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Electromagnetic spatial coherence wavelets.

The recently introduced concept of spatial coherence wavelets is generalized to describe the propagation of electromagnetic fields in the free space. For this aim, the spatial coherence wavelet tensor is introduced as an elementary amount, in terms of which the formerly known quantities for this domain can be expressed. It allows for the analysis of the relationship between the spatial coherence properties and the polarization state of the electromagnetic wave. This approach is completely consistent with the recently introduced unified theory of coherence and polarization for random electromagnetic beams, but it provides further insight about the causal relationship between the polarization states at different planes along the propagation path.

Journal Article↗

Clinical decision-support for diagnosing stress-related disorders by applying psychophysiological medical knowledge to an instance-based learning system.

OBJECTIVE: An important procedure in diagnosing stress-related disorders caused by dysfunction in the interaction of the heart with breathing, i.e., respiratory sinus arrhythmia (RSA), is to analyse the breathing first and then the heart rate. Analysing these measurements is a time-consuming task for the diagnosing clinician. A decision-support system in this area would reduce the analysis task of the clinician and enable him/her to give more attention to the patient. We have created a decision-support system which contains a signal classifier and a pattern identifier. The system performs an analysis of the physiological time series concerned which would otherwise be performed manually by the clinician. METHODS: The signal-classifier, HR3Modul, classifies heart-rate patterns by analysing both cardio- and pulmonary signals, i.e., physiological time series. HR3Modul uses case-based reasoning (CBR), using a wavelet-based method for retrieving features from the signals. The system searches for familiar shapes in the signals by comparing them with shapes already stored. We have applied a best fit scheme for handling signals of different lengths, as the length of a breath is highly dynamic. We also apply automatic weighting to the features to obtain a more autonomous system. The classified heart signals indicate if a patient may be suffering from a stress-related disorder and the nature of the disorder. These classified signals are thereafter sent to the second subsystem, the pattern-identifier. The pattern-identifier analyses the classified signals and searches for familiar patterns by identifying sequences in the classified signals. The identified sequences give clinicians a more complete analysis of the measurements, providing them with a better basis for diagnosis. RESULTS AND CONCLUSION: We have shown that a case-based classifier with a wavelet feature extractor and automatic weighting is a viable option for building a decision-support system for the psychophysiological domain, as it is at par, or even outperforms other retrieval techniques and is less complex.

Algorithms↗

Time-frequency analysis reveals multiple functional components during oddball P300.

A time-frequency decomposition was applied to rare target and frequent non-target event-related potentials (ERPs) elicited in an oddball condition to assess whether multiple functional components occur in the P300 latency range. The wavelet transform (WT) was used because it allows capture of simultaneous or partly overlapping components in ERPs without loosing their temporal relationships. The application of a four-octave quadratic B-spline wavelet transform at the level of single-sweep data allowed us to obtain new information and revealed the presence of separate events during P300 development. Several delta, theta, and alpha frequency components in the P300 latency range differed between target and non-target processing. These findings indicate that P300 is composed of multiple functional components and that the WT method is of use for the study of P300 functional correlates more precisely.

Acoustic Stimulation↗

The contourlet transform: an efficient directional multiresolution image representation.

The limitations of commonly used separable extensions of one-dimensional transforms, such as the Fourier and wavelet transforms, in capturing the geometry of image edges are well known. In this paper, we pursue a "true" two-dimensional transform that can capture the intrinsic geometrical structure that is key in visual information. The main challenge in exploring geometry in images comes from the discrete nature of the data. Thus, unlike other approaches, such as curvelets, that first develop a transform in the continuous domain and then discretize for sampled data, our approach starts with a discrete-domain construction and then studies its convergence to an expansion in the continuous domain. Specifically, we construct a discrete-domain multiresolution and multidirection expansion using nonseparable filter banks, in much the same way that wavelets were derived from filter banks. This construction results in a flexible multiresolution, local, and directional image expansion using contour segments, and, thus, it is named the contourlet transform. The discrete contourlet transform has a fast iterated filter bank algorithm that requires an order N operations for N-pixel images. Furthermore, we establish a precise link between the developed filter bank and the associated continuous-domain contourlet expansion via a directional multiresolution analysis framework. We show that with parabolic scaling and sufficient directional vanishing moments, contourlets achieve the optimal approximation rate for piecewise smooth functions with discontinuities along twice continuously differentiable curves. Finally, we show some numerical experiments demonstrating the potential of contourlets in several image processing applications. Index Terms-Contourlets, contours, filter banks, geometric image processing, multidirection, multiresolution, sparse representation, wavelets.

