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At least 1,027 records · Page 57Linked to original sources
PubMed2003

A case of large dermoid cyst in the floor of the mouth.

Dermoid cysts in the floor of the mouth are rarely observed. When they develop, they do not appear until they grow large enough or appear through infection. Some operative approaches and management have been performed to large dermoid cysts in the floor of the mouth with some variations. Intra-oral approach is the most useful for cosmetic appearance. We presented a 24-year-old female who underwent expedient surgical excision using finger end serviceable enucleation through the intra-oral approach.

Adult↗
PubMed1995

A reappraisal of the platysma myocutaneous island flap. A follow-up study of the functional outcome after reconstruction of the floor of the mouth.

The functional results of primary reconstruction of the floor of the mouth after ablative surgery for oral cancer using a platysma myocutaneous island flap are reviewed. Seventeen patients who had simultaneous neck dissection, tumor resection, and reconstruction were evaluated. It appears from this study that primary reconstruction of the floor of the mouth with a platysma flap is not ideal. This is believed to be due partly to the high occurrence of direct, postoperative complications.

Adult↗
PubMed1998

Treatment of squamous cell carcinomas of the floor of the mouth and tongue by interstitial high-dose-rate irradiation using iridium-192.

The results are presented of afterloading high-dose-rate-radiation with iridium-192 in 34 patients with squamous cell carcinomas of the floor of the mouth and tongue. Some patients were also treated surgically or given percutaneous radio- or chemotherapy. At the time of diagnosis, 28.0% had a T2 tumour, 41.9% a T3 tumour and 30.1% a T4 tumour, 41.2% had positive lymph nodes and 2.9% distant metastases. The response rate was 64.7%, 26.5% of which were complete remissions and 38.2% partial remissions. In 61.8% of cases, the tumour was recurrent and responded with a rate as high as 57.2%, 23.9% of which were complete remissions and 33.3% partial remissions. Survival times were dependent upon therapy results. The mean survival of patients with complete remission was 40.3 months, with partial remission 16.1 months as opposed to 7.2 and 3.5 months respectively in patients showing no change or progressive disease. It can be concluded that afterloading therapy using high-dose-rate-radiation with iridium-192 achieves good palliative results and should be looked at as a supplementary treatment modality for squamous cell carcinomas of the floor of the mouth and tongue.

Adult↗
PubMed1999

Quality of life after surgical excision followed by radiotherapy for cancer of the tongue and floor of the mouth: evaluation of 78 patients.

The aim of this study was to evaluate the quality of life of 78 patients treated for cancer of the tongue and the floor of the mouth, by subjective impressions and by objective assessment through different types of tests. Patients were divided into two groups according to the size of the post-excisional defect: (1) defect less than 5 cm (46); and (2) defect more than 5 cm (32). Patients were divided into three groups according to the type of reconstruction: 28 were partly reconstructed, 31 were reconstructed with local flaps and 19 with pectoralis major myocutaneous flaps. The following aspects were studied: overall well-being, food intake, speech intelligibility, dryness of mouth, willingness to undergo further surgery if necessary, tongue mobility, sensibility disturbances within the reconstructed region and oral competence. Overall results revealed that patients' quality of life was more or less disturbed. Among them, patients reconstructed with myocutaneous flaps and patients with larger post-excisional defects had a poorer quality of life.

Adult↗
PubMed1977

Cancer of the floor of the mouth: surgical management.

After discussing the changing incidence and known difficulties in the management of mouth floor cancer, reasons are given for the increased use of surgery in treating the more extensive lesions. The significance of the topographic anatomy, patterns of lymph drainage and surgical pathology is emphasized. Principles of treatment, indications and types of operation are discussed for the main lesions encountered. Following this the preparation of patients for surgery, the methods of anaesthesia and certain technical details of surgical treatment are given. The importance of after-care and particular measures to avoid complications are stressed and conclusions reached. The paper is based on experience in the Head and Neck Unit of the Royal Marsden Hospital, London, mainly since 1965. It also derives from an extensive report on 189 cases of floor of mouth cancer seen and treated at the Hospital from 1950-1974.

