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Aortotomy and endarterectomy of the ascending aorta for aortic valve replacement in a patient with porcelain aorta.

Patients with a calcified "porcelain" aorta may also have aortic valve stenosis, necessitating aortic valve replacement to prevent cerebral complications. However, a porcelain aorta can be difficult to open, and ascending aorta repair sutures are almost impossible to insert in a calcified plate. We devised a method of aortotomy using a small oscillating saw, which allowed us to incise the aortic wall cleanly without destruction or the formation of debris. After partial endarterectomy of the calcified plate with aortotomy, closure of the aorta was buttressed with bovine pericardium. During the endarterectomy, we used an elevator designed for hand surgery to exfoliate the calcified intimal plate.

Aged↗

A minimally invasive technique in occlusive disease of the superficial femoral artery: remote endarterectomy using the MollRing Cutter.

Remote endarterectomy is a minimally invasive technique for revascularization that shortens hospital length of stay and reduces patient morbidity and mortality. With the use of the MollRing Cutter (Vascular Architects, Inc., San Jose, CA), a modification of the single ring stripper, the surgeon is able to cut the endoluminal atheroma core remotely from the site of entrance to the vessel. The surgical exposure for remote endarterectomy of the superficial femoral artery can thus be limited to a small, single groin incision.

Arterial Occlusive Diseases↗

Surgical endarterectomy for suprarenal iliac artery stenosis in renal allograft recipient.

Aortoiliac surgery performed in renal transplant recipients carries the risk of inducing a prolonged period of ischemia that can threaten organ survival. Recently, endovascular techniques have been increasingly applied but the rate of complications and recurrences remains significant. We report the case of a kidney heterotopic allotransplant recipient who presented with a history of new-onset arterial hypertension, right lower limb claudication, and allograft dysfunction related to a long, eccentric, and ulcerated plaque causing hemodynamic stenosis of suprarenal iliac artery that was successfully managed with surgical endarterectomy. Despite new advances in less invasive procedures such as transluminal angioplasty and stent implantation, surgical endarterectomy of suprarenal iliac artery may be safely performed in selected heterotopic kidney transplant recipients. It allows for complete removal of the plaque, with better long-term results, and does not preclude subsequent endovascular or surgical procedures; therefore it should be considered a therapeutic option in this clinical setting.

Arterial Occlusive Diseases↗

Carotid eversion endarterectomy: perioperative outcome and restenosis incidence.

Carotid endarterectomy (CEA) for stroke prevention can be performed with minimal perioperative mortality and morbidity rates. The type of surgical technique used is important to achieve optimal outcome from CEA. The purpose of this study was to analyze the perioperative and late results of carotid eversion endarterectomy (CEE) in more than 400 procedures. From August 1992 to December 1999, 402 primary CEEs were performed in 388 selected patients for symptomatic (235/58.4%) and asymptomatic (167/41.6%) carotid lesions. During the same period, 234 primary CEAs with patch closure were performed in 229 selected patients. All CEAs were carried out with continuous electroencephalographic monitoring for selective shunting, using deep general anesthesia. All patients underwent postoperative duplex ultrasound study and clinical follow-up at 1, 6, and 12 months and every year thereafter. The mean follow-up was 50 months (range 3-88). Main end points were perioperative stroke and death, and restenosis. Our results showed that use of the CEE procedure can reduce perioperative mortality and stroke risk rates to around zero and results in no restenosis.

Aged↗

EEG as a criterion for shunt need in carotid endarterectomy.

The efficacy of continuous intraoperative electroencephalographic (EEG) monitoring as a criterion for selective shunt use during carotid endarterectomy is evaluated in a group of 1661 operations in which the EEG was the sole criterion for shunt insertion. EEG monitoring is measured by the intraoperative stroke rate. Carotid stump pressure measurements were recorded as an additional observation in 1517 operations and represent a subset of the study group allowing comparison of this technique with EEG. Intraoperative stroke rate for the 1661 operations in the study group was 0.03% (five strokes). A statistically significant increase in intraoperative stroke rate was associated with the development of an abnormal EEG (1.1%), contralateral internal carotid artery occlusion (1.8%), and the combination of both abnormal EEG and contralateral internal carotid occlusion (3.3%). The EEG remained normal in 1295 operations including 75 operations with contralateral internal carotid artery occlusion. One minor intraoperative stroke (0.08%) which resolved in 1 week occurred in the absence of an EEG change with no intraoperative strokes in the 75 operations in which the contralateral internal carotid artery was occluded. Intraoperative EEG monitoring accurately (99.92%) identified patients who may safely have carotid endarterectomy without the need of a shunt.