Algorithms↗

Time-dependent geometry and energy distribution in a spiral vortex layer.

The purpose of this paper is to study how the geometry and the spatial distribution of energy fluctuations of different length scales in a spiral vortex layer are related to each other in a time-dependent way. The numerical solution of Krasny [J. Comput. Phys. 65, 292 (1986)], corresponding to the development of the Kelvin-Helmholtz instability, is analyzed in order to determine some geometrical features necessary for the analysis of Lundgren's unstrained spiral vortex. The energy distribution of the asymptotic solution of Lundgren characterized by a similar geometry is investigated analytically (1) in the wavelet radius-scale space, with a wavelet selective in the radial direction, and (2) in the wavelet azimuth-scale space, with a wavelet selective in the azimuthal direction. Energy in the wavelet radius-scale space is organized in "blobs" distributed in a way determined by the Kolmogorov capacity of the spiral D(K) in [1,2] (which determines the rate of accumulation of spiral turns). As time evolves these blobs move towards the small scale region of the wavelet radius-scale space, until their scale is of the order of the diffusive length scale square root[nut], where t is the time and nu is the kinematic viscosity. In contrast, energy in the wavelet azimuth-scale space is not localized, and is characterized by a shear-augmented viscous cutoff proportional to sqaure root[nut(3)]. An accelerated viscous dissipation of the enstrophy and energy of Lundgren's spiral vortex is found for D(K) > 1.75, but not for D(K) < or =1.75.

Journal Article↗

Distributed vector processing of a new local multiscale Fourier transform for medical imaging applications.

The recently developed S-transform (ST) combines features of the Fourier and Wavelet transforms; it reveals frequency variation over both space and time. It is a potentially powerful tool that can be applied to medical image processing including texture analysis and noise filtering. However, calculation of the ST is computationally intensive, making conventional implementations too slow for many medical applications. This problem was addressed by combining parallel and vector computations to provide a 25-fold reduction in computation time. This approach could help accelerate many medical image processing algorithms.

Algorithms↗

Noisy speech recognition using de-noised multiresolution analysis acoustic features.

This paper describes a novel application of multiresolution analysis (MRA) in extracting acoustic features that possess de-noising capability for robust speech recognition. The MRA algorithm is used to construct a mel-scaled wavelet packet filter-bank, from which subband powers are computed as the feature parameters for speech recognition. Wiener filtering is applied to a few selected subbands at some intermediate stages of decomposition. For high-frequency bands, Wiener filters are designed based on a reduced fraction of the estimated noise power, making the consonant features much more prominent and contrastive. The proposed method is evaluated in phone recognition experiments with the TIMIT database. In the presence of stationary white noise at 10-dB SNR, the de-noised MRA features attain a phone recognition rate of 32%. There is a noticeable improvement compared with the accuracy of 29% and 20% attained by the commonly used mel-frequency cepstral coefficients (MFCC) with and without cepstral mean normalization (CMN), respectively. The effectiveness of the MRA features is also verified by the fact that they exhibit smaller distortion from clean speech.

Attention↗

The application of time-frequency analysis to the air-coupled ultrasonic testing of concrete.

Air-coupled ultrasound has been used for the nondestructive evaluation of concrete, using broad bandwidth electrostatic transducers and chirp excitation. This paper investigates the benefits of using time-frequency analysis in such situations, for both waveform retrieval and imaging in the presence of low signal levels. The use of the short-term Fourier transform, the Wavelet transform, and the Wigner-Ville distribution all are considered, in which accurate tracking of the ultrasonic chirp signals is demonstrated. The Hough transform then is applied as a filter. An image of a steel reinforcement bar in concrete has been produced to illustrate this approach.

Journal Article↗

Human skin microcirculation after brachial plexus block evaluated by wavelet transform of the laser Doppler flowmetry signal.