Anesthesia↗
PubMed1993

Naso-labial flap in the reconstruction of floor of the mouth defects.

Defects caused by tumour excision in the floor of the mouth can be closed by different methods. We present thirteen cases treated in our department over the last seven years in whom naso-labial flaps were used. Twelve patients had squamous cell carcinoma of the floor of the mouth and one had fibro-sarcoma of the right lower mandible. Five received post-operative radiotherapy, one was resected following radiotherapy and seven were treated with surgery alone. Patient selection is important to give good functional results without compromising tumour clearance.

Aged↗
PubMed2004

[Highligts from the interdisciplinary consultation for diseases of the mouth in Basel].

A number of medical specialties traditionally face changes and lesions in the mouth, specific for diseases seen routinely in their everyday practice: gastroenterologists, paediatricians, orthodontists, to name just a few, will easily identify the typical aspect of the tongue, the Koplik spots or a dysgnathia respectively, and the treatment of the underlying diseases in question will resolve the local problem. However, more unusual lesions with chronic or recurrent course may cause a much longer patient career, which may last for months or even years and is interspersed with more or less ineffective local antiseptic or steroid treatment regimens before underlying diseases like pemphigus, lichen, diseases of haematopoetic organs, paraneoplastic lesions or even simple mechanical consequences of parafunctions like bruxismus, are identified as the underlying cause. The otorhinolaryngologist, the dermatologist and the dentist-oral-maxillofacial surgeon offer an interdisciplinary consultation at the Center for Dental Medicine at the University of Basel, in which the advantages of an advanced diagnostic armamentarium and a combined pool of experience proves to be a gain for both the patients and involved medical persons. The otolaryngologist offers diagnostic procedures of the entire upper airways, the dermatologist bridges the gap to allergology, immunology and systemic diseases well known to his specialty. Dental medicine offers diagnostic and therapeutic alternatives, of which the first two have but scarce knowledge. In this article, the different approaches to the most frequently seen diseases and associated problems are described by the dermatologist and dental specialist. The dermatologist, in a succinct state of the art review, describes the problem of pemphigus and pemphigoid, diseases which may cause diagnostic problems because of their tendency to stay limited to the oral mucosa for a longer time. Recurrent aphtosis is another problem encountered frequently, in which a vast research effort has not yet abutted into pertinent knowledge on ethiology and effective therapy for all cases. The dentist-oral-maxillofacial surgeon is especially interested in the specific problem in the diagnosis and treatment of lichen planus i.e. the differentiation of true idiopathic lichen and the lichenoid reaction due to foreign bodies in the mouth. He describes the modern diagnostic and treatment procedures. In spite of missing parts in the puzzle of all these diseases, special consideration in every individual case contributes to more effective management and offers a gain in experience and knowledge to all medical persons involved.

Combined Modality Therapy↗
PubMed2002

Functional rehabilitation following resection of the floor of the mouth: the nasolabial flap revisited.

INTRODUCTION: The aim of this study was to analyse the results of treatment following reconstruction of intraoral soft tissue using a nasolabial flap, with particular consideration of functional aspects. MATERIAL AND METHODS: In 26 patients (over a period of 10 years), the intraoral repair of the defect was carried out in the anterior floor of the mouth, 19 have received a unilateral and seven a bilateral nasolabial flap. The defects were caused by resection of squamous cell carcinomas (T1-T2) of the intraoral mucosa in 24 cases and osteoradionecrosis with soft tissue loss in two cases. RESULTS: Complications of local wound healing were observed in three cases. In 23 patients the subsequent prosthetic rehabilitation was successful and allowed a return of masticatory function. In the other three cases, a secondary operation for flap remodelling would have been preferred, but the patients declined these operations. CONCLUSION: The nasolabial flap for replacement of soft tissue in the floor of the mouth represents a functional and aesthetically satisfactory alternative to reconstruction by microsurgically anastomosed flaps in cases with defects of up to 5 x 5 cm in size, especially in older, medically compromised patients who are therefore of poorer surgical risk.

