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PubMed2001

Spatial distribution of the vestibulospinal neurons in the frog vestibular nuclei.

In experiments on the preparation of a frog perfused brain (Rana ridibunda), intracellular potentials were recorded from neurons of the vestibular nuclei following stimulation of the vestibular nerve and the spinal cord. The vestibulospinal neurons were identified on the basis of excitatory postsynaptic potentials evoked by the stimulation of the ipsilateral vestibular nerve and antidromic activation from the stimulation of the cervical and lumbar enlargements of the spinal cord. The cells that could be activated antidromically only by cervical cord stimulation have been designated as C cells, and the cells that could also be activated antidromically as a result of lumbar stimulation have been termed L cells. The average conduction velocity determined for C neurons was 10.67 m/s and for L neurons 15.84 m/s. The ratio of C and L neurons over the vestibular nuclear complex was very similar to each other: 52% C neurons and 48% L neurons. The majority of both types of neurons were localized in the lateral vestibular nucleus (58.6%), to a lesser extent in the descending vestibular nucleus (30.7%) and very little in the medial vestibular nucleus (10.6%). In the lateral vestibular nucleus, C neurons prevailed in the caudal part of the nucleus and L neurons prevailed in the rostral part. By contrast, in the descending and medial vestibular nuclei there was a gradual increase of C and L cells quantitatively from the rostral to the caudal part. Fast and slow cells were detected among the vestibulospinal neurons. The fast neurons of L cells did not prevail greatly over the slow ones, whereas the slow neurons of C cells prevailed comparatively largely over the fast neurons. Thus, it became possible to reconstruct the spatial distribution of the identified vestibulospinal neurons. The results of spatial distribution of C and L vestibulospinal neurons in the frogs failed to conform to definite somatotopy, which is characteristic of mammalian vestibular nuclei. The results of this study have confirmed an earlier assumption that C and L neurons in the frog's vestibular nuclei as a source of vestibulospinal fibers, are scattered separately or more frequently in groups, so that they establish a 'patch-like' somatotopy and do not form a distinctly designed field as in mammals.

Action Potentials↗
PubMed1998

Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig.

In the guinea pig, a unilateral labyrinthectomy is followed by an initial depression and a subsequent restoration of the spontaneous activity in the neurons of the ipsilateral vestibular nuclei. In two previous works, we have established the time course of these changes in the alert guinea pig using electrical stimulation as a search stimulus to select the analyzed neurons. The latter criterion was important to capture the many ipsilateral neurons that are silent at rest during the immediate postlabyrinthectomy stage. Because it is known that a pathway originating from the vestibular nuclei on one side crosses the midline and functionally inhibits the activity of the vestibular nuclei on the other side, we investigated in the first part of this study the spiking behavior of the neurons in the vestibular nuclei contralateral to the labyrinthectomy using the same procedure as that used for the ipsilateral neurons. The spiking behavior of 976 neurons was studied during 4-h recording sessions in intact animals and 1 h, 1 day, 2 days, or 1 wk postlabyrinthectomy. Neurons selected according to the electrical activation criterion were classified further as type I (their firing rate increased during ipsilateral rotation), type II (their firing rate increased during contralateral rotation), or unresponsive. The resting activity of type I neurons, which was 38.1 +/- 20.9 spikes/s (mean +/- SD) in the control state, increased statistically significantly 1 h after the lesion (53.3 +/- 29.1 spikes/s) and remained at this level 1 wk later (56.0 +/- 20.3 spikes/s). The sensitivity of type I units, which was 0.80 +/- 0.46 spikes/s per deg/s in the control population, decreased to 0.49 +/- 0.26 spikes/s per deg/s 1 h after the lesion and remained at this level 1 wk later (0.50 +/- 0.39 spikes/s per deg/s). When all monosynaptically activated neurons (type I, type II, unresponsive) were pooled, the sensitivity to horizontal rotation fell from 0.58 +/- 0.51 spikes/s per deg/s in the control state to 0. 15 +/- 0.25 spikes/s per deg/s 1 h after the lesion and to 0.20 +/- 0.32 spikes/s per deg/s 1 wk later. The major findings of the first part of this study in the alert guinea pig are thus in accord with those of Curthoys et al. and Smith and Curthoys in anesthetized guinea pigs. In the second part of this work, we studied the spiking behavior of the neurons in the vestibular nuclei after bilateral labyrinthectomy. After unilateral labyrinthectomy, the resting discharge of the ipsilateral monosynaptically activated vestibular neurons fell from 36.9 +/- 21 spikes/s (basal activity) to 6.7 +/- 17.0 spikes/s 1 h after the lesion and then recovered, reaching 17.4 +/- 18.9 and 40.8 +/- 23.7 spikes/s 1 day and 1 wk after the lesion, respectively. These observations raise the two following questions. What are the relative contributions of the loss of the excitatory influence from the ipsilateral labyrinth (destroyed) and of the persistence of the inhibitory influence from the contralateral labyrinth (intact) in the labyrinthectomy-induced depression of activity? And are the left-right asymmetries caused by a unilateral labyrinthectomy the driving force for restoration of activity? Here, we addressed these two questions by studying the spiking behavior of 473 second-order vestibular neurons in the alert guinea pig after a bilateral labyrinthectomy. In the acute stage, 1 h after bilateral labyrinthectomy, the resting discharge of the second-order vestibular neurons was 16.2 +/- 22.4 spikes/s. From comparison with the results obtained in the acute stage after a unilateral labyrinthectomy, we inferred that the ipsilateral excitatory influence was between two and three times more powerful than the contralateral inhibitory influence. (ABSTRACT TRUNCATED)

