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Breastfeeding experience and breast cancer risk among postmenopausal women.

Results of studies of breastfeeding and postmenopausal breast cancer risk have been inconsistent, with many investigators concluding that breastfeeding does not influence risk. We examined whether breastfeeding reduces postmenopausal breast cancer risk as well as the details of this relationship, including possible modification in risk by the age that a woman first breastfed a child and the number of children she breastfed. This population-based case-control study compared 974 women who were residents of Los Angeles County and newly diagnosed with breast cancer to 973 women with no history of breast cancer who were matched to patients by age (within 3 years) and neighborhood of residence. Subjects were parous and postmenopausal. Breast cancer patients were ages 55-64 years at diagnosis. Women who breastfed at least 16 months experienced a reduced odds of breast cancer relative to women who never breastfed (odds ratio, 0.73; 95% confidence interval, 0.52-1.01). Risk decreased as the number of children breastfed increased, but the association was attenuated after accounting for lifetime duration of breastfeeding. Breast cancer risk was 30% lower among women ages 20-24 years at first breastfeeding than women who had never breastfed (odds ratio, 0.69; 95% confidence interval, 0.54-0.88), independent of the effect of age at first birth. This study provides some evidence that the protective effect of breastfeeding persists into the postmenopausal years. The potential for nondifferential error in recall of breastfeeding habits among postmenopausal patients and controls may explain the inconsistent results observed across studies and underscores the need for careful assessment of this relationship.

Adolescent↗

Interacting effects of multiple roles on women's health.

Our study tests several hypotheses concerning the effects of employment, marriage, and motherhood on women's general physical health. These hypotheses predict how the health effect of each role varies, depending on specific role characteristics and the other roles a woman holds. Our analyses utilize longitudinal panel data for 3,331 women from the National Longitudinal Surveys of Young Women (follow-up intervals: 1978-83 and 1983-88). The Role Substitution Hypothesis proposes that employment and marriage provide similar resources (e.g., income and social support), and consequently, employment and marriage can substitute for each other in their beneficial effects on health. As predicted, we found that employment had beneficial effects on health for unmarried women, but little or no effect for married women. Similarly, marriage had beneficial effects on health only for women who were not employed. The Role Combination Strain Hypothesis proposes that employed mothers experience role strain, resulting in harmful effects on health. However, we found very little evidence that the combination of employment and motherhood resulted in harmful health effects. Contrary to the predictions of the Quantitative Demands Role Strain Hypothesis, it appears that neither longer hours of employment nor having more children resulted in harmful effects on health. As predicted by the Age-Related Parental Role Strain Hypothesis, younger age at first birth, particularly a teenage birth, appeared to result in more harmful health effects.

Adolescent↗

Respiratory water loss in relation to activity in fullterm infants on their first day after birth.

Respiratory water loss (RWL), oxygen consumption and carbon dioxide production were measured in ten fullterm infants on their first day after birth, using an open flow-through system with a mass spectrometer, specially equipped with a water channel, for analysis of gas concentrations. Measurements were made both with the infant asleep and during different levels of motor activity. The ambient temperature was maintained at approximately 32.5 degrees C and the ambient relative humidity at 50%. RWL increased from 4.2 +/- 0.7 (SD) mg/kg min when the infant was asleep to 6.3 +/- 1.0 mg/kg min when he or she was awake but calm; with increasing activity there was a further increase in RWL. The oxygen consumption increased from 5.4 +/- 0.9 (SD) ml/kg min during sleep to 6.9 +/- 0.8 (SD) ml/kg min when awake, and also increased further with increasing activity.

Female↗

Serum zinc and copper concentrations in low birth weight infants during first three months of life: correlation to birth weight and different feedings.

