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At least 1,009 records · Page 56Linked to original sources
PubMed2001

[Propane-induced tissue damage: burn or freezing injury?].

Tissue damage due to direct contact of liquid propane with the integument is extremely rare. Only five such cases have been described in the literature. We report the case of a girl who sustained a full-thickness skin necrosis of 14.5 % of her body surface area. There is little agreement about the optimal treatment of these injuries in previous reports. The pathophysiological mechanism suggests a freezing injury. The treatment, however, should be analogous to that of third-degree burns.

Adolescent↗
PubMed2004

Albumin as a marker of plasma transudation in experimental skin lesions.

Liquid chromatography measurements of albumin levels were obtained for experimental incision wounds, excoriations, and heat and freezing injuries of different ages. Hemoglobin levels in tissue specimens were measured and an equivalent amount of blood-related albumin was subtracted from the analysis results. In specimens taken immediately after death, the mean albumin level as compared to control skin was increased by about 2-fold in freezing injuries aged 60 min. In all other lesions, the same increase was observed even after 30 min. The mean albumin level was about 3-fold as compared with the control skin in excoriations aged 30 min, heat and freezing injuries aged 4 h, and incision wounds aged 12 h. An approximately 5-fold increase was seen in heat and freezing injuries aged 1 and 2 weeks. A marked decrease occurred in mean albumin levels in all lesions aged 4 weeks. An increase in albumin in wounds and excoriations was demonstrable also in specimens taken 3 days postmortem. Postmortem hypostasis resulted in a 1.1 to 1.4-fold increase in mean albumin levels in wounds and excoriations inflicted 1 min postmortem.

Animals↗
PubMed1998

Clinical and morphological aspects of death due to liquid nitrogen.

A 24-year-old student died while filling flasks with liquid nitrogen. The arms, legs and back were frozen and the face, ears and neck showed a dark red and livid colour with horizontal lines of demarcation. In the electrocardiogram, the heart showed asystolia followed by wide ventricular complexes. The patient was intubated orally as the situs of the larynx and pharynx showed no pathology findings. Cardiopulmonary resuscitation was carried out and terminated after 90 min. Unfortunately, the body temperature was not measured. The gas analysis of venous blood showed metabolic acidosis and oxygen deficiency. The student had worked alone with nitrogen, without opening the windows and without a working ventilation system. While filling the third flask he lost consciousness. As nitrogen does not cause characteristic prodromal signs he laid on the floor and was unable to help himself. The liquid nitrogen which was still escaping spread over the floor and vaporized. The student died from asphyxia due to oxygen deficiency in an atmosphere of nitrogen.

Adult↗
PubMed1991

Cooling to heat of fusion (HOF), followed by rapid rewarming, does not reduce the integrity of microvascular corrosion casts.

This study utilized microvascular corrosion casting techniques to evaluate changes in the microvascular patency of rat hindpaws cooled to four different subzero temperatures. Left hindpaws of anesthetized rats in group 1 were cooled to -5 degrees C, in group 2 to -15 degrees C, in group 3 to heat of fusion (HOF), and in group 4 to HOF and then to -15 degrees C. Although freezing did not take place in the hindpaws of groups 1 and 2, initiation of freezing in the tissues, as indicated by HOF, did occur in groups 3 and 4. Cooled hindpaws were rapidly rewarmed. Right hindpaws served as controls. Microvascular corrosion casts were made from the left and right hindpaws of all animals. There was no significant difference when the mean cast weights of cooled hindpaws from groups 1, 2, and 3 were compared to the mean cast weights of their respective control hindpaws. In group 4, there was a significant difference (P less than 0.05) when the mean cast weight of the cooled hindpaws (47.69 +/- 9.05, mg +/- SEM) was compared to that of the control hindpaws (80.63 +/- 12.23). Since, in this acute experiment, a loss of vascular integrity occurred when the hindpaws in group 4 were cooled to -15 degrees C after reaching HOF, the initiation of freezing alone was not sufficient to reduce mean cast weight.

Animals↗
PubMed2006

Prediction of facial cooling while walking in cold wind.

A dynamic model of cheek cooling has been modified to account for increased skin blood circulation of individuals walking in cold wind. This was achieved by modelling the cold-induced vasodilation response to cold as a varying blood perfusion term, which provided a source of convective heat to the skin tissues of the model. Physiologically-valid blood perfusion was fitted to replicate the cheek skin temperature responses of 12 individuals experimentally exposed to air temperatures from -10 to 10 degrees C at wind speeds from 2 to 8 ms(-1). Resultant cheek skin temperatures met goodness-of-fit criteria and implications on wind chill predictions are discussed.

Adult↗