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Profile of Community Mental Health Service Needs in the Moretele District (North-West Province) in South Africa.

BACKGROUND: The emergence of democracy in South Africa led to a need to transform all public structures, including the health care system. The aim has been to transform these structures in order to bring them in line with the new culture of human rights. Transformation of the whole health care system is motivated by a number of key objectives, which include achieving equity in resource allocation and health service delivery, developing primary health care infrastructure and decentralising services to promote community participation. AIMS OF THE STUDY: In the context of de-institutionalising mental health services in South Africa, this study aimed to investigate community mental health service needs of mental health service users and that of their families in the Moretele district, North-West province, South Africa. METHODS: The study was conducted in three clinics situated in three different communities in the Moretele district. Data collection consisted of : 147 clinical record reviews, 105 interviews with patients followed by a joint interview with a family member, 83 interviews with caregivers and eight interviews with community key informants (traditional healers, a civic leader, a councillor, a retired teacher, and a physician). RESULTS: The majority of service users were males (54%). The mean age was 41 years and 63% had completed primary schooling.Patients were recorded as having only one of two primary diagnoses, namely schizophrenia (57%) or epilepsy (41%). However, a review of prescribed drugs and caregiver interviews showed that there was a presence of mood disorders among service users. The local hospital was service users primary entry point into the mental health care system, followed by traditional healers (30%). Interviews with service users, service providers and caregivers reveal limited knowledge of patient illness. Nevertheless, service users who had epilepsy were more likely to provide details of their illness than those with mental illness. Above half of service users had basic social skills such as bathing, eating, washing and using public transportation independently. Feelings of loneliness and isolation were common among service users in the community; seventy nine percent (79%), for example spent their days entirely in their homes. Only 7% reported contact with friends. Experiences of community discrimination and exploitation of people with mental illness were reported in key informant interviews and by service users themselves. DISCUSSION: The main community mental health service needs identified in this study were: (i) Improved quality of mental health services at clinics. (ii) Better co-ordination of services (clinic, hospital, social work and traditional healers) and removal of barriers to health service utilisation. (iii) Alleviation of the social isolation of mental health service users by building on existing community structures and individuals willing to engage in partnerships with service providers. The authors indentify a need to train primary health care providers in mental health in order to promote the adequate diagnosis and detection of common psychiatric illnesses.They also point out the need for social support interventions to enable people with mental illness to deal with loneliness and isolation and a need for psycho-educational programmes to make patients and caregivers better informed about mental illness.

Journal Article↗

[Management of children with sickle cell disease in Africa: experience in a cohort of children at the Royal Albert Hospital in Dakar].

Management of major sickle hemoglobinopathies in industrialized countries has improved significantly over the last few years thanks to strict application of the preventive and curative measures developed as a result of a better understanding of the underlying pathophysiological mechanisms. However patients in Africa have benefited little from progress in the field due to the lack of human and physical resources in sharp contrast with the high prevalence of the disease. The purpose of this study was to analyze problems involved in management of childhood sickle cell disease in Africa based on our experience in a cohort of 556 cases treated over a period of 12 years. The main problems were the same as those encountered in other black African nations, i.e., delayed diagnosis due to a lack of routine neonatal diagnostic screening, difficulty implementing anti-infectious prophylaxis due not only to the high cost of recommended vaccinations not covered by the Expanded Program on Immunization but also to poor compliance with antiobioprophylaxis, and insufficient transfusion facilities hindering application of long-term transfusion protocols when indicated. In addition the high prevalence of digestive-tract parasitosis and malaria raise the need to combine standard preventive measures with routine parasiticidal treatment and malarial prophylaxis adapted to each geographical area. The high frequency of associated iron deficiency requires systematic laboratory testing to identify and treat resulting manifestations during follow-up. An important prerequisite for widespread implementation of appropriate preventive and curative measures in Africa is recognition of sickle cell disease as a priority in public health care policy.

Adolescent↗

Rationalizing historical successes of malaria control in Africa in terms of mosquito resource availability management.