Serum zinc (Zn) and copper (Cu) concentrations were measured in infants weighing 740 g to 2,500 g at birth. They were divided into three groups depending on their birth weight; Group I ranged from 740 to 1,500 g (N = 35), Group II from 1,501 to 2,000 g (N = 26), and Group III from 2,001 to 2,500 g (N = 19). They were fed breast milk (N = 24), commercially available non-supplemented formula with low Zn and low Cu content (N = 42), or Zn- and Cu-supplemented formula (N = 14). Serum Zn levels of breast fed infants were apparently higher than those of the other two different formula fed infants, the difference being significant at 1 month of age in Group I. After the decline of serum Zn level during the first month of life, the level in Groups II and III remained unchanged, whereas the level in Group I further declined progressively until 3 months of age. An incidence of hypozincemia (0.65 micrograms/ml) was highest in Group I, medium in Group II, and lowest in Group III. The serum Cu level was elevated progressively after birth in all groups, but the mean level was consistently highest in Group III, medium in Group II and lowest in Group I. No difference in serum Cu level was found among the infants with different feedings.

Birth Weight↗

Respiratory water loss in fullterm infants on their first day after birth.

Measurements of water loss from the airways, oxygen consumption and carbon dioxide production were made in 12 fullterm, newborn infants on their first day after birth, using an open flow-through system. The system includes a mass spectrometer, specially equipped with a water channel, for analysis of gas concentrations. To avoid condensation of water vapour, the tubing in the flow-through system is heated. Respiratory water loss was 4.9 +/- 1.2 (SD) mg/kg min, which meant an insensible water loss from the respiratory tract of 25.4 +/- 6.9 (SD) g per infant and 24 h at rest, at an ambient temperature of 32.2 degrees C and with an ambient humidity of 50%. Oxygen consumption was 6.0 +/- 0.8 (SD) ml/kg min. An inverse relationship was found between respiratory water loss and ambient humidity, with higher losses at a low than at a high humidity. Oxygen consumption did not change very much with ambient humidity.

Body Water↗

Estimating the public costs of teenage childbearing.

A formula for making national, state and local estimates of the cost to the public of teenage childbearing is derived from a review of 12 studies. The formula is then applied to U.S. data. The calculations yield a single-year cost for 1985 of $16.65 billion paid through three programs--Aid to Families with Dependent Children, food stamps and Medicaid--for women who first gave birth as teenagers. The calculations also show that the public will pay an average of $13,902 over the next 20 years for the family begun by each first birth to a teenager in 1985 and $5.16 billion over the same period for the families of all teenagers experiencing a first birth in 1985. If all teenage births were delayed until the mother was 20 or older, the potential savings to the public would be $5,560 for each birth delayed and $2.06 billion for the entire cohort of teenagers who would otherwise have had a first birth in 1985.

Adolescent↗

Respiratory water loss and oxygen consumption in full-term infants exposed to cold air on the first day after birth.

Respiratory water loss, oxygen consumption, carbon dioxide production and skin blood flow were measured continuously in nine full-term infants on the first day after birth. After at least 18 min of measurements with the infant asleep in an incubator, with an air temperature of 33 degrees C and a relative humidity of 50%, the temperature of the incubator air was lowered to less than 27.5 degrees C. This resulted in a significant decrease in skin temperature and peripheral skin blood flow, while the infant's core temperature remained unchanged. At the same time, mean respiratory water loss increased from 3.7 to 6.1 mg/kg.min, which can be explained partially by the decrease in ambient humidity that accompanied the decrease in air temperature. In addition, mean oxygen consumption increased from 5.3 to 7.9 ml/kg.min and mean carbon dioxide production increased from 3.8 to 5.9 ml/kg.min. There was no concomitant increase in motor activity. Thus, when the newborn infants were exposed to cool air, they reacted with an increase in respiratory water loss, oxygen consumption and carbon dioxide production before their core temperature was affected and without increasing their motor activity.

Body Temperature Regulation↗

Response of the organs of rabbits to feeding during the first days after birth.

An experiment described previously showed a large increase in weight and protein of the intestinal mucosa of suckling piglets during the first 24 h after birth. This did not take place in piglets that were starved. The results might have been partly due to the inclusion of protein molecules in the mucosa in process of absorption. Rabbits do not absorb large quantities of protein after birth, and the experiment has now been repeated on them. The gastrointestinal tract of suckled rabbits also grew rapidly in the first 24 h, but again not in those that were given only water, which is in line with the suggestion that colostrum contains a factor which stimulates the growth of the gastrointestinal tract. The brain gained weight in the suckled animals, due to incorporation of lipid and protein. It gained weight too in the starving rabbits, demonstrating its high priority for nutrients at a time when its growth velocity is at its peak.

