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Results for “LIPOSARCOMA”

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At least 1,009 records · Page 56Linked to original sources
PubMed2004

Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas.

Myxoid/round cell liposarcomas (MLS/RCLS) are characterized by chromosome translocations that result in formation of FUS-CHOP or EWSR1-CHOP fusion oncogenes. More than 95% of the tumors carry one of these fusion genes. FUS-CHOP transforms 3T3 cells and causes MLS/RCLS-like tumors in transgenic mice. The fusion oncoproteins act as abnormal transcription factors and are believed to induce abnormal expression of growth controlling genes as part of their transforming activities. The aim of this study was to search for recurrent abnormal expression patterns of cell cycle regulating proteins and growth factor receptors. A series of 14 MLS/RCLS, 2 MLS/RCLS derived cell lines and a FUS-CHOP transfected human sarcoma cell line were analyzed using immunohistochemistry, Western blotting, and cDNA microarray based screening. The results revealed a highly abnormal expression pattern of several growth controlling proteins. The G1 cyclins D1 and E and their associated kinases CDK4 and CDK2 were strongly overexpressed in all of the tumors. High expression levels were also found for Cdk4/6 inhibitor P16 and CDK2 inhibitors P27 and P57. The growth factor tyrosine kinase receptors PDGFRB and EGFR were present in most cells of all investigated tumors. We conclude that deregulation of G1 controlling proteins is common in MLS/RCLS and that aberrant expression of these proteins is of importance in the pathogenesis of this tumor type.

Adult↗
PubMed2005

Liposarcoma of the spermatic-cord: description of two clinical cases and review of the literature.

Spermatic cord liposarcoma is a rare tumor; currently only 161 cases are described in literature. Natural history of these tumors is marked by the high local recurrence rate. Radical surgery represents the therapy of choice whilst uncertain is the role of regional and retroperitoneal lymphadenectomy as well as the usefulness of adjuvant radiotherapy or chemotherapy. In this paper we describe our experience of two cases treated at our Department between 1995 and 2002 and discuss about the clinical management of this misleading tumor in the light of the several experiences reported in literature.

Aged↗
PubMedDate not supplied

[Liposarcoma of the leg].

The Authors report an interesting case of liposarcoma of the leg and review the international Literature. Moreover, a particular analysis of different aspects such as anatomy, clinic, diagnosis and treatment has been carried out.

Aged↗
PubMed2005

[Giant retroperitoneal liposarcomas].

According to literature liposarcomas account to less than 0.1% of all human tumors, 13% of which are localiced retroperitoneally. Authors describe two cases of giant retroperitoneal liposarcoms treated in their department. CT findings and the course of the disease discussed. Conlusively authors remark of high probability of microscopical residual disease with need of patients' follow up with eventual reoperation and adjuvant radiotherapy.

Aged↗
PubMed2001

Mesenteric liposarcoma or lipodystrophy: an elusive diagnosis.

Mass lesions of the mesentery may be fortuitously encountered on computerized tomographic (CT) scans, posing a diagnostic challenge. Despite CT, magnetic resonance (MR) imaging and a surgical biopsy, a patient with mesenteric lipodystrophy was misdiagnosed as having a low-grade mesenteric liposarcoma. Spontaneous regression of the mass on control CT scan and review of the pathological material prompted us to reconsider the diagnosis of malignancy. Because a wide variety of tumors and pseudotumors produce alterations in the density and volume of mesenteric fat on CT scan, a surgical biopsy is usually necessary to obtain a tissue-specific diagnosis, but even then pathological findings may be equivocal. As final resort the natural evolution assessed by radiological follow-up can be of help in determining the nature of the disease.

Biopsy↗
PubMedDate not supplied

Giant posterior mediastinal liposarcoma invading the esophagus: a case report.

Giant liposarcoma is an unusual variant of mediastinal tumors. The case of a 73-year-old woman is reported. She presented with a posterior mediastinal tumor invading the third middle tract of the thoracic esophagus and the adventitia of the descending aorta, close to the posterior pericardium; a neoplastic thrombus 2cm in size was located in the upper left pulmonary vein. The tumor was completely excised by left thoracotomy, in extracorporeal circulation. The postoperative course was uneventful and the patient received adjuvant chemotherapy. She is currently alive after 8 months, disease-free. The natural history, pathology, and prognosis of the disease are reviewed and management of such lesions is discussed.

Aged↗
PubMed2006

Myxoid liposarcoma of the breast--report of a rare case.

Breast sarcomas are very rare. A 40 year old lady presented with a well-defined hard lump, 6 cm in size, in the left breast. Patient underwent simple mastectomy with axillary clearance following a diagnosis of phylloides tumour on fine needle aspiration cytology. Grossly, it was a circumscribed myxoid tumour. Histopathologically, it fulfilled all the criteria for a diagnosis of myxoid liposarcoma. The absence of epithelial component excluded phylloides tumour.

Adult↗
PubMed2006

Liposarcoma of the uterine corpus coexisting with preinvasive cervical cancer--a case report.

