancy, frequently in an atypical way.

Age Factors↗

[Intravesical instillation of epirubicin hydrochloride in superficial bladder tumor--prophylactic and therapeutic instillation for carcinoma in situ].

Between May 1990 and May 1993 we performed intravesical instillation of epirubicin hydrochloride (EPI) to 52 patients with superficial bladder tumor after transurethral resection. Indications of these instillations were classified into 3 groups. Group 1 was for carcinoma in situ (CIS) or the CIS other than the original tumor, group 2 was for multiple tumors, and group 3 was for pT1G3 tumor. Intravesical instillations of the drug were given weekly for 10 weeks and close follow-up examinations were performed routinely. Group 1 was treated for CIS, whereas group 2 and group 3 were prophylactic instillations. The disease-free rate in group 1 was 67%, and that in group 2 and group 3 was 77% at 12 months, and 42% at 24 months according to the Kaplan-Meier method. The major side effects of the instillations were bladder irritation, hematuria and pyuria. However, we experienced 5 patients with severe side effects; 2 of atrophic bladder and 3 of hemorrhagic cystitis. Although this study was conducted retrospectively, these findings suggest that intravesical instillations of EPI can be as effective as other drugs, such as mitomycin C, and doxorubicin, by adding the maintenance instillation or by elevating the drug density and shortening the instillation time.

Administration, Intravesical↗

[Ureteritis cystica--report of a case diagnosed by biopsy under ureteroscopy].

A 62-year-old male with left ureteritis cystica was reported. Extracorporeal shock wave lithotripsy (ESWL) was performed for his left renal stone 14 and 17 months earlier. However, small fragments remained in the lower calyx and pyuria, microhematuria and bacteriuria continued. Drip infusion pyelography (DIP) showed a small filling defect of the left dilated ureter. Retrograde pyelography revealed multiple, small filling defects of the left middle through the lower ureter. Multiple small submucosal cysts were observed mostly in the pelvic ureter by ureteroscopic examination. Ureteroscopic cold punch biopsy proved ureteritis cystica. The ureteral dilatation improved and filling defects disappeared after the treatment with antibiotics.

Biopsy↗

[Clinical and epidemiological studies on urolithiasis in Ilan].

Clinical and epidemiological studies were performed on 1,184 cases of urolithiasis treated in the Department of Urology, Poh Ai Hospital. The incidence of urolithiasis was 147/100,000 population in 1991. The highest incidence was found in patients in their 50s. The male to female ratio was 2.9:1. There were 895 cases with single stones, and 289 cases with multiple stones. The ratio of upper to lower urinary tract stones was 13.6:1. Among the hospitalized patients, 673 cases (56.8%) underwent surgical treatment and 511 cases (43.2%) received conservative treatment with spontaneous stone passage. Among 1071 cases of upper urinary tract calculi, 567 cases (52.9%) underwent surgical treatment: 236 cases (41.6%) were treated by endoscopic surgery, 176 cases (31.0%) were treated by open-surgery and 131 cases (23.1%) by extracorporeal shock wave lithotripsy. Among 79 cases of lower urinary tract calculi, 75 cases (94.9%) were treated surgically: 68 cases (90.7%) by transurethral endoscopic surgery and 7 cases (9.3%) by cystolithotomy. According to analysis of 365 stones, the most frequent type was calcium-containing stones (92.3%). Pyuria was noted in 250 out of 1,086 (23.0%) cases. Bacteriuria was noted in 202 out of 914 (22.1%) cases. Concerning organisms isolated from the urine, Staphylococcus epidermidis was found most frequently (55/202). Stone patients increased in number during the summer season (July and August). Systematic questionnaires completed by the patients with urolithiasis, lead us to the following conclusions: 1) 50.7% (216/438) of patients gave a past history of urolithiasis, and 2) family histories showed that males whose siblings had urolithiasis were at the highest risk of uolithiasis, followed by those whose fathers had a history of urolithiasis.

Adult↗

Staphylococcus aureus bacteriuria.

One hundred twenty-seven episodes of Staphylococcus aureus bacteriuria were reviewed retrospectively in two hospitals to establish the rate of occurrence, clinical importance, and associated predisposing factors. Staphylococcus aureus was an infrequent urinary isolate, and accounted for only about 1% of all positive urine cultures. Although almost all cases in a Veterans Hospital occurred in elderly men, episodes in a community hospital were observed in women and children as well. Patients usually had pyuria (71%) but only 39% had urinary symptoms of fever. Among predisposing factors, serious underlying diseases were uncommon, but urinary tract manipulations or abnormalities were present in nearly two thirds of patients. Fifty-five percent of cases were nosocomial, and 73% of these were associated with urinary catheterization or other invasive urinary tract procedures. Most patients (61%) were not treated for their bacteriuria, and there was a secondary bacteremia rate of 5.5% in the Veterans Hospital. Although infrequently encountered, the presence of S aureus in urine should be treated with at least as much concern as more frequently encountered bacteria.