Adult↗

Safety and efficacy of eversion carotid endarterectomy for the treatment of recurrent stenosis: 20-year experience.

Current options for treating recurrent carotid stenosis (RCS) include standard longitudinal arteriotomy and patch angioplasty with or without carotid endarterectomy (s-PCEA), carotid-carotid bypass, or carotid angioplasty and stent (CAS). Eversion carotid endarterectomy (e-CEA) is an effective procedure for treating primary carotid stenosis, yet it has not been reported for treating RCS. We evaluated the feasibility and outcome of e-CEA for treating of RCS in comparison to s-PCEA. The records of all patients undergoing elective CEA for symptomatic and asymptomatic high-grade RCS from January 1981 to July 2002 were reviewed. Although during the earlier period s-PCEA was performed preferentially, this paradigm changed to e-CEA being the preferred technique for treatment of RCS. During the course of postoperative follow-up when duplex sonography suggested high-grade RCS, the diagnosis was confirmed via arteriography. Data on cranial nerve injury, recurrent stenosis, stroke, and death were prospectively collected into a vascular registry database and analyzed retrospectively, Students' t-test and chi-square analysis were used to compare the group's baseline characteristics and outcomes. Over a 21-year period, 7001 patients underwent primary CEA for symptomatic (n = 2405, 34%) or asymptomatic (n = 4596, 66%) high-grade stenosis via standard (n = 1501, 21%) or eversion (n = 5500, 79%) techniques. Fifteen (25%) patients had 70 to 80% stenosis, 30 (51%) had 81 to 90% stenosis, and 14 (24%) had 91 to 99% stenosis. During this time period, 59 patients presented with symptomatic (n = 18, 31%) or asymptomatic (n = 41, 69%) high-grade RCS and underwent operative repair via s-PCEA (n = 22, 37%) or eversion (n = 37, 63%) techniques. The mean time interval for repeat carotid surgery for RCS was 49 months in the s-PCEA group and 48 months in the e-CEA group. Permanent cranial nerve injuries, stroke, and recurrent restenosis occurred in one (4.5%), one (4.5%), and one (4.5%) of the patients undergoing s-PCEA, respectively. In the e-CEA group, these events occurred in one (27%), none (0%), and one (2.7%) patients, respectively, There were no deaths during the 30-day postoperative period. Eversion CEA is a feasible option for the treatment of many RCSs and can be performed safely with a low rate of cranial nerve injury, recurrent stenosis, stroke, and death.

Aged↗

Hyperperfusion syndrome after carotid endarterectomy.

The hyperperfusion syndrome is a rare delayed postoperative complication of carotid endarterectomy (CEA) characterized by headache and seizure, with or without intracranial edema or hemorrhage. Between January 1996 and December 2003, 1,602 CEAs were performed. Six patients (0.4%) developed symptoms of hyperperfusion within 2 weeks of surgery. All patients had critical stenoses, five > or =90% and one 80-90%, with poor backbleeding from the distal internal carotid artery noted at operation in all cases. Five patients were asymptomatic prior to operation; one had a hemispheric transient ischemic attack. Three patients had severe contralateral internal carotid disease (two occlusions and one severe stenosis). Two patients developed severe, self-limiting headache that prolonged hospitalization. Three patients had ipsilateral intracranial bleeding, two occurring after an uneventful postoperative course. After initial discharge from the hospital, severe intracranial hemorrhage caused death in two patients. One patient experienced focal seizures 1 week after discharge. Hypertension did not appear to be related to the symptoms in any case. During the study period, the hyperperfusion syndrome caused three of five perioperative strokes (60%) and two of seven deaths (29%) in the entire endarterectomy population. Although rare, the hyperperfusion syndrome accounts for a significant percentage of the neurological morbidity and mortality following CEA.

Aged↗

Endovascular repair of carotid artery aneurysms following carotid endarterectomy.

Aneurysm of the carotid artery following endarterectomy is a rare entity that historically has required reoperation. Endovascular deployment of a covered stent can theoretically exclude an aneurysm while minimizing the risks seen with reoperation. Herein, we review the scientific literature on this evolving technique and report an additional case involving successful treatment of an aneurysm that developed following remote endarterectomy.

Aged↗

Pseudoaneurysm formation following carotid endarterectomy: two case reports and a literature review.

