Large dose urography in children.
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We have described a patient with fixed bullous eruption, usually associated with severe fever, occurring on five occasions after a series of seven intravenous urograms between 1974 and 1979. Diagnosis was initially obscured because the onset of fever and dermatitis was delayed as long as 72 hours. This is only the second report of true ioderma ascribed to urographic contrast media.
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PURPOSE: To retrospectively analyze the reliability of opacification and image quality of a modified MDCTU examination protocol using furosemide and an individual acquisition delay by low-dose test images MATERIALS AND METHODS: Excretory phase images obtained from 4-row and 16-row MSCTU examinations in 103 patients (69 men, 34 women) were independently reviewed by two radiologists. MDCTUs were performed by using a low-dose furosemide iv injection. No fixed delay for urographic image acquisition was applied. Urographic timing was individually adjusted by performing low-dose test images of the distal ureters to display their current opacification. Image analysis included grading of opacification and image quality of the segmented collecting system. Average urographic delay was calculated. Stratified comparisons of mean scores were assessed. Interobserver kappa values were calculated. RESULTS: Calculated median scan delay for patients with normal creatine levels (n = 92) was 420 sec (mean 453 sec; SD, 121 sec). The median number of acquired test images was 2 (range 1-6 images). The analysis of opacification demonstrated that 97% of the ICS, 89% of the proximal, 86% of the middle, and 81% of the distal ureter segments showed opacification greater than 90%. 7.8% of the distal ureteral segments could not be visualized. Statistics did not show significant differences of opacification between proximal, middle, and distal ureteral segments (P > 0.05). Overall image quality of MSCTU showed to be high when latest test images indicated homogeneous bilateral contrasted ureters (Pearson correlation coefficient r= 0.81). Interobserver kappa values were 0.8 and 0.78. CONCLUSION: Furosemide and scan delay timing by means of test images for MDCTU proved to be a reliable procedure to reach improved opacification of the upper urinary tract. It features the individual adaption of MDCTU to the excretory rate of the kidneys.
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A case of iododerma caused by iodinated urographic contrast media is presented. It seems possible that iodide is split from the organic molecule in patients with severe renal impairment.
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This study attempts to find out what is the appropriate dose of non-ionic contrast media to provide an acceptable study at the lowest possible cost. 139 adults with normal renal function were studied. Four different dose regimes were employed and a standardised set of I.V.U. films were obtained. These were reviewed by two independent assessors who were unaware of the dose regime used. Each I.V.U. was scored on a modified Fry regime. This survey showed a clear relationship between quality and dosage.
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