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Contact sensitization in chronic venous insufficiency: modern wound dressings.

Patch tests with an expanded European standard series and 20 different wound dressings revealed sensitization in 78% of all (36) patients. The charts of allergens were headed by ointment bases (wool wax alcohols sensitization in 33% of all patients; Amerchol L-101 19.4%; cetearyl alcohol 13.9%; propylene glycol 8.3%), followed by plant resins/ethereal oils (balsam of Peru 22.2%; colophony 13.9%, fragrance mix 8.3%; propolis 5.6%) and topical antibiotics (neomycin sulfate 16.7%, chloramphenicol 13.9%), while usually common sensitizers like metal salts were not found as often (nickel sulfate 16.7%; potassium dichromate 13.9%; cobalt chloride 5.6%). Sensitization to modern wound dressings was found in 8.3% (3 cases) and was caused by propylene glycol as an ingredient of hydrogels; no sensitization was found to hydrocolloids, alginates or polyurethane foams. The overall sensitization rate in 2nd degree CVI was nearly as high as in 3rd degree CVI, but sensitization to ointments, their additives and topical antibiotics was significantly higher in 3rd degree CVI. Significant differences in sensitization frequencies to individual allergens were found between male and female patients. Our investigation points out the high risk of sensitization in 2nd as well as 3rd degree CVI, especially to ointment bases and active principles of topical drugs. Even wound dressings may cause allergic contact reactions.

Adult↗

Influence of irrigation and intracanal dressing on the healing process of dogs' teeth with apical periodontitis.

Dogs' teeth with apical periodontitis were treated endodontically, Dakin's solution being used in an experimental group as the irrigation solution, and camphorated paramonochlorophenol as an intracanal dressing. For a second group of teeth, the irrigation solution used was physiologic saline, dry cotton only being placed into the pulpal chamber to take the place of an intracanal dressing. In a second visit, overinstrumentation and a new application of the same kind of dressing were performed, the root canals being then filled with gutta-percha cones and zinc oxide-eugenol cement. Other specimens were treated, in one visit, where physiologic saline or Dakin's solution were the irrigation solutions. The animals were sacrificed 6 months after the obturation of the root canals. Histologic exams showed better results for the experimental group where Dakin's solution and camphorated paramonochlorophenol had been used, with signs of repair characterized by newly formed cementum and bone tissue, as well as a marked reduction in size of the periapical lesions. No differences were seen in the results with physiologic saline or Dakin's solution as irrigants.

Animals↗

Effect of calcium hydroxide dressing on seal of permanent root filling.

Low apical leakage along root fillings following an application of calcium hydroxide was reported in a few methylene blue dye penetration studies. It has been found recently that methylene blue is decolored by calcium hydroxide, indicating that the short penetration of methylene blue may not be due to a tight seal only. Of the 80 roots of human maxillary central incisors used in this study, 40 roots (group 1) received calcium hydroxide root canal dressing whereas another 40 roots (group 2) did not. All the roots were then obturated with gutta-percha and Tubli-Seal sealer. Leakage along 20 filled roots in each group was measured using a modified fluid transport model at 48 h, 2, 4, 8 and 16 weeks after obturation; whereas leakage of another 20 filled roots in each group was measured using dye penetration with 1% methylene blue. Using the fluid transport model, no significant difference was found between the two groups at any time interval (P = 0.4847, 0.3875, 0.9490, 0.4786, 0.9148 respectively after 48 h, 2, 4, 8 and 16 weeks); using the methylene blue penetration method, leakage in group 1 (with root canal dressing) was significantly less than that in group 2 (without root canal dressing) (P = 0.0374). The contradiction in results from the different models indicated that problems existed with the models.

Calcium Hydroxide↗

Evaluation of Tielle hydropolymer dressings in the management of chronic exuding wounds in primary care.

