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PubMed1994

Clinical experience of 123I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with 99mTc-MDP.

Although bone scintigraphy with 99mTc-MDP is a sensitive diagnostic method to detect bone metastasis, it is not specific for malignancy. A radioactive substance which accumulates specifically into metastatic lesions should be of value. 123I-IMP and bone scintigraphy with 99mTc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in 123I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as "hot" lesions (56%) and 7 as "cold" lesions (44%). 123I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, 123I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings.

Amphetamines↗
PubMed1993

Chest radiographs as a screening test for diffuse idiopathic skeletal hyperostosis.

OBJECTIVE: To evaluate the sensitivity, specificity, predictive value, interrater reliability and intrarater reliability of using chest radiographs as a screening tool for the diagnosis of diffuse idiopathic skeletal hyperostosis (DISH). METHODS: After review of thoracic spine radiographs by 2 "gold standard" physicians, 45 patients with DISH meeting the criteria of Resnick and Niwayama were contrasted with 106 control patients consisting of 45 with thoracic spondylosis, 45 who lacked spondylosis and whose thoracic spine radiographs were otherwise normal for the age of the patient, and 16 with ankylosing spondylitis. The chest radiographs on the 151 subjects were placed in random order and read independently using an ordinal diagnostic certainty scale by 2 "test" radiologists, experienced in reading bone radiographs. Two months later the order of chest radiographs was rerandomized and the films reassessed by the same test radiologists. RESULTS: The averages for the diagnostic and population test characteristics were sensitivity = 77%; specificity = 97%; positive predictive value = 91%; and, negative predictive value = 91%. The area under the receiver operating characteristic curves was 0.975 and 0.976 for the radiologists, and kappa was 0.93, demonstrating that interrater reliability was high. On rereading the chest radiographs, intrarater reliability was exceptional (weighted kappa of 0.90 and 0.96 for the two test radiologists). DISH patients whose chest radiographs were read as not demonstrating DISH had significantly less extensive disease. CONCLUSIONS: We conclude that chest radiographs are a reliable and valid screening tool for the diagnosis of DISH.

Adult↗
PubMedDate not supplied

Nonoperative management of lumbar spinal stenosis.

OBJECTIVE: To describe the successful treatment of a patient with lumbar spinal stenosis utilizing nonoperative procedures. CLINICAL FEATURES: A 76-yr-old male with a chief complaint of low back pain and left lower extremity pain demonstrated the following per history and physical examination: 1. A right antalgic shift. 2. Restricted lumbar range of motion with provocation of left lower extremity pain during extension. 3. Generalized lumbar spondylosis as revealed on plain film X rays. 4. MRI confirmed lumbar stenosis. A diagnosis of lumbar spinal stenosis secondary to spondylosis was made. INTERVENTION AND OUTCOME: Twelve treatments of flexion-distraction manipulation, deep tissue massage, ultrasound, therapeutic exercise, heel lift, and modification of activities of daily living. He was discharged from care asymptomatic in 3 wk. Objective improvement was also noted. CONCLUSIONS: Conservative treatment designed to increase lumbar flexion, thus increasing lumbar spinal canal volume, has a positive influence on the diminution of neural ischemia and its resultant neural dysfunction. Additional research is needed to elucidate these concepts.

Aged↗
PubMed1977

[Radiological diagnosis of the narrow lumbar spinal canal syndrome (author's transl)].

31 myelograms of patients with the syndrome of lumbar spinal canal constriction were analysed. Two forms can be distinguished - a primary form with hypoplasia of the lumbar section of the spinal canal, and a secondary form with circumscribed constriction through olisthy or spondylosis deformans. The characteristics symptoms of the primary form (n = 21) are: difficult lumbar puncture, the ascent of the contrast medium in the thoracic section of the vertebral canal, multiple protrusions of the intervertebral discs, reduced sagittal diameter of the dural area which is marked by additional signs of spondylosis. In this connection, the alterations were so characteristic that it was possible to diagnose the condition even before the operation. The myelogram with water-soluble contrast-medium is considered to be markedly superior to other methods of radiological examination.

Adult↗
PubMed1995

[Electrophysiological and MRI study on poor outcome after surgery for cervical myelopathy].