Adipose Tissue↗

Energy, fat and nitrogen balance in healthy newborn infants during the first week after birth.

There are limited data in the literature concerning the energy, fat and nitrogen balances in healthy newborn infants of normal weight. For this reason, five healthy newborn infants were studied during the first week after birth. Balance studies on energy, fat, nitrogen, dry matter and water were performed. Oxygen consumption was determined by an open method. The weight decrease the first days was explained by a deficit of water and energy intake. Weight gain was seen when the water intake was 80-100 ml/kg/day and the energy intake 200-300 kJ/kg/day. A linear relation was found between the total evaporative water losses and ambient vapour pressure. The mean resting metabolic rate was 174 kJ/kg/day with the range 144-200 kJ/kg/day. With higher activity the metabolic rate increased 20-45%. Positive balances of nitrogen and fat were obtained when the intakes exceeded 150 and 275 mg/kg/day, respectively.

Anthropometry↗

The economic consequences of preterm birth during the first 10 years of life.

OBJECTIVE: To examine the association between gestational age at the time of birth and long-term use and cost of hospital inpatient services. DESIGN: Multi-level modelling of the hospital service utilisation and cost profile of each child born in hospital during 1978-1988 in two areas covered by the Oxford Record Linkage Study. SETTING: Oxfordshire and West Berkshire. POPULATION: 117,212 children divided into four subgroups by gestational age at birth: <28 weeks, 28-31 weeks, 32-36 weeks, 37 weeks or greater. MAIN OUTCOME MEASURES: Number and duration of hospital admissions during the first 10 years of life. Costs, expressed in pound sterling and valued at 1998-1999 prices, of hospital inpatient services. RESULTS: The cumulative cost of hospital inpatient admissions incurred during the first 10 years of life, including the initial birth admission, averaged 17,819.94 [22,322.87 UK pounds] for children born at <28 weeks gestation, 17,751.00 [19,055.53 UK pounds] for children born at 28-31 weeks gestation, 5,376.39 [7,393.78 UK pounds] for children born at 32-36 weeks gestation, and 1,658.63 [3,409.14 UK pounds] for children born at 37 weeks gestation or greater. The adjusted number of hospital inpatient admissions, inpatient days and costs, respectively, over the first 10 years of life was 130%, 77% and 443% higher for children born at <28 weeks gestation than for children born at term. CONCLUSION: The adverse sequelae of preterm birth are likely to have considerable long-term economic consequences for the health services and for society as a whole.

Child↗

Reproductive characteristics of a population of urban Swiss women.

OBJECTIVE: To describe the variability of reproductive life, from menarche to menopause, in the Geneva female population. DESIGN: Women's Health Survey, 1992-1993. SETTING: Mobile epidemiology unit of a University Hospital. SUBJECTS: One thousand and thirty-two women aged 30 to 74 years, resident in Geneva, Switzerland. MAIN OUTCOME MEASURE: Menstrual and reproductive history. RESULTS: A 'typical' woman of Geneva has her menarche at 13 years, regular 28 day cycles with 5 days of menstrual flow. She is 26 years old when she first gives birth and has her last baby (which is typically the second) at age 31. She has 37 years of potential fecundity and a natural menopause at age 50. In addition, 11% of the women have tried to be pregnant during two years without success, 67% have ever used oral contraceptives, 20% had a first birth at age 30 or more and 23% were nulliparous. Younger women reported earlier ages at menarche. Women with lower education tended to be a younger age at the birth of her first child. CONCLUSIONS: In this first study of the reproductive characteristics of women in Geneva, nulliparity and a late first birth appeared unusually frequent, especially when compared with American or Chinese women. The observed distributions of reproductive history are compatible with the very high incidence rate of breast cancer in the Geneva population.

Adult↗

Comparison of the experience of women and men in dual-earner families following the birth of their first infant.

This paper describes an extension of the concept of "redefining roles" developed from an initial study that described the experience of eight women in dual-earner families following the birth of their first infant. A second study used redefining roles as a springboard and described the experience of ten men. Although constant comparative analysis generated a core variable in both studies best described as "redefining roles," the two groups redefined their roles somewhat differently. When the women redefined their roles, they took on multiple roles, experienced role strain, and reduced role strain. The men monitored and limited role strain. The implications for nursing practice are outlined.