Action Potentials↗
PubMed1984

Response properties of neurons in posterior parietal cortex of monkey during visual-vestibular stimulation. II. Optokinetic neurons.

Recordings have been made from single neurons in area 7a or PG (11) in alert monkeys. Studies were limited to those neurons that were activated during optokinetic stimulation in a particular direction but not during foveal pursuit of a small moving target in the dark. Neurons responding in this way were called optokinetic. There was a considerable number of passive visual neurons, which responded to the movement of a visual stimulus during visual fixation but did not respond during optokinetic nystagmus (OKN). Most optokinetic neurons (46/51) also responded during suppression of OKN and usually displayed the same directional preference (43/46). Average discharge rates during constant-velocity optokinetic stimulation in the preferred direction increased monotonically with increases in stimulus velocity in the range 0-60 degrees/s (9/9), and most (7/9) tended to saturate at higher velocities. While the monkey fixated a stationary target light in the dark, most optokinetic neurons (20/24) responded to small moving visual stimuli, and more than half of them (13/20) had the same directional preferences as during OKN. When the chair in which the monkey was seated was oscillated sinusoidally in combination with optokinetic stimulation, most optokinetic neurons seemed to fall into one of two groups; one mainly responded when the animal was oscillated inside a stationary cylinder, and the other when the chair and the lighted cylinder were moved in synchrony together. The results suggest that some of the optokinetic neurons in area 7a or PG may receive extraretinal inputs similar to those that have been suggested to impinge on visual tracking neurons.

Animals↗
PubMed2006

The effects of vibration on the baseline spike activity of neurons in the superior vestibular nucleus.

The characteristics of the baseline spike activity of neurons in the superior vestibular nucleus of rats were studied after exposure to vibration for five, 10, and 15 days using a computerized method for recording and analyzing interspike intervals. The distributions of neurons in terms of their regularity, their dynamic types, and the modalities of their interspike interval histograms were assessed. In intact animals, the mean spike frequency was 14.0 +/- 1.4 Hz. Changes in the main measures were seen at different durations of exposure to vibration, along with a significant increase in the mean neuron spike frequency. The results demonstrate changes in the level of the functional state of neurons in the superior vestibular nucleus after exposure to vibration. The characteristics and significance of the results are discussed.

Action Potentials↗
PubMedDate not supplied

Electrophysiologic evidence for involvement of acetylcholine as a neurotransmitter in the lateral vestibular nucleus.

Monosynaptic spike generation of lateral vestibular nucleus (LVN) neurons with vestibular nerve stimulation in cats was inhibited by microiontophoretic atropine and gamma-aminobutyric acid (GABA). Spontaneous firing of the LVN monosynaptic neuron was increased by iontophoretic acetylcholine and glutamate. Atropine inhibited acetylcholine-induced firing without affecting glutamate-induced firing, while GABA blocked spike generation produced by acetylcholine and glutamate. Acetylcholine probably plays a role in transmission from the vestibular nerve to the LVN monosynaptic neurons.

