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At least 1,009 records · Page 56Linked to original sources
PubMed1989

Circulatory crisis in free toe-to-hand transfer and its management: I. Clinical experience.

On the basis of experience with 226 patients undergoing free toe transfer for reconstruction of the thumb and fingers, circulatory crises during and after surgery are analyzed and classified according to the time of crisis occurrence. Prompt re-exploration is indicated when the crisis occurs within 24 hr postoperative. Crises occurring 48 hr and more postoperative are usually due to vasospasm, and antispasmodic therapy should be instituted. Surgical intervention in these later cases may prove fruitless.

Finger Injuries↗
PubMedDate not supplied

[Long-term results using a Swanson silastic endoprosthesis of the metatarsophalangeal joint of the great toe. Discrepancy between clinical and radiologic findings].

53 patients underwent 68 Swanson's Silastic prosthesis implantations in great toes from 1979-1984. 51 patients (96%) with 66 implantats were followed up from 1 to 7 years. The results of self-judgement and clinical examination at control were favourable, in contrast to the large number of unfavourable radiologic findings at control. Statistical analysis revealed a significant association between the number of weared prostheses with narrowing or fragmentation and increasing follow-up time (p = 0.04), but no significant association between the results of self-judgement and clinical examination and follow-up time.

Adult↗
PubMedDate not supplied

[Arthrodesis of the metatarsophalangeal joint of the large toe].

Since it was first described by Clutton in 1894, numerous techniques for arthrodesis of the metatarsophalangeal joint of the great toe have been proposed; the most common methods are described. At the Orthopedic Clinic of Lübeck Medical School, arthrodesis of this joint has been performed since 1975 using a small fragment plate. The surgical technique and postoperative management are outlined. The results are described on the basis of follow-up examination of 76 patients (95 arthrodeses). They are in conformity with other figures cited in the literature, with a high consolidation rate of over 95%. The positive rating by the patients thus treated (80% very good and good) are, in our opinion, strong arguments for adopting this method on a broader scale in Europe also.

Arthrodesis↗
PubMed2001

A new variant neuropathic type of Gaucher's disease characterized by hydrocephalus, corneal opacities, deformed toes, and fibrous thickening of spleen and liver capsules.

We report a new variant type of Gaucher's disease characterized by hydrocephalus, corneal opacities, deformed toes, gastroesophageal reflux, and fibrous thickening of splenic and hepatic capsules. This patient had 1 D409H allele. He differed from other reported cases with a 1342G to C (D409H) homozygous mutation (onset at 4 months, no cardiac involvement until the age of 12 years, and massive hepatosplenomegaly with fibrous thickening of spleen and liver capsules). Enzyme replacement therapy was given for 4 years, resulting in an improvement of visceral and hematologic abnormalities but no neurologic improvement.

Biopsy↗
PubMed1982

"Purple toes" syndrome.

"Purple toes" syndrome and a generalized skin eruption developed in a 73-year-old woman who was taking warfarin sodium (Coumadin) as well as antiarrhythmic agents after a stroke. Both the rash and the discoloration of her feet were apparently related to use of warfarin and gradually resolved after discontinuation of the drug.

Aged↗
PubMedDate not supplied

Giant cell tumor of tendon sheath arising in the toe.

Giant cell tumor of the tendon sheath (nodular synovitis) is a benign soft tissue tumor, usually affecting older women, that most often occurs in the interphalangeal joints of the fingers. Occurrence is rare in children. We present a 12-year-old boy and a 6-year-old girl with giant cell tumors of tendon sheaths occurring in the toes. The tumor from the 12-year-old demonstrated the cytogenetic finding of t(1;2)(p13;q37), which previously has been associated with giant cell tumor of tendon sheath in adults. Giant cell tumors of the tendon sheath occurring in children have similar histological and cytogenetic features as adults, however, there may be a predilection for lower extremity involvement.

Child↗
PubMed1961

An electron microscopic study of eccrine sweat glands of the catfoot and toe pads--evidence for ductal reabsorption in the human.

The eccrine sweat glands of the cat foot and toe pads have been studied by light and electron microscopy before and after stimulation with mecholyl. The ultrastructure of these glands in the cat is found to be entirely comparable to that in the human (13). The ultrastructure and staining properties of the secretory segment of the two species are identical. The ductal part of the feline gland is shorter and the ductal cells have only scant mitochondria as compared with the human. Since Brusilow et al. (1) have observed that the secretion of the cat foot pad is isotonic as compared with human sweat, which is hypotonic, and since the secretory segments of the two species are structurally identical, the striking difference in the morphology of the duct is regarded as being responsible for the difference in the chemistry of the secretion of the two species. Thus the duct in the human is capable of reabsorbing sodium and chloride.

Animals↗
PubMed2002

Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin.

