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At least 1,009 records · Page 56Linked to original sources
PubMed1976

Effects of reserpine on the responses of the isolated rat fundus strip to catecholamines and specific adrenoceptor antagonists.

The effects of reserpine on the sensitivity to catecholamines and adrenoceptor antagonists propranolol and azapetine were studied on the fundus strips of the rat. The results obtained in this study would support the view that reserpine may increase the sensitivity of beta receptor to isoprenaline and adrenaline by the mechanism which may be independent of the uptake of catecholamines in the sympathetic nervous system.

Animals↗
PubMedDate not supplied

[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].

Tests conducted on anesthetized rats with experimental renal hypertension demonstrated that octadine, reserpine and methyl-DOPA with their one-time administration produce at the onset of the maximal hypotensine effect of fall of the arterial pressure at the expense of the lowered total peripheral resistance. Most characteristic of the action exercised by these drugs is an increased fraction of the cardiac ejection going to the gestro-intestinal tract. In hypertension all the substances under study reduce the coronary and splenic fractions of the cardiac ejection. Reserpine and methyl-DOPA do not change, while octadine reduces the fraction of the cardiac ejection that goes to the kidney.

Animals↗
PubMedDate not supplied

Reserpine induces increase in neuropeptide Y immunoreactivity in rat amygdala neurons.

The effect of reserpine, a monoamine-depleting agent, on the neuropeptide Y (NPY) immunoreactivity was studied immunohistochemically in the amygdaloid complex (amygdala) of rat brain. It was found that reserpine, at a dose of 10 mg/kg i.p., after 24 h, enhanced the NPY immunoreactivity in amygdala neurons, which was expressed as an increase in the staining intensity and in the number of immunoreactive neurons visible in that structure. The obtained results suggest that monoamines take part in the regulation of NPY expression in amygdala neurons of rat brain, and that elimination of these monoaminergic regulation leads to an increase in the NPY content in that structure.

Amygdala↗
PubMedDate not supplied

[Potentiation of the action of reserpine on the frog as a characteristic effect of antidepressants].

Antidepressants-thymoanaleptics chlorimipramine, amitriptyline, imipramine, melitracen potenciated the inhibitory effect of reserpine in a frog (supression of the turning over from the back reflex) stronger than did antidepressants with less marked thymoanaleptic action (Lu-5-003, azaphen, quipazine, desipramine) and also neuroleptics (promazine, stelazine, haloperidol) cholinolytics (atropine and benectyzine) and stimulator--phenamine. The potentiating action of tertiary amines--imipramine, amitriptyline protixen was stronger than that of the corresponding secondary amines (desipramine, norprotixen, nortriptyline). Phenothiazines with the chlorine atom in the second position (chlorprotixen and chlorpromazine) potentiated the effect of reserpine less intensively than did their chlorine-free analogues (protixen, promazine).

Amphetamine↗
PubMed1978

Cerebral tissue response to reserpine: a morphological study.

The acute influence of reserpine injection on cerebral tissue was studied in baboon and rat models. Five h after the infusion of reserpine, bilateral cortical areas were found to contain perivascular changes only, whereas basal ganglia regions contained advanced oedematous responses. Mitochondrial swelling was commonly found in the latter regions, as were loci containing microvascular crenation with accompanying pericytic changes.

Animals↗
PubMed1975

Influence of reserpine pretreatment on cardiovascular effects of angiotensin II in rabbits.

Angiotensin II induced a dose-related increase in the amplitude of contraction of preparations of isolated atria and aortic strip of rabbit. These effects were significantly higher in organs obtained from reserpine pretreated animals (4 mg/kg i.p. 24 hr before experiments) than in controls. After reserpine, the effect of four doses of angiotensin II on the blood pressure of rabbits under pentobarbital anesthesia was also significantly higher than in untreated controls.

Angiotensin II↗
PubMed1975

Influence of reserpine pretreatments on cardiovascular effects of angiotensin II in rabbits.

Angiotensin II induced a dose-related increase in the amplitude of contraction of preparations of isolated atria and aortic strip of rabbit. These effects were significantly higher in organs obtained from reserpine pretreated animals (4 mg/kg i.p. 24 hr before experiments) than in controls. After reserpine, the effect of four doses of angiotensin II on the blood pressure of rabbits under pentobarbital anesthesia was also significantly higher than in untreated controls.

