Cutaneous listeriosis.
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A dairy herd experienced an abortion epidemic during which 43 per cent of the cows at risk aborted. Neospora caninum infection was demonstrated in four of six fetuses suitable for examination and the group of at-risk cows that aborted had significantly higher N. caninum antibody concentrations than the at-risk cows that delivered a live calf at term (P<0.001). The antibody concentrations in the cow herd were significantly higher than in the youngstock (P<0.001), and the concentrations in the youngstock increased significantly (P<0.001) with age. When seven months to a year old, the calves born at term to the at-risk cows had significantly higher (P=0.007) antibody concentrations than age-matched calves born before the epidemic. At the time of the epidemic, there was a significant increase in the antibody levels of the herd that was not consistent with vertical infection alone, indicating that there appeared to have been a sudden large increase in the incidence of horizontal postnatal transmission of N. caninum to the cow herd, or to the surviving offspring of the at-risk cows, or to both of these groups.
Intravenous inoculation of Histophilus ovis to pregnant ewes at mid or late gestation resulted in acute bacterial endometritis, placentitis and foetal death. There were no lesions in the foetuses but H. ovis was recovered from the uteri of the ewes and the placentas. Oral or intravaginal administration had no effect.
Neonatal herpes simplex virus (HSV) infection is considered to be rare in the UK, affecting less than 3 per 100,000 live births, but the true incidence is probably higher due to under-reporting. In contrast, neonatal HSV infection is more common in the USA affecting 1 per 7500 live births overall. Infection in neonates is frequently serious and may be fatal.
The epidemiology of leptospirosis in Iowa swine was examined on the basis of serologic results and herd data from 55 herds in the National Animal Health Monitoring System (NAHMS) program and culture results and histories from 578 cases of reproductive failure submitted to the Iowa Veterinary Diagnostic Laboratory during a 3-year period. Thirty-eight percent of sera from NAHMS herds contained antibodies against 1 or more of 12 leptospira antigens. Leptospires were isolated from 9 (1.6%) of 578 cases of reproductive failure. Seven (78%) of the isolates were identified as Leptospira interrogans serovar kennewicki and 2 (22%) as serovar grippotyphosa. In 7 herds from which leptospires were isolated, attack rates ranged from 1% to 84%. Clinical leptospirosis, characterized by reproductive failure and confirmed by isolation of leptospires, was sporadic. No significant differences in farrowing averages and reproductive problems were observed between vaccinated and nonvaccinated NAHMS herds or between herds with higher (43-63%) or lower (14-40%) percentages of animals that were serologically positive against serovar bratislava.
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OBJECTIVES: This study examined risk factors for congenital syphilis in South Carolina. METHODS: Case infants with presumptive and confirmed congenital syphilis were compared with control infants born to women with reactive serologies during pregnancy, allowing investigation of risk factors for congenital rather than acquired transmission of syphilis. Data were collected from congenital syphilis report forms and birth certificates for 186 case infants and 487 controls born from 1991 to 1993. Odds ratios were calculated for maternal risk factors. RESULTS: Significant statistical trends were found for timing of first prenatal visit and number of visits. Other significant factors included rural residence (odds ratio [OR] = 2.0, 95% confidence interval [CI] = 1.4, 2.9) and previous pregnancy loss (OR = 0.3, 95% CI = 0.2, 0.6). CONCLUSIONS: Prevention of congenital syphilis may be less effective among pregnant women with syphilis in South Carolina who have fewer prenatal care visits. Health care providers need further education on maternal/child syphilis management and techniques for motivating and educating patients.
OBJECTIVE: To examine the relationship between exposure to Neospora caninum and abortion in dairy cows during their first, second, third, and fourth or later lactations and to establish the main mode of transmission in female calves from birth until their first pregnancy was terminated by abortion or parturition. DESIGN: Prospective observational study. ANIMALS: 460 Holstein cows and 79 female calves. PROCEDURE: Cows were classified as seropositive or seronegative to N caninum within 7 days after calving; incidence of abortion was compared between groups during different lactations. Blood samples were collected from female calves before ingestion of colostrum and every 6 months until their first pregnancy was terminated by abortion or parturition; number of seropositive calves was compared between seropositive and seronegative dams. RESULTS: During the first pregnancy of their second lactation, risk of abortion for seropositive cows was 2.8 times that of seronegative cows. Among 10 calves born to seropositive cows, 4 were classified as seropositive at birth and thereafter. Among 69 calves born to seronegative cows, all were classified as seronegative at birth; 67 calves remained seronegative thereafter. CONCLUSIONS AND CLINICAL RELEVANCE: Exposure to N caninum alone was not significantly associated with abortion in cows during the first, third, and fourth or later lactations. Seropositive cows that have aborted previously may have subsequent abortions attributable to N caninum. Congenital infection was the main mode of N caninum transmission in a cohort of female calves.
