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At least 1,009 records · Page 56Linked to original sources
PubMed1975

Amines, anticonvulsants, and epilepsy.

Concentrations of 5-hydroxyindoleacetic acid (5-H.I.A.T.) in cerebrospinal fluid (C.S.F.) were significantly raised in twenty-seven anticonvulsant-treated epileptic patients compared with fifteen untreated epileptics and twenty-two neurological controls. This rise was not seen until therapeutic blood-levels of phenobarbitone and diphenylhydantoin had been achieved, and was most striking in clinically intoxicated patients. Similar trends were seen in C.S.F. homovanillic acid (H.V.A). There was a close correlation between C.S.F. 5-H.I.A.A. and H.V.A., especially in the treated epileptics. These findings have implications for the antiepileptic and toxic effects of anticonvulsant drugs.

Adolescent↗
PubMed1976

One drug (phenytoin) in the treatment of epilepsy.

Thirty-one, previously untreated, adult outpatients with idiopathic or focal grand-mal and/or focal minor seizures were treated initially with phenytoin. Serum-phenytoin concentrations were monitored to achieve an optimum range of 10-20 mug/ml if necessary. With a mean duration of follow-up of 14-7 months, only three (10%) patients have required the addition of a second drug, although without the guidance of serum concentrations sixteen (54%) might have been treated with a further drug. In the optimum serum-phenytoin range only 1 grand-mal attack occurred in this series, compared with a mean pre-treatment grand-mal seizure-rate of 1-1/month. Serum phenytoin declined slowly in fourteen (45%) patients. These observations suggest that many epileptic patients could be satisfactorily treated with one drug instead of the polypharmacy which they usually receive.

Adolescent↗
PubMed1977

How doctors deal with epilepsy.

All of those adults with epilepsy on the lists of 17 general practitioners in Metropolitan London were identified. 87% of these agreed to be separately interviewed in their homes by a neurologist and a sociologist. The vast majority had been referred to hospital for investigation, and their hospital notes were inspected. The pattern of care suggests unnecessary referral, unnecessary electroencephalography, inadequate communication of the diagnosis, inadequate medication, and follow-up supervision not related to patient need.

Adolescent↗