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PubMed1991

Therapeutic sleep deprivation and antidepressant medication in patients with major depression.

Although there is a body of literature on the therapeutic efficacy of sleep deprivation (SD) there are only a few investigations in which the relevance of antidepressive medication for the clinical efficacy of SD has been studied. Based on the literature and on our own investigations with major depressed patients it seems that for the day-1 response it does not matter if and what type of antidepressive medication the patient receives. Furthermore, the results of our double blind study reveal that the day-1 response to total sleep deprivation (TSD) is not associated with a clear relationship to the outcome after 4 weeks treatment with either fluvoxamine or maprotiline. On the other hand, our data indicate that the day-2 response to TSD is significantly correlated with a beneficial outcome after subchronic treatment with maprotiline.

Antidepressive Agents↗
PubMed1988

[Characteristics of the catecholamine system in patients with endogenous depression before and after sleep deprivation therapy and tricyclic antidepressants].

Results are presented of the study of catecholamine system in endogenic depressive patients before and after treatment with sleep deprivation (26 patients) of tricyclic antidepressants (30 patients). Epinephrine, norepinephrine, and DOPA excretion were studied as related to clinical picture of the syndrome (2 groups: melancholic and anesthetic depressions). Sleep deprivation therapy was an effective method, as indicated by both clinical and catecholamine system signs.

Adult↗
PubMed1994

Interleukin-1 is involved in responses to sleep deprivation in the rabbit.

Interleukin-1 (IL-1) is hypothesized to be involved in sleep regulation. Antibodies directed against interleukin-1 beta (anti-IL-1 beta) were injected intracerebroventricularly (ICV) into normal rabbits to determine the effects of the reduction of endogenous IL-1 beta on spontaneous sleep/wake behavior. A 100 micrograms dose of anti-IL-1 beta reduced non-rapid eye movements sleep (NREMS) by about 20-min during the first 4-h postinjection without affecting REMS, amplitudes of electroencephalographic (EEG) slow waves, or brain temperature. Plasma concentrations of IL-1 beta, as determined by radioimmunoassay, were detectable in 39 of 79 (49%) blood samples taken before and after 4-h total sleep deprivation (SD). Plasma concentrations of IL-1 beta were, on average, significantly elevated following SD. There was a rebound in NREMS duration and of amplitudes of EEG slow waves of about 2-h duration following SD. This rebound in both parameters was exaggerated if rabbits received vehicle or anti-IL-1 beta in conjunction with SD. However, ICV administration of anti-IL-1 beta at the beginning or end of the SD period attenuated, relative to values obtained after administration of vehicle, the NREMS rebound following SD. It is concluded that SD alters the responsiveness of rabbits to experimental manipulation and that responses to SD in the rabbit are mediated, in part, by IL-1.

Animals↗
PubMed1993

Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation.

Recent developments in the understanding of the neurophysiological mechanisms underlying electroencephalographic (EEG) slow waves and sleep spindles imply an inverse relationship between these two EEG activities. The interrelationship between slow wave activity (0.75-4.5 Hz) and sleep-spindle activity (12-15 Hz) in electroencephalograms recorded in nine male subjects, during nocturnal baseline sleep and during recovery sleep from 40 h of wakefulness, was analyzed by power spectral analysis based on the fast Fourier transform and by transient patterns detection algorithms. Both techniques revealed that spindle activity was highest in sleep stage 2, increased over consecutive non-rapid-eye-movement sleep (non-REM sleep) episodes and was suppressed during recovery sleep. In contrast, slow wave activity decreased over consecutive non-REM sleep episodes and was enhanced during recovery sleep. Analysis of the dynamics of spindle and slow-wave activity within non-REM sleep episodes demonstrated that in the initial 20% of these episodes both spindle activity and slow wave activity increased, whereafter slow wave activity continued to increase but the average amplitude of spindles and total spindle activity, but not spindle density, decreased. At the end of non-REM sleep episodes the reverse pattern was observed. Sleep deprivation induced a more rapid rise of both spindle and slow wave activity in the very beginning of sleep. These data demonstrate that when averaged per sleep episode or non-REM sleep episode an inverse relationship between SWA and spindle activity exists but that in the initial and final part of non-REM sleep episodes the association between these two activities is positive. This biphasic relationship is discussed with reference to the hypothesis that the transition from sleep spindles to slow waves is dependent on a progressive hyperpolarization of thalamo-cortical neurons.

Adult↗
PubMed2004

Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats.

