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PubMed1990

[Cytokeratin expression of tumor tissue in cutaneous merkeliomatosis (disseminated cutaneous Merkel cell carcinomas)].

In 2 patients suffering from cutaneous merkeliomatosis, we investigated the immunohistochemical expression of cytokeratin in cutaneous tumors, making use of 3 monoclonal antibodies. We observed a strong selective cytoplasmic fluorescence of the tumor cells in formalin-fixed tissue sections. Thus we were able to detect single intra-epidermal tumor cells. Both these findings and the intracorneal occurrence of tumor cells argue for a transepidermal elimination process. The reactivity patterns with monoclonal anticytokeratins revealed a cytokeratin expression of simple epithelial including cytokeratin 19.

Antibodies, Monoclonal↗
PubMed1991

Giant neuroendocrine (Merkel cell) carcinoma of the skin.

An 82-year-old woman had a dark red to purple tumor on the left buttock that had gradually enlarged during the last 5 years. Although routine histologic examination was not sufficient for diagnosis, neuroendocrine carcinoma was diagnosed by immunohistochemical and ultrastructural studies. Immunohistochemical-positive reactions to neurofilament, cytokeratin, neuron-specific enolase, and epithelial membrane antigen were noted. Electron microscopically, membrane-bound, dense core granules that yielded a positive uranaffin reaction and intermediate filaments in the perinuclear area were observed in the cytoplasm of most tumor cells. Desmosome-like structure between them was also found. Approximately 6 months after local excision, metastatic lesions developed in the regional lymph nodes and liver.

Actins↗