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PubMed1987

Single-sample method for the estimation of glomerular filtration rate in children.

A method for the determination of the glomerular filtration rate (GFR) in children which involves the use of a single-plasma sample (SPS) after the injection of a radioactive indicator such as radioiodine labeled diatrizoate (Hypaque) has been developed. This is analogous to previously published SPS techniques of effective renal plasma flow (ERPF) in adults and children and GFR SPS techniques in adults. As a reference standard, GFR has been calculated from compartment analysis of injected radiopharmaceuticals (Sapirstein Method). Theoretical volumes of distribution were calculated at various times after injection (Vt) by dividing the total injected counts (I) by the plasma concentration (Ct) expressed in liters, determined by counting an aliquot of plasma in a well type scintillation counter. Errors of predicting GFR from the various Vt values were determined as the standard error of estimate (Sy.x) in ml/min. They were found to be relatively high early after injection and to fall to a nadir of 3.9 ml/min at 91 min. The Sy.x Vt relationship was examined in linear, quadratic, and exponential form, but the simpler linear relationship was found to yield the lowest error. Other data calculated from the compartment analysis of the reference plasma disappearance curves are presented, but at this time have apparently little clinical relevance.

Adolescent↗
PubMed1985

The use of cerebral ventriculography for verification of intracerebroventricular cannula placement in the live rat.

A technique using cerebral ventriculography for verification of intracerebroventricular cannula placement in the live rat is described. A radiopaque contrast medium, diatrizoate meglumine, was injected into the right lateral ventricle through a cannula stereotaxically implanted into the brain. Radiographic visualization of the radiopaque contrast material in the lateral ventricle and the subarachnoid space verified cannula placement. Transient muscular spasms were observed in about 38% of the injected rats but no lasting changes were observed in the behavior or appearance of these rats.

Animals↗
PubMed1985

Acute renal failure in primary macroglobulinemia with small-molecule IgM.

Primary macroglobulinemia with acute renal failure developed in a 46-year-old man after administration of contrast medium (containing diatrizoate sodium and meglumine [Urografin]) for intravenous pyelography. On admission, the monoclonal protein peak could not be detected in serum by cellulose acetate electrophoresis, but the serial electrophoresis revealed a gradual increase in monoclonal protein peak, which later became two peaks. The serum of the patient contained the monoclonal small-molecule IgM kappa-chain protein with 13 to 14 Svedberg units in sedimentation constants, which is antigenetically the same as native IgM heavy chain. Although acute renal failure is extremely rare in primary macroglobulinemia, the small-molecule IgM seems to be one factor that induces acute renal failure.

Acute Kidney Injury↗
PubMedDate not supplied

A comparison of the cardiovascular responses to carotid injections of ionic and nonionic contrast media.

Selective injection of contrast media into the canine common carotid artery results in alterations in carotid flow, heart rate, and systemic arterial pressure. In this study the responses to injections of the nonionic agents metrizamide and iopamidol were compared to the responses to the ionic agents meglumine iothalamate, meglumine sodium diatrizoate, mannitol, and saline solution. Heart rate and pressure responses were smallest for metrizamide, greater for iopamidol, and greater still for the hypertonic ionic agents: responses were roughly correlated to agent osmolality. Carotid flow increased with all agents and was roughly proportional to the agent's osmolality. The exception was metrizamide which despite its lowest osmolality, produced a large increase in flow which was maintained much longer than for other agents. The total response to the nonionic agents was judged less severe than to the ionic agents; however, the responses to all agents were transient and not life threatening.

Animals↗
PubMedDate not supplied

Effects of intracoronary administration of contrast materials on left ventricular dimensions and rate of relaxation.