Environmental management of mosquito resources is a promising approach with which to control malaria, but it has seen little application in Africa for more than half a century. Here we present a kinetic model of mosquito foraging for aquatic habitats and vertebrate hosts that allows estimation of malaria transmission intensity by defining the availability of these resources as the rate at which individual mosquitoes encounter and use them. The model captures historically observed responses of malaria transmission to environmental change, highlights important gaps in current understanding of vector ecology, and suggests convenient solutions. Resource availability is an intuitive concept that provides an adaptable framework for models of mosquito population dynamics, gene flow, and pathogen transmission that can be conveniently parameterized with direct field measurements. Furthermore, the model presented predicts that drastic reductions of malaria transmission are possible with environmental management and elucidates an ecologic basis for previous successes of integrated malaria control in Africa before the advent of DDT or chloroquine. Environmental management for malaria control requires specialist skills that are currently lacking in sub-Saharan Africa where they are needed most. Infrastructure and human capacity building in clinical, public health, and environmental disciplines should therefore be prioritized so that growing financial support for tackling malaria can be translated into truly integrated control programs.

Animals↗

Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon.

Rickettsia africae was identified in seven (6%) of 118 patients with acute fevers of unknown etiology proven not to be malaria or typhoid fever from clinics along the coastal region of Cameroon by polymerase chain reaction (PCR) amplification and sequencing of the citrate synthase (gltA) and outer membrane protein A (ompA) genes of Rickettsia. The majority (71%) of the patients were female. Clinical manifestations included fever (100%), headache (71%), myalgia (71%), arthralgia (43%), pulmonary involvement (29%), and diffuse rash (14%). Moreover, R. africae was detected by PCR amplification and sequence analysis of the gltA and ompA genes in 62 (75%) of 83 adult Amblyomma variegatum ticks collected from cattle in the same region. These results confirm the presence of a previously unrecognized infectious disease in the indigenous Cameroonian population, as well as extend the established range of R. africae.

Adult↗

[Failure of prevention of malaria by mefloquine in West Africa].

Mefloquine (Lariam) is extensively prescribed for the prevention of malaria in chloroquine-resistant areas. However, in west Africa, most of the strains of Plasmodium falciparum are still sensitive to chloroquine. In addition, a few of these strains are inherently resistant to mefloquine. Under these conditions, we must expect to see the failure of mefloquine prophylaxis in travellers returning from west Africa. We report here 5 such failures. The in vitro susceptibility of Plasmodium falciparum isolates from 4 of these patients was evaluated and showed that all 4 had normal sensitivity to chloroquine and quinine, 3 were resistant to mefloquine and one had reduced susceptibility to mefloquine. Mefloquine blood levels (measured 3 times) were within the normal protective range. These case reports indicate that mefloquine should be used cautiously for malaria prevention in west Africa. They also point out that, regardless of the prophylactic method used, fever in a traveller returning from endemic malaria regions always dictates the analysis of a thick blood smear to rule out the diagnosis of malaria.

Adult↗

[Clinical manifestations of infection with (HIV) human immunodeficiency virus in Africans. Comparison of cases observed in Africa and Europe].

The AIDS case definition of Bangui WHO workshop is more convenient for Africa and increases the number of cases reported to WHO. Natural history of HIV infection is the same in Africa as in the developed countries of western world. The clinical pattern of African Aids is mainly the result of opportunistic infections and specially those involving the intestinal tract. Some of them are more frequent in tropical area as Candidiasis and Cryptococcosis. The follow up of seropositive patients is more difficult in Africa, due to technical problems of use and interpretation of some tools (antigenemia... lymphocytes CD4 count...).

Acquired Immunodeficiency Syndrome↗

[Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986].