Arterial pseudoaneurysms lack all three layers of the arterial wall and are therefore prone to enlargement. They are common after injuries to the artery in the form of blunt trauma, puncture, or prior surgery. They present frequently with swelling, pain, thrombosis, and rupture and occasionally with infection. Options for repair include primary arteriorrhaphy, partial excision with patch angioplasty, and total excision with interposition grafting. We present two cases of pseudoaneurysm following carotid endarterectomy: one with infection, and one with sterile enlargement. A review of the literature suggests that pseudoaneurysm formation following carotid endarterectomy is an uncommon event, and infection of these lesions is even less likely. There appears to be no difference in incidence whether or not the patient had closure of the arteriotomy with a patch angioplasty. The principles of repair include removal of all infected tissue, reconstruction with autogenous vein if possible, and vascularized flap coverage.

Aged↗

Postoperative morbidity of closely staged bilateral carotid endarterectomies: an intersurgical interval of 4 days or less.

The purpose of this study was to determine if there is increased morbidity and mortality with bilateral carotid endarterectomies (CEAs) done with an intersurgical period of less than 4 days compared to historical groups of unilateral CEAs, or those with a greater intersurgical delay. From January 1991 to July 1998, 1390 carotid endarterectomies were performed, of which 154 (11.1%) were closely staged bilateral CEAs. Seventy-seven patients (51 male, 26 female; mean age 72.5 years) underwent bilateral CEAs within 4 days or less. Immediate and 30-day postoperative morbidity, including neurologic deficits, cranial nerve deficits, and mortality, were documented. Although controversial, there is no increased morbidity or mortality with bilateral CEAs done with an intersurgical delay of less than 4 days, when compared to the unilateral CEA historical groups.

Aged↗

Evaluation of thrombogenicity of fluoropassivated polyester patches following carotid endarterectomy.

The use of a patch after carotid endarterectomy (CE) is recommended to reduce the incidence of restenosis. Most studies on this subject report the implantation of saphenous vein or PTFE patches, because polyester has always been considered to be a thrombogenic material. The purpose of this study was to evaluate the thrombogenicity of a knitted polyester patch passivated by fluoropolymer surface treatment (FPD patch), which experimental studies have demonstrated to be less thrombogenic than other materials. This prospective, randomized study was performed in 22 patients who underwent CE. In 11 patients the arteriotomy was sutured directly, while in the other 11 an FPD patch was applied. Patients' 111in-oxine labeled platelets were reinjected on the first postoperative day, and scintigraphies were performed after 4, 24, and 48 hr, respectively. The study confirmed that an FPD patch is no more thrombogenic than a simple carotid endarterectomy. The application of the patch, therefore, can be recommended to reduce restenosis without any adjunctive thromboembolic risk.

Aged↗

A comparison of angioplasty with stenting versus endarterectomy for the treatment of carotid artery stenosis.

Carotid endarterectomy has been established as the standard treatment for high-grade carotid stenosis. The results of an ongoing prospective trial for the safety of percutaneous angioplasty with stenting (PTAS) were compared to retrospectively reviewed patients treated with carotid endarterectomy (CEA). During the same 14-month period, 273 patients underwent treatment of 310 carotid bifurcation stenoses: 107 by PTA with stenting, 166 by CEA. Indications for treatment included stroke 46 (16.8%), transient ischemic attack 109 (39.9%), syncope 7 (2.6%), and high-grade asymptomatic stenosis 111 (40.7%). Combined early stroke and death rates are listed as follows: [table: see text] Important nonneurologic complications were evident in six (5.6%) PTAS patients and two (1.2%) CEA patients. Six-month follow-up data was available for 193 patients (71%) with the following results: seven (6.5%) minor strokes in the PTAS group, one (0.6%) minor stroke in the CEA group, one (0.9%) major stroke in the PTAS group, one (0.6%) major stroke in the CEA group, four deaths (3.7%) in the PTAS group, and six deaths (3.6%) in the CEA group. Early results from PTA with stenting are promising but not safer than CEA for the treatment of carotid artery stenosis. Long-term follow-up is needed to determine the ultimate durability of this new technique. PTA with stenting may be an alternative for the treatment of carotid bifurcation lesions in selective high-risk surgical patients.

Aged↗

Transcranial Doppler intraoperative monitoring during carotid endarterectomy: experience with regional or general anesthesia, with and without shunting.