BACKGROUND: The skin microcirculation may be evaluated noninvasively by laser Doppler flowmetry and iontophoresis with acetylcholine and sodium nitroprusside. Wavelet transform of the perfusion signal shows periodic oscillations of five characteristic frequencies in the interval 0.0095-1.6 Hz. The aim of the current study was to investigate alterations in skin microcirculation induced by brachial plexus block, with emphasis on the periodic oscillations. METHODS: Healthy nonsmokers undergoing hand surgery (n = 13) were anesthetized with brachial plexus block, using bupivacaine, lidocaine, and epinephrine. Skin microcirculation was evaluated by laser Doppler flowmetry and iontophoresis with acetylcholine and sodium nitroprusside before and after brachial plexus block. Wavelet transform of the perfusion signal was performed. As a control group, 10 healthy nonsmokers were included. RESULTS: In the anesthetized arm, skin perfusion after brachial plexus block increased from 19 (12-30) to 24 (14-39) arbitrary units (P < 0.01). A significant increase was also seen in the contralateral arm from 17 (14-32) to 20 (14-42) arbitrary units (P < 0.01). After brachial plexus block, spectral analysis revealed a significant reduction in relative amplitude of the oscillatory components within the 0.0095- to 0.021- (P < 0.001) and 0.021- to 0.052-Hz (P < 0.001) intervals in the anesthetized arm. CONCLUSION: Alterations in skin microcirculation induced by brachial plexus block can be evaluated by wavelet transform of the laser Doppler flowmetry signal. Brachial plexus block reduces the oscillatory components within the 0.0095- to 0.021- and 0.021- to 0.052-Hz intervals of the perfusion signal. These alterations are related to inhibition of sympathetic activity and a possible impairment of endothelial function.

Acetylcholine↗

Wavelet-based multi-resolution statistics for optical imaging signals: Application to automated detection of odour activated glomeruli in the mouse olfactory bulb.

Optical imaging techniques offer powerful solutions to capture brain networks processing in animals, especially when activity is distributed in functionally distinct spatial domains. Despite the progress in imaging techniques, the standard analysis procedures and statistical assessments for this type of data are still limited. In this paper, we perform two in vivo non-invasive optical recording techniques in the mouse olfactory bulb, using a genetically expressed activity reporter fluorescent protein (synaptopHfluorin) and intrinsic signals of the brain. For both imaging techniques, we show that the odour-triggered signals can be accurately parameterized using linear models. Fitting the models allows us to extract odour specific signals with a reduced level of noise compared to standard methods. In addition, the models serve to evaluate statistical significance, using a wavelet-based framework that exploits spatial correlation at different scales. We propose an extension of this framework to extract activation patterns at specific wavelet scales. This method is especially interesting to detect the odour inputs that segregate on the olfactory bulb in small spherical structures called glomeruli. Interestingly, with proper selection of wavelet scales, we can isolate significantly activated glomeruli and thus determine the odour map in an automated manner. Comparison against manual detection of glomeruli shows the high accuracy of the proposed method. Therefore, beyond the advantageous alternative to the existing treatments of optical imaging signals in general, our framework propose an interesting procedure to dissect brain activation patterns on multiple scales with statistical control.

Algorithms↗

Computed tomography diagnosis utilizing compressed image data: an ROC analysis using acute appendicitis as a model.

Using receiver-operating characteristic (ROC) methodology, the ability to diagnose acute appendicitis with computed tomography (CT) images displayed at varying levels of lossy compression was evaluated. Nine sequential images over the ileocecal region were obtained from 53 consecutive patients with right lower quadrant pain who were clinically suspected to have acute appendicitis. Thirty were proven surgically to have acute appendicitis, alternative diagnoses confirmed in 23. The image sets were subjected to a lossy wavelet-based compression algorithm "Embedded Predictive Wavelet Image Coder" (EPWIC). Compression levels were: none, 8:1, 16:1, and 24:1, resulting in 4 sets of images per patient. Image sets were randomized and evaluated separately by 4 body radiologists on a 1,024 x 768-pixel SVGA color PC monitor in 512 x 512 format. The readers were aware of the clinical suspicion of appendicitis but were unaware of the positive fraction of cases. Individual and combined reader ROC and c2 analyses of sensitivity, specificity, and accuracy were determined. For all readers, sensitivity decreases at 16:1 and 24:1 levels (P <0.01, P <0.001, respectively). Accuracy decreased at 24:1 levels (P <0.01). Specificity was unaffected. By ROC analysis there was statistically significantly decreased area under the curve at 24:1 levels (P <0.02) as compared with uncompressed images. Finite levels of lossy wavelet compression may be applied to CT images without compromising diagnostic performance.