Anastomosis, Surgical↗
PubMed2001

[Dysphagia without clinically relevant pathological correlation: to exclude tumours of the floor of the mouth and the base of the tongue ultrasound diagnosis is mandatory].

In patients suffering from dysphagia, a tumour of the tongue and its base must be excluded. This is not always possible by means of endoscopy and palpation. In contrast it is possible to visualize deep-seated structures of this region by ultrasound. Unfortunately, this technique is rarely used, as shown in the cases demonstrated. We present five patients suffering from dysphagia for a long period of time (up to 30 years) where ultrasound was not performed and a tumour of the floor of the mouth and the base of the tongue was overlooked. Thus, adequate therapy was delayed, which proved to be especially relevant in three patients suffering from a malignoma. Three patients suffered from a malignant tumour of the base of the tongue. Up to two years passed between the beginning of dysphagia and the necessary surgical treatment. One of these patients even underwent psychological treatment for his symptoms. In two other patients a dermoid cyst and ectopic thyroid tissue were removed. In patients suffering from dysphagia with normal endoscopic findings and normal palpation of the neck ultrasound of the floor of the mouth and the base of the tongue is imperative. Tumours of this area can be detected early with high sensitivity and cost-effectiveness by ultrasound.

Adult↗
PubMed1996

[Effects of chronic alcohol drinking on mouth mucosa. A morphometric study].

BACKGROUND: Chronic alcohol consumption is a major risk factor for oral and pharyngeal cancer. Besides other mechanisms a toxic effect of ethanol and/or its metabolite acetaldehyde on the oral mucosa and a resulting increased cell regeneration seem to play an important role in tumor promotion. METHODS: In the present study the effect of chronic ethanol consumption on the morphology of the oral mucosa of 20 male wistar rats that had been fed nutritionally adequate liquid diets containing 36% of total calories either as ethanol or isocaloric carbohydrates for six months was investigated. RESULTS: Morphometric analysis showed that in the ethanol rats, the size of the basal cell nuclei of the oral mucosa from the floor of the mouth, the edge of the tongue, and the base of the tongue was significantly increased (p < 0.001). The size of the basal cell layer in these rats was increased, and the stratification of the cells was altered. Mean epithelial thickness of the mucosa from the floor of the mouth was significantly reduced in the ethanol rats (p < 0.01). CONCLUSIONS: In conclusion, our results indicate that chronic ethanol consumption causes oral mucosa atrophy associated with hyperregeneration, which may result in an enhanced susceptibility of the mucosal epithelium to chemical carcinogens.

Alcohol Drinking↗
PubMed1995

[Establishment and characterization of 2 cell lines of squamous epithelial carcinoma of the mouth floor and tongue].

OBJECTIVE: The cultivation of squamous cell carcinoma cells of the upper aerodigestive tract is more difficult compared to other malignancies because of microbial contamination. The establishment of new squamous cell carcinoma cell lines is absolutely necessary to further characterize this tumor entity. METHODS: Two squamous cell carcinoma cell lines of the floor of the mouth and the tongue were established from tumor biopsies. They were examined by light and electron microscopy. Furthermore immunocytochemical and DNA cytofluorometric studies were performed. The growth features were tested in a tumor-stem cell assay and through transplantation in thymusless nude mice. RESULTS: The epithelial character of the cells was determined morphologically, immunocytochemically, and immunologically. Both cell lines shaved an aneuploid DNA Index of 1.92 for the tongue carcinoma cell line (HCTK-1) and 1.77 for the floor of the mouth cell line (HCFMK-1). The plating efficiency was 0.008 and 0.01%. Cell differentiation in the original tumor and the nude mice tumor was identical. HCTK-1 is in the 25th passage and HCFMK-1 in the 42nd. CONCLUSIONS: The two new squamous cell carcinoma cell lines HCFMK-1 and HCTK-1 may serve as a basis for various in vitro investigations and may help to further characterize squamous cell carcinomas of the upper aerodigestive tract.