The involvement of opioidergic neurotransmission in the modulation of genital reflexes induced by paradoxical sleep deprivation (PSD) and cocaine in rats was the aim of the present study. Morphine (0, 1, 5 and 10 mg/kg) and naloxone (0, 0.3, 3 and 30 mg/kg) were administered prior to saline or cocaine to rats that had been deprived of sleep and the incidence of penile erections (PE) and ejaculations (EJ) was measured. PSD alone induced PE in 50% and EJ in 20% of the rats, but these behaviors were not influenced by morphine or naloxone. Cocaine potentiated the incidence of genital reflexes in PSD rats to 90% (PE) and 70% (EJ). Morphine and not naloxone significantly reduced the percentage of rats displaying this response at the highest doses. Morphine also significantly reduced PE and EJ frequencies at 10 mg/kg. Furthermore, this inhibitory effect of morphine on genital reflexes was prevented by the prior injection of naloxone. Although a number of factors are involved in such a complex phenomenon as PE and EJ, our data show that activation of the opioidergic systems by the agonist morphine reduces genital reflexes-induced by cocaine in PSD males while the antagonist, naloxone, did not have any significant effect. The findings suggest that the stimulating effects of cocaine in potentiating genital reflexes in PSD rats can be unidirectionally modified by opioidergic systems.

Animals↗
PubMed2002

Effects of REM sleep deprivation on a multiple schedule of appetitive reinforcement.

The effects of rapid eye movement sleep deprivation (REMSD) on appetitively reinforced responding by rats was studied in two experiments. In Experiment 1, a lever press was maintained on a baseline multiple FR 30 FI 60-s schedule of reinforcement that was reestablished after each experimental manipulation. Animals were then repeatedly exposed to 24, 48, or 96 h of REMSD and equivalent periods of tank control and cage control conditions. For all animals responding was reduced only after 96 h of REMSD, but tolerance to REMSD developed following repeated exposures. Experiment 2, replicated the procedures of Experiment 1 except that the apparatus was modified to prevent ad libitum access to REMSD during operant sessions. Animals were repeatedly exposed to 96 h of REMSD and equivalent periods of tank control and cage control conditions. No reduction in responding was observed in Experiment 2. The current findings, in conjunction with previous research, suggest that REMSD may have qualitatively different effects on responding maintained by positive versus negative reinforcement.

Animals↗
PubMed1989

Behavioral evaluation of the stress induced by the platform method for short-term paradoxical sleep deprivation in rats.

To evaluate whether the results of short-term PSD (Paradoxical Sleep Deprivation) using the platform method can be influenced by stress, changes in body weight and in behavioral indices (food and water intake and ambulation and defecation in an open field) were measured in rats after each of four 5-hour sessions of confinement to small or large platforms. The animals of the two platform groups when compared to animals kept in home cages showed a similar decrease in body weight which was significant only after the first day of treatment, while no changes in the other measures were observed. It is concluded that 1) the effects of stress induced by short-term confinement to platforms do not seem to be a remarkable confounding factor in short-term PSD studies and 2) large platforms can be used both as an adequate stress control for small platforms and as a means of adapting the animals to the method.

Animals↗
PubMed2005

The effect of cold exposure on the hormonal and metabolic responses to sleep deprivation.

OBJECTIVE: The purpose of this study was to determine the effect of 12 degrees C cold exposure for 180-minutes on the hormonal responses of sleep-deprived individuals. METHODS: Participants underwent 2 cold-air trials: 1 after a normal night of sleep (ie, 6-8 hours) and 1 after 33 hours of sleep deprivation (SDEP). A venous blood sample was taken at baseline and then at 90-and 180-minute cold-exposure time points. Repeated-measures analysis of variance was used to determine significance between a normal night of sleep and SDEP for norepinephrine, epinephrine, cortisol, insulin, thyroid hormones triiodothyronine and thyroxine, glucose, and non-esterifled fatty acids. RESULTS: There was no significant main effect for time, trial, or interaction for insulin, thyroid hormones, epinephrine, cortisol, and glucose (P < or = .05). A significant main effect for time for norepinephrine and non-esterified fatty acids was demonstrated (P < .001). DISCUSSION: The lack of significant differences in the hormonal and metabolic responses to cold exposure combined with SDEP may have been because of an ability of the individual to continue to respond despite the environmental stressor or the physiological effect elicited from cold exposure, thereby possibly masking physiological responses of SDEP. CONCLUSIONS: On the basis of these data, SDEP combined with protracted cold exposure apparently was not a great enough stressor to cause a differential response in the hormonal and metabolic parameters.

Adolescent↗
PubMed1992

Rapid eye movement sleep deprivation in elderly patients with concurrent symptoms of depression and dementia.

