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At least 1,027 records · Page 57Linked to original sources
PubMed2005

[Changes of cardiac electrophysiological parameters after destruction of epicardial nervous plexi innervating sinoatrial node].

Electrophysiological methods were used in experiments on 15 dogs for the study of topography of right atrial epicardial nerves, their connections with sinoatrial node, and possibilities of selective surgical denervation of sinoatrial node. Epicardial nerves were electro-coagulated or cryo-destructed in ventral, lateral and dorsal atrial zones near base of vena cava inferior. The following parameters were registered: heart rate, time of restoration of sinus node function, conduction through atrioventricular node, refractoriness of atria and atrioventricular node. Comparison of cardiac parameters before and after destruction of epicardial nerves showed that in lateral and ventral zones sympathetic nerves reach sinus node through lateral and ventral zones while parasympathetic -- along dorsal zone. Selective surgical destruction allows to modify sinus node function in a desired way.

Animals↗
PubMed2006

[Preservation of the autonomic nerve in rectal cancer surgery: anatomical factors in ligation of the inferior mesenteric artery].

OBJECTIVE: To evaluate the regional anatomy between the abdominal autonomic nerves including the abdominal aortic plexus (AAP) and the inferior mesenteric artery (IMA), and explore the safe ligation point on the IMA and the optimal dissection method to avoid autonomic nerve injuries. METHODS AND RESULTS: Dissections and observation were carried out on 16 fixed male cadavers. The AAP located in the thin fascia layer covering the surface of the aorta and its branches. No autonomic nerves were found in the area around the root of the IMA, and the point where the IMA and the left trunk of the AAP intersected was highly variable. The left trunk of the AAP adhered more closely to the IMA than to the aorta. CONCLUSIONS: In view of autonomic nerve preservation, the only safe site for ligation of the IMA is at its origin, and no other such sites are available along the IMA trunk and its branches. The IMA and the posterior fascia layer containing the autonomic nerves constitute the optimal surgical plane for IMA ligation, which should be performed following skeletonization of the IMA with careful preservation of the integrity of the posterior fascia layer.

Autonomic Pathways↗
PubMed2006

[Total mesorectal excision and preservation of autonomic nerves].

The procedure of total mesorectal excision (TME) becomes a gold standard for the treatment of rectal cancer. The reason is the marvelously low incidence of local recurrence after TME even without other adjuvant treatment, which has been reported by several independent groups. Although controversy still exists about the role of TME in upper rectal cancer, it is now widely accepted for cancers of the middle and lower third. There are number of histopathological evidences that cancer cells can spread distally several centimeters from the lower margin of cancer, and cancer bearing lymph nodes are found in the distal portion of the mesorectal tissues far from the cancer. Therefore, the distal clearance of mesorectum should be performed downwardly to the level of pelvic diaphragm (puborectalis) and the rectum is divided within a few centimeters from the pelvic floor musculature. TME defines an en-bloc procedure, along the plane between parietal and visceral pelvic fasciae. If the dissection plane is breached, the chance of visceral pelvic fascia tearing is raised and mesorectal tissue might reside in the pelvis. There are problems in auditing the procedure. As many surgeons agree, this procedure requires a learning curve. Theoretically, the autonomic nerves run between the visceral and parietal pelvic fasciae since the nerves must be preserved to make visceral fascial envelop. Any patient who become incontinent or impotent after the surgery should have received decorticating surgery other than TME. Thus, the high quality of TME should fulfill two clinical measurements: absence of impotence or incontinence and at least single digit, 5-year, cumulative recurrence rate regardless of adjuvant therapy.

Autonomic Pathways↗
PubMed2006

[Innervation of adrenal glands in some types of cardiovascular pathology].

We examined adrenal glands obtained at early autopsy of 56 men aged 21-70 years. According to the age five groups of cases were distinguished. The study was performed with the use of methods of silver impregnation of nerve plexuses and planimetric pointcounting. Density of nerve plexuses in adrenal medulla was significantly increased by 30 years of age due to the development of nervous relations in this organ. After age of 30 years density of nerve plexuses in adrenal medulla remained relatively stable providing high morphofunctional activity of adrenal glands. Morphological and morphometrical changes in nervous plexuses of adrenal medulla of patients were associated with cardiovascular diseases.

Adrenal Glands↗
PubMedDate not supplied

Peripheral neurons innervating the extrinsic smooth penile musculature of the pig: experimental study by retrograde transport and immunohistochemistry.