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The pathogenicity of Brucella suis biovar 4 for bison (Bison bison) was evaluated by inoculation of 2.1 x 10(7) colony forming units (CFU) in 0.1 ml saline into the conjunctival sac of six pregnant cows. Six pregnant bison were inoculated with 1.27 x 10(7) CFU of Brucella abortus strain 2308 as a positive control. Bison were inoculated on 23 January 1992, and observed until calving or abortion after which they were euthanized, and necropsied. Bacteriological and histological examinations were conducted on lymph nodes, reproductive tract, mammary gland, and internal organs. Terminal serum samples from calves and cows were evaluated by card, rivanol precipitation, standard tube agglutination, cold complement fixation tube, indirect bison conjugated enzyme linked immunosorbent assay (ELISA), competitive ELISA, and particle-concentration fluorescence immunoassay. No clinical signs of brucellosis were seen in bison inoculated with B. suis biovar 4, and infection was found only in lymph nodes of two animals. There was no evidence of metastasis of this organism to the mammary gland or the reproductive tract. There were no detectable levels of antibodies to Brucella spp. in terminal blood samples taken from B. suis biovar 4-challenged bison. Brucella abortus was isolated from several tissues in all control bison. All B. abortus-challenged animals developed uterine infection and five developed mammary gland infection. Reproductive disease resulted in abortions in five B. abortus-challenged bison and neonatal death in the remaining calf. Brucella suis biovar 4 does not appear to be pathogenic for bison.
Preventing pregnancy in brucellosis-infected bison (Bison bison) provides a potential means of preventing transmission of disease. To determine whether a gonadotropin-releasing hormone (GnRH) vaccine was effective in reducing pregnancy in bison and to study the safety of injecting GnRH in pregnant bison, a study was conducted at the Idaho Fish and Game Wildlife Health Laboratory in Caldwell, Idaho (USA). Four pregnant and two nonpregnant female bison were given a single injection of GnRH vaccine, and five pregnant adult females were given a sham injection that contained only adjuvant. Three of the GnRH-vaccinated bison that were pregnant at the time of vaccination delivered healthy calves. One treated bison had dystocia that resulted in a dead calf. All control bison delivered healthy calves. After calving, females of both groups were exposed to two bulls. Treated bison were palpated 6 wk after exposure to the bulls, and blood was drawn for pregnancy-specific protein B analysis. The six treated bison were not pregnant. The sham-treated bison became pregnant and delivered viable calves. This study demonstrates that a single dose of GnRH vaccine is effective in preventing pregnancy in female bison for at least 1 yr.
The equine virus arteritis (EVA) consistently epidemically varying throughout the different breeds of the horse breeding countries is up to now only of lower significance by means of the typical clinical manifestation as well as an abortion causing factor. The susceptibility of the sexual mature stallions against the equine arteritis virus (EAV) causes different infection response which may lead to some restrictions in their use in natural breeding especially in the artificial insemination. In a certain not precisely predictable part of the stallion population EAV infection will cause a transient or permanent virus presence in the accessorial apparatus of the genital tract with transient or permanent shedding of the virus via seminal secretions. This makes the stallion to one of the dominant factors of the propagation of the field virus. The use of EAV shedding stallions in natural breeding or AI is very risky and only justifiable under certain precautions and additional measurements e.g. in EAV-seropositive or vaccinated mares. A consistent progress in the defeat of the disease can be expected from vaccination of the seronegative stallions with dead or inactivated live vaccines as they are considered to be able to prevent the establishing of EAV shedder status.
The prevalence of Rubella-IgG antibody was assessed in 152 Nigerian women consisting of 62 pregnant women. 82 non-pregnant women of childbearing age and 7 women who had suffered miscarriage. Rubella-IgG antibody was detected in sera of the female subjects by Immunocomb II Rubella IgG test kit (Orgenics, Israel) which is an indirect solid face Immunoassay (EIA). Rubella-IgG antibody was detected in 76% of pregnant women, 77% of non-pregnant women of childbearing age and 86% of women who had miscarriage. Similarly, the Rubella-IgG antibody titres of between 15 iu/ml and 120 iu/ml was encountered among the female subjects. Thus in general 77% of all the female subjects were positive for Rubella-IgG antibody while 23% had no detectable Rubella IgG antibody. There is need to protect this set of people considering the potential dangers of congenital anomalies associated with Rubella infection during pregnancy. The implications of the presence or absence of Rubella IgG antibody and titres are discussed.
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The article describes present knowledge of teratogenicity, which final manifestation are functional disorders, growth retardation, fetal carcinogenesis, malformation and death.
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