Although fixation of the stapes is usually progressive and secondary to otosclerosis, it may present congenitally, with other skeletal manifestations, as an autosomal dominant syndrome-such as proximal symphalangism (SYM1) or multiple-synostoses syndrome (SYNS1), both of which are caused by mutations in NOG, the gene encoding noggin. We describe a family that was ascertained to have nonsyndromic otosclerosis but was subsequently found to have a congenital stapes ankylosis syndrome that included hyperopia, a hemicylindrical nose, broad thumbs and great toes, and other minor skeletal anomalies but lacked symphalangism. A heterozygous nonsense NOG mutation-c.328C-->T (Q110X), predicted to truncate the latter half of the protein-was identified, and a heterozygous insertion in NOG-c.252-253insC, in which the frameshift is predicted to result in 96 novel amino acids before premature truncation-was identified in a previously described second family with a similar phenotype. In contrast to most NOG mutations that have been reported in kindreds with SYM1 and SYNS1, the mutations observed in these families with stapes ankylosis without symphalangism are predicted to disrupt the cysteine-rich C-terminal domain. These clinical and molecular findings suggest that (1) a broader range of conductive hearing-loss phenotypes are associated with NOG mutations than had previously been recognized, (2) patients with sporadic or familial nonsyndromic otosclerosis should be evaluated for mild features of this syndrome, and (3) NOG alterations should be considered in conductive hearing loss with subtle clinical and skeletal features, even in the absence of symphalangism.

Abnormalities, Multiple↗
PubMed1996

Metastatic endometrial adenocarcinoma to the skin of a toe.

A 55-year-old woman had a history of prolonged vaginal bleeding. Dilatation and curettage confirmed poorly differentiated endometrial adenocarcinoma. After hysterectomy, salpingo-oophorectomy, and 5,040 cGy of postoperative irradiation, lung metastases developed, which temporarily responded to chemotherapy that included adriamycin and cisplatin. Metastatic lesions developed later in the left acetabulum and the hallux. The latter, clinically reminiscent of pyogenic granuloma, affected only skin. The poorly differentiated toe metastasis duplicated areas of the primary endometrial adenocarcinoma and was immunohistochemically similar to it. While appearing quite rarely, and generally late in the disease, pedal skin lesions may represent metastases from known or occult visceral cancers.

Adenocarcinoma↗
PubMed1984

Island toe flaps in neurotrophic ulcers of the foot and ankle.

Eight plantar island toe flaps for the management of 7 neurotrophic ulcers of the foot and ankle are presented. The plantar vascular anatomy is reviewed with emphasis on functional features and alternate sources of supply. The surgical technique closely parallels that of the Littler neurovascular island flap in the hand. The release of the plantar fascia by incision is the most important technical step in the flap transfer. The procedure is advantageous because it substitutes weight-bearing skin, causes minimal disruption of the plantar anatomy, and is effective even in the presence of small vessel disease.

Adult↗
PubMed1981

Toe pulse reappearance time in prediction of aortofemoral bypass success.

The noninvasive vascular laboratory has a great potential to influence patient care if it can offer predictive information, which significantly adds to the clinical and angiographic assessment. To evaluate such preoperative data, 80 patients (143 symptomatic limbs) who underwent aortofemoral bypass were re-evaluated one to seven years following surgery. Preoperative vascular laboratory data (segmental pressure profile, quantitative Doppler velocity indices, postocclusive reactive hyperemia and toe pulse reappearance time [TPRT], following a four-minute cuff occlusion), angiography and clinical status were compared with the postoperative symptomatic result. Overall, 27% of the limbs were asymptomatic, 56% of the limbs markedly improved, 7% of the limbs remained unchanged or worse, and 10% of the patients died. Computer analyses of all preoperative data yielded several significant predictive indices, of which the most sensitive was the TPRT. With a TPRT of 0-10 seconds, all patients became either asymptomatic (63%) or markedly improved (37%). With increases in the TPRT, the results worsened, in stepwise fashion. Combinations of pressure and reactive hyperemic indices also permitted successful predictions in patients with multilevel disease. Such preoperative information can play a significant role in identifying the relative risks and benefits of surgery, and may significantly influence the decision for surgery in borderline situations.

Aorta, Abdominal↗
PubMed2003

Cleft palate and toe malformations in a child with fetal methotrexate exposure.

Methotrexate, a commonly administered chemotherapeutic agent, is a well-known human teratogen. Exposure of a fetus between 6 and 8 weeks of gestation is postulated to cause birth defects. However, fetal exposure to this drug after this critical period is thought to have little to no effect on eventual fetal development and growth. The authors report a case of an infant whose mother was exposed to methotrexate during pregnancy. The infant was evaluated at their clinic for an incomplete cleft palate and associated asymmetric deformities of the toes on both feet.

Antimetabolites, Antineoplastic↗
PubMed1975

Unusual fracture-dislocation of the great toe: case report.

An unusual fracture-dislocation of the great toe is presented and discussed. A review of the literature is included and a possible mechanism discussed. The lack of information in the literature relative to this injury led us to report this case.

Adult↗
PubMed1988

Post-traumatic bony regeneration in a toe.

A case of regeneration of the major part of the distal phalanx of the first toe after traumatic avulsion in a 15-year-old boy is reported. It is concluded that, owing to the possibility of bony regeneration, it is advisable to be extremely reticent in removing soft tissue in cases of such lesions. Regeneration of the bone was demonstrated after 1 month.

Adolescent↗