The effects of intracoronary administration of ionic and nonionic contrast materials on (LV)left ventricular contractile state, relaxation rate (peak -dp/dt and [-dp/dt]50), and dimensions were determined in eight morphine-chloralose anesthetized dogs. Meglumine sodium diatrizoate caused decreases in peak dp/dt and -dp/dt and increases in left ventricular end systolic dimension (LVESD'), end diastolic dimension (LVEDD'), and end diastolic pressure(LVEDP). The decreases in peak -dp/dt and(-dp/dt)50 persisted after peak dp/dt returned to and exceeded control levels. Calcium meglumine sodium metrizoate caused increases in peak dp/dt but decreases in peak -dp/dt and(-dp/dt)50 and no significant changes in LVEDP, LVESD', or LVED'D. Metrizamide caused no significant changes. Ionic contrast materials induce important changes in LV dimensions and rate of relaxation in addition to producing a depression in contractile state. The decreases in relaxation rate are not reversed by addition of calcium ions.

Animals↗
PubMed1977

[Anticoagulant activity of triiodinated x-ray opaque media (author's transl)].

The anticoagulant activity of the triiodinated X-ray opaque media iodipamide, iothalamate and diatrizoate on standardized normal human pool plasma was investigated in vitro. We found a dose dependent lengthening of the thrombin time, the reptilase time and the partial thromboplastin time together with a dose dependent drop of the calcium thromboplastin and factor V activity. Iodipamide proved to exert the most pronounced anticoagulant activity of the 3 contrast media tested. The results are interpreted as latent disseminated intravascular coagulation with hyperfibrinolysis following the direct interaction of contrast media with the coagulation enzymes.

Blood Coagulation↗
PubMed1980

Effects of contrast media on aortic endothelium. Experiments in the rat with non-ionic monomeric and monoacidic dimeric contrast media.

Injury to the aortic endothelium in rats was evaluated under a light microscope by a silver staining method after application of ionic monomeric (diatrizoate and metrizoate), non-ionic monomeric (C29 with different pH and buffers, 593, iohexol and metrizamide) and monoacidic dimeric (ioxaglate) contrast media, and iso- and hypertonic solutions of sodium chloride. In iodine equivalent concentrations the ionic monomers were significantly more toxic than the other contrast media. No significant was found between the non-ionic monomers, monoacidic dimer and sodium chloride solutions equiosmolal to the ionic monomers. Isotonic saline was the least harmful solution.

Animals↗
PubMed1980

Coronary angiography with iohexol and other contrast media in the dog. I. Electrocardiographic alterations.

In the dog the effects on ECG at coronary angiography with the non-ionic contrast media iohexol and metrizamide and the ionic medium diatrizoate were compared. Iohexol and metrizamide produced less prolongation of the PQ time during left-sided infusions and less prolongation of the QT time during right-sided infusions. Thus, as a cardiovascular contrast medium iohexol may cause fewer incidences of heart block and ventricular fibrillation than ionic contrast media.

Animals↗
PubMed1980

Coronary angiography with iohexol and other contrast media in the dog. II. Left ventricular contractility and work.

At left coronary angiography in the dog the non-ionic media iohexol, 711 and metrizamide caused a similar reduction of the left ventricular pressure, stroke volume and work as Na/Ca/meglumine metrizoate but less than diatrizoate. After the initial reduction all media produced equal increase in the data, exceeding their preinjection levels. The calcium ameliorating the reduced cardiac function produced by metrizoate did not seem to impose an extra load on the left ventricle during the second phase.

Animals↗
PubMed1980

Coronary angiography with iohexol and other contrast media in the dog. III. Contractility of the left ventricle.

Compared with the ionic contrast medium diatrizoate the new non-ionic media iohexol and 711 produced significantly less reduction of contractile force, left ventricular pressure and the first derivative of left ventricular pressure during left coronary angiography in the dog. These two media may be expected to have similar effects on the function of the myocardium as metrizamide.

Animals↗
PubMed1978

Contrast media-induced oliguric renal failure.

