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Results for “CEREBELLAR NEOPLASMS”

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PubMed2004

An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies.

Eight patients with paraneoplastic cerebellar degeneration (PCD) and anti-Yo antibodies were investigated to determine whether there is any association between cytotoxic T lymphocyte (CTL) responses reactive with two previously defined Yo-derived, HLA-A2.1 restricted epitopes (cdr2-1 and cdr2-2) and the presence of tumour-infiltrating CD8+ CTLs. cdr2-1 and cdr2-2-specific CTL responses could not be detected in 5 HLA-A2.1(+) patients in an ex vivo interferon-gamma ELISPOT assay and only 2/9 tumour sections contained CD8(+) intratumoural lymphocytes suggesting a very limited role for CTL-mediated tumour immunity in this patient group, all of whom had evidence of widespread malignancy at the time of diagnosis and/or death.

Antibodies, Neoplasm↗
PubMed1994

Pediatric cerebellar medulloblastoma and extraneural metastases: a case study.

Brain tumors, the most common solid tumors affecting children, account for nearly 20% of all pediatric neoplasms. They occur second in incidence only to leukemia and are the leading cause of cancer-related death in children under 15 years of age. Of the many different brain tumors, medulloblastoma is one of the most common, accounting for 20% of all intracranial neoplasm. Once a reportable event, extraneural metastases of this tumour now occur at a rate of 7% and reports suggest the prevalence may be increasing. These children represent a major therapeutic challenge, that for optimal results require the coordinated efforts of a multidisciplinary approach. The nurse may play a vital role in the mobilization and coordination of many specialists. The intent of this case study is to highlight the essential link in the role of the nurse as a facilitator, coordinator and liaison, within the context of caring for a child with a malignant brain tumour.

Bone Neoplasms↗