The concept of moist wound healing is not fully implemented in daily practice in Germany. Thus, the objective of this investigation was to evaluate the use of Tielle hydropolymer dressings in chronic exuding wounds in primary care. A total of 6,993 patients with pressure sores (26.6%), venous leg ulcers (59.8%), diabetic foot disease (9.5%) and other wounds (5.1%) were enrolled into three multicentre, open-label, single-arm, prospective phase-IV studies for an observational period of either 4 or 12 weeks. Within the 4 (12)-week study using Tielle, 43.3% (59.1%) of the wounds healed and 51.6% (36.9%) improved. Wound area was reduced by 78.2% (85.1%). Medium or strong levels of exudates were reduced from 57.4% to 6.7% (4.0%). Cosmetic results were excellent or good in 96.3%. Compared with patients' previous treatment, efficacy and tolerability were assessed as better or much better in 92.5% and 70.4%, respectively. 97.1% of the patients remained free of adverse events. The frequency of dressing changes was reduced from 5 to 3 per week (-43%). Tielle provides an effective and safe dressing in the management of chronic exuding wounds in primary care improving patient's comfort. Due to longer wearing times, Tielle may also be cost saving.

Adolescent↗

Evaluation of dressings to aid healing of mulesing wounds on sheep.

Five proprietary and one experimental dressing were compared with no treatment in their ability to aid healing of mulesing wounds in over 1900 young lambs. Healing was judged as the completeness of shrinkage of the mulesing cuts and the condition of scabs on the new skin surface. When assessed at 21 d it was found that treatment with Heriots Crown Wound Powder or Coopers Mulesing Powder offered a significant advantage over leaving the wounds untreated. Neither aqueous organophosphate washes, Defiance nor Defiance containing 0.08% chlorfenvinphos offered any healing advantage over controls. However, washing the wounds with an aqueous organophosphate solution aided healing more than the Defiance-based dressings. It was considered that the powders or the washes encouraged quick scab formation either by creating a dry covering (powders) or by washing away blood and allowing fast drying of the wound. The Defiance-type dressings slowed healing by keeping the wound moist for up to 10 d, but healing was not significantly different to the untreated group by 21 d.

Animals↗

Efficacy of dressings for killing larvae of the sheep blowfly.

Resistance to organophosphorus (OP) insecticides in the Australian sheep blowfly has decreased the larvicidal effectiveness of several popular products used as dressings for flystrike. Laboratory bioassays in which near full-size Australian sheep blowfly larvae were immersed in flystrike dressings at registered concentrations for times ranging from 5 to 180 s indicated that none of the products was completely effective in killing highly OP-resistant larvae. Several products performed poorly, even against a susceptible population. Effectiveness did not always reflect the concentration of active ingredient. For example, the products considered to be the most, and least effective overall, contained 0.036% propetamphos but were formulated very differently. Larvicidal efficacy is important in terms of minimising injury to stock but also in the management of insecticide resistance. In situations when the degree of resistance is known, it will be possible to make recommendations for the most cost-effective treatment of flystrike. In the meantime, there appears to be a clear advantage for woolgrowers to use a propetamphos-based flystrike jetting product to dress flystrike lesions.

Administration, Topical↗

Wound dressing adherence: a clinical comparative study.

This prospective study was undertaken to compare the adherence of dressings currently used as non-adherent dressings. Four different dressings were studied on a total of 40 patients. An overall adherence of 50% was encountered, Silicon Polymer Foam being the most successful under the trial conditions.

Adhesiveness↗

Treatment of refractory atopic dermatitis using 'wet-wrap' dressings and diluted corticosteroids: results of standardized treatment in both children and adults.

BACKGROUND: 'Wet-wrap' dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). OBJECTIVE: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. METHODS: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. RESULTS: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. CONCLUSION: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD.

Administration, Topical↗

Efficacy of crisis intervention treatment with topical corticosteroid prednicarbat with and without partial wet-wrap dressing in atopic dermatitis.