Seven patients had acute oliguric renal failure after intravenous urography (2), celiac arteriography (2), or cardiac angiography (3). Diatrizoate meglumine was the contrast media used in all of the cases. These patients had an average age of 63 years and six were 55 years of age or older. Diabetes mellitus, negative fluid balance before the procedure, underlying renal insufficiency, and hypertension were common, being present in three, four, five, and six of the patients respectively . Anuria or oliguria occurred within 24 hours of the procedure and persisted from 36 to 96 hours (72 hours average). The serum creatinine level rose significantly in all of the patients and reached a peak in two to seven days after the procedure. In six patients, recovery was complete by two to three weeks. The seventh patient experienced only partial recovery. These cases taken together with a mounting number of recent reports suggest that contrast media-induced oliguric renal failure is more common than generally believed. Diabetes mellitus, older age, and underlying renal insufficiency seem to be important predisposing factors.

Acute Kidney Injury↗
PubMed1983

Renal vasoconstrictive response to contrast medium. The role of sodium balance and the renin-angiotensin system.

The injection of contrast medium into the renal artery causes a biphasic change in renal blood flow, a transient vasodilation followed by a more prolonged vasoconstrictive phase. The role of sodium balance in the vasoconstrictive response to contrast medium was evaluated in sodium-deplete dogs (n = 5) and sodium-replete dogs (n = 5). Contrast medium, 2 ml of diatrizoate solution per 4 sec, was injected into the renal artery in anesthetized dogs. Renal blood flow was 117 +/- 25 ml/min and 173 +/- 12 in the sodium-deplete and sodium-replete dogs, respectively. After the injection of contrast medium and following the transient vasodilation phase, renal blood flow significantly decreased from baseline by 42.2% +/- 4.2 and 12.2% +/- 1.1 in sodium-deplete and sodium-replete dogs, respectively. The duration of the vasoconstriction phase was significantly prolonged in the sodium-deplete dogs, 343 +/- 27 sec vs. 147 +/- 48 in sodium-replete dogs. Blockade of the intrarenal renin-angiotensin system with the renal artery infusion of Sar1-Ala8-All (50 micrograms/kg/min) did not significantly alter the magnitude of vasoconstrictive response to contrast medium in sodium-deplete animals; however, the duration of the vasoconstrictive phase was decreased from 277 +/- 59 sec to 86 +/- 13. We conclude that (1) sodium depletion accentuates both the magnitude and duration of the vasoconstrictive phase of the renal blood flow response to injection of contrast medium and (2) blockade of the intrarenal renin-angiotensin system shortens the duration of this response.

Animals↗
PubMedDate not supplied

Autoradiographic method for quantitative evaluation of the blood-brain barrier effects of contrast media.

Opening of the blood-brain barrier after intravenous injection of different contrast media has been investigated by a quantitative autoradiographic technique using 14C-aminoisobutyric acid (AIB) as the blood-brain barrier radiotracer. In this study, experiments were carried out in adult rats. Animals were injected intravenously with 2 ml/kg of the tested contrast medium, and immediately afterward with the blood-brain radiotracer AIB. The following contrast media have been tested: diatrizoate 38%, ioxithalamate 38%, ioxaglate 38%, the nonionic product metrizamide 40%, and a new nonionic product P-297, 400 mg l/ml. Control animals were injected intravenously with saline 0.9% (2 ml/kg) before the injection of the tracer. The degree of blood-brain barrier opening was quantitatively assessed by calculating the capillary rate constant for blood-to-brain transfer of AIB (ki) from the brain activity and the arterial integral for a 6 min experiment. Preliminary data seem to indicate that the intravenous injection of 2 ml/kg of a constant medium may produce a tiny opening of the blood-brain barrier. But, if this is so, this blood-brain barrier opening is of a very low magnitude in the normal brain and there are no obvious differences between the test contrast agents injected intravenously.

Animals↗
PubMed1978

Proteinuria following nephroangiography. II. Influence of contrast medium and catheterization in dogs.