Peripheral autonomic and sensitive neurons projecting to the extrinsic smooth penile musculature of the pig were studied by means of retrograde tracing and single-labelling immunofluorescence methods. The fluorescent retrograde tracer Fast Blue was injected into the left retractor penis muscle, that was taken as an experimental model of the male genital smooth musculature, of 4 castrated pigs. After a 7 day survival time, the ipsilateral paravertebral ganglion S1, the caudal mesenteric ganglion and the dorsal root ganglion S2 were collected. In these ganglia, the presence and the distribution of immunoreactivities to cathecolamine- (Tyrosine Hydroxylase), acetylcholine- (Vesicular Acetylcholine Transporter), or nitric oxide-synthesizing (neuronal Nitric Oxide Synthase) enzymes and to some biologically active peptides (Calcitonine Gene-Related Peptide, Leu-Enkephaline, Neuropeptide Y, Substance P and Vasoactive Intestinal Peptide) were studied. In paravertebral ganglion S1, Tyrosine Hydroxylase and Neuropeptide Y were the most frequently present substances. Also Leu-Enkephaline and neuronal Nitric Oxide were present quite frequently, while there was scarce immunoreactivity for the other antisera (in decreasing order Substance P, Vasoactive Intestinal Peptide, Vesicular Acetylcholine Transporter, Calcitonine Gene-Related Peptide). In caudal mesenteric ganglion, in addition to Tyrosine Hydroxylase- and Neuropeptide Y-immunoreactivity, Substance P-, Vesicular Acetylcholine Transporter-, Vasoactive Intestinal Peptide-, Leu-Enkephaline- immunoreactivity were also frequently present, followed by neuronal Nitric Oxide- and Calcitonine Gene-Related Peptide- immunoreactivity. In dorsal root ganglion S2, Calcitonine Gene-Related Peptide and neuronal Nitric Oxide resulted to be the most frequently present neurotransmitters, followed by Vasoactive Intestinal Peptide, Vesicular Acetylcholine Transporter, Leu-Enkephaline, Substance P, Tyrosine Hydroxylase and Neuropeptide Y.

Animals↗
PubMedDate not supplied

Long-term survival and recurrences after total nerve-sparing surgery for rectal cancer.

BACKGROUND/AIMS: In advanced extraperitoneal rectal cancer Japanese surgeons perform the lateral pelvic nodal dissection with only partial pelvic autonomic nerves preservation; instead most Western surgeons prefer the total mesorectal excision (TME) with complete pelvic nerve sparing except for evident neoplastic nervous involvement. Long-term oncological results of the total nerve-sparing TME are reported. METHODOLOGY: From January 1992 to October 1998 71 [corrected] patients with extraperitoneal rectal carcinoma underwent TME with total nerve sparing except in two cases in which only a partial sparing was possible because of macroscopic neoplastic nervous infiltration: 54 anterior resections and 17 abdominoperineal resections were performed. Sixty-one curatively operated patients (9 stage I, 20 stage II, 29 stage III and 3 stage IV) were included. RESULTS: No postoperative death occurred. Postoperative radiochemotherapy was performed in 31 cases, radiotherapy in 9 cases and chemotherapy in 9 cases. The mean follow-up was 98.7 months. The 5-year overall and disease-free survival rates were 88.8% and 77.7%, 90% and 75.1%, 62.3% and 45% for stage I, II and III respectively. The 8-year actuarial overall and disease-free survival rates were 77.7% and 77.7%, 78.3% and 75.1%, 50.4% and 40% for stage I, II and III respectively. Local failures with or without distant metastases were 6 (9.8%). CONCLUSIONS: Total nerve-sparing surgery is not contraindicated unless grossly neoplastic involvement is present.

Adult↗
PubMed1990

Tinnitus. I: Auditory mechanisms: a model for tinnitus and hearing impairment.

A model is proposed for tinnitus and sensorineural hearing loss involving cochlear pathology. As tinnitus is defined as a cortical perception of sound in the absence of an appropriate external stimulus it must result from a generator in the auditory system which undergoes extensive auditory processing before it is perceived. The concept of spatial nonlinearity in the cochlea is presented as a cause of tinnitus generation controlled by the efferents. Various clinical presentations of tinnitus and the way in which they respond to changes in the environment are discussed with respect to this control mechanism. The concept of auditory retraining as part of the habituation process, and interaction with the prefrontal cortex and limbic system is presented as a central model which emphasizes the importance of the emotional significance and meaning of tinnitus.

Auditory Pathways↗
PubMed1989

[Measurement of blood glucose variations due to surgical stress].

It has been confirmed that the oral surgical invasion not only arouses emotions, such as anxiety and fear, but causes physiological changes at the same time through 2 different pathways, the autonomic nervous system and endocrine system. The change in blood glucose concentration is known as one of representative vital reactions associated with these 2 functional systems. Although secure measurement manipulation producing errors as small as possible is essential to the comparison of blood glucose concentrations obtained from a same individual at different times, various errors are often made during specimen preparation and measurement. Resulting values of glucose concentration are known to be especially influenced by specimen pretreatment, kinds of specimens, meals, menstruation and anesthetics among factors affecting the measurement. Thus we determined these factors in order to establish a measurement procedure to produce the least errors. As a result, it was thought to be desirable that the measurement is performed using the following procedure: 1) blood is sampled more than 90 minutes after meal; 2) whole blood collected from the median basilic vein is used as a specimen; 3) measurement is performed as soon as possible, within 60 minutes after sampling; 4) quantitative values of blood glucose concentration are obtained using dextrosticks and a dextrometer; 5) every specimen is measured 5 time to obtain a mean value used as blood glucose concentration in that specimen through averaging 3 measurement values, omitting the highest and lowest values, and 6) as for female patients, measurement (as well as operation) is performed on a day 2 weeks after the beginning of menstruation. It was concluded that blood glucose concentration can be used as a highly reliable parameter for the observation of vital reactions to external stimulation and for the determination of internal environment at a certain point of time if the measurement is performed with careful consideration of the above-mentioned factors.