Adolescent↗

[Interleukin-8].

Interleukin 8 (IL-8) is one of the most widely studied chemoattractants for leukocytes. It belongs to the newly classified CXC family of chemokine which possesses biological activities mainly on neutrophils. The potential role of IL-8 in inflammation is substantiated by the growing evidences of clinical relevance of IL-8 in various diseases such as infection, ischemia and autoimmune disorders. The common characteristic pathological feature of these events is neutrophil infiltration. Although little is known about the mechanism of neutrophil recruitment into the urine, urinary tract infections (UTI) are accompanied by pyuria. Elevated urinary IL-8 levels were found in patients with UTI. Bioactive, multiple forms of IL-8 were produced locally within the urinary tract, and implied that IL-8 participated in the induction of neutrophil migration into the inflammatory site. Similar findings were observed in the peritoneal dialysate of patients on continuous ambulatory peritoneal dialysis with peritonitis. The notion of involvement of IL-8 in local infection was reinforced by the findings obtained on the rabbit UTI model. Finally, the clinical usefulness, as well as the problems of IL-8 level determination in various body fluids are discussed.

Humans↗

Endoscopic management of the symptomatic caliceal diverticular calculus.

Caliceal diverticular calculi are most often asymptomatic and of little clinical significance. In certain cases they may be associated with flank pain, pyuria and chronic urinary tract infections. Treatment has evolved from open surgical techniques to a purely endoscopic approach. Percutaneous techniques are frequently used to address the diverticular stone burden and to dilate the diverticular neck, improving drainage. Small volume caliceal diverticular calculi and those in the anterior portion of the collecting system represent a greater technical challenge to the endoscopist. We describe a purely retrograde endoscopic technique for treating small stone burdens trapped in caliceal diverticula. Flexible ureteroscopy combined with 3F dilating balloons passed through the endoscopic working channel facilitated treatment. This retrograde technique was combined with a simultaneous primary percutaneous puncture into the diverticulum to treat larger stone burdens and calculi within long-necked diverticula. This combination facilitated prompt, through and through access of a percutaneously placed guide wire, increasing the overall efficiency of treatment. In conclusion, a retrograde endoscopic technique using the actively deflectable, flexible ureteroscope can successfully treat certain caliceal diverticular calculi. By combining this technique with a simultaneous percutaneous puncture, caliceal diverticular calculi throughout the collecting system may be cleared expeditiously.

Diverticulum↗

Genitourinary tuberculosis: the importance of early diagnosis and management. Case presentation.

Genitourinary tuberculosis is the second most common form of extrathoracic tuberculosis. The most common signs are persistent sterile pyuria in up to 90% of patients, irritative voiding symptoms and painless hematuria in up to 80% of the patients. In Puerto Rico the incidence of tuberculosis is rising, being 9.2 per 100000 population in 1992. A.I.D.S. has had a steady rise since 1983. With the rise in the incidence of both diseases and with the influx immigrants from countries were tuberculosis is endemic we should expect a rise in the number of cases of genitourinary tuberculosis. Chemotherapy is the mainstay of treatment. Surgery is performed less often. Early recognition and management is important to avoid irreversible damage to the genitourinary tract. The cases of a 43 y/o man and a 30 y/o male with A.I.D.S. are discussed.

Acquired Immunodeficiency Syndrome↗

Surveillance of treated and untreated funguria in a university hospital.

STUDY OBJECTIVE: To determine the influence of treatment on the microbiologic outcome of funguria. DESIGN: Retrospective case series. SETTING: A 300-bed tertiary care teaching hospital in a large metropolitan area. SUBJECTS: 141 hospitalized patients, 18 years of age or older, with at least one urine culture positive (> or = 10(2) cfu/ml) for fungi. INTERVENTIONS: Retrospective review of medical records to determine the microbiologic outcome of funguria. MAIN RESULTS: Funguria developed rapidly in individuals with known predisposing factors. Urinalysis did not routinely detect the presence of fungi or pyuria. Symptoms such as fever, dysuria, and frequency were generally absent. Funguria persisted whether it was due to Candida albicans or nonalbicans species. There were no statistical differences in the microbiologic outcomes of treated and untreated funguria. CONCLUSIONS: Funguria is a rapidly developing, often benign and persistent process. Minimizing predisposing risks, such as removing indwelling urinary catheters, is beneficial in its management. Pharmacologic treatment of funguria due to C. albicans or non-albicans species does not influence the microbiologic outcome.