Major increases of urinary albumin were common following nephroangiography in dogs using Urografin (diatrizoate) or Isopaque Cerebral (metrizoate) as contrast medium. Neither the catheterization procedure nor the injection of a supposed inert solution resulted in significant albuminuria but following injection of contrast medium albuminuria commenced within a few minutes; normalization occurred within 2 days. Higher doses of contrast medium induced massive albuminuria than lower ones.

Albuminuria↗
PubMedDate not supplied

Neurotoxic effects of water-soluble contrast agents on rat hippocampus.

Electrical activity in cells directly exposed to water-soluble radiographic contrast agents was investigated by intracellular and extracellular recordings from neurons in in vitro rat hippocampus slices. Measurements included extracellular field potentials, intracellular resting membrane potential and membrane conductance, postsynaptic events, action potential configurations and spontaneous electrical activity. The neurons were exposed to test solutions of an ionic contrast agent, sodium diatrizoate, and a nonionic contrast agent, metrizamide, as well as control solutions. The ionic contrast agent produces bursts of action potentials having epileptogenic characteristics which is temporally followed by a depression of all electrical activity. The nonionic contrast agent produces minimal convulsive-like electrical bursts, but does produce a consistent depression of transmembrane electrical potentials, though in a lesser degree than the ionic contrast agents. The excitatory electrical events appear to be related to large depolarizing post-synaptic events while the later electrical depression is at least partially due to hyperpolarization. The depressing effects may be related to the hyperosmolality of the test solutions; however, no excitatory changes are related to hyperosmolality. These results provide the initial data on the neurotoxicity of water-soluble contrast agents at the intraneuronal level.

Action Potentials↗
PubMed1984

[Contrast medium elimination by hemodialysis].

In 6 patients with no apparent kidney function the elimination of contrast medium was examined using 125I-labelled diatrizoic acid. Also blood level time curves and concentrations of dialysate were measured, showing a biexponential fall. The kinetic data established by computer-aided analysis according to the two-compartment model yielded elimination values not achieved by a healthy kidney; however a maximum elimination rate of 80.7 +/- 4.7% of the dose administered was calculated for a dialysis period of more than 10 hours. As the contrast medium plasma level was reduced the efficacy of haemodialysis fell.

Contrast Media↗
PubMed1984

[Contrast material with oxygenated Fluosol-DA, 20 for the protection against complications of catheter cerebral angiography].

Although computed tomography may change the criteria of cerebral angiography in neurosurgery, the neurosurgeon still requires angiographic confirmation of vascular anatomy at the operative sites, and catheterization for intra-luminal constructive surgery is also seeing progress. Cerebral angiography is a rather safe procedure; however, persistent serious neurological deficits and fatal complications are occasionally reported. The mechanisms of these complications are considered to be due to mechanically dislodged fragments of clots and/or atheroma, or direct endothelial damage by the catheter, contrast agents toxicity to brain tissue, anoxic neurocytologic injury due to the disturbance of the blood flow. Fluosol-DA (a type of perfluorochemical) has a potent oxygen-carrying capacity and has been safely used in humans as an artificial blood substitute. Meglumine diatrizoate (65% Angiografin) has not lost the x-ray opacification faculty in cerebral angiography by mixing with oxygenated Fluosol-DA, 20 up to 30 vol % of the latter in clinical use. In animal experiments, from 0.25 to 4 ml/kg of Angiografin-65 or Angiografin-65 with oxygenated Fluosol-DA, 20 were injected into the internal carotid artery of mongrel dogs. When 2.0 ml/kg of Angiografin-65 was injected into the carotid artery, remarkable arrhythmia was observed for 7.5 seconds. Blood pressure dropped 28.3 mmHg for 20.2 seconds; thereafter, it increased 25 mmHg in rebound for 15 seconds. Intracranial pressure increased 5 mmHg for 35 seconds, respiratory disturbance continued for 22.6 seconds. When a 20 vol % mixture of Fluosol-DA, 20 with Angiografin-65 was applied, these adverse reactions were markedly reduced.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