To determine whether continuous transcranial Doppler (TCD) can significantly alter therapeutic conduct during carotid endarterectomy, a retrospective study of 117 carotid endarterectomies was done. There was no perioperative mortality; one perioperative stroke was recorded in a patient who was symptomatic preoperatively. Continuous TCD of the ipsilateral middle cerebral artery (MCA) was attempted in 99 cases, and successful in 90; nine patients (9.1%) had inadequate temporal windows for MCA access. MCA velocities and emboli were recorded before and during carotid cross-clamping, and on clamp release. There were no significant velocity differences between the patients with regional and general anesthesia, and patients with and without carotid shunts, but there was a statistically significant difference in the total number of emboli (air and particulate transients) noted for the shunted and nonshunted patients after clamp release: 12.7 versus 23.6, respectively (p = 0.05). There was no significant difference when particulate and air microemboli were compared. During surgery TCD identified residual flow of less than 40% in the MCA in 17 patients (18.8%). TCD also identified hyperperfusion in two patients, shunt abnormalities in three patients, and influenced postop treatment in four patients, one of whom was returned to surgery. TCD is an important tool for identifying patients who would benefit from a shunt, preventing hyperperfusion, identifying postop emboli, and detecting technical errors.

Aged↗

Preoperative testing before carotid endarterectomy: a survey of vascular surgeons' attitudes.

Traditional surgical practice and published consensus statements from major vascular surgery specialty societies have considered contrast arteriography to be a routine part of the diagnostic evaluation prior to carotid endarterectomy (CEA). However, some surgeons now omit routine preoperative arteriography if a technically adequate carotid duplex scan is performed and indications for CEA are clear. To better establish current practice patterns and to characterize vascular surgeons' opinions about the role of preoperative arteriography, the Peripheral Vascular Surgery Society membership was surveyed by mail. Eighty-six percent of the members responded (430 of 502). Ninety-three percent of all patients considered for CEA are evaluated with duplex scanning; 82% with arteriography. While the majority of surgeons typically obtain both a duplex scan and an arteriogram, 70% have performed CEA without a preoperative arteriogram. Brain imaging studies (CT or MRI) are obtained in 26% and MR angiograms in 10% of cases. Seventy-five percent of the surgeons agreed with the statement that CEA without preoperative arteriography is an acceptable practice if appropriate indications for surgery are present. Furthermore, one third believed that CEA without a preoperative arteriogram is generally acceptable (acceptable more than half the time). Respondents were stratified by surgical experience time in practice and practice type. No significant differences in responses were found, suggesting the acceptance of CEA without preoperative arteriography is broad-based. This survey demonstrates changing attitudes among practicing vascular surgeons regarding the necessity for routine arteriography prior to CEA. Carotid endarterectomy on the basis of duplex scanning and clinical assessment should be considered an accepted alternative.

Attitude of Health Personnel↗

Prophylactic carotid endarterectomy in patients with high-grade carotid stenosis undergoing coronary bypass: does it decrease the incidence of perioperative stroke?

The etiology of perioperative stroke in patients undergoing isolated coronary artery bypass grafting (CABG) is multifactorial. One significant cause is thought to be high-grade internal carotid artery stenosis. Between April 1992 and June 1995, 1686 patients undergoing isolated CABG underwent preoperative carotid duplex scanning. This represented 77% of patients who underwent CABG during that time period (2188 patients). Sixty-eight patients (4.0%) had 80%-99% stenosis of at least one carotid artery. Fifteen patients underwent CABG without carotid intervention (Group I) and 53 patients underwent either carotid endarterectomy prior to CABG or simultaneous with CABG (Group II). Age, sex, history of prior neurologic events, ejection fraction, number of distal bypasses performed, total pump time, and aortic cross clamp times were similar between the two groups. Three patients in Group I developed a permanent postoperative neurologic deficit (20%) and one patient developed a transient deficit. The defect was focal and ipsilateral to high-grade stenosis in three patients and global in one. No patient in Group II developed either a transient or permanent neurologic deficit. There was one death in Group I in the patient who developed a global neurologic deficit and one death in Group II 2 weeks after CABG in a patient who had undergone prophylactic preCABG-carotid endarterectomy. Statistical analysis (Fisher's exact test, 2-tail) demonstrated a significant decrease both in total neurologic events (p = 0.001) and permanent neurologic defects (p = 0.005) in those patient undergoing prophylactic CE (Group II). Patients with 80%-99% carotid stenosis undergoing CEA prior to or in conjunction with isolated CABG have a decreased incidence of neurologic events postoperatively.

Aged↗

Carotid endarterectomy: the mandate for high quality duplex.

