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Successful resection of cardiac fibroma with ventricular tachycardia.

A 22-year-old male was admitted to Niigata University Hospital complaining of palpitation. Echocardiogram, cineangiogram, and Holter electrocardiogram revealed a cardiac fibroma complicated by ventricular tachycardia (VT). The tumor extended from the interventricular septum to the anterior surface of the left ventricle, and an electrophysiological study demonstrated that the focus of the VT was situated at the tumor. The tumor was excised successfully. The patient is doing well two years after operation without any antiarrhythmic drugs, and VT has not recurred.

Adult↗

[Desmoid fibroma of the abdominal wall. Apropos of a case].

A case of desmoid fibroma of anterior abdominal wall, an exceptional benign tumor, is reported. Based on results of CT scan imaging of this lesion, differential diagnosis of other expansive processes of abdominal wall are discussed. This benign tumor is a potentially serious lesion due to its infiltrating character and the high incidence of recurrence. The need for total surgical excision is emphasized.

Abdominal Muscles↗

Inhibition of virus replication does not alter malignant rabbit fibroma virus-induced immunosuppression.

Malignant rabbit fibroma virus (MV) directly suppresses generation of antibody responses and mitogen induced T and B lymphocyte proliferation. We investigated whether this phenomenon required expression of the complete viral genome. Phosphonoacetic acid (PAA) inhibits poxvirus specific DNA polymerases. Adding PAA to cultures reduces both MV replication and mitogen-driven rabbit lymphocyte proliferation in a dose-dependent fashion. A dose of PAA adequate to inhibit MV replication by about 97%, but insufficient to reduce lymphocyte proliferation appreciably, does not affect the ability of MV to suppress lymphocyte proliferation or initiation of antibody production. Spleen cells from MV tumour-bearing rabbits contain very little virus, but inhibit the proliferative and antibody forming responses of normal spleen cells. This activity is shown here to reflect the production by T lymphocytes of a soluble mediator of greater than 25 kD molecular weight. Adding PAA to these mixed spleen cell cultures does not alter the ability of MV to induce T suppressor activity in host lymphocytes. Thus, these immunosuppressive capabilities of MV appear to reflect early MV gene functions.

Animals↗

[Gigantic giant cell fibroma in Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University].

An unusual case of gigantic giant cell fibroma was reported and included in the series of 3 cases seen at Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, during the past 14 and a half years since this particular lesion was first described in 1974. These 3 cases, representing 0.5% of all fibrous lesions, were presented and discussed according to their distribution, location, sex, incidence, clinical and histologic appearance in reference to the literature. This article also discussed the importance of biopsy and recommended that it should be routinely done to obtain a definite diagnosis of the lesion.

Adolescent↗

[Fibroma of the tendon sheath].

Fibroma of the tendon sheath (FTS) is a rare benign soft tissue tumor. Its location and clinical findings may be similar to the giant cell tumor of tendon sheath or to infantile digital fibromatosis. Accurate diagnosis of FTS depends on microscopic examination of the excised tumor. The present report deals with two cases.

Adult↗

Juvenile aponeurotic fibroma.

Among the fibrous tumors of childhood, the juvenile aponeurotic fibroma is rare. After removal, there is a high rate of recurrence in the younger age group. If the recurrence is not aggressive and does not interfere with function, a prolonged observation may be permitted. Otherwise, a more radical extirpation may be needed.

Adolescent↗

[Desmoplastic fibroma as a rare bone tumor].

A desmoplastic fibroma of the left humerus with a pathological fracture in a 9-year-old girl is presented. The postoperative course was uncomplicated: no recidive occurred. The histological picture of this rare bone tumor (76 similar cases were reported in the literature) is identical both with aggressive fibromatosis and with the desmoid tumor. It contains areas with abundant collagen fibers and densely packed areas composed of fibrocytes, fibroblasts as well as myofibroblasts. Myofilaments have been detected by electron microscopy in the latter cell type.

Bone Neoplasms↗

Intracavitary heart fibroma. A case of successful total excision.

Tumors of the heart are relatively rare events and fibromas represent no more than 5% of these. A central source of peripheral embolization suggests the possibility to kept in mind in the absence of other causes and is therefore worthy of closer investigation.

Adult↗

Fibroma of tendon sheath.

Fibroma of the tendon sheath is a distinct clinicopathologic entity rarely occurring on the foot. It is a benign tumor derived from the fibroblast that clinically appears as a slow-growing painless mass. Complete surgical excision is curative. Recurrence occurs in 24% of the cases, usually due to inadequate excision. This report describes a 36-year-old man with such a tumor of the foot.

Adult↗

Tenosynovial fibroma arising from the posterior cruciate ligament.

In a 16-year-old girl, a locking and effusion of the left knee occurred without a history of any specific trauma. Arthroscopic examination of the knee revealed a soft tissue mass arising from the posterior cruciate ligament. The mass was completely excised, arthroscopically. The microscopic diagnosis was tenosynovial fibroma, a new entity reported by Chung and Enzinger in 1979. After a follow-up study of 20 months, the patient was asymptomatic.

Adolescent↗

[Left ventricular fibroma in childhood: 2-dimensional echocardiographic diagnosis and surgical treatment. Description of a case].

We describe the case of a patient 4 months old transferred to our hospital for evaluation of occasionally detected cardiac alterations: ecg showed abnormal Q and negative T waves in D1 - aVL leads and chest x-ray was consistent with enlargement of the left ventricular cavity. After admission, 2D echocardiographic examination disclosed, in the left ventricular cavity, a large mass extending from the papillary muscles to the outflow tract. The mass was of uniform density and easily recognizable as a tumor. Although asymptomatic, the patient underwent operation 10 months later because of the risk of occurrence of severe conduction disturbances or arrhythmias. Histological examination demonstrated that the mass was a fibroma. At post-op echocardiographic and angiographic evaluation the left ventricle appeared abnormally dilated with a large aneurysm of the lateral wall and very poor pump function. Nevertheless the patient did well in the following months until a ventricular fibrillation occurred at home. He was immediately brought to hospital and resuscitation was attempted unsuccessfully. We discuss the role of 2D echocardiography in the diagnosis of cardiac tumors, the indication of the early surgical removal and the possible limitations of the technique we used in this case.

Echocardiography↗

[Cardiac fibroma in a neonate].

Fibroma of the interventricular septum 3 cm in diameter caused a heart failure in a 2-day-old neonate. The tumour infiltrated neighboring heart muscle the fibres of which grew atrophic.

Female↗

[Nevoid perifollicular fibromas (Zackheim and Pinkus)].

We present a short report on a patient with nevoid perifollicular fibromas. The histology, differential diagnosis and etiology of these proliferations, which arise only from connective tissue, are discussed on the basis of the literature.

Adult↗

[Fibroma of the small intestine with heterotopia of the pyloric glands in the mucous membrane covering the tumor].

Small bowel tumour, 5 X 3 X X 3 cm in size, in a woman of 52 provoked intestinal invagination. Small bowel was resected with the tumour which was diagnosed histologically as a soft fibroma. Focal areas of the pyloric glands with single argyrophil endocrine cells as well as "stomach metaplasia" of the epithelium of one crypt were detected in the intestinal mucous membrane covering tumour. In the author's opinion, this heterotopia is related to the developmental malformation.

Choristoma↗