Adult↗

Factors associated with repetition of low birthweight: Missouri longitudinal study.

The tendency to repeat low birthweight (LBW < 2500 g) was studied in 182,285 linked first and second birth Missouri livebirths for 1978-90, of which 10,701 had first birth LBW. We examined the likelihood of LBW repetition by first birth birthweight, preterm delivery, and small-for-gestational-age (SGA) status by race, and the odd ratios (ORs) of repeat LBW for risk factors such as smoking, in comparison with ORs of second birth LBW among women with normal-weight first births. We found a strong tendency to repeat LBW (21%), especially following more extreme LBW first births. Adjusted ORs for repeat LBW were 10.1 for births that were preterm and SGA; 7.9 for preterm non-SGA; and 6.3 for SGA term births. Significant ORs of LBW repetition were found for smoking (1.52 and 1.85 for smoking in second pregnancy only and both pregnancies, respectively), short interpregnancy interval (1.33), and advanced maternal age (1.17), but the ORs were generally lower than those for women with normal-weight first births. Low pre-pregnancy weight was a significant risk factor for LBW repetition.

Birth Order↗

[Social and hygienic conditions of family creation and birth of the first child].

Discusses the problems of public health reformation using the so-called new social contract, put forward in Russia by J. Rice, heading the ZdravReform program. Based on analysis of the socio-hygienic conditions of family creation and birth of the first child, the authors propose the following assumption: creation of a family and appearance of the first child is one factor occupying a special place within the framework of the new social contract and validate this assumption by the data of their sociomedical research.

Child Rearing↗

Dilution kinetics of H(2)18O for the measurement of total body water in preterm babies in the first week after birth.

The aim of this study was to determine the kinetics of H(2)18O equilibration and elimination in preterm babies for the estimation of total body water. Thirteen, clinically stable, preterm babies of less than 32 weeks' gestation were studied in the first week after birth. Blood and urine samples were obtained for baseline measurement of 18O:16O ratio and 1 ml/kg of 10% H(2)18O (0.1 g/kg isotope) administered orally. Eleven blood samples were obtained over the next six hours and between one and four over the next 18 hours. During the same 24 hour period between three and eight urine samples were also obtained. The dilution space at zero time (volume of distribution or total body water) was estimated using double exponential curve fitting using all available points, from single samples and from linear regression on the log data using two or three samples. Equilibration time was variable and showed a significant correlation with percentage change in body weight from birth. For blood samples, the median time to equilibrium was 81 minutes (range 2 to 191). A plateau phase was not detected, with H(2)18O enrichment declining after the point of maximum enrichment. The median volume of distribution at time 0, based on double exponential curve fit analysis, was 859 ml/kg (range 755 to 995). The volume of distribution, estimated from linear regression on the log data using two serum samples obtained at three and six hours, approximated most closely to that based on exponential curve fit analysis with a median difference of -4 ml/kg (range -41 to 73). It was concluded that in most situations blood sampling at three and six hours may be acceptable. However, as equilibration time is variable and influenced by the state of expansion or depletion of body water compartments, when studying overhydration states, multiple sampling is advised in order to be certain that the elimination phase has been reached.

Blood Specimen Collection↗

[Social support network evolution after the birth of their first baby: comparison between lower and middle class mothers].

The social support networks of a group of low socio-economic status (S.E.S.) mothers (n = 87) and a group of higher S.E.S. mothers (n = 44) are described and compared at the 30th week of pregnancy and at the third week after the birth of their first baby. The evolution of the support networks for these two groups of mothers during this period is also examined. A modified form of the ASSIS from Barrera has been used to measure the social support network. Results show that, during pregnancy, the social support network of low-S.E.S. mothers is more restricted than that of higher S.E.S. mothers. Although the actual number of people around them after the birth of the baby did not increase, low-S.E.S. mothers said they felt a slight increase in the number of people available to give support in some way. They also reported that conflicts were more frequent with some of them. For higher S.E.S. mothers, all social network variables remained stable from pregnancy through the first postpartum month.

Adult↗