Rapid eye movement (REM) sleep measures distinguish elderly patients with depression from those with dementia. The authors used a 2-night REM sleep deprivation (RSD) protocol to characterize patients with mixed symptoms of depression and dementia in comparison with patients with "pure" depression or dementia and healthy controls. Mixed-symptom patients resembled dementia patients in baseline sleep measures, but their large change in phasic REM activity following RSD suggests neurobiological similarities to depression. Mixed-symptom patients with stable cognitive impairment had greater REM sleep rebound than those with a more progressive dementing course. These results are consistent with previous neuropathological and neurochemical data.

Aged↗
PubMed2004

The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers.

Modafinil is a selective wakefulness-promoting agent that has been shown to enhance cognitive performance under conditions of sleep deprivation but which has equivocal effects in normal young volunteers. In a double-blind parallel group design study, 45 non-sleep-deprived middle-aged volunteers (20 men and 25 women, aged 50-67 years) were randomly allocated to receive two capsules containing placebo, 100 or 200 mg modafinil, and 3 h later they completed 100 mm visual analogue scales of mood and bodily symptoms, before and after an extensive battery of cognitive tests [pen and paper and the Cambridge Neuropsychological Test Automated Battery (CANTAB)]. There were no significant treatment-associated changes in ratings of mood or bodily symptoms and no significant effects on most of the cognitive tests used in this study. The group treated with modafinil (200 mg) was significantly faster in a simple colour naming of dots and also significantly better in a test of constructional ability (Clock Drawing Test) compared with the placebo group. However, subjects in the 200-mg group also made significantly more total errors in the Intra/Extradimensional Set Shift (ID/ED) task than both the other groups. Thus, this study found limited evidence of cognitive-enhancing properties of modafinil in healthy middle-aged volunteers.

Aged↗
PubMed2003

Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleep-deprived subjects.

OBJECTIVE: This study examined the effects of posture on electroencephalographic (EEG) activity and psychomotor vigilance task (PVT) performance in 16 sleep-deprived volunteers. METHODS: EEG data were collected while participants completed 10 min PVTs under two counterbalanced sitting/standing conditions during 28 h of continuous wakefulness. RESULTS: In both the sitting and standing conditions, theta activity progressively increased as a function of sleep loss, but standing upright significantly attenuated this effect, suggesting that alertness was improved by the more upright posture. The PVT results showed that cognitive psychomotor performance was maintained at nearly well-rested levels by standing upright, whereas reaction time and attention noticeably deteriorated when participants were seated. CONCLUSIONS: These results suggest that an upright posture increases EEG arousal and sustained attention, indicating that postural manipulations can be useful for counteracting fatigue in sleep-deprived individuals.

Adult↗
PubMed2006

Frequent lapses of responsiveness during an extended visuomotor tracking task in non-sleep-deprived subjects.

We investigated the occurrence of lapses of responsiveness (lapses) in 15 non-sleep-deprived subjects performing a 1D continuous tracking task during normal working hours. Tracking behaviour, facial video, and electroencephalogram (EEG) were recorded simultaneously during two 1-h sessions. Rate and duration were estimated for lapses identified by a tracking flat spot and/or video sleep. Fourteen of the 15 subjects had one or more lapses, with an overall rate of 39.3 +/- 12.9 lapses per hour (mean +/- SE) and a lapse duration of 3.4 +/- 0.5 s. We also found that subjects' performance improved towards the end of the 1-h long session, even though no external temporal cues were available. Spectral power was found to be higher during lapses in the delta, theta, and alpha bands, and lower in the beta, gamma, and higher bands, but correlations between changes in EEG power and lapses were low. In conclusion, lapses are a frequent phenomenon in normal subjects - even when not sleep-deprived - engaged in an extended monotonous continuous visuomotor task. This is of particular importance to the transport sector in which there is a need to maintain sustained attention for extended periods of time and in which lapses can lead to multiple-fatality accidents.

Adolescent↗
PubMed2004

Effects of total sleep-deprivation on waking human EEG: functional cluster analysis.

OBJECTIVE: The purpose of the present study was to investigate the effects of total sleep deprivation (TSD) on brain functions with an identification procedure for strongly interactive brain regions, relying on functional cluster (FC) analysis in multichannel electroencephalogram (EEG) data. METHODS: EEGs from 16 electrodes in 18 healthy, right-handed, young male volunteers were recorded before TSD (after normal sleep) and after 24 h of experimentally induced sleep deprivation. We estimated cluster index to characterize joint interactions among many brain regions in order to determine if a particular FC is present or not, and if so, its anatomy. RESULTS: As a result, we confirmed the presence of FC and found different FC patterns in both before and after TSD. The C3 and F7 locations were outside the cluster under the TSD condition, but belonged to the cluster with C4 and F8 before the TSD condition, and the F3/F4, and O1 locations were new entries to the functional cluster during sustained wakefulness. CONCLUSIONS: These results indicate that the neuronal activities of the C3 and F7 location are functionally unrelated, whereas the F3/F4 locations are functionally involved with the C4, F8, and O1 locations after 24 h TSD. Our results suggest that FC changes with elapsed awake time and reflects the change of brain function due to TSD. SIGNIFICANCE: This paper shows the existence of FC both before and after TSD, and the anatomy of each FC is different. So FC analysis would be a potential tool to investigate the simultaneous neuronal activity of human EEGs.