Angiotensin II↗
PubMed1975

Effect of guanethidine and of reserpine on angiotensin responsiveness in man.

The respective effects of guanethidine and reserpine on angiotensin responsiveness in man have been investigated. Oral administration of 0.5 mg guanethidine per kg for a week has been found to reduce angiotensin responsiveness considerably, while plasma renin activity remained unaffected. Daily 1 mg reserpine for a week did not influence either angiotensin responsiveness or renin activity. Comparison of the results obtained with the enhancing effect of alphamethyldopa on angiotensin responsiveness has led to the conclusion that there is no relationship between the hypotensive activity of the two drugs in question and their respective effects on angiotensin responsiveness.

Adolescent↗
PubMed1975

Effects of reserpine and L-DOPA in the globus pallidus of freely behaving rats.

Paired click stimuli applied at varying time intervals were used to study the responses to polysynaptic input in the globus pallidus of freely behaving rats chronically implanted with semi-microelectrodes (60 mu). The average acoustic evoked responses (AAER) to 32 successive acoustic stimuli consisted of large amplitude potentials of long duration composed of 5 components (P1, N1, P2, N2 and P3) with latencies. The neuronal recovery function was long. Intraperitoneal reserpine administration heightened the amplitude of the AAER and shortened the neuronal recovery function. L-DOPA injection 2 hr after resperine treatment caused further heightening of the AAER but had no effect on the neuronal recovery function. When L-DOPA was given first, the AAER increased in the amplitude response and the neuronal recovery function was shortened consistently. Reserpine treatment 2 hr after L-DOPA, decreased the amplitude of the AAER but had not marked effect on the neuronal recovery function.

Acoustic Stimulation↗
PubMed1975

Pharmacological actions of some simple analogues of reserpine. I. Analgesic effects.

In view of the fact that reserpine treatment lowers pain threshold, structural analogues of reserpine molecule were tested against thermal and visceral pain. Some compounds belonging to piperidino- and morpholino derivatives of acetanilide showed promising analgesic activity. These compounds in earlier studies had shown tranquillizing effect. Combination studies with meperidene, phenylbutazone, phenazone and meprobamate did not significantly change the analgesic activity in thermal methods but the test-compounds were potentiated by phenylbutazone and phenazone in writhing test.

Acetates↗
PubMedDate not supplied

The effects of adrenaline, reserpine, and atropine on acetylcholine content of the brain and peripheral ganglia in stress.

The effects of adrenaline, reserpine and atropine on ACh content in the cerebral cortex and brain stem and in the gastric tissues were investigated in the rats at rest and during stress induced by forced swimming. Adrenaline administered intraperitoneally twice at an interval of two hours in doses of 0.1 mg/kg and then subcutaneously in a dose 0.5 mg/kg increased acetylcholine content in the cerebral cortex of resting and in the gastric tissues of resting and swimming rats. Reserpine in doses of 3 mg/kg given 48, 24 and 7 hours before the experiment caused a significant rise in ACh content in the cerebral cortex of resting rats and in the brain stem during stress. Atropine given in a dose of 6 mg/kg at 8 h intervals during 2 days caused a significant fall in ACh level in the cerebral cortex and brain stem of resting rats, in the cortex of swimming animals, as well as a considerable rise in the gastric tissues of swimming rats.

Acetylcholine↗
PubMedDate not supplied

The influence of a new benzonaphtyridone derivative (IFC-45) with antidepressant activity on the central nervous system. Part II. The influence on the amphetamine and reserpine effects and other pharmacological studies.

The Influence of a New Benzonaphtyridone Derivative (IFC-45) with Antidepressant Activity on the Central Nervous System. Part II: The Influence on the Amphetamine and Reserpine Effects and Other Pharmacological Studies. Pol. J. Pharmacol, Pharm. 1975, 27, 479--491. IFC-45 (chem. formula see p. I, page 471) potentiated amphetamine action in a similar manner as standard drugs, had significant but slightly less than the compared standards anti-reserpine activity. IFC-45 did not act anticonvulsivantly, did not affect physostigmine toxicity or evipan anaesthesia.

