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PubMedDate not supplied

[Histoplasmosis (infection with Histoplasma capsulatum, capsulatum variety)].

Histoplasmosis is an endemic mycosis in some regions in the US, but it can be more and more often imported to Europe. One of the clinical characters of the infection is the variety of shapes it can have, many similar to tuberculosis. It can be associated to HIV infection, being the most frequent mycosis in these patients in endemic regions. Diagnosis is based on evidence of mycotic filaments on microscopy or culture. Treatment consists of Amphotericin B and Itraconazole, the latter being also the foundation of primary and secondary prevention.

Amphotericin B↗
PubMedDate not supplied

[A brain abscess of mycotic origin due to Histoplasma capsulatum].

The case here presented is one of the histoplasmosis cases occurring sporadically in Romania. It is the first case with cerebral site and with the aspect of an extensive intracranial process. The diagnosis was made by a careful microscopic examination of the intraoperative specimens.

Adult↗
PubMed1990

[Histoplasma capsulatum infection, a manifestation of AIDS unusual for The Netherlands].

The history of 29-year-old male from Surinam with antibodies to HIV-1 and long-lasting fever, lymphadenopathy, pain in the right upper abdomen and a granulomatous hepatitis is described. The patient suffered from disseminated histoplasmosis, a fungal disease rare in The Netherlands, which is the indicator disease for the diagnosis of AIDS (CDC-IVCI). It is stressed that in seropositive patients coming from endemic areas, including Surinam, the possibility of this disease should be considered.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Modulation of the macrophage oxidative burst by Histoplasma capsulatum.

The production of reactive oxygen species by phagocytic cells is an important host defense against invading microorganisms. Because pathogens that achieve intracellular survival escape destruction by reactive oxidants, we investigated the relationship between the intracellular survival of H. capsulatum and the macrophage oxidative burst. H. capsulatum yeast failed to stimulate the release of reactive oxygen metabolites in unprimed murine macrophages despite extensive phagocytosis of the microorganisms. This effect was observed with live as well as heat-killed fungi over a wide range of yeast-to-macrophage ratios. Preincubation of murine macrophages with heat-killed H. capsulatum (but not with latex spheres), followed by incubation with unopsonized zymosan, resulted in inhibition of oxidative burst triggering without inhibition of zymosan phagocytosis. Ingestion of H. capsulatum yeast opsonized with the cognate mouse antibody resulted in significant oxidant release, suggesting that suppression of the respiratory burst may be circumvented through Fc-mediated phagocytosis.

Animals↗