Excellent correlation between carotid angiography and duplex scanning has made it possible to perform carotid endarterectomy without angiography. The accuracy of scans from practices without a dedicated vascular laboratory must be validated prior to their use for clinical decisions. Seventy six patients had a carotid duplex performed at an outside institution and were referred for vascular surgery. All patients underwent a repeat study at our dedicated vascular lab. The overall accuracy of our lab was 93.8% for all carotid categories as demonstrated by angiography. Outside carotid duplex reports correlated with repeat exams as follows: occlusions: 10/13 carotids (76.9%); 80%-99% stenoses: 15/39 carotids (38.5%); 50%-79% stenoses: 28/44 carotids (63.6%). If a surgeon's practice is to operate for asymptomatic 80%-99% stenoses by report, then unnecessary surgery might have been performed in 61.5% of these carotids and appropriate surgery denied in 3.6%. Outside duplex velocities consistent with a 60%-99% stenosis correlated in 13/17 carotids (76.5%). If a surgeon's practice is to operate for asymptomatic 60%-99% stenoses based on velocity criteria, then unnecessary surgery might have been performed in 23.5% of these carotids, and appropriate surgery denied in 7.6% placing these patients at increased risk of stroke. Outside scans significantly overestimated the severity of carotid disease (p = 0.003). The weighted kappa analysis for agreement between scans was only 60.2%. Failure to have validated high-quality duplex in labs performing carotid studies can lead to unnecessary angiography or surgery. Carotid endarterectomy without angiography should be performed only when duplex accuracy has been previously validated by angiographic correlation studies. Poor agreement with studies from practices without a dedicated vascular lab makes it mandatory to repeat the duplex on all patients prior to clinical decision making. Reimbursement for such repeat studies should not be denied.

Blood Flow Velocity↗

Proposed new duplex classification for threshold stenoses used in various symptomatic and asymptomatic carotid endarterectomy trials.

Current duplex ultrasound criteria for internal carotid artery (ICA) stenosis (1%-15%, 16%-49%, 50%-69%, 70%-99%) may not be applicable to threshold stenoses used in symptomatic (North American Symptomatic Carotid Endarterectomy Trial [NASCET], Veterans' Administration [VA]) and asymptomatic (Asymptomatic Carotid Atherosclerosis Study, VA) carotid endarterectomy (CEA) trials. This, along with increasing reports advocating CEA based on duplex results alone, prompted us to identify (1) new velocity criteria consistent with threshold stenoses used by these trials, and (2) velocity criteria with a high positive predictive value (PPV) (> 95%) and accuracy for detecting > or = 60% and > or = 70% ICA stenoses. This is the first study to propose criteria which can be used for all current CEA trials. The color duplex ultrasound (CDU) and arteriogram results of 462 ICAs were analyzed in blind fashion. Angiographic stenosis was calculated as in NASCET. Three velocity criteria (peak systolic velocity [PSV] of the ICA, end diastolic velocity [EDV] of the ICA, and the ratio of the PSV of the ICA/common carotid artery) were recorded and subjected to receiver operator characteristic curves (ROC) analysis to determine optimum criteria for identifying ICA stenoses of > or = 30%, > or = 50%, > or = 60%, and > or = 70%-99%. For > or = 30% stenosis (st): PSV > or = 120 cm/sec had an overall accuracy (OA) of 87%, sensitivity (sen.) of 93%, specificity (spec.) of 67%, PPV of 90%, and negative predictive value (NPV) of 77%; for > or = 50% st: PSV > or = 140 cm/sec had an OA of 93%, sen. of 92%, spec. of 95%, PPV of 97%, and NPV of 89%; for > or = 60% st: PSV > or = 150 cm/sec and an EDV of > or = 65 had an OA of 90%, sen. of 82%, spec. of 97%, PPV of 96%, and NPV of 86%; for > or = 70%-99% st: PSV > or = 150 cm/sec and an EDV of > or = 90 had an OA of 92%, sen. of 85%, spec. of 95%, PPV of 91%, and NPV of 92%. An ICA-PSV and EDV of 150, 65, and 150, 110 had the best PPV (> or = 95%) in detecting > or = 60% and > or = 70% st, respectively. When these new criteria are used, CDU can accurately detect threshold stenoses used by various CEA trials. Selected velocities with a high PPV (> 95%) may be used as the sole preoperative imaging.

Adult↗

Computerized tomographic angiography scan following carotid endarterectomy.

The purpose of this study was to evaluate the role of computed tomographic angiography (CTA) for postoperative assessment of carotid endarterectomy (CE). Twenty carotid endarterectomies were performed and controlled by using (1) intraoperative angiography, (2) postoperative duplex scanning and CTA with multiprojection volume reconstruction (MPVR). Intraoperative angiographic controls were deemed satisfactory for all patients. In 12 patients, the postoperative morphological aspect was satisfactory with CTA and duplex scanning. In the eight remaining patients, CTA and/or duplex scanning revealed 12 abnormalities: 3 were equally visualized on CTA and duplex scanning, 6 only on CTA and 3 only on duplex scanning. CTA is a rapid and noninvasive technique allowing the surgeon to get informative and comparative data. It might be an interesting alternative to postoperative angiography.

Aged↗