Acetylcholine↗
PubMed1984

[Antidromic and synaptic potentials of neurons of the lateral vestibular nucleus of the cat evoked by stimulation of the interstitial nucleus of Cajal and the nucleus of Darkschewitsch].

Effects of stimulation of the Cajal interstitial nucleus and Darkschewitsch nucleus on the activity of neurons of the lateral vestibular nucleus of Deiters was studied in experiments on cats anesthetized with nembutal. It was shown that stimulation of the mentioned structures lead to antidromic and synaptic activation of Deiters neurons. Ascending axon collaterals of vestibular neurons to the marked brain stem structures were revealed. Stimulation of both Cajal and Darkschewitsch nuclei evoked mono- and polysynaptic EPSP and IPSP in Deiters neurons. The convergence of influences from both nuclei on the investigated neurons was shown. Peculiarities and functional significance of the indicated influences are discussed.

Animals↗
PubMed2005

[Influence of vibration on the spontaneous neuronal activity of the neurons of the superior vestibular nucleus].

The results of vibration action (5, 10 and 15 daily) on spontaneous neuronal activity of superior vestibular nucleus were studied using software for biological signals. Average histograms and autocorrelograms were drawn up after computerized interspike interval analysis. The results have demonstated that neurons of superior vestibular nucleus have mean frequency 14.0 +/- 1.4 Hz. The results obtained suggest significant reconstruction of spontaneous impulse activity in neurons of the superior vestibular nucleus within postvibration period.

Action Potentials↗
PubMed2000

Input of anterior and posterior semicircular canal interneurons encoding head-velocity to the dorsal Y group of the vestibular nuclei.

Neurons in the Y group of the vestibular nuclei are activated disynaptically from the ipsilateral VIIIth nerve and polysynaptically from the contralateral nerve. The ipsilateral anterior and posterior semicircular canals project to the Y group via interneurons in the vestibular nuclei. Candidate interneurons located in the rostrolateral corner of the superior (SVN) and in the caudal medial (MVN) vestibular nuclei were retrogradely labeled by the iontophoretic injection of biocytin into the Y group. The physiology of these interneurons named Y-group projecting neurons (YPNs) was studied in the SVN. SVN-YPNs were activated antidromically by electric pulse stimulation in the Y group. The properties of SVN-YPNs are distinct from those of SVN flocculus projecting neurons (FPNs). Namely, YPNs have a lower resting rate than FPNs, have more irregular interspike intervals, show a different phase and gain during the vestibuloocular reflex, and are located differentially within the SVN. After the injection of biocytin into the Y group, the locations of Purkinje cells that project to the Y group were confined to the vertical zones of the flocculus and ventral paraflocculus. However, mossy fibers originating in the Y group terminate in both the vertical and horizontal zones of the flocculus and ventral paraflocculus as well as in the ipsilateral nodulus.

Action Potentials↗
PubMed1992

[Influence of ethanol on the background activity of neurons in the lateral vestibular nucleus of the cat].

Single intravenous administration of ethanol (1 g/kg) to experimental cats influences 95% of investigated neurons of the lateral vestibular nucleus. In most (56.5%) neurons possessing primarily high-frequency background activity of the uninterrupted arrhythmic type ethanol administration has caused a decrease in the impulsation frequency by 84-93%; 14.5% neurons of the burst-group activity demonstrate a primary distinct increase of the average frequency of discharges, prolongation of bursts and the numbers of impulses in them changed 20-30 min after ethanol administration by sharp inhibition of the background activity up to its complete ceasing. A distinct exciting effect has arisen due to the ethanol effect during the whole period of observation in 23.6% of neurons mostly with primary low frequency of the background activity. The rehabilitation of the activity up to the primary level as a rule did not appear even 90 min later. Repeated administration of ethanol in the same dose has induced a cumulative effect.

Animals↗
PubMed2002

Asymmetric integration recorded from vestibular-only cells in response to position transients.

