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PubMed1984

[The effect of a tar admixture to dithranol-salicylic-acid-white-petrolatum therapy on the cytokinetics of psoriasis].

The initial stimulation of DNA-synthesis after application of dithranol as single agent is completely inhibited by addition of tar. The autoradiographic analyse indicates that the good clinical effect of the new antipsoriatic therapy with TCSV may be due to suppression of dithranol-caused irritation by tar. But, restored cytokinetic values do not correspond to clinical remission of psoriasis.

Adolescent↗
PubMed1980

Titratable acidities of crystalline amino acid admixtures.

Titration curves for total parenteral nutrient (TPN) products were developed and used to determine the amount of alkali needed to make various pH changes. Equations and graphs for determining the titratable acidities of TPN solutions are presented. Samples of five crystalline amino acid products and of 1:1 mixtures of the products with 50% dextrose solutions were titrated to pH 7.4 (with a standard sodium bicarbonate solution) or 8.0 (with a standard sodium hydroxide solution). The samples titrated with sodium hydroxide were first adjusted to pH 5.0 with hydrochloric acid. The pH of the sample was measured after each 0.1-ml addition of hydroxide or bicarbonate to develop a titration curve. Titratable acidities for the five crystalline amino acid products varied widely, ranging from 13.4--45.2 meq of hydroxide/liter and from 135--420 meq of bicarbonate/liter. The amino acid/dextrose mixtures had titratable acidities ranging from 7.8--24.8 meq of hydroxide/liter and from 87--226 meq of bicarbonate/liter. The pH titration data can be used as a guide for determining the amount of base to add to TPN solutions to obtain the desired pH.

Amino Acids↗
PubMed1982

Effect of freezing and microwave thawing on the stability of six antibiotic admixtures in plastic bags.

The stability of six antibiotics in intravenous fluids in polyvinyl chloride containers after freezing and microwave-thawing is reported. Tobramycin sulfate 160 mg, amikacin sulfate 1 g, ticarcillin disodium 3 g, clindamycin phosphate 300 mg, nafcillin sodium 1 g, and ampicillin sodium was also diluted in plastic bags of 0.9% sodium chloride injection 50 ml. For each antibiotic except ampicillin sodium, three bags were prepared and assayed immediately for antibiotic content. Two of the bags were frozen at -20 degrees C for 30 days and then thawed, one by exposure to room-temperature air and the other by microwave radiation. Each was assayed immediately and after 8 and 24 hours storage at room temperature. The third bag was not frozen, but was stored at room temperature and assayed at 8 and 24 hours. Five bags of ampicillin sodium were prepared-three in 0.9% sodium chloride, which were frozen at -20, -30, and -70 degrees C, and two in 5% dextrose, which were frozen at -30 and -70 degrees C. All ampicillin solutions were stored 30 days, assayed, microwave-thawed, and assayed again. All antibiotics except ampicillin retained 90% or more potency when microwave-thawed after storage at -20 degrees C for 30 days, and after subsequent storage at room temperature for 24 hours. Ampicillin sodium was stable in 0.9% sodium chloride when stored at -30 or -70 degrees C, microwave-thawed, and stored up to eight hours at room temperature. Ampicillin sodium was stable in 5% dextrose when stored at -70 degrees C and microwaved-thawed, but its potency declined to 70.5% after eight hours storage at room temperature.

Anti-Bacterial Agents↗
PubMed1978

[Standardization of implant materials shown by "bone cement". Comparative investigations in consideration of antibiotic admixtures (author's transl)].

Test methods for acrylic based bone-cements proposed by a draft international standard are approved by investigation of different bone cements. The cements showed different qualities and different mechanical properties. Added antibiotics slow down the polymerisation, possible influences to mechanical properties are covered by handlingcaused deviations. Pressure test and impact test are leading to different strength statements.

Anti-Bacterial Agents↗