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At least 1,009 records · Page 56Linked to original sources
PubMed1975

[Determination of specific IgE serum antibodies using the Radio-Allergo-Sorbent-Test (RAST) and its significance for the diagnosis of atopic allergy].

The Radio Allergo Sorbent Test (Phadebas-RAST) is a recently developed radioimmunological in-vitro test for determining IgE specific serum antibodies in reaginic allergy. The overall correspondence between RAST and skin tests in 1,128 tests with a total of 19 allergens was 70.2%. The agreement between positive RAST and skin tests was 22.1%. In instances of disagreement the combination of a positive skin test and a negative RAST was much more frequent (24.1%) than the reverse (5,7%). The agreement between RAST and skin tests was 94.5% for cat epithelium, 89.3% for egg white, 86.2% for timothy pollen, 84.2% for milk, 80.3% for mite Dermatophagoides pteronyssinus, 78.8% for birch pollen, 71.9% for dog epithelium, 67.7% for horse dandruff, 57.3% for moulds and only 40.3% for house dust. Positive RAST results for atopic patients with respiratory allergy usually indicate a clinically relevant sensitization (positive case history or positive provocation test), while negative results do not rule out the possibility of significant sensitization. Circulating reagins were detected in 9.4% of the mite and 12.7% of the mould RAST, although the skin tests were negative. The greatest discrepancy between RAST and inhalation test results occurred with house dust (47% agreement, only 12% positive correlation). The RAST was negative in 53% of the cases with positive provocation tests. The first step in the diagnosis of allergy is still a thorough case history combined with careful prick and intracutaneous testing. When the case history and skin tests are in disagreement, RAST may be helpful as a supplementary test. In addition, the RAST may be useful in clarifying cases in which the patient is on continuous steroid or antihistamine therapy, as well as for children who are frightened of skin tests. If house dust asthma is suspected, it is advisable in all but a few instances to utilize the bronchial provocation test to confirm the diagnosis and for initiation of specific desensitization.

Asthma↗
PubMed1975

[Clinical experiences with a new topical steroid].

44 patients have been treated in a double-blind trial with Desoximetason (0.25%) and with Betamethasone-valerate (0.1%). It was a randomised left-right comparative trial, and Desoximetason was significantly better than the comparative drug in all observation periods (except the period 1-2 days). Desoximetason has also been tested on 280 patients in an open trial, showing good efficacy and good tolerance.

Adolescent↗
PubMed1975

[Frequent dermatologic diseases in the newborn and children].

Sebaceous gland activity in the newborn and children is extensive at first in the epidermis, and later decreases owing to defective operation of the sweat glands, circulation changes, growth of the hair, and a predisposition to infection, for which significant treatment is required. In addition to the genetic "typus neurodermiticus", pharmaceutical, alimentary and respiratory allergens and psychological factors may play a part in the appearance of atopical dermatitis. Onset is usually in the 2nd to 6th month and the side of the face and the scalp are affected. The clinical picture varies considerably with age and includes sanious foci covered with scabs on the head and eczema flexurarum. Differences in family history, age and the location of sites will distinguish this form from seborrhoeic dermatitis. Gluteal dermitis is secondary to congestion caused by dampness, rugging and soaking, and the action of stools and urine (bacterial amniogenesis). The main complications of neonatal and infantile impetigo are: glomerulonephritis, exfoliative dermatitis, pulmonary abscess, pulmonitis and osteomyelitis; phlyctenular, serpiginous impetigo with large and small bullae is particularly important. Treatment of neonatal and infantile dermatosis must take account of the fact that increased reabsorption and congestion are contraindications for the local application of corticoids and preparations containing salicylic and boric acid.

Anti-Bacterial Agents↗
PubMed2003

Evaluation of contact sensitization in vulvar lichen simplex chronicus. A proposal for a battery of selected allergens.

OBJECTIVE: To determine the role of contact sensitization in vulvar lichen simplex chronicus and to select appropriate batteries of allergens to test. STUDY DESIGN: Between 1993 and 2000, 61 women affected by vulvar lichen simplex chronicus were enrolled to evaluate the role of contact hypersensitivity. All the patients underwent patch tests with the Italian standard series and with a wide battery of allergens (preservatives, perfumes, emulsifiers, medicaments) and products they used routinely. RESULTS: Of the women, 47.5% had at least one positive patch test, and relevant positivities were observed in 26%. The relevant allergens were usually medicaments and preservatives. CONCLUSION: It would be acceptable to reduce the number of allergens tested, in particular omitting the perfume series. Patch tests are a helpful diagnostic tool in vulvar lichen simplex chronicus and improve prescribing practice.

Adult↗