Angular and translational accelerations excite the semicircular canals and otolith organs, respectively. While canal afferents approximately encode head angular velocity due to the biomechanical integration performed by the canals, otolith signals have been found to approximate head translational acceleration. Because central vestibular pathways require velocity and position signals for their operation, the question has been raised as to how the integration of the otolith signals is accomplished. We recorded responses from 62 vestibular-only neurons in the vestibular nucleus of two monkeys to position transients in the naso-occipital and interaural orientations and varying directions in between. Responses to the transients were directionally asymmetric; one direction elicited a response that approximated the integral of the acceleration of the stimulus. In the opposite direction, the cells simply encoded the acceleration of the motion. We present a model that suggests that a neural integrator is not needed. Instead a neuron with a long membrane time constant and an excitatory postsynaptic potential duration that increases with the firing rate of the presynaptic cell can emulate the observed behavior.

Acceleration↗
PubMed1998

Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice.

The competitive N-methyl-D-aspartate (NMDA) antagonist DL-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CAS 127910-31-0, 4-methyl-APPA, CGP 37849) and its ethyl ester (CAS 127910-32-1, CGP 39551) potently block NMDA-evoked whole-cell current on mouse spinal neurones in primary dissociated cell cultures with IC50 (+/- SE) values of 189 +/- 9 nmol/l (CGP 37849) and 2100 +/- 220 nmol/l (CGP 39551), respectively. The compounds dose-dependently blocked vestibular stimulation-induced convulsions in EL mice, 2 h after oral administration, with ED50 (95% CI) values of 135 (78-236) mumol/kg (CGP 37849) and 65 (45-94) mumol/kg (CGP 39551). In male Swiss albino mice, performance in the step-through passive avoidance procedure was dose-dependently impaired with ED50 (95% CI) values of 85 (56-157) mumol/kg (CGP 37849) and 27 (18-42) mumol/kg (CGP 39551). In addition performance of these animals in the rotarod test of motor coordination was impaired, 2 h after oral administration of CGP 39551, with an ED50 (95% CI) of 142 (100-201) mumol/kg. These findings demonstrate anticonvulsant activity in these potent NMDA antagonists after oral administration with CGP 39551 possessing greater relative potency. However, the unfavourable ratio of therapeutic dose versus dose inducing memory or motor impairment supports the prevailing notion that such adverse effects of the presently available compounds preclude the use of NMDA antagonists as long-term therapies.

2-Amino-5-phosphonovalerate↗
PubMed2004

Trunk position influences vestibular responses of fastigial nucleus neurons in the alert monkey.

Vestibulospinal reflexes play an important role for body stabilization during locomotion and for postural control. For an appropriate distribution of vestibular signals to spinal motoneurons, the orientation of the body relative to the head needs to be taken into account. For different trunk positions, identical vestibular stimuli must activate different sets of muscles to ensure body stabilization. Because the cerebellar vermis and the underlying fastigial nucleus (FN) might be involved in this task, vestibular neurons in the rostral FN of alert rhesus monkeys were recorded during sinusoidal vestibular stimulation (0.1-1.0 Hz) in the roll and pitch planes at different trunk-re-head positions (center and +/-45 degrees ). From the sensitivity and phase values measured in these planes, the response properties in the intermediate planes and the stimulus orientation eliciting the optimal response [response vector orientation (RVO)] were calculated. In most neurons, the RVOs rotated systematically with respect to the head, when trunk-re-head position was altered, so that they tended to maintain their orientation with respect to the trunk. Sensitivity and phase at the RVO were not affected. This pattern was the same for neurons in the right and left FN and independent of stimulus frequency. The average sensitivity of this partially compensatory RVO shift in response to trunk-re-head displacements, evaluated by linear regression analyses, was 0.59 degrees / degrees (n = 73 neurons). These data show that FN neurons may encode vestibular information in a coordinate system that is closer to a trunk-centered than to a head-centered reference frame. They indicate an important role of this nucleus in motor programs related to posture and gait control.

Animals↗
PubMed1988

Neuronal coding of linear motion in the vestibular nuclei of the alert cat. III. Dynamic characteristics of visual-otolith interactions.