One thousand and twenty six P. falciparum strains isolated from cases imported in France and field surveys in four regions of Africa and Madagascar were studied in vitro against chloroquine, monodesethylamodiaquine, quinine and mefloquine, 917 in vivo tests were performed during field studies with chloroquine (10 and 25 mg/kg) and amodiaquine (10, 25, 35 mg/kg). In Madagascar, the chemoresistance remained low and stable during the study period, concerning mostly chloroquine (11% in vitro and in vivo) without obvious geographical variation. 25 mg/kg chloroquine or amodiaquine were satisfactory as respectively first and second line therapeutic regimen. In Central Africa, chemoresistance emerged with an epidemic profile and increased dramatically in disseminated urban focus. High level and prevalence of chloroquine resistance and multiresistance were observed few months after the index cases in these foci. In South West Cameroon, amodiaquine remained efficient as curative treatment but only at a dose of 35 mg/kg/5 days. Decrease of in vitro sensitivity and in vivo efficacy of quinine is a matter of concern. Given the heterogeneous and evolutive situation of drug resistance, the need for epidemiological surveillance and monitoring of P. falciparum drug sensitivity in Africa is obvious to adjust therapeutic regimen.

Amodiaquine↗

Influenza in East Africa, 1969-70.

Very little information is available concerning the frequency of influenza in East Africa. Following recent outbreaks of influenza in Uganda, that were due to the A2/Hong Kong/68 virus, it was considered useful to obtain information relating to the prevalence of infection due to this virus and to the current strain of influenza B virus, not only in Uganda but also in the neighbouring territories of Kenya and Tanzania. The results of serological testing of sera showed that widespread outbreaks of influenza A2/Hong Kong/68 infection had occurred recently in all three territories, while there was evidence of sporadic infection in all territories by the current influenza B strain. Despite the favourable climate of East Africa, it is evident that widespread outbreaks of influenza can occur, and these may arise during the period of the year when influenza is rare in countries with temperate climates. Influenza can easily spread to other countries via air travellers to and from East Africa.

Adolescent↗

Human T-cell leukaemia virus in Africa: possible roles in health and disease.

Observation of clustering of adult T-cell leukaemia/lymphoma (ATL) in the coastal areas of southern Japan led to speculations about its association with an environmental agent. Human T-cell lymphoma/leukaemia virus (HTLV) was later identified as the probable causal agent in these and similar cases of lymphoma/leukaemia, which were subsequently observed in first-generation West Indian Black emigrants living in England and the USA, in the forest areas of South America and in some south-eastern states of the USA. HTLV antibodies have also been identified in cases of malignant lymphoproliferative diseases (MLPD) in Ibadan and Zaria in Nigeria and in the sera of cancer patients from various parts of Africa, thus indicating that Africa is a major region for HTLV infection. Evidence is presented of the association of HTLV infection in Africa not only with T-cell but also B-cell neoplasia, such as Burkitt's lymphoma and chronic lymphocytic leukaemia (CLL). The prevalence rates of infection in normal blood donors appear to range from 3.7% in sub-Sahelian northern Nigeria to 10-15% in the south-western rain-forest area of Nigeria.

Adolescent↗

Cutaneous leishmaniasis in Southern Africa. A case report.

The microscopical findings in a case of cutaneous leishmaniasis from South West Africa are presented in order to highlight the pathology of this disease and facilitate its recognition, should unsuspected cases occur in the Republic of South Africa. In addition, the ultrastructural findings confirm the presence of typical Leishmania which occur in the cytoplasm of macrophages where they are undergoing destruction. This adds a further dimension to the characterization of this disease in southern Africa.

Female↗

[Ecology of Cryptococcus neoformans in central Africa].

Cryptococcosis associated with AIDS is mainly due to Cryptococcus neoformans var. neoformans which is found in saprophytic form in pigeon droppings. This variety has been isolated in Central Africa, particularly in Zaire, Burundi and Rwanda, from dust collected from the houses of patients with cryptococcosis. Several patients confirmed frequent contact with pigeons. Recent studies in Australia demonstrated a link between the yeast and Eucalyptus of the camaldulensis and teriticornis species. These two species were imported to Central Africa from Australia. Examination of 657 Eucalyptus specimens collected in Rwanda did not detect the yeast in any type of tree. This finding casts doubt on the role of Eucalyptus in the ecology of cryptococcosis in Central Africa.