Occasionally, the outcome from laminoplasty for cervical spondylosis is disappointing despite an adequate operation. Before surgery, it is difficult to diagnose the pathological extent of the involvement of the spinal cord. The purpose of this study is to determine the efficacy of magnetic resonance imaging (MRI) and of the motor evoked potentials (MEPs) for the indication of the surgery and prognosis. Retrospectively, we investigated the MEPs and the MRI image of 31 patients in surgery for cervical myelopathy, involving 21 cases with cervical spondylosis and 10 cases with ossification of the posterior longitudinal ligamentum, and compared the findings from those with a poor outcome (n = 31) with the findings from those with a good outcome (n = 32). The MEPs from the thenar muscle and the tibialis anterior were evoked by transcranial magnetic brain stimulation. In the poor-outcome patients, the spinal canal was narrow and lumbar spinal canal stenosis was seen in 5 cases which required lumbar laminectomy. Before operation, the MEPs from the thenar muscle could not be evoked in 5 cases while there was a remarkably prolonged central motor conduction time in the other 26 cases. MRI revealed the deformed spinal cord in the involved area, and the signal intensity of the involved spinal cord in the T2 weighted image was remarkable high. The signal intensity ratio was significantly higher in the poor-outcome patients than in the good-outcome patients. This study suggested that a high signal intensity in the T2 weighted image and a prolonged conduction time or absence of MEPs largely corresponded to the clinical and other investigative features of myelopathy responsible for a poor outcome.

Aged↗
PubMed1995

[Evaluation of bone mass in hip fractures measuring lumbar spine and contralateral hip with bone densitometry].

Hip fracture is frequent in postmenopausal women with osteoporosis. The aim of this work was to assess bone mass in women with hip fracture and compare it with that of normal women. Bone densities of lumbar spine (considering areas with and without spondylosis), femoral neck, greater trochanter, and unfractured hip Ward's triangle were measured with a double beam isotopic densitometer. Thirty-one women aged 58-95 years old were studied and compared with normal women studied at the same laboratory. Bone densities in fractured and normal women were 0.82 +/- 0.16 and 0.85 +/- 0.05 g/cm2 in lumbar spine respectively (NS), 0.74 +/- 0.15 and 0.85 +/- 0.05 g/cm2 in lumbar spine without spondylosis respectively (p < 0.001), 0.60 +/- 0.11 and 0.65 +/- 0.08 g/cm2 in femoral neck respectively (NS), 0.49 +/- 0.09 and 0.57 +/- 0.05 g/cm2 in greater trochanter respectively (p < 0.001) and 0.48 +/- 0.12 and 0.52 +/- 0.09 g/cm2 in Ward's triangle respectively (NS). It is concluded that the larger differences in bone density between women with and without hip fracture are observed in the greater trochanter.

Absorptiometry, Photon↗
PubMed1996

An unusual cause of dysphagia.

A case of dysphagia caused by anterior cervical osteophytes is presented. Although dysphagia and cervical spondylosis are common presenting problems, they are often unrelated to each other. The association between the two should, therefore, be accepted with caution; adequate investigation is necessary to avoid misdiagnosis. Review of the literature showed that this condition is relatively rare. The most likely mechanism of dysphagia is interference with swallowing at the pharyngo-oesophageal junction, although osteophytes in the lower cervical spine may also interfere with oesophageal peristalsis. Apart from the osteophytes of cervical spondylosis, those resulting from Forestier's disease, or Diffuse Idiopathic Skeletal Hyperostosis (DISH) have also been described to cause dysphagia.

Cervical Vertebrae↗
PubMed1996

[Surgical treatment of cervical spondylotic myelopathy in the Czech and Slovak Republic in 1994].

The authors investigated the state of surgery on account of cervical spondylosis and in particular spondylogenic cervical myelopathy in the Czech and Slovak Republic in 1994. They assessed the number of operated patients, surgical methods, indication criteria and the diagnostic strategy of different departments. The total number of patients operated on account of cervical spondylosis in 1994 was 347, incl. 113 on account of cervical spondylogenic myelopathy. As to surgical techniques in the majority the anterior approach was selected (Smith-Robinson's method). Laminectomy was performed in 14 and laminoplasty in 22 cases. The number of operated patients is, as compared with the frequency of similar operations in the United States, six times lower. As all departments where enquiries were made operate every cervical compression regardless of the degree of functional deficiency, this may reflect inadequate diagnosis of the disease.

