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PubMed1986

Transitional (cylindric) cell carcinoma with endodermal sinus tumor-like features of the nasopharynx and paranasal sinuses. Clinicopathologic and immunohistochemical study of two cases.

We report two cases of adult patients with primary tumors in the nasopharynx and paranasal sinuses, which were characterized histologically by areas of transitional cell (cylindric or "schneiderian") carcinoma and other foci virtually indistinguishable from endodermal sinus tumor (yolk sac carcinoma). Immunohistochemical studies supported the impression of yolk sac differentiation. Both patients were treated with irradiation and multidrug chemotherapy. One patient died of uncontrollable recurrence of tumor, whereas the other developed locally recurrent, transitional cell carcinoma in the absence of yolk sac tumor. The concurrence of these patterns of carcinoma, which has been undescribed previously to the best of our knowledge, seems to be associated with more aggressive biologic behavior than pure transitional cell carcinomas of this region.

Adult↗
PubMed1979

Recurrent endodermal sinus tumor during pregnancy.

A case is reported of a patient who was found to have an endodermal sinus tumor coincident with pregnancy. She maintained a complete clinical response for 12 months after conservative surgery, uterine aspiration, and multiple-agent chemotherapy. Tumor recurrence appeared with a second pregnancy. A healthy infant was delivered despite resumption of chemotherapy. The use of cytotoxic chemotherapy during pregnancy is reviewed.

Adolescent↗
PubMed1976

Association of endodermal sinus tumour, testicular teratoma and alpha1-fetoprotein.

An endodermal sinus tumour in the retroperitoneal region was associated with the presence of alpha1-fetoprotein (AFP) in the patient's serum. At autopsy a simple cystic teratoma of the right testicle was also found. The association of these two tumours has been reported before. The classification of these malignant germ-cell tumours and an understanding of their evolution may be aided by the discovery that AFP is often found in the patient's serum.

Adult↗
PubMed1980

Endodermal sinus tumor arising in the endometrium.

A case of primary endodermal sinus tumor (EST) of the endometrium in a 28-year-old woman is described. EST has been reported to arise in several extragonadal sites, but to the authors' knowledge this is the first documented instance of origin in the endometrium. The histologic study is verified by the detection of alpha-fetoprotein in the tumor by an immunoperoxidase-peroxidase-antiperoxidase technique reported here. Displaced germinal cells, abnormal ovum, and residual fetal tissues are considered as possible origins of the neoplasia.

Adult↗
PubMed1981

Endodermal sinus tumor of the ovary.

Endodermal sinus tumor (EST) of the ovary is a germ cell tumor that is now recognized more frequently than in the past. Since problems concerning natural history, prognosis and therapy of these neoplasms are not entirely resolved, it should be underlined the need to report new cases. The authors describe four cases of EST with reference to serial alphafetoprotein determination by radioimmunoassay; they also emphasize the importance of this technique as a very sensitive method in monitoring therapy and in detecting recurrences of disease even before any clinical evidence.

Adolescent↗
PubMed1983

Endodermal sinus tumor of the ovary: the M. D. Anderson experience.

Forty-one patients with pure endodermal sinus tumor of the ovary who were treated at the M. D. Anderson Hospital from 1944 to 1981 are retrospectively reviewed. The median age of these patients was 19 years. The most common presenting symptom was abdominal pain, occurring in 33 patients (80%). No bilateral ovarian involvement was noted at initial surgery. With the exception of 1 patient treated by surgery alone, only patients treated with postoperative combination chemotherapy survived. Twenty-one of the 41 patients are alive and well. Sixteen of 22 patients treated with vincristine, actinomycin-D, and cyclophosphamide have survived. The roles of second-look laparotomy and alpha-fetoprotein monitoring are discussed. Optimal treatment seems to consist of surgery followed by aggressive combination chemotherapy.

Adolescent↗
PubMed1984

[Endodermal sinus tumor of the ovary--clinical aspects and therapy].

Pathomorphology, clinic and therapy of endodermal sinus tumor in pregnancy are explained and discussed by means of a women of 25 years. The importance of estimation of alpha-fetoprotein with regard to diagnosis and follow up is referred, too. The prognosis in former times very bad could be improved by a combination of radical surgery and polychemotherapy.

Adult↗
PubMedDate not supplied

Peritoneal implantation of endodermal sinus tumor of the pineal region via a ventriculoperitoneal shunt. Cytodiagnosis with immunocytochemical demonstration of alpha-fetoprotein.

A 17-year-old male developed an endodermal sinus tumor in the pineal region that metastasized to the peritoneal cavity via a ventriculoperitoneal shunt and caused ascites. Neoplasm was diagnosed by cytologic examination of the peritoneal fluid, and the precise histologic nature of the neoplasm was confirmed by immunocytochemistry, which demonstrated alpha-fetoprotein in the neoplastic cells.

Adolescent↗
PubMed1984

[Clinical aspects of ovarian endodermal sinus tumor].

To study the clinical characteristics of ovarian endodermal sinus tumor, 22 patients with this disease who were managed at the Kurume University Hospital from 1970 to 1983 are analysed retrospectively. Before 1977 the patients received mainly radiation therapy as a postoperative treatment, and only two of 13 patients during this period survived. After 1978, multi-drug combination chemotherapy brought a remarkable improvement in the prognosis showing six survival cases out of 8 patients, and four of them are still alive with no evidence of the disease. Although the therapeutic efficacy of the combination of vincristine, actinomycin D and cyclophosphamide, or cis-diamminedichloroplatinum, vinblastine and bleomycin was evident as previously reported, half of the cases achieved a drug-resistance against these regimens during the first line therapy and this required a change in the program. Further, two drop out cases caused by the severe side effects of these aggressive treatment were noted. The best treatment for malignant germ cell tumors is not yet known, and a more effective and acceptable program is demanded to attain the goal of chemotherapy.