Adult↗
PubMed2003

Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan.

Our objective was to directly compare the effects of rapid eye movement (REM) sleep deprivation (REMSD) and serotonin 5-hydroxytryptamine (5-HT) depletion on free-operant avoidance behavior in rats. These experiments were designed to determine if declining 5-HT levels observed during REMSD might mediate the increases in avoidance responding observed in REM sleep deprived rats. Rats were trained on a free-operant avoidance task. Following training, the animals were assigned to one of three sleep conditions (REMSD, tank control, or cage control). Animals in each sleep condition were exposed to four 5-HT manipulations: (a) saline plus saline; (b) p-chlorophenylalanine (PCPA) plus saline; (c) saline plus 5-hydroxytryptophan (5-HTP) and (d) PCPA plus 5-HTP. Both REMSD and 5-HT depletion via PCPA resulted in an increase in avoidance responding that was reversed by administration of 5-HTP. REMSD and 5-HT depletion via PCPA resulted in increased avoidance efficiency and were reversed by 5-HTP administration, but only changes following PCPA injection were statistically significant. Decreases in 5-HT levels that occur during REMSD likely mediate increases in avoidance responding.

5-Hydroxytryptophan↗
PubMed1981

[Effect of phenazepam and barbamyl on normalization of the sulfhydryl group content of brain tissue following sleep deprivation].

Rats placed into the rotating cylindrical tretbahn (diameter 50 cm, 2.3 r. p. m.) for 24, 48 and 96 hrs developed the sleep deprivation resulting in elevation of SH-group level for over 20% in mesencephalon and diencephalon. The normalizing occurred within 48 hrs. The high level of brain SH-groups in 24-hr sleep-deprived rats changed insignificantly after 12 hrs of resting. The intraperitoneal administration of phenazepam (1 mg/kg) or barbamyl (70 mg/kg) had no effect whereas their combination normalized the SH-groups level within 12 hrs of rest.

Amobarbital↗
PubMed1991

Effect of REM sleep deprivation on rat brain acetylcholinesterase.

Acetylcholinesterase activity was compared in control, rapid eye movement sleep-deprived and recovered rat brain. The activity was estimated in the whole brain, cerebrum, brain stem and cerebellum. Flower pot technique was used for continuing deprivation for two, four and eight days. The results showed that the enzyme activity increased significantly in the deprived rat brain and it returned to control/normal level on recovery. The enzyme activity increased first in the brain stem, while the activity in the cerebellum showed no significant change. Control experiments suggest that the increase was primarily caused by the deprivation. The finding fits well with existing knowledge and would possibly help in explaining earlier observations.

Acetylcholinesterase↗
PubMed1993

Effect of morning and afternoon naps on mood after total sleep deprivation in patients with major depression.

In 30 depressed patients who had responded to total sleep deprivation therapy, morning naps led more frequently to relapses into depression than did afternoon naps. Longer naps were less detrimental than shorter ones, and there was no significant relationship between the effect of a nap on mood and its content of slow-wave-sleep. The amount of the rapid eye-movement sleep, too, was unrelated to clinical nap effects. Thus, some of the current theories on the relationship between sleep and depressive symptomatology are not supported by the data. Our results demonstrate the importance of nap timing, suggesting a circadian variation of propensity to relapse into depression.

Adult↗
PubMed1991

Monotonic and rhythmic influences: a challenge for sleep deprivation research.

There are both monotonic and rhythmic factors in the patterns of change seen in physiological, psychological, and performance variables during sleep deprivation. These monotonic and rhythmic factors can be orthogonal, or they may interact with each other, with various task variables, or both. The importance of separating the rhythmic from the monotonic factors and of elucidating their interactions is discussed. Experimental methods and types of analysis appropriate to evaluating these factors are examined, with special emphasis on the complex demodulation time series analysis applied to group or individual subject data. The discussion is accompanied by data illustrations. It is suggested that sleep deprivation research should be designed so as to generate physiological and behavioral data that include information on both monotonic and rhythmic factors, the nature and extent of their interaction, and how they interrelate with systematically manipulated independent variables.

Arousal↗