Cervical Vertebrae↗
PubMed1997

Motor and somatosensory conduction time between the cortex and the Erb point in patients suffering from cervical spinal stenosis and tumour.

Motor and sensory conduction time between the cortex and the Erb point were examined in patients with cervical cord compression. Patients were divided into two groups: the compression was caused either by cervical extramedullary tumour (9 cases), or by cervical spondylosis or herniated disc (16 cases). In response to median nerve stimulation, pathological somatosensory evoked potentials were recorded in 66% of the patients suffering from tumour and in 60% of the patients suffering from spondylosis. All of the patients disclosed pathological motor evoked potentials. On the basis of these observations it could be concluded that, in cases of cervical spinal cord compression, the involvement of the motor system could be more reliably detected than that of the sensory system with electrophysiological methods.

Adult↗
PubMed1998

[Static and dynamic changes of the cervical spine after laminectomy for cervical spondylotic myelopathy].

PURPOSE OF THE STUDY: Extensive cervical laminectomy has been widely used in the treatment of progressive myelopathies secondary to stenotic conditions. Complications of this procedure such as spinal instability, accelerated spondylotic changes, postoperative spinal deformity and constriction of the dura mater by extradural scar tissue formation have been recognized. However, the frequency of these complications is probably overestimated and their consequences on the clinical outcome remain unknown. The purpose of this report was to describe the incidence and consequences of cervical spinal deformity and instability after multilevel laminectomy in adult patients with myelopathy caused by cervical spondylosis and to determine the usefulness of preoperative dynamic films in the prevention of postoperative destabilization. MATERIALS AND METHODS: 30 patients older than 30 years who underwent a laminectomy of more than 3 levels without fusion for myelopathy secondary to cervical spondylosis were reviewed retrospectively with an average follow-up of 5 years. Functional results were evaluated according to the Japanese Orthopaedic Association scoring system. Lateral views in neutral position, in flexion and in extension of the preoperative cervical roentgenograms were analyzed in comparison with the last follow-up one in order to identify the changes in the curvature of the cervical column, in the range of motion of the neck, in the intervertebral angular mobility and antero-posterior displacement of the vertebral bodies, and finally to identify the incidence of spinal instability. RESULTS: 18 patients (31 per cent) developed postoperative changes in cervical spine curvature. 15 patients (25 per cent) had one or more destabilized levels. Deformities of the cervical spine occurring after surgery do not appear to cause any symptom or neurologic abnormalities. Destabilization required repeat surgery in 3 patients. All the levels found destabilized on the postoperative films were hypermobile on the preoperative dynamic radiographs. A preoperative olisthesis without hypermobility was not a risk factor for postoperative destabilization. CONCLUSION: The use of preoperative dynamic radiographs should improve the selection of patients undergoing laminectomy for the treatment of multilevel cervical cord compression. Dynamic X-rays may also reinforce the need for possible adjunctive procedures such as fusion and instrumentation, in order to prevent a postoperative destabilization. A preoperative olisthesis with a hypermobility in sagittal or horizontal planes must be fused and instrumented.

Aged↗
PubMed1998

Globus sensation: pharyngoesophageal function, psychometric and psychiatric findings, and follow-up in 88 patients.

BACKGROUND: The globus sensation has been widely regarded as psychogenic, but organic disorders were found to be etiologically significant. OBJECTIVE: To investigate the structural, functional, psychological, and psychiatric factors possibly eliciting the globus sensation and influencing its course. METHODS: Eighty-eight patients, 67 women and 21 men (aged 22-71 years), referred to 2 tertiary care centers underwent history taking, otolaryngological examination, pharyngoesophageal videofluoroscopy and manometry, psychosocial evaluation, psychometric tests, psychiatric interview, and when indicated, esophagogastroduodenoscopy, esophageal bolus transport, gastroesophageal reflux, and gastric emptying studies. According to revealed disorders, therapy was initiated, and the outcome was studied. RESULTS: Only 15 patients had normal pharyngoesophageal function; of these 15, 6 had chronic tonsillitis or pharyngitis, 3 had thyroid adenomata, 4 had cervical spondylosis, and 1 each had dry oropharyngeal mucosa and chronic bronchitis. Of the other 73 patients, 2 had pharyngeal dysfunction, 24 had achalasia, 1 had diffuse esophageal spasms, 3 had "nutcracker esophagus," 30 had nonspecific esophageal motor disorders, and 13 had gastroesophageal reflux. Psychometry revealed no more anxiety and depression than in general medical outpatients. Of 58 patients interviewed, 37 met criteria for psychiatric disorders. Psychometric scores and psychiatric characteristics were unrelated to the sensation's course. Therapy was recommended, but only 26 patients were treated accordingly; 22 received nonspecific treatment. Follow-up 3 to 59 months later revealed that the sensation had vanished in 13 patients who had received specific treatment, 5 who had received nonspecific treatment, and 6 who had received no treatment; it was alleviated in 10 who had received specific treatment, 13 who had received nonspecific treatment, and 9 who had received no treatment; and it was unchanged in 3 who had received specific treatment, 5 who had received nonspecific treatment, and 23 patients who had received no treatment. CONCLUSIONS: Pharyngoesophageal disorders may be sensed only vaguely, inducing the globus sensation. Psychological and psychiatric characteristics could be relevant to the discomfort experienced but are unlikely to be etiologically significant.