Adolescent↗
PubMed1984

[Primary intracranial endodermal sinus tumor with a skull base extension--a case report].

The authors described a case of primary intracranial endodermal sinus tumor (EST), and presented a review of 24 reported cases. From the middle of December 1981, this 15-year-old boy experienced progressive diplopia. At the other hospital, partial removal of the intrasellar tumor was performed by a left frontotemporal craniotomy approximately 2 months after the onset of symptoms. The histological diagnosis was suspected to be a pituitary adenoma, and thereafter, 60Co irradiation was carried out for about a month. On June 5th. 1982, the patient was admitted to the Kochi Medical School Hospital, because of increasing headache with diplopia, hoarseness, dysphagia and limitation of tongue movement. On admission, he had a small stature for his age with moderate diabetes insipidus. Neurological examination showed left abducens, glossopharyngeal and vagal nerve palsies in addition to bitemporal hemianopsia. CT scans revealed a heterogenously enhanced high density mass lesion behind the dorsum sellae with an extension from the upper clivus to the sphenoid sinus. Cerebral angiograms showed posterior displacement of the basilar artery. In the endocrinological examination, panhypopituitarism was recognized with a high level of serum alfa-fetoprotein (AFP). While, serum carcinoembryonic antigen (CEA) and human chorionic gonadotropin (HCG) were in normal range. On July 1st. 1982, a left suboccipital craniectomy was performed. The tumor existed mainly in the extradural space along the clivus, and only a small intradural portion of the tumor was excited.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

[Modified VAB-3 combination chemotherapy of stage IV endodermal sinus tumor of the ovary].

A case of pure endodermal sinus tumor (EST) of the ovary with huge multiple liver metastases was treated with modified VAB-3 protocol. Serum alpha-fetoprotein (AFP) before treatment was 137,775 ng/ml. A complete clinical response was achieved with rapid shrinkage of liver metastases and normalization of serum AFP. Second-look laparotomy preformed 17 months after the start of chemotherapy revealed no evidence of disease. VAB-3 combination chemotherapy, which was proved to be very effective in the treatment of metastatic testicular cancer, also seems to be effective in the treatment of advanced EST of the ovary. This is believed to be the first detailed report of the successful management of advanced EST of the ovary.

Adult↗
PubMed1976

[Primary combined chemotherapy following removal of an endodermal sinus tumor or yolk-sac tumor of the ovary (author's transl)].

The yolk-sac tumor or endodermal sinus tumor is a rare but highly malignant ovarian teratoma with its highest incidence in young women. The tumor is relatively resistant to radiotherapy but sensitive to combined chemotherapy and should therefore be differentiated in the diagnosis from embryonal carcinoma and radio-sensitive dysgerminomas of the ovary. It is possible that the determination of alpha-fetoprotein is of differential diagnostic value. Two patients are alive and well 8 months and 2 1/2 years following removal of a yolk-sac tumor and primary chemotherapy. One patient received chemotherapy for peritoneal recurrence after removal of the tumor and radiotherapy. She died 1 1/2 years following the primary operation. Long term chemotherapy of the yolk-sac tumor is indicated following operation, irrespective of the stage of the tumor.

Adult↗
PubMed1984

[Endodermal sinus tumor--a contribution to the clinical aspects of ovarian tumors].

Two cases of endodermal sinus tumor (EST) are described in a 19-year-old girl and a 50-year-old menopausal women, respectively. Exstirpation uteri totalis cum adnexis was carried out in both cases. According to the FIGO the tumors were classified as Ic. The histologic diagnosis of EST was based on the presence of elements such as extraembryonic mesoderm, yolk sac mesoderm, vascular structures with Schiller-Duval bodies, PAS-positive globules in Duval sinus spaces. In the first case, where the proposed chemotherapy was refused, the patient died 4 months later with symptoms of abdominal metastases. In the other case, chemotherapy was applied according to the VAC program. At 13 months of the treatment a relaparotomy was made and the lymphatic nodes taken showed no metastases. Three months later, the tumor relapsed and the patient died at 22 months of the therapy. In the light of their observations and literature data the authors recommended a radical surgical intervention combined with intense polychemotherapy as the only effective approach to the problem.

Adult↗
PubMed1982

[Development of the adenylate cyclase activity of the embryonic chorda-mesoderm and endoderm during the migration of primordial germ cells in Xenopus laevis (anuran amphibian)].

In the embryo of Xenopus laevis, adenylate cyclase activity is higher in the chorda-mesoderm than in the endoderm. The peak of activity in the chorda-mesoderm is observed at the beginning of the migration of the primordial germ cells (PGC). There could be a correlation between the adenylate cyclase activity of the chorda-mesoderm and the intraendodermic migration of the PGC.

Adenylyl Cyclases↗
PubMed1978

131I uptake of one-day old chicken endodermal organs.

In the one-day old chicken, the organs of endodermal origin, these the thymus, trachea, lung, and intestine take up significantly more iodine than the muscles which are of mesodermal origin. The thymus shows an especially high iodine incorporation, amounting in absolute values to that of the thyroid gland. An organ accumulates the more iodine, the closer to the thyroid its anlage is situated and vice-versa.

Age Factors↗