BACKGROUND: The wet-wrap treatment has been reported to be beneficial in acute episodes of atopic dermatitis (AD) skin lesions. OBJECTIVE: The efficacy of topical corticosteroid prednicarbat with and without additional wet-wrap dressing was investigated in a prospective, randomized and controlled study. METHODS: In the left-right comparison study, 24 adults and children with an acute episode of AD were included. One arm or leg was randomly treated with the topical corticosteroid prednicarbat plus wet-wrap dressing; only prednicarbat was applied on the leg or arm of the other side. RESULTS: After 48-72 h of treatment, in both groups an improvement of the local SCORAD was observed. In comparison to the side of the body treated with corticosteroid alone, the decrease of the local SCORAD in the corticosteroid plus wet-wrap dressing group was significantly better. The severity of AD improved in the wet-wrap group at an average of 4.4 points, in the corticosteroid group 3.0 (p<0.011). CONCLUSIONS: Wet-wrap therapy with a topical corticosteroid is an effective treatment option in patients with exacerbated AD. The treatment is helpful in improving skin conditions, shortening the time of corticosteroid application.

Adolescent↗

Calcium alginate dressings--I. Physico-chemical characterization and effect of sterilization.

In order to analyze the alginate components of alginate dressings and the fractions which are released when the dressing is in contact with model biological fluids, the use of various analytical methods was considered. The first step was the conversion of a calcium alginate batch to pure sodium alginate. The recovery of the latter from either insoluble or soluble mixed sodium/calcium alginates was performed by complexation of calcium ions with sodium citrate followed by ultrafiltration. Comparisons were made between sugar analysis, 1H NMR and circular dichroism (CD) data to determinate the contents in guluronic and mannuronic acids of sodium alginate chains. It was shown that CD measurements afford a rapid and nondestructive method for determination of %G when one takes the ratio theta200/theta220 into account. Fractionation of crude alginate (generally ranging from 30 to 70% G) was achieved by the triangle dissolution/precipitation method in order to increase the range of alginate in sugar composition. The various validated procedures were applied to investigate the effects of irradiation sterilization on alginate dressings. It was shown that sugar composition is retained whereas molecular weight decreased dramatically due to chain scission.

Alginates↗

Evaluation of Opsite catheter dressings for parenteral nutrition: a prospective, randomized study.

A prospective, randomized study compared the use of Opsite and standard gauze/tape dressings in 261 patients receiving parenteral nutrition. Eighty-four patients had a source of external drainage and were evaluated as a separate group. Catheter-related sepsis was assessed by blood culture, catheter tip culture, clinical sepsis, and clinical defervescence of fever after catheter removal. Although no statistically significant difference between Opsite and standard dressings could be identified, Opsite-treated patients consistently had increased parameters of catheter-related sepsis in all comparisons. As used here, Opsite is probably not a suitable catheter dressing system for parenteral nutrition.

Bandages↗

In-patient treatment of chronic varicose venous ulcers. A randomized trial of cadexomer iodine versus standard dressings.

A total of 67 patients with treatment resistant chronic venous ulcers were admitted to hospital for 6 weeks of bed rest and daily dressings. The patients came from a rural area in Poland with poor socioeconomic conditions. They were randomized to treatment with either standard dressings or with cadexomer iodine. After 6 weeks all but four patients had shown a clear reduction of ulcer area; the mean reduction was 54% within the former group and 71% with cadexomer iodine. The latter treatment was significantly more effective than the standard hospital dressings in debriding the ulcer, accelerating healing and reducing pain. Elevation of serum concentrations of protein-bound iodine occurred after treatment with cadexomer iodine in patients with large ulcers, but tests of thyroid function showed no changes associated with the use of cadexomer iodine. It is concluded that cadexomer iodine significantly accelerates the healing of chronic, infected, treatment-resistant, venous ulcers in hospitalized patients.

Bandages↗

A review of current practice for boys undergoing hypospadias repair: from pre-operative work up to removal of dressing post-surgery.