Adult↗
PubMed1983

Reflex sympathetic dystrophy (causalgia) treatment with guanethidine.

Three cases of reflex sympathetic dystrophy (causalgia) were associated with cervical spondylosis. Two of them were related to sudden cervical trauma. Patients showed burning pain, hyperalgesia in a segmental distribution, and edema of the arms, hands, and fingers bilaterally. Oral administration of guanethidine sulfate was effective in all cases. Our results support the hypothesis that hypersensitivity to norepinephrine plays a role in reflex sympathetic dystrophy.

Aged↗
PubMed1986

Segmental myoclonus. Clinical and pharmacologic study.

We observed 37 patients (mean age at onset, 48.5 years; range, 13 to 84 years) with segmental myoclonus (18 branchial, 19 spinal). Etiologies for branchial myoclonus included brain-stem demyelination, cerebrovascular disease, Meige's syndrome, cerebral arteritis secondary to bacterial meningitis, central nervous system Whipple's disease, acute cervicomedullary trauma, and cerebellar degeneration. Spinal myoclonus was associated with laminectomy, remote effect of cancer, spinal cord injury, post-operative pseudomeningocele, laparotomy, thoracic sympathectomy, poliomyelitis, herpes myelitis, lumbosacral radiculopathy, spinal extradural block, and myelopathy due to demyelination, electrical injury, acquired immunodeficiency syndrome, and cervical spondylosis. The latency between the predisposing condition and the onset of myoclonus ranged from immediate to 33 years (mean, 2.9 years). In six patients, the myoclonus was the presenting symptom of a serious underlying disease. Treatment with clonazepam, tetrabenazine hydrochloride, or other medications provides a satisfactory control in most patients.

Adolescent↗
PubMed1994

Central motor conduction time to upper and lower limbs in cervical cord lesions.

OBJECTIVE: Diagnostic value of central motor conduction time (CMCT) to upper and lower limbs in cervical cord lesions was investigated. DESIGN: A series of patients underwent transcranial magnetic stimulation. SETTING: Patients hospitalized in our department were investigated. PATIENTS: Forty-seven consecutive patients with cervical spinal lesions (31 patients with myelopathy due to cervical spondylosis, eight with syringomyelia, eight with tumors) were tested. MAIN OUTCOME MEASURES: Compound muscle action potentials were recorded from the abductor digiti minimi (ADM) and the anterior tibial (TA) muscles bilaterally. The CMCT was calculated after transcranial magnetic and electrical nerve root stimulation. Correlation of abnormal CMCT to radiologically proved cord compression and to clinical signs of upper motor neuron involvement were tested. RESULTS: Of 37 patients with extramedullary lesions, CMCT to the ADM was abnormal in 19 cases (51%) and to the TA in 26 cases (70%). In 10 patients with intramedullary lesions, abnormal CMCT to the ADM was observed in three cases (30%) and to the TA in three cases (30%) as well. Higher sensitivity of measurements to the TA in extramedullary disorders was not significant. Abnormal CMCT correlated to cord compression and to upper motor neuron involvement. In eight patients (42%), subclinical lesions were detected by an abnormal CMCT. CONCLUSION: In extramedullary lesions, measurement of CMCT to the TA is more sensitive. The procedure is valuable in detecting subclinical lesions. Abnormal CMCT correlates with cord compression and clinical signs of upper motor neuron involvement.