Acute Disease↗

Quantitative MRS: comparison of time domain and time domain frequency domain methods using a novel test procedure.

For quantitative analysis of in vivo MR spectra, a state-of-the-art time domain method was compared with a recently reported time domain frequency domain method which uses wavelets for background characterization. The comparison was made on the basis of results for simulated test problems that were constructed by combining measured and simulated MRS data at different signal-to-noise ratios in order to simultaneously reflect real world difficulties, in particular the overlapping background problem, and to allow for quantitative judgment of a method's accuracy. Incorporating prior knowledge was also considered. The results obtained give insight into the accuracy of the methods when applied to measured MRS data. Due to the improved background characterization, the time domain frequency domain method outperformed the time domain method in some of the test cases. Both methods were also applied to serial brain MR spectra of a healthy volunteer on 10 occasions.

Brain↗

Index for spatial heterogeneity in breast cancer.

Histopathological heterogeneity in cancer is a general concern. Breast carcinoma heterogeneity is now widely admitted as a source of histological grading imprecision and reproducibility problems. Classically, homogeneity is defined as equivalent to stationarity. A measure of heterogeneity based on asymptotic properties of spatial statistics is developed. Long-range dependences in heterogeneous spatial processes make estimation of the proposed heterogeneity measure unreliable. A robust estimator based on the wavelet transform is presented; this bypasses long-range dependences. The estimator extends previous works on one-dimensional stochastic processes to two dimensions as appropriate for histopathological analysis. As a side result, the estimator gives confidence intervals for the heterogeneity measure that enables the formulation and validation of testable hypothesis on the observed histopathological samples. This approach is applied to the characterization of breast cancer tumours. We show that the heterogeneity measure for various blocks of a single tumour is invariable, even when various blocks differ in size and in number of marked nuclei.

Breast Neoplasms↗

Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis.

Osteoarthritis (OA) is one of the most prevalent chronic conditions. The histological cartilage changes in OA include surface erosion and irregularities, deep fissures, and alterations in the staining of the matrix. The reversibility of these chondral alterations is still under debate. It is expected that clinical and basic science studies will provide the clinician with new scientific information about the natural history and optimal treatment of OA at an early stage. However, a reliable method for detecting microscopic changes in early OA has not yet been established. We have developed a novel system for evaluating articular cartilage, in which the acoustic properties of the articular cartilage are measured by introducing an ultrasonic probe into the knee joint under arthroscopy. The purpose of this study was to assess microscopic cartilage damage in OA by using this cartilage evaluation system on collagenase-treated articular cartilage in vivo and in vitro. Ultrasonic echoes from articular cartilage were converted into a wavelet map by wavelet transformation. On the wavelet map, the maximum magnitude and echo duration were selected as quantitative indices. Using these indices, the articular cartilage was examined to elucidate the relationships of the ultrasonic analysis with biochemical, biomechanical and histological analyses. In the in vitro study, the maximum magnitude decreased as the duration of collagenase digestion increased. Correlations were observed between the maximum magnitude and the proteoglycan content from biochemical findings, and the maximum magnitude and the aggregate modulus from biomechanical findings. From the histological findings, matrix staining of the surface layer to a depth of 500 mum was closely related to the maximum magnitude. In the in vivo study, the maximum magnitude decreased with increasing duration of the collagenase injection. There was a significant correlation between the maximum magnitude and the aggregate modulus. The evaluation system therefore successfully detected microscopic changes in degenerated cartilage with the use of collagen-induced OA.

Algorithms↗

Validation of the wavelet spectral estimation technique in biceps brachii and brachioradialis fatigue assessment during prolonged low-level static and dynamic contractions.