Blood Glucose↗
PubMed1976

Gastric acid secretion, serum-gastrin levels and psychomotor function under the influence of placebo, insulin-hypoglycemia, and/or bromazepam.

Gastric acid output, blood-glucose, serum-gastrin and psychomotor-performance were measured in four healthy subjects one hour before and two hours after the intravenous injection of (a) 2ml saline, (b) 0.2 U/kg b.w. insulin, (c) 0.1 mg/kg b.w. bromazepam. Each subject underwent one experiment of each type. The study was layed out as a Latin-square and analysed accordingly. Gastric acid secretion was measured by means of intragastric titration and a telemetering capsule; blood-glucose and serum-gastrin levels as well as psychomotor performance as a measure of vigilance were determined in 15-minute-intervals. In the saline series (a), none of the four parameters showed any systematic variation. In series (b), a bimodal response of acid output to insulin, initial inhibition and subsequent stimulation was observed in all subjects. Serum-gastrin levels showed only a slight and transient increase in the first thirty minutes. Psychomotor performance decreased markedly with progressing hypoglycemia, and increased when glucose levels rose again. In the bromazepan series (c), acid output and psychomotor performance decreased and, after the first hour, increased almost parallely, while glucose and gastrin levels remained unchanged. In series (d), an additive effect of insulin and bromazepam occurred: acid output and psychomotor performance were lower than after insulin alone; peak acid secretion, maximal hypoglycemia and peak of serum-gastrin were shifted to the right. It is concluded that the lowered basal as well as insulin-stimulated acid secretion after bromazepam is due to the central effect of the drug, and that this effect is mediated to the gastric glands directly via autonomic nervous pathways without involving a release of endogenous gastrin.

Adult↗
PubMedDate not supplied

[Role of non-specific cerebral systems in the pathogenesis of thyroid gland diseases].

Ten patients with diffuse toxic goiter, 1-2 nd degree, ten ones with hypothyrosis of medium severity, and a group of healthy controls were examined. Manifest emotional, personality, and vegetative disorders were revealed in patients of both groups, as well as changes in the electrical activity of the brain and in status of the afferent systems of the brain, this being indicative of marked dysfunction of nonspecific cerebral systems in patients with thyroid diseases. Anxiety depressive emotional disorders and activation of the in-depth compartments of the membranous reticular complex were revealed in both groups of patients. These changes are nonspecific and appear to represent a common neurogenic mechanism of thyroid dysfunction. General activation of the brain and peripheral cerebral activation detected in patients with hyperthyroidism are secondary and result from effects of thyroid hormones on the nervous system.

Adult↗
PubMedDate not supplied

Autonomic nerve affection in leprosy.

Leprosy has been shown to affect almost all systems of human body and abnormalities in functions of autonomic nerves innervating various parts have been observed in several studies. In the skin and its appendages, the common changes are anhidrosis and varying degree of impaired sweat response. Signs of denervation of iris and reduced intraocular pressure are permanent features of autonomic involvement in the eye. In the cardiac autonomic functions, rhythm disturbances have been documented by several investigators. Respiratory function test studies have shown impaired breath holding time and decreased response to cough as well as other changes indicating blockade of vagus nerves and sympathetic plexus. Abnormal testicular pain sensation and diminished nocturnal penile tumiscence provide evidence of afflication of autonomic nerves of male genital system. Other important autonomic nervous system involvements include the nerves innervating the capillaries of legs. These changes have been observed to be more in extensive and long standing disease which indicate the need to study all these aspects in prospective studies specially in the light of early institution of multidrug treatment.

Autonomic Pathways↗
PubMed1996

Neurohistochemical evaluation of adrenergic innervation in fetal development of the white rat.

Physiological development of adrenergic innervation, an important component of trophic and homeostatic regulation in the mammals was estimated. Our research is directed to evaluate both exo- and endogenous factors contributing to its impairment. The present investigation was carried out on 32 rat fetuses from three various 7-day periods of gestation. Histochemical studies included reactions to catecholamines according to Falck and Owman, and silver staining with AgNO3 according to the Bielschowsky-Gros method. Adrenergic innervation was examined in all fetal body regions, with a special reference to the pelvis. Catecholamines distribution and accumulation in plexuses, ganglia, neurons and chromatophilic cells, as well as serotonine content in mast cells were analyzed. It was found that in the initial period of gestation noradrenaline is absent. In the third week of gestation, the neurotransmitter's accumulation takes place to subsequently decrease gradually until the end of gestation. From this stage synaptic connections of adrenergic innervation with chromatophilic and mast cells could be detected.

Adrenergic Fibers↗