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