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At least 1,009 records · Page 56Linked to original sources
PubMed1999

Mining the Swedish clinical archives to develop pharmacogenomic tests.

Eurona Medical is a Swedish company that develops diagnostic tests to predict response to drugs or treatment. Sweden offers unparalleled retrospective clinical data resources, with epidemiological registers and collections of tissue samples built up over decades. Efficient pharmacogenomic research can be performed using these registers and sample collections in collaboration with experienced medical researchers. Eurona's tests are based on Genetic Signatures, groups of polymorphic, polygenic genomic positions linked to and therefore predictive of drug response. These are elucidated from complex data sets using unique applications of multivariate and combinatorial statistics and a multigenic approach. The company develops tests applicable to current medical practice and is preparing to launch its first within the hypertension field. Quality control (including ISO9001 certification) and clinical regulatory compliance are applied throughout all programs to produce data that can be directly translated into clinical tests.

Archives↗
PubMed2004

Temporal trends and spatial distributions of brominated flame retardants in archived fishes from the Great Lakes.

To explore the geographical distribution and temporal trends of polybrominated diphenyl ethers (PBDEs) in the Great Lakes, lake trout from Lakes Superior, Michigan, Huron, and Ontario and walleye from Lake Erie, collected during the period of 1980-2000, were analyzed. The concentrations of fifteen PBDE congeners and one polybrominated biphenyl (PBB-153) were determined in each fish sample. Lake trout from Lakes Michigan and Ontario had the highest sigmaPBDE concentrations during the years investigated. The sigmaPBDE concentrations in fishes from the five lakes increased exponentially with time, doubling every 3-4 years. The relative proportion of BDEs-47, -99, and -100 compared to BDEs-153 and -154 increased significantly as a function of time. Over the period 1980-2000, the concentrations of PBB-153, which was a component of a flame retardant banned in the 1970s, generally remained the same in these Great Lakes fishes, except for lake trout from Lake Huron, where the PBB-153 concentrations decreased significantly, but slowly.

Animals↗