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To circ or not to circ: indications, risks, and alternatives to circumcision in the pediatric population with phimosis.

Summary Although there continues to be considerable debate over the merits of circumcision, it is clear that preservation of the pediatric foreskin, even in the presence of phimosis, is a viable option. Steroid topical cream is a painless, less-complicated, and more economical alternative to circumcision for treating phimosis. Success rates are quite high, especially when patient selection is appropriate and parents are adequately instructed on application. In those children in whom topical steroid therapy has failed, there remains a variety of foreskin-preserving surgical options for treating phimosis. Compared to circumcision, these less-invasive techniques are associated with lower morbidities and cost. Furthermore, depending on the tissue-preserving technique used, satisfactory cosmesis is also achieved. Thus, those males who were not circumcised at birth now have medical and surgical options, which will decrease the likelihood of requiring circumcision at an older age. As health care providers in the United States see more and more uncircumcised male children, it is important for these children and their parents to understand the natural history of physiologic phimosis. Additionally, it is the responsibility of health care providers to present the management options available for the treatment of the persistent nonretractile foreskin and/or pathologic phimosis. These options are particularly important for those individuals whose religious, cultural, or personal preference is to retain the foreskin.

Adolescent↗

[Cerebral renin-like activity in different functional conditions (author's transl)].

Using the Boucher micromethod of determining renin activity in the frontoparietal cortex, brain stem, hypothalamus, hypophysis, and epiphysis rat tissue in different functional conditions, we have observed the following: 1 In rats previously treated with an I. V., injection of 1-1.5 ml 10% NaCl, an increase of renin-like activity was found in the cerebral cortex, brain stem and hypothalamus, whereas in the grandular tissue there was a significant decrease...

Angiotensin II↗

[A case of penile cavernitis following a penile prosthesis implantation].

A 25-year old man, who had an inferiority of having a small penis and normal potency, underwent intracavernous implantation of hand-made silicone rods by a cosmetic surgeon in order to enlarge his penis. He had pyrexia and swelling of the penis 2 days after the implantation, and penile cavernitis developed. The penile symptoms improved by drainage and strict chemotherapy, and then the silicone rods were removed from his penis. Histopathological findings of the corpus cavernosum showed marked inflammatory and granulomatous changes. The patient lost his potency due to poor blood flow into the cavernous.

Adult↗

[The value of the echographic exam in the diagnosis of intra-abdominal "textilomas"].

In the absence of radioopaque marker, the diagnosis of textiloma, a rare iatrogenic lesion, is difficult. The wide use of abdominal ultrasonography significantly improved the preoperative diagnosis, the most typical image being that of a echogenic area with a posterior shadow cone. Nine cases of intraabdominal textiloma, in the diagnosis of which ultrasound played the most intra-abdominal textiloma, in the diagnosis of which ultrasound played the most important role, are presented. Although the ultrasound image is not specific, it is nevertheless enough suggestive the diagnosis of textiloma and thus for indicating an early surgery, before complications occur.

Abdomen↗

[Human papillomavirus--(HPV)/balanoposthitis--a new disease?].

Two cases of symptom-producing balanoposthitis associated with Human papillomavirus infection are described. These patients had spotty, macular, erythematous rash on the glans penis and prepuce. The symptoms and objective findings resemble those of Candida infection but the diagnosis can be established by histological examination of biopsy from the acetowhite elements.

Adult↗

[Lichen sclerosus et atrophicus].

A review of lichen sclerosus et atrophicus is presented in this article. Clinical manifestations, possible complications and histology are described. Particular emphasis is given to the aetiological hypotheses, which include genetic, autoimmune, hormonal and infectious mechanisms. Finally, the various treatments are discussed.

Adolescent↗

[A case of true phimosis with bilateral hydroureteronephrosis and bilateral vesicoureteral reflux].

A 12-year-old boy presented with nocturnal enuresis. He could not void in a stream and urine dropped out of the external urethral orifice. Physical examination revealed the stenosis of prepuce and balanoposthitis. An intravenous pyelogram and a cystogram showed bilateral hydroureteronephrosis and bilateral vesicoureteral reflux. He was diagnosed with severe true phimosis complicated with bilateral hydroureteronephrosis and bilateral vesicoureteral reflux. His balanopothitis was treated with antibiotics for a few days. Dorsal slit of prepuce and release of adhesion between glans and prepuce were subsequently performed. Four months after operation, an intravenous pyelogram revealed regression of hydronephrosis. Bilateral vesicoureteral reflux was not observed on the cystogram. The possibility of upper urinary tract involvement must be considered in patients with true phimosis and dysuria.

Bacterial Infections↗

[The role of the mycocenosis due to Candida albicans and the herpes simplex virus type II in urethritis and vulvovaginitis].

Dissemination of mycocenosis induced by C. albicans and herpes simplex (type 2) virus and the role of this condition in the development of inflammatory diseases of the genitals were under study. Development of urogenital candidiasis in the presence of recurrent vesicular lichen simplex (RVLS) enhanced the intensity of RVLS recurrences and made them more frequent, augmenting the gravity of the clinical picture. Factors contributing to mycocenosis formation were defects of the cellular and humoral immunity systems, of interferon production, and changes in eukaryotic cell adsorption characteristics and reduction of neutrophilic fungicidal activity in RVLS patients.