Amitriptyline↗
PubMed1975

[Study of the correlation between the effects of phenamine and reserpine on models of the caudate arrest reaction].

Chronic experiments were conducted on cats. It was revealed that the effect of d, 1-amphetamine reducing the inhibitory effects of the caudate nucleus on the motor function persisted after the reserpinization of the animals. Reduction of the inhibitory function of the caudate nucleus in the form of increased threshold of the causate retardation of movement under the effect of d,1-amphetamine was expressed more 24 hours after the administration of large doses of reserpine (0.3 mg'kg). This could be the result of increased sensitivity of dopaminergic receptors of the niqro-striate routes to the mediator by the principle of denervation.

Amphetamines↗
PubMed1975

The activity of some dehydrogenases and NADH and NADPH tetrazole reductases in the seminiferous epithelium of reserpinized white rats.

Investigations on the effect of reserpine on the histochemical reactions to some dehydrogenases (succinic, lactic, glucose-6-phosphate dehydrogenase) as well as to NADH and NADPH tetrazole reductases in the seminiferous epithelium of white rats have been performed. A weakening of the dehydrogenase activities has been mainly observed in the young cells of seminal epithelium i, e. in spermatogone and spermatocytes. The changes in histoenzymatical reactions caused by reserpine may be the evidence of the inhibition of oxidation-reduction processes in the studied reproductive cells.

Animals↗
PubMed1975

Effect of nialamide and reserpine on brain free amino acids of rat dependent on and withdrawn from morphine.

The brain free amino acid levels were estimated in rats dependent on and withdrawn from morphine. The effects of nialamide and reserpine on the levels of brain free amino acids were investigated during the development of physical dependence on morphine and after the abrupt withdrawal of morphine. The relationships between brain free amino acid levels, and physical dependence and withdrawal syndrome, the relationships between the degree of the manifestations in abstinence under the effects of nialamide and reserpine, and the changes in brain amino acid levels are discussed.

Amino Acids↗
PubMed2002

Brainstem auditory response in the reserpinized rat.

The brainstem auditory evoked potential (BAEP) is a brief, low-level response that reflexes the brainstem transmission of auditory signals. The presence of catecholamines (CA) has been reported in cochlea and auditory pathway. However, the role of CA in the BAEP pattern is unknown. Five Wistar rats were anesthetized with pentobarbital (50 mg/kg; i.p.), in order to record BAEP using one active needle electrode placed on vertex. The common and ground electrodes were located on the opposite ear. Auditory stimuli consisted of alternated loudspeaker clicks given at 70 cm in front of the animal's head. After that a basal record was taken, reserpine (10 mg/kg, i.p.) was injected and BAEP was recorded every 15 min for 75 min. Results showed that reserpine increased latency in waves III, IV and V. These results suggest that dopamine and norepinephrine are involved in the electrical transmission at the superior olivary complex, lateral lemniscus and inferior colliculus levels.

Animals↗
PubMed1976

The vasopressin and oxytocin content in the hypothalamus and neurohypophysis as influenced by reserpine treatment during long-term dehydration in the white rat.

In dehydrated rats both neurohypophysial hormones diminished in hypothalamus as well as in the neurohypophysis. Oxytocin disappearef from the hypothalamus and neurohypophysis at a more rapid rate than vasopressin did. The minimal content of vasopressin and oxytocin in the hypothalamus was observed during 3rd--4th day, but even in extreme dehydration it was found to be relatively high: 65 per cent of vasopressin and 27 per cent of oxytocin as compared with intact animals. At that time the neurohypophysial vasopressin and oxytocin content were almost fully exhausted. In dehydrated and additionally reserpinized animals (10 mg/kg intraperitoneally, then each 48 hr 5 mg/kg of initial body weight) the vasopressin and and oxytocin hypothalamus and neurohypophysis changed in a similar manner. In some experimental groups the decrease of neurohormones in both sites was more marked under reserpine treatment. The drug seems therefore rather to potentiate the effects of physiological stimulation of osmodetectors. So the existence of monoaminergic stimulatory synapses, directly involved in the neural pathway between the osmodetector and the neurosecretory cell, appears to be hardly probable.

Animals↗