The aim of this article was to examine an area from dinical practice, in this instance, paediatric urology and to look at the information needs of families prior to their young sons' having surgery to correct a hypospadias. Involving families and promoting informed decision-making with families prior to hypospadias repair for their child is important. To be able to facilitate real involvement the information has to be shared and parents and families given adequate support and opportunity to seek answers to questions. Providing an environment to undertake this, to then learn from the families for the future and to support the development of a National Support group, www.hypospadias.co.uk have been outcomes from setting up a pre-admission clinic. Literature in respect of after-care is very sparse. It became evident from clinical practice that the rationale for applying a dressing postoperatively needed to be explored. Furthermore limited evidence about dressing removal, coupled with the anxiety and upset this caused parents, identified the need to consider two issues (i) a better method of removal of dressings and (ii) the effects on pain scores. A blinded randomized controlled feasibility study was developed and implemented, with completion due at the end of 2001.

Aftercare↗

Psychiatrists and their patients: views on forms of dress and address.

BACKGROUND: Dress styles and forms of address vary among psychiatrists. METHOD: A semi-structured interview was administered to a sample of psychiatric in-patients, and a questionnaire was sent to junior and consultant psychiatrists, to identify preferences for dress styles and terms of address. RESULTS: Forty-nine (71%) of the in-patient sample participated. A preference was found for smart attire and white coats. Of the 69 (80%) doctors returning questionnaires, the majority supported smart dress as the most appropriate attire. Most patients preferred to be called by their first name while addressing doctors by title and surname. Junior doctors preferred to use first names when talking to patients while almost all consultants used title and surname. Doctors of all grades liked to be called by their title and surname. CONCLUSIONS: Paying more attention to the way we present ourselves and interact at work may help to facilitate the therapeutic alliance.

Adolescent↗

A comparison of two hydrocolloid sheet dressings.

This article examines the clinical application of hydrocolloid dressings as a whole. Two thin hydrocolloid sheets - Tegasorb thin and Duoderm extra thin - were essayed in the clinical area, and compared for their ease of application and removal, conformability, wear time and patient comfort. Both dressings were found to be highly acceptable in clinical practice, with advantages and disadvantages to each type of dressing. There was a high level of patient acceptability and no adverse reactions were noted during this evaluation. Pain reduction was noted by patients with superficial pressure sores and trauma wounds that were treated with thin hydrocolloid sheets.

Bandages, Hydrocolloid↗

Honey as a dressing for chronic wounds in adults.

The aim of this review was to identify whether in adults with chronic wounds the use of honey as a wound dressing improves wound management outcomes. As no randomized controlled trials or comparative studies comparing the use of honey as a chronic wound dressing with usual treatment could be found, the review is based on case studies and serial case studies. These were reviewed using a framework broadly based on wound care case study guidelines (Nelson, 2000) and cohort study guidelines (Greenhalgh and Donald, 2000). Based on the case studies reviewed, honey appears to be a useful dressing in adults with chronic wounds, but the available evidence is weak and therefore must be interpreted with caution.

Chronic Disease↗

Melgisorb: a highly absorbent calcium/sodium alginate dressing.

Alginates have been used in wound care for many years. In recent years alginate dressings have developed to provide an extremely cost-effective way of managing wounds with a moderate to high level of exudate. The dressing gel has traditionally been either soft or firm on removal, but with new technology softness and fast gelling may now be combined with high integrity in a single product. An example of such a product is Melgisorb from Mölnlycke Health Care (the makers of Mepore). Melgisorb is just one dressing in their range of chronic wound care products.

Alginates↗

Hydrocoll: a 'new breed' of hydrocolloid wound dressing.

Hydrocolloid dressings were first used in wound management in the 1960s. They provide the optimal environment for wound healing, i.e. a moist environment, constant wound temperature and infrequent dressing changes, and can be used on wounds in various stages of healing. As a result they are a popular treatment option for health professionals in both the community and hospital settings. This article describes the properties of Hydrocoll--a new and exciting range of hydrocolloid dressings from Paul Hartmann Ltd--which was launched in the UK in January 1998 and became available on the Drug Tariff in June 1998.

Bandages, Hydrocolloid↗