AIDS-Related Opportunistic Infections↗

Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.

BACKGROUND: Endemic Kaposi's sarcoma (KS) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of KS occurring in Africa. Kaposi's sarcoma is now the most frequently reported cancer in some areas of Africa. OBJECTIVE: To determine if a KS-associated herpesvirus (KSHV) is present in both endemic HIV-seronegative and HIV-seropositive KS lesions from African patients. METHODS: Paraffin-embedded tissue specimens from Ugandan patients with KS and non-KS tumor control patients attending a university-based oncology clinic were examined in a blinded case-control study. Tissue DNA specimens were examined for detectable KSHV genome by nested polymerase chain reaction performed at two independent laboratories. RESULTS: We identified KSHV in 17 (85%) of 20 KS tissue specimens from HIV-seronegative patients and 22 (92%) of 24 KS tissue specimens from HIV-infected persons. Kaposi's sarcoma lesions from four HIV-infected persons and four HIV-seronegative persons were positive for KSHV. Unlike previous studies in North America and Europe, three (14%) of 22 non-KS cancer control patients' tissue specimens were also positive for KSHV that resulted in an overall odds ratio of 49.2 (95% confidence interval, 9.1 to 335) for detecting KSHV in KS lesions from patients in Uganda. CONCLUSION: As in North America and Europe, KSHV infection is strongly associated with both HIV-seropositive and HIV-seronegative KS in Africa. However, it is likely that infection with this virus is more highly prevalent in Uganda.

Case-Control Studies↗

The development and state of health and safety in the workplace in west Africa: perspectives from Nigeria.

Occupational health practice originated in Europe following the systematic work of Bernadino Ramazzini in Italy at the turn of the 17th century. It grew mostly under the notion of Industrial health, concentrating on the chemical, mechanical and social conditions of labourers as well as the work of the arts and trades, until the work of Charles Turner Thackrah in Britain broadened its understanding to include the professions and certain civic ways of living. In West Africa, as in most of the developing world, occupational health and safety practice came to us mostly as side products of the colonial company health work, in their attempt to fulfil the requirements of their national health laws to their citizens here. The first organised effort to boost occupational health and practice for the Africans among the Africans, and involving mainly Africans, came in the 1960s with the first African Conference on Occupational health in Africa in Lagos in 1968. This process has gone on now, albeit rather slowly, until the citing of a Chair of Occupational health at the University of Ibadan by the Society of Occupational Health Physicians of Nigeria in the 1992/93 academic year. The health and safety in industries in Nigeria have however not been in anyway adequate from studies in that area, especially among the indigenous small and medium sized companies. This paper reviews these developments and proposes some suggestions on how to improve on the speed and accuracy of these developments, specifically in Nigeria; and by extrapolation, for the West Africa sub-region as well.

Developing Countries↗

Management of community-acquired pneumonia in adults. Working groups of the South African Pulmonology Society and the Antibiotic Study Group of South Africa.

OBJECTIVE: To recommend an initial choice of antibiotic therapy in immunocompetent patients with community-acquired pneumonia encompassing the following subgroups: (i) adults < 60 years without co-morbid illness; (ii) older patients > 60 years and/or cases with associated co-morbidity; and (iii) those with severe pneumonia. OPTIONS: Few studies exist worldwide comparing patient outcome with the various treatment regimens. The choice of antibiotic is based on the most commonly isolated pathogens with cost as consideration. OUTCOMES: The empiric antibiotic therapy covers all commonly encountered organisms in patients with community-acquired pneumonia and is thus likely to be associated with the best prognosis. EVIDENCE: Working groups of clinicians, pharmacologists and medical microbiologists, following detailed literature review, particularly of studies performed in South Africa Benefits, harms, costs. The guidelines pay particular attention to cost-effectiveness in South Africa. RECOMMENDATIONS: These include details of likely pathogens, an appropriate diagnostic approach, factors suggesting need for hospitalisation and severity of illness, and treatment options. VALIDATION: Developed by working groups of the South African Pulmonology Society and the Antibiotic Study Group of South Africa. Reference was made to recent international guidelines from the UK, Canada and the USA.