Balanitis↗

[Anatomic and functional characteristics of resistant ovaries].

Resistant ovary syndrome has been confirmed in 42 women using clinical, roentgenologic (craniography, hysterosalpingography, pneumogynecography, electroencephalography), genetic, sonographic, endoscopic and histologic studies. Fibrocystic breast disease was identified in 64% and normal ovarian size in 74% of the patients with resistant ovary syndrome. Progesterone test was positive in 84% of the patients. Resistant ovary syndrome was associated with higher serum estradiol levels as compared with ovarian dystrophy and pure gonadal dysgenesis. Diagnosis confirmation requires ovarian biopsy with a histological examination of ovarian specimen, but its outcome is not always significant.

Adult↗

[Cicatricial pemphigoid disclosed by superficial desquamative gingivitis. Clinical and immuno-electron microscopic study of a case].

Six months before consulting, a 71-year old man developed buccal and genital erosions which gradually became worse. Physical examination showed signs of superficial desquamative gingivitis, wide erosions on the bony palate, erythemato-erosive balanoposthitis and 7 bullae or skin erosions on the upper part of the back. At histopathological examination of a cutaneous bulla there was dermoepidermal cleavage and an inflammatory infiltrate without eosinophils. At direct immunofluorescence, linear deposits of IgG and C3 were present along the basement membrane. A search for anti-skin autoantibodies was negative at indirect immunofluorescence but positive at immunoblotting (240 Kd band). The cicatricial pemphigoid was treated with dapsone alone in doses of 100 mg/day. Treatment was continued for 6 months, resulting in complete cure of the mucosal and cutaneous lesions. An immunoelectromicroscopic study, performed according to the technique described by Prost et al., on a fragment of skin from around the bullae, showed deposits of granular IgG in the lamina lucida and the lamina densa and deposits of C3 in the lamina densa. This case of cicatricial pemphigoid exhibited 3 features which are not usually found in bullous pemphigoid. Clinically, the buccal lesions were located on the gums and on the hard palate, i.e. where the mucosa adheres to the underlying bone through the periosteum. This location is habitual in cicatricial pemphigoid and differs from that of the bullous pemphigoid lesions which affect the free mucosa lining the cheeks and the soft palate. Treatment with dapsone was dramatically successful in our patient whose lesions disappeared in 6 months.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

[Chancriform pyoderma as a clinical problem: observation of 45 patients treated at the Dermatology Clinic, Medical Academy, in Cracow 1962-1986].

A clinical, bacteriological and serological pictures of 45 patients with chancriform pyoderma are presented, A single ulcer (92.8%), localized on genitals (91.1%) in adult males (93.3%), imitating or very similar to syphilitic primary chancre in our material was observed. A second case in the literature, of chancriform pyoderma on the dorsal surface of the tongue was recorded.

Adult↗

[Treatment of experimental genital herpes with liposomal interferon].

Treatment of genital herpes was studied in experiments on male guinea pigs infected with herpes simplex II virus in suspension, by means of the penis skin scarification. The medication was provided by interferon (reaferon) prepared by the technique was provided by interferon (reaferon) prepared by the technique of genetic engineering, and incorporated into liposomes composed of phosphatidyl choline and cholesterol (molar ratio, 1:1). Free or liposome-contained interferon solutions, either mixed with hydrocolloidal substance or pure, were applied to the affected site of the animals' genitalia three times daily. The severity of clinical symptoms and disease duration were used as markers of preparation efficacy. The obtained results showed the liposomal interferon preparations to be most effective irrespective of being mixed with the hydrocolloidal substance or pure. Free interferon solutions demonstrated the lowest therapeutic efficacy, while the effect of hydrocolloidal interferon was found to be median. Experimental use of such antiviral preparations as BIOLF-62 and acyclovir as a medication against genital herpes also showed the advantages of the liposomal drug forms over free solutions.

Administration, Cutaneous↗

[Preputial sclero-atrophic lichen in children].

Clinicopathological findings and outcomes in ten pediatric cases of lichen sclerosus and atrophicus of the foreskin are reported. This well-defined entity usually presents as acquired sclerous phimosis. Diagnosis rests on histologic studies of biopsy specimens. Pathologic features change during the course of disease and are useful for selecting the most appropriate therapy. Local corticosteroid therapy may be helpful in early disease. However, circumcision is usually required for advanced disease, failure of medical therapy or prevention of squamous cell carcinoma. Pathophysiology is discussed. The incidence of this condition seems to be underestimated. Possible connections with diabetes mellitus and other conditions are reviewed.

Adolescent↗

[Plasmocellular balanoposthitis of Zoon].

Plasma cell balinitis of Zoon is a well-defined and easily-recognized disease entity that is little-known in urology. Our clinical experience in 5 cases is reported herein. The uncommon presentation of this condition in a 12-year-old patient is underscored. The clinical picture, gross features of the typical erythroplastic plaque, the differential diagnosis with special reference to Queyrat's erythroplasia, and the characteristic histologic features are described. Our experience confirms the inefficacy of topical treatment with antiseptic agents and corticosteroids. Circumcision is still the only effective treatment of this disease.

Adrenal Cortex Hormones↗