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PubMed1977

[TNM-system orientated radiological therapy in prostatic carcinoma (author's transl)].

The classification of prostatic cancer according to the TNM-system in contrast to the older staging systems results in a change in radiological therapy planing. The radiological techniques for the classification of N (lymphnodes) and M (metastases) are explained. Together with T (local tumore growth) these categories define the outline for the radiological therapy. The different radiation techniques are explained.

Bone Neoplasms↗
PubMedDate not supplied

[Multicellular spheroids for use in radiobiological experiments].

Cell spheroids are conglomerates of closely arranged cells with reciprocal effects among them. Spheroids are histologically similar to nodulary tumours. Cells constituting these spheroids are heterogenous in their sensitivity to X-rays and fast neutrons. Radiosensitivity of cells in a small spheroid is lower than that of similar cells grown in a monolayer.

Cell Survival↗
PubMed1983

Comparison of the physical characteristics of I-131 and I-123, with respect to differentiating the relative activity in the kidneys.

Iodine-123 (159 keV, T1/2 = 13.3 hr) has been proposed for renal investigations, as opposed to I-131 (364 keV, T1/2 = 8.06 days), because of its more practical photon energy and lower radiation dose to the patient. The cyclotron production method 124Te (p,2n) 123I for I-123 results in contamination with I-124 (T1/2 = 4.5 days). The latter emits high-energy photons whose relative abundance increases with time after end of bombardment (EOB). This paper is an evaluation of the effects of photon penetration, scatter, and attenuation on the phantom calibration measurements required for determining relative renal uptake using I-123. Measurements using I-131 were performed for comparison. Parameters investigated included: (a) the relationship between the integrated count and ROI size, (b) the magnitude of the "cross-talk" in counts between the kidneys, and (c) the attenuation corrections for source (kidney) depth. Phantom results obtained for I-123 suggest that this radionuclide will allow a better measurement of the activity in individual kidneys. Collimator penetration effects were greater for I-131 than for I-123. With I-123 for example, a higher fraction of the counts due to the activity in the kidney phantom were observed within the ROI enclosing its image. However, the attenuation corrections for source depth for I-123 were dependent on both the size of the ROI and time after EOB.

Animals↗