Aged↗
PubMed1989

Physiological effects of a mouth-borne heat exchanger during heavy exercise in a cold environment.

A mouth-borne heat and moisture exchanger (HME) was tested. Nine healthy subjects performed an incremental-load cycle ergometry test to exhaustion, breathing once through the HME and once through a similar device without heat-exchange function (control). HME substantially increased inspired gas temperatures and decreased expired gas temperatures measured at the mouth; at 260 W (pulmonary ventilation (VE) approximately 1001 min-1) these changes amounted to + 15 degrees C and -5 degrees C, respectively. The breathing resistance was increased by HME but remained well within tolerable levels even during severe exercise. This was reflected in the subjective assessments of breathing resistance and breathing discomfort which, at any given workload, were rated similarly in the HME and control conditions. Also, time to exhaustion as well as oxygen uptake and VE at a given workload were unaffected by HME. That even at high pulmonary ventilations HME provided a good heat-exchange function while keeping breathing resistance relatively low suggests HME to be a useful aid for individuals suffering from cold-induced bronchospasm.

Adult↗
PubMed2006

Expression of the Foot-and-Mouth Disease Virus VP1 protein using a replication-competent recombinant canine adenovirus type 2 elicits a humoral antibody response in a porcine model.

To develop a new type vaccine for Foot-and-Mouth Disease (FMD) prevention by using canine adenovirus as vector, the VP1 cDNA of Foot-and-Mouth Disease Virus (FMDV) type O strain China 99 was amplified by RT-PCR and cloned into pEGFP-C1 by replacing the GFP gene with the VP1 cDNA, resulting in an expression plasmid pVP1-C1. The expression cassette of VP1 composed of the CMV promoter, the VP1 gene and the SV40 early mRNA polyadenylation signal was recovered by Nsi I / Mlu I digestion of pVP1-C1 and cloned into the Canine adenovirus type-2 (CAV-2) genome in which E3 region was partly deleted by removing the Ssp I- Ssp I fragment. The recombinant virus (CAV-2-VP1) was obtained by transfecting the recombinant CAV-2-VP1 genome into MDCK cells with Lipofectamine 2000. Immunization trial in pigs with the recombinant virus, CAV-2-VP1, showed that CAV-2-VP1 could stimulate a specific immune response to both FMDV and the vector virus. Immune response to the VP1 and FMDV after VP1 expression was confirmed by ELISA, western blotting analysis and neutralization test. It was indicated that CAV-2 may serve as a vector for FMD vaccine development in pigs.

Adenoviruses, Canine↗
PubMed1998

An orthotopic floor-of-mouth cancer model allows quantification of tumor invasion.

OBJECTIVES: To establish an orthotopic murine floor-of-mouth cancer model for the analysis of the role of proteases such as urokinase-type plasminogen activator (u-PA) and the matrix metalloprotease MMP-9 (MMP-9) in in vivo invasion. STUDY DESIGN: Randomized, prospective animal study. METHODS: Two human squamous cell carcinoma cell lines, UM-SCC-1 and 022, were assayed via zymography for their in vitro secretion levels of u-PA and MMP-9. Both cell lines (5 x 10(6) cells) were injected into the cervical subcutaneous tissues of female athymic nude (nu/nu) mice superficial to the mylohyoid muscle. Mice were sacrificed after 30 days, and tumor invasion characteristics were histologically compared. Additional mice were then inoculated with invasive UM-SCC-1 cells and sacrificed 10, 30, and 40 days after inoculation to identify distinct stages of invasion. RESULTS: In vitro secretion levels of MMP-9 and activity of u-PA were higher in UM-SCC-1 cells than in 022 cells. In the in vivo studies, tumors formed from 022 cells were found to be noninvasive, whereas tumors derived from UM-SCC-1 cells progressed through distinct and readily identifiable histologic stages of invasion. These stages included invasion of adjacent muscle layers (mylohyoid, geniohyoid, and genioglossus muscles) and of associated structures (blood vessels, bone, nerve, and regional lymph nodes). A staging system was devised accordingly. CONCLUSION: We developed an in vivo quantitative cancer invasion model that allows determination of the effect of the expression and activity levels of the proteases MMP-9 and u-PA. Tumor invasion occurred in an orderly and stepwise fashion involving muscles and related vascular, nervous, and bony structures of the floor of the mouth and tongue. This orderly invasion allowed the development of a staging system. We anticipate that this model will have wide applicability in the study of in vivo tumor response to a variety of novel therapeutic approaches.