Adolescent↗

The dipslide in diagnosis of urinary tract infections.

Urinary tract infections (UTI's) are common in medicine. Symptoms may include fever, chills, frequency, and dysuria. Asymptomatic UTI's are also common, with a prevalence of one percent in school girls and ten percent in pregnant women. Pyuria, dysuria, and frequency may be absent in patients with UTI's or present in patients without UTI's. Therefore, a UTI must be bacteriologically diagnosed as greater than 100,000 organisms/ml, usually of a single organism, in a properly obtained urine specimen. The dipslide is a simple, convenient, inexpensive device for the quantitative diagnosis of a UTI. Culture media are layered on both sides of the dipslide, one medium allowing growth of all organisms and the other medium favoring growth of enterobacteriae. After immersion in a clean catch urine specimen, the dipslide is incubated for 24 hours at 37 C. Each urinary organism forms a colony "dot". The density of colony "dots" can be quantitated easily by comparison with standardized graphs. The dipslide is a highly accurate and sensitive tool that can be used for the diagnosis of UTI's, assessment of antimicrobial effectiveness, follow-up for presence of recurrence or relapse, and screening of high-risk individuals.

Bacteriological Techniques↗

[Gardnerella vaginalis as urinary pathogen].

AIM: To study the significance of Gardnerella vaginalis in urine by comparing urine culture results, leucocytes count and clinical findings. METHODS: A total of 1,365 urine specimens submitted consecutively were inoculated on Bilayer media. G. vaginalis was recovered from 76 urine specimens with the following distribution: in 12 samples G. vaginalis was isolated as the only organism, 9 with counts > 10(5) CFU/ml and 3 between 10(5)-10(3); in the remaining 64 samples G. vaginalis was always found in counts > 10(5) CFU/ml but associated in 13 occasions with another organism and in 51 occasions with 2 or more organisms from the periurethral and vaginal flora. RESULTS: G. vaginalis in pure cultures corresponded to 8 women and 4 males whose ages ranged from 20 to 86 years. Six patients complained of symptoms of lower urinary tract infection (UTI), 3 had fever and in 3 the urine culture was practised as a control. Seven patients presented predisposing factors to UTI and 2 were pregnant. In only 2 cases pyuria was detected. Of 12 patients with pure cultures, only 3 were found to have G. vaginalis UTI. CONCLUSIONS: Our data indicate that G. vaginalis in urine not always implies an UTI and that this organism is found most often in patients with predisposing factors.

Adult↗

Prevalence of urinary tract infection in adult women.

Five hundred adult women of Sylhet town of different socio-economic status were screened to detect urinary tract infection by a random "door-to-door" survey. Significant bacteriuria was considered as an important criterion in the diagnosis of urinary tract infection. Pyuria with bacteriuria was, but without bacteriuria was not, considered a good evidence of infection. The ratio between the asymptomatic and symptomatic bacteriuria was found to be 7:1. The significance of asymptomatic bacteriuria in preventive medicine has been stressed.

Adolescent↗

Genito-urinary tuberculosis--experience with 52 urology inpatients.

The current trend in South African health services is toward primary care. Pulmonary tuberculosis is well understood by the majority of primary care doctors and nurses, whereas genito-urinary tuberculosis may not be as easy to diagnose and treat. We reviewed our experience with this condition in 52 patients, who represented 0.74% of urology admissions between 1986 and 1991. There was a 3:2 male/female ratio, the age range was 7-76 years (mean 43 years), and the disease was more common among blacks and coloureds than among whites. Multiple sites of involvement were fairly common. Seventy-five per cent of patients had renal involvement and 17% epididymal involvement. The commonest presenting complaints were urinary frequency and haematuria, although flank and scortal pain were also reported by a number of patients. Physical examination seldom helped to suggest the diagnosis. On microscopic examination and culture of the urine, sterile pyuria was present in only 50% of our patients and 29% had positive cultures for a 'normal' coliform organism. Fifty patients underwent excretory urography and the findings were very varied. Patients were treated primarily with antituberculosis drugs, but 58% also required some form of surgery; nephrectomy was the commonest operation. Ureteral strictures developed in over 50% of cases with renal involvement. We conclude that the diagnosis of genito-urinary tuberculosis is not simple, and that treatment must include regular follow-up at a specialist institution.

Adolescent↗