In the present study we have investigated in the awake cat the response dynamics of vestibular nuclei neurons to visual or/and otolith stimulation elicited by vertical linear motion. Of the 53 units tested during sinusoidal motion at 0.05 Hz (9.1 cm/s), 1 (1.9%) was responsive to the otolith input only, 13 (24.5%) were influenced by the visual input only and 23 (43.4%) responded to both modalities. Neurons were excited either during upward or downward animal or visual surround movement. Most units displayed a firing rate modulation very close to motion velocity. All the neurons receiving convergent visual and otolith inputs (0.05 Hz, 9.1 cm/s) exhibited synergistic patterns of response. Motion velocity coding was improved in terms of input-output phase relationship and response sensitivity when visual and otolith signals were combined. Depending on the units, visual-otolith interactions in single neurons could follow a linear or a nonlinear mode of summation. The dynamic characteristics of visual-otolith interactions were examined in the 0.05 Hz-0.50 Hz frequency bandwidth. Visual signals seemed to predominate over otolith signals at low stimulus frequencies (up to 0.25 Hz), while the contrary was found in the higher frequency range of movement (above 0.25 Hz). The effects of visual stabilization (VS: suppression of visual motion cues) was observed in a small sample of units. As a rule, VS induced a reduction in the amplitude of unit response as compared to visual + otolith stimulation, the lower the motion frequency, the more pronounced the attenuation. VS also decreased the amplitude of the otolith-dependent component of response. The possible modes of visual-vestibular interactions in single cells are discussed. The present study supports the hypothesis that visual and vestibular motion cues are weighted according to their internal relevance.

Action Potentials↗
PubMed1984

Responses to somatosensory input by afferent and efferent neurons in the vestibular nerve of the frog.

In the frog, we have recorded the activity of efferent and afferent fibers in the nerve of the horizontal semicircular canal in response to somatosensory stimulation. Recordings were made extracellularly by means of glass micropipettes filled with 2 M NaCl, and somatosensory stimulation was produced either by electrical stimulation of the sciatic nerve (ipsi- or contralateral to the recording side) or by vibratory stimulation of the gastrocnemius. The discharge frequency of 43% of the efferent fibers recorded was significantly increased by such stimulation, while the activity of the others was unaffected. The discharge rate of the afferent fibers was either significantly increased (in about 11% of the cases when the results were pooled together) or significantly decreased (in about 22% of the cases) by stimulation of the somatosensory system. The latencies of the responses ranged from 5 to 50 ms. These results show that: somatosensory input can influence the activity of the vestibular apparatus at the most peripheral level; modulation of the afferent discharge is mediated by the efferent vestibular system (EVS); the influence of the EVS on the vestibular afferent activity is both inhibitory and facilitatory, and the responses to somatosensory stimulation are mediated by both long-latency polysynaptic and short-latency oligosynaptic pathways. The functional significance of these two pathways is discussed.

Animals↗
PubMed2004

Membrane and firing properties of glutamatergic and GABAergic neurons in the rat medial vestibular nucleus.

In previous studies, neurons in the medial vestibular nucleus (MVN) were classified mainly into 2 types according to their intrinsic membrane properties in in vitro slice preparations. However, it has not been determined whether the classified neurons are excitatory or inhibitory ones. In the present study, to clarify the relationship between the chemical and electrophysiological properties of MVN neurons, we explored mRNAs of cellular markers for GABAergic (glutamic acid decarboxylase 65, 67, and neuronal GABA transporter), glutamatergic (vesicular glutamate transporter 1 and 2), glycinergic (glycine transporter 2), and cholinergic neurons (choline acetyltransferase and vesicular acetylcholine transporter) expressed in electrophysiologically characterized MVN neurons in rat brain stem slice preparations. For this purpose, we combined whole cell patch-clamp recording analysis with single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis. We examined the membrane properties such as afterhyperpolarization (AHP), firing pattern, and response to hyperpolarizing current pulse to classify MVN neurons. From the single-cell RT-PCR analysis, we found that GABAergic neurons consisted of heterogeneous populations with different membrane properties. Comparison of the membrane properties of GABAergic neurons with those of other neurons revealed that AHPs without slow components and a firing pattern with delayed spike generation (late spiking) were preferential properties of GABAergic neurons. On the other hand, most glutamatergic neurons formed a homogeneous subclass of neurons exhibiting AHPs with slow components, repetitive firings with constant interspike intervals (continuous spiking), and time-dependent inward rectification in response to hyperpolarizing current pulses. We also found a small number of cholinergic neurons with various membrane properties. These findings clarify the electrophysiological properties of excitatory and inhibitory neurons in the MVN, and the information about the preferential membrane properties may be useful for identifying GABAergic and glutamatergic MVN neurons electrophysiologically.

Animals↗