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At least 1,009 records · Page 56Linked to original sources
PubMed1992

External skin excision in the sebaceous nose and supratip deformity.

Some sebaceous noses cannot be properly reduced in size because of redundant skin. After standard rhinoplasty some noses develop a supratip deformity that recurs even after subcutaneous removal of the scar tissue. These noses can be corrected only by wedge-shaped skin excision. Most patients much prefer a pleasantly shaped nose, even at the cost of a midline scar on the nose. Most surgeons are hesitant to add scars to the face. However, the vast experience with wounds following accidents, tumor excisions, or corrections of malformations has shown that generally scar formation on the nose is inconspicuous. Nineteen patients were treated successfully by skin excision at the time of primary rhinoplasty or by a second operation.

Adult↗
PubMed1979

The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism.

The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturase enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.

5,8,11,14-Eicosatetraynoic Acid↗
PubMed2003

[Follicular penetration. An important pathway for topically applied substances].

The knowledge of penetration pathways in and through the skin is a prerequisite for the development and optimization of topically applied drugs and cosmetics. Skin penetration has been assumed to occur via diffusion though the lipid domains of the stratum corneum. Recent studies show that the skin appendages, especially the hair follicles, play an important role in skin penetration processes. Topically applied substances cannot enter all follicles. We discuss the reasons for the phenomenon of open and closed hair follicles.

Administration, Cutaneous↗
PubMed2003

[Noninvasive diagnosis of skin functions].

Noninvasive investigation of skin functions is increasingly employed in dermatology and cosmetology. It enables one to study aspects of skin functions that cannot always be appreciated by sensory perception. Noninvasive methods permit objective and reproducible investigation of distinct biophysical parameters. In the age of evidence-based medicine this becomes more and more important. Biophysical data can be quantified, analyzed, and stored electronically. In an overview, selected noninvasive techniques of skin function testing are introduced and their relevance in dermatology, dermatopharmacology, and cosmetology is discussed.

Aged↗
PubMed1977

The biologic bases for using hair and nail for analyses of trace elements.

Sampling of human beings for trace element content can be a complex and costly procedure. The use of hair and nails simplifies the process and it is for this reason that such samples are extensively used. The primary consideration, however, is not how easily the samples can be collected nor even how accurately trace elements can be measured in hair and nails; rather, it is what do the values mean, i.e., to what extent does the measured level reflect the concentration and/or activity of the element in other parts of the body? The structure and histogenesis of hair and nails are discussed in relation to mechanisms by which trace elements are incorporated into these tissues. Problems of contamination in vivo are also considered. A résumé of current literature is presented, considering the trace elements that are appropriate for measurement in samples of human hair and nail and some of the problems involved in analysis.

Animals↗
PubMed1994

Carcinogens show comedogenic activity: a potential animal screen for tumorigenic substances.

Formation of a comedo, an impaction of horny cells in sebaceous follicles, entails a metaplastic change in the differentiation patterns of the follicular epithelium. Since metaplasia is a requisite early stage in carcinogenesis, we postulated that carcinogens might be comedogenic. The rabbit ear was used to assay the comedogenic potentialities of an array of known tumorigens. Complete carcinogens and some tumor promotors were invariably strongly comedogenic at concentrations of 1.0% and below. Comedogenic chemicals commonly found in skin care products usually required concentrations of 40% and greater to induce comedones which were small in comparison to carcinogen induced comedones. We suggest that the rabbit ear model might be an easy and reliable way to screen for carcinogenicity.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1983

Skin lipids.

Explore the source record for details and available documents.

Aging↗
PubMed1989

Skin changes in menopause.

Skin signs and symptoms were examined in 46 menopausal women prior to estrogen replacement therapy. Several symptoms such as pruritus, bruising, dryness and thinning were seen more frequently in sun-exposed skin emphasizing the contribution of photoaging. At the end of a 6-mth treatment period, no significant difference was observed in the prevalence or severity of the cutaneous signs and symptoms when patients receiving transdermal 17 beta-estradiol (Estraderm) were compared with controls (the only exception was cutaneous flushing). Elastic fibers from sun-protected (buttock) skin of menopausal women were studied by light and electron microscopy. In 3 women (ages 30-37) with a history of premature menopause, the elastic fibers had several degenerative changes including coalescence of cystic spaces into lacunae, peripheral fragmentation, granular degeneration and splitting of the fibers into strands. Similar age-related ultrastructural changes are normally found in individuals that are at least 20 yrs older than these patients. These findings are suggestive of a relationship between premature aging of the dermal elastic fibers and estrogen deprivation.

Adult↗
PubMed1986

Effects of different doses of cyproterone acetate (CA) on preputial gland structure and activity in intact male mice.

The preputial is an androgen-dependent structure which appears to be used in pheromonal signalling in rats and mice. The structure of representative glands from intact oil injected male laboratory TO strain mice was contrasted with tissue from intact counterparts treated with the anti-androgen cyproterone acetate (CA). Sixteen days of an i.m. application of a modest range of CA doses (0.5, 1.0 and 2.0 mg/day given as oily solutions) and a variety of control treatments were used to assess influences on the structure and function of the preputial. The glands of intact male mice treated with oil were well-developed and actively secreting with parenchymatous acini at different stages of maturation. Such glands are generally highly Sudanophilic, with the lipophilic stain concentrated in acini in frozen sections and many acini are compressed by their neighbours to assume irregular shapes. Wax and frozen preputial sections from intact subjects treated with 0.5 or 1.0 mg CA were, in contrast, less well-developed and had fewer and smaller lipid droplets. Treatment of counterparts with 2 mg CA reduced acinar number and diameter in both wax and frozen sections with a concomitant increase in the proportion of connective tissue. The data confirm that this anti-androgen antagonizes the androgen secreted by the testis and adrenal cortex in terms of its expression of function on the preputial gland. These data provide further evidence that cyproterone acetate's suppressive actions on murine aggression are primarily via its ability to depress the secretion of odour cues that facilitate attack.

Animals↗