An experiment was carried out to investigate the myoelectrical manifestations of fatigue of the Biceps Brachii and Brachioradialis muscles in low-level (15% MVC) prolonged isometric and dynamic contractions. The range of the joint angle was 70-110 degrees and the mean speed of flexion and extension was about 33.33 degrees /s (1.2 s for 40 degrees ). The use of Wavelet transform (IMNF) in weakly stationary dynamic SEMG signals was validated in comparison with the Fourier transform (MPF). The development of fatigue and its myoelectrical manifestations (increase in RMS and decrease in mean frequency) in dynamic contractions show no deviations from what is found in literature for both spectral estimation techniques. The benefit of Wavelets is its future use in non-stationary conditions. Lower IMNF slopes in dynamic compared to isometric contractions for Biceps Brachii might be an indication that wavelets reflect more the changes in muscle fiber propagation velocity. The results of the use of Wavelet transform in detecting frequency modulations in different movement phases of the dynamic tests show that in the eccentric phase a systematic shift towards lower frequencies occurs. It also reveals the great possibilities of phase separation using Wavelets with high resolution and low interaction.

Adult↗

Noise reduction for magnetic resonance images via adaptive multiscale products thresholding.

Edge-preserving denoising is of great interest in medical image processing. This paper presents a wavelet-based multiscale products thresholding scheme for noise suppression of magnetic resonance images. A Canny edge detector-like dyadic wavelet transform is employed. This results in the significant features in images evolving with high magnitude across wavelet scales, while noise decays rapidly. To exploit the wavelet interscale dependencies we multiply the adjacent wavelet subbands to enhance edge structures while weakening noise. In the multiscale products, edges can be effectively distinguished from noise. Thereafter, an adaptive threshold is calculated and imposed on the products, instead of on the wavelet coefficients, to identify important features. Experiments show that the proposed scheme better suppresses noise and preserves edges than other wavelet-thresholding denoising methods.

Algorithms↗

Nonparametric discriminant analysis of phytoplankton species using data from analytical flow cytometry.

BACKGROUND: Analytical flow cytometry (AFC) provides rapid and accurate measurement of particles from heterogeneous populations. AFC has been used to classify and identify phytoplankton species, but most methods of discriminant analysis of resulting data have depended on normality assumptions and outcomes have been disappointing. METHODS AND RESULTS: In this study, we consider nonparametric methods based on density estimation. In addition to the familiar kernel method, methods based on wavelets are also implemented. Full five-dimensional wavelet estimation proves to be computationally prohibitive with current workstation power, so we employ projection pursuit for reduction of dimensionality. AFC typically produces very large samples, so we also investigate data simplification through binning. Further modifications to the discrimination strategy are suggested by specific features of phytoplankton data, namely, a hierarchical group structure, the possible presence of many groups, and the likelihood of encountering an aberrant group in a test sample. CONCLUSIONS: We apply all the resultant procedures to appropriate subsets of a very large data set, demonstrate their efficacy, and compare their error rates with those of more conventional methods. We further show that incorporation of the specific features of phytoplankton data into the analysis leads to improved results and provides a general framework for analysis of such data.

Animals↗

Characterizing airway and alveolar nitric oxide exchange during tidal breathing using a three-compartment model.

Exhaled nitric oxide (NO) may be a useful marker of lung inflammation, but the concentration is highly dependent on exhalation flow rate due to a significant airway source. Current methods for partitioning pulmonary NO gas exchange into airway and alveolar regions utilize multiple exhalation flow rates or a single-breath maneuver with a preexpiratory breath hold, which is cumbersome for children and individuals with compromised lung function. Analysis of tidal breathing data has the potential to overcome these limitations, while still identifying region-specific parameters. In six healthy adults, we utilized a three-compartment model (two airway compartments and one alveolar compartment) to identify two potential flow-independent parameters that represent the average volumetric airway flux (pl/s) and the time-averaged alveolar concentration (parts/billion). Significant background noise and distortion of the signal from the sampling system were compensated for by using a Gaussian wavelet filter and a series of convolution integrals. Mean values for average volumetric airway flux and time-averaged alveolar concentration were 2,500 +/- 2,700 pl/s and 3.2 +/- 3.4 parts/billion, respectively, and were strongly correlated with analogous parameters determined from vital capacity breathing maneuvers. Analysis of multiple tidal breaths significantly reduced the standard error of the parameter estimates relative to the single-breath technique. Our initial assessment demonstrates the potential of utilizing tidal breathing for noninvasive characterization of pulmonary NO exchange dynamics.

Adult↗