Action Potentials↗
PubMed2004

Persistent vertigo following particle repositioning maneuvers: an analysis of causes.

OBJECTIVE: To analyze the causes of persistent vertigo following treatment with particle repositioning maneuvers (PRMs) in patients with benign paroxysmal positional vertigo. DESIGN: Prospective study of outcomes in patients with benign paroxysmal positional vertigo. STUDY SETTING: Outpatient clinic of a tertiary care referral center. PATIENTS: A sample of 90 consecutive patients with documented benign paroxysmal positional vertigo of the posterior semicircular canal who had persistent vertigo after at least 3 sessions of PRMs during a period of 2 weeks. INTERVENTION: Particle repositioning using a modified Epley maneuver. MAIN OUTCOME MEASURE: Persistent vertigo following at least 3 sessions of PRMs over a period of 2 weeks. RESULTS: Seven patients showed partial or no improvement following treatment. The causes subsequently determined included coincident horizontal canal positional vertigo (2 cases), Ménière's disease (2 cases), persistent posterior canal benign paroxysmal positional vertigo in association with cervical spondylosis (2 cases), and a posterior fossa meningioma (1 case). CONCLUSIONS: Patients with persistent or frequently recurring positional vertigo following treatment with PRMs should undergo detailed investigation to exclude coincidental pathology for which specific treatment is required. In patients in whom no coincident pathology requiring therapy is identified, treatment options other than the PRM already instituted should be considered.

Aged↗
PubMed1999

Frameless stereotaxy and anterior cervical surgery.

OBJECTIVE: The role of a frameless image guidance system for anterior cervical surgery was evaluated in 40 patients with cervical spondylosis. An assessment was made of the challenges posed in achieving accurate three-dimensional image registration in the absence of multiple fixed anatomical landmarks, and a solution to this problem is outlined using a novel registration tracking device. MATERIALS AND METHODS: Patients underwent preoperative CT scanning of the surgical field of interest, and the image data was reconstructed on a StealthStation (Sofamor Danek, Memphis, Tennessee, USA). An image guidance tracking device was attached to a modified Caspar retractor. Point matching and surface mapping were used for registration. RESULTS: It was not possible to achieve accurate registration in the first 7 patients. In the next 5 patients, the time taken to achieve registration was prolonged. For 28 patients, registration was achieved in an acceptable time with an accuracy of 0.74 +/- 0.4 mm. Anatomical resection margins were accurately identified and 36 anterior cervical screws were precisely placed. CONCLUSIONS: Frameless stereotaxy can now be applied to procedures involving the anterior cervical spine. Potential benefits include accurate definition of the anatomy, demonstration of resection margins, and intraoperative guidance. The technique may prove particularly useful in cases of complex or disrupted anatomy.

Adult↗
PubMed1997

Detection of Borrelia burgdorferi DNA and complement membrane attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease.

We report a patient who developed a chronic sensory-motor polyneuropathy and a progressive myelopathy 4 years after a tick bite. An increased serum antibody titer to Borrelia burgdorferi suggested a diagnosis of Lyme neuroborreliosis, although a concomitant cervical spondylosis probably contributed to spinal cord damage. Treatment with ceftriaxone resulted in a marked improvement of neuropathic symptoms, providing indirect evidence of spirochetal infection. Search for B. burgdorferi DNA by polymerase chain reaction amplification on sural nerve confirmed the diagnosis, demonstrating that the spirochete localized in the peripheral nervous system. The presence of complement membrane attack complex deposits and macrophage infiltrates around epineurial vessels and within the endoneurium suggests that the neuropathy in our patient was immune-mediated.

Aged↗
PubMed1996

Anatomical observations of the developmental and spondylotic cervical spinal canal in South African blacks and whites.

Cervical vertebral columns (214) of South African black and white cadaver populations were examined and measured to determine the mean midsagittal and transverse diameters of cervical vertebral foramina. Findings reveal that blacks have significantly narrower midsagittal and transverse diameters of their cervical vertebral foramina than do whites. The significance of the findings with particular regard to spondylosis is discussed in some detail. In a discussion on the causes of differences in canal size in the two ethnic groups, the role of heredity and environment was addressed and attention was drawn to the importance and pervasive influence of socioeconomic factors during the early growing years of the child.

Adult↗