Animals↗
PubMed1977

Lip and laryngeal flaps for reconstruction of the floor of the mouth following glossectomy.

Following glossectomy, the reconstruction of the floor of the mouth is a major problem facing the head and neck surgeon. We have devised split-lip and laryngeal mucosal flaps for this. In selected patients, they have a significant advantage over distant skin flaps. The initial postoperative deformity, from the lip being drawn into the mouth, is corrected by a secondary operation with split-skin graft reconstruction of the vestibule. These lip and laryngeal flaps do not require a delay procedure prior to the cancer surgery, and the operating time is considerably reduced. The cosmetic and functional results have been satisfactory.

Glossectomy↗
PubMed2002

Serial passage of foot-and-mouth disease virus in sheep reveals declining levels of viraemia over time.

If an infectious agent is to maintain itself within a closed population by means of an unbroken serial chain of infections, it must maintain the level of infectiousness of individuals through time, or termination of the transmission chain is inevitable. One possible cause of diminution in infectiousness along serial chains of transmission may be that individuals are unable to amplify and transmit comparable levels of the infectious agent. Here, the results are reported of a novel experiment designed specifically to assess the effects of serial passage of foot-and-mouth disease virus (FMDV) in experimental groups of sheep. A virus isolate taken from an epidemic of foot-and-mouth disease (FMD) characterized by rapid fade-out of infection was passed serially through four groups of sheep housed in an isolation unit. Although it was not possible to measure individual infectiousness directly, blood virus load from infected individuals was quantified using a real-time PCR assay and used as an underlying indicator of the level of infection. The results of this assay concurred well with those of the traditional tissue-culture assay and were shown to be highly repeatable. The level of peak viraemia was shown to fall significantly with the time of infection and with passage group, both in terms of the group mean and regression analysis of individual values, suggesting that this isolate of FMDV may, under certain conditions, be unable to maintain itself indefinitely in susceptible sheep populations. The results of these experiments are discussed in terms of the epidemiology of FMD in sheep.

Animals↗
PubMed2005

Analysis of the epidemiological dynamics during the 1982-1983 epidemic of foot-and-mouth disease in Denmark based on molecular high-resolution strain identification.

An epidemic of foot-and-mouth disease (FMD) causing a total of 23 cases in 1982-1983, primarily on the island of Funen, Denmark, was subjected to molecular epidemiological investigations. In an attempt to exploit the quasi-species nature of foot-and-mouth disease virus strains for molecular high-resolution strain identification in order to analyse the dynamics of this epidemic, full-length VP1 coding regions were sequenced for 17 isolates collected at different farms during the epidemic. The sequence information together with epidemiological information gathered during the epidemic suggests that the epidemic was caused by at least three introductions across Danish borders and one case of airborne transmission between two islands in Denmark over a distance of 70 km. The assortment of nucleotide markers among the three strains is indicative of common recombination events in their evolutionary history, and the prerequisite of co- or superinfection of animals with variant strains in turn implies that they have a common source or epidemiologically related sources originating from an area with endemic FMD.

Animals↗