International alliances for quantitative modeling in systems biology.
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Genome sequence data are enabling clinical genomic investigation, in which the characteristics of human patients are explored using comprehensive inventories of biomolecules. Successful investigators must navigate rapid technological change, collect and analyse large volumes of data, and engage systems of clinical care. Such projects will increasingly rely on fully integrated multidisciplinary teams, demanding new organizational models in academic biomedical research.
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Membrane and organelle assembly has emerged as a dominant theme in cell biology of the twenty-first century. Current approaches and questions have been formulated as a result of numerous historical threads that together weave a complex picture of cellular compartments. The confluence of morphologic, genetic and biochemical approaches laid the foundations for study in this area, and they continue to strengthen our understanding of this essential aspect of cell structure and function.
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On the genetics timeline, the first complete sequence of a free-living organism, that of the bacterium Haemophilus influenzae in 1995, was finished 130 years after Gregor Mendel published the results of his famous pea-breeding experiment. Since that sequence, others have followed thick and fast, including those of the nematode Caenorhabditis elegans, the fruitfly, humans and now the dog. But each sequence alone cannot provide researchers with much information about the organism. For that, they have to go through the painstaking process of knocking out genes, one at a time, and observing how these deletions affect biological function.
When high-throughput screening of proteins and genes made its debut, it was the darling of industry--but new academic facilities are now being set up to make the expensive technology involved available to researchers. As a result, new institutes are recruiting scientists to liaise between academia and industry; and industry, in turn, continues to seek graduates and postdocs--as long as they are fresh thinkers with multiple skills. In addition, centres are being set up to train students in the latest technologies.
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