Case report of isolated liposarcoma of the uterine corpus coexisting with preinvasive cervix cancer in 71-year-old woman, who 41 years ago underwent the enucleation of the uterine corpus myomas. In tumor histogenesis the malignant transformation of fat cells, which might have been previously transferred to myometrium, was taken into consideration. The 8 year long follow-up revealed neither recurrence nor metastases.

Aged↗
PubMed1991

Extradural spinal liposarcoma in a dog.

An 8-year-old female Doberman Pinscher was examined because of progressive, asymmetric, ambulatory caudal paraparesis. Myelography revealed extradural left ventrolateral spinal cord compression over the first and second lumbar vertebral bodies. A left hemilaminectomy, extending from the thirteenth thoracic to the second lumbar vertebrae, was done, and an extradural mass was removed. The tumor was identified histologically as myxoid liposarcoma. The dog's neurologic function improved gradually after surgery; however, at 7 months after surgery, hind limb neurologic function deteriorated rapidly over a 5-week period, presumably because of local recurrence of the tumor. The dog was euthanatized; necropsy was not permitted.

Animals↗
PubMed1991

[Contribution of the CT scanner to the diagnosis of liposarcoma].

Analysis of the CT aspect and anatomopathologic correlation of 11 liposarcomas of the abdomen and chest enabled definition of CT criteria for diagnosis. Anatomo-radiologic correlation could be established both for well-defined and poorly-defined tumors. However, due to the uneasy localization and high recurrence rate of poorly defined tumors, the data provided by CT did not improve the prognostic rates.

Abdominal Neoplasms↗
PubMed1991

[Liposarcoma of the infratemporal fossa. Apropos of a case].

The authors report about one female patient with a liposarcoma of the right infratemporal fossa. Such tumors are rare, making up 10 to 12% of all soft-tissue sarcomas. Their occurrence in a cervical site is rare, unlike that in the inguinal region, the retroperitoneum or the lower limbs. Their diagnosis is mainly established by the histopathological study. Computed tomography and magnetic resonance imaging are particularly useful to choose the surgical approach. The technique chosen for this infratemporal tumor was a transmandibular cervical approach. Evolution was favorable, and the patient has currently had no reoccurrence after two years.

Adult↗
PubMed1991

Liposarcoma of the nasopharynx: a case report.

We present a case of liposarcoma of the nasopharynx in a 28-year-old woman. The tumor was incompletely resected through an intraoral approach and supplementary radiotherapy of 50 Gy in a restricted field was therefore administered. Eleven years of follow-up show the patient to be disease free.

Adult↗
PubMedDate not supplied

[Giant liposarcoma of the retroperitoneum. Description of a case].

The paper reports the case of a particularly large retroperitoneal liposarcoma (diameter 60 x 28 x 32 cm, weight 11.200 kg) and focuses on the diagnostic and therapeutic aspects of this tumour. The need for radical surgery to remove the entire mass is stressed, even if it is particularly large; likewise, the patient must be carefully monitored since retroperitoneal recurrence is frequent and must be treated, wherever possible, surgically.

Follow-Up Studies↗
PubMed1991

[Liposarcoma of the retroperitoneum. A case report].

The authors describe a case of retroperitoneal liposarcoma developing between the leaflets of the transverse mesocolon. They briefly summarise the classification and the symptomatology of retroperitoneal tumours and discuss the way of presentation of their case comparing it with literature data.

Aged↗
PubMed1991

[Embolization of the foramen ovale in metastatic course of abdominal liposarcoma].

The authors report a case of embolization of the foramen ovale by a liposarcoma metastasis in a young woman of 28 years of age. Cardiac impact due to the progress of this rare tumor type remains unusual. The various clinical situations resulting from secondary cardiac locations are recalled. The diagnostic role of ultrasonography and the information which can be provided by nuclear magnetic resonance imaging in this context are also recalled.

Abdominal Neoplasms↗
PubMed1991

Liposarcoma of the esophagus.

Presented here is a report on an unusual liposarcoma of the esophagus. A 66-year-old-woman was treated successfully by surgical excision without removal of the esophagus. Thirty months after surgery and radiation she presented with neither complaint nor recurrence.

Aged↗
PubMedDate not supplied

[Retroperitoneal liposarcoma].

The paper presents a case of giant retroperitoneal liposarcoma treated in our unit. New diagnostic and therapeutic perspectives for such uncommon tumours are commented upon.

Female↗
PubMedDate not supplied

[Leiomyosarcoma and liposarcoma: rare tumors of the kidney].

Sarcoma accounts for 2.8% of all renal tumours. We report a case of renal leiomyosarcoma (T2 N0 M0) and a case of renal liposarcoma (T3 N0 M0) submitted to surgery and chemo- and radiotherapy. Follow-up at nine months and 4 years, respectively, revealed the patients are tumor-free. The literature is reviewed highlighting the beneficial effect of chemo- and radiotherapy combined with surgery in the treatment of these tumors with a poor prognosis per se.

Adolescent↗