Adult↗

The geographical distribution of diagnostic medical and dental X-ray services in South Africa

AIM: The aim of this study was threefold, viz.: (i) to evaluate the availability and accessiblity of medical and dental X-ray services in South Africa; (ii) to evaluate geographical information systems (GIS) as a tool for management of health care technologies; and (iii) to guide policy and develop a process to provide optimal utilisation of X-ray services in South Africa. METHODS: Information supplied by the Department of Health on licensed X-ray equipment was integrated with census data and processed with GIS. Four key areas were assessed, viz. distribution, accessibility, age and availability of X-ray services in South Africa. RESULTS: The analysis shows a vast inequity in the distribution of X-ray services on a provincial as well as a district level, although on the national level the distribution of X-ray services meets the World health Organisation criteria. CONCLUSION: GIS is a useful tool in evaluating and planning of essential health services/techniques. However, care must be taken in interpreting the data on a macro level, as this masks vast inequities on the district level. RECOMMENDATIONS: The indicators of coverage should be expanded, similar reports should be prepared for the nine provinces, and these data should be integrated into the clinic planning programme. Radiological services should be added to and managed as part of an essential district health care technology package.

Journal Article↗

The distribution of enzyme variation in populations of Plasmodium falciparum in Africa.

Isolates of Plasmodium falciparum collected from the east and west coasts of tropical Africa and also from several inland regions have been examined for electrophoretic forms of the enzymes GPI, LDH and 6PGD. Variation within and between isolates was found in the parasite forms of all three enzymes. While not disproving the existence of genetic divisions between P. falciparum populations in Africa the distribution of this variation provides no evidence for such a hypothesis.

Africa, Eastern↗

Comparison of the in vitro drug sensitivity of Trypanosoma brucei gambiense strains from West and Central Africa isolated in the periods 1960-1995 and 1999-2004.

The situation of human African trypanosomiasis remains serious with one of the main threats being the increasing number of relapses or treatment failures after melarsoprol treatment. In order to investigate and to compare drug sensitivities of trypanosomes isolated at different time periods and in different locations, two sets of Trypanosoma brucei gambiense strains were used. One set was isolated in the time period 1960-1981 and the other one in 1995-2004 from different locations of West and Central Africa. These isolates were not selected based on the treatment outcome but on availability. The drug sensitivity profile for all available drugs in use and the diamidine compound DB75 was established. IC(50) values were not significantly different between the "old" and "new" stocks. No indications for emerging drug resistance to any drug could be observed. The results indicate a relative stability of in vitro sensitivity of T. b. gambiense to trypanocidal drugs in space (West and Central Africa) and time (1960-2004).

Africa, Central↗

The current status of neurocysticercosis in Eastern and Southern Africa.

Some information has been documented on the epidemiology of neurocysticercosis in Eastern and Southern Africa through the monitoring of hospital-based patients with neurocysticercosis, community-based serological surveys of particular socio-economic groups of people and surveys of porcine cysticercosis. Studies have revealed that non-pork eaters have as great a chance of infection as a pork eater, the Xhosa-speaking people of the Eastern Cape Province have the highest prevalence of cysticercosis/taeniosis in South Africa probably due to the common practice of free-range pig farming and the lack of sanitation in these areas. Several studies have revealed high prevalence rates in children and interestingly, patients with active cysts suffering from epilepsy. A startling mode of transmission is where self-trained healers use Taenia segments either for benevolent (e.g. in the treatment of severe intestinal tapeworm infections) or malevolent (evil) purposes (e.g. women "poisoning" an unfaithful husband or lover by adding the contents of Taenia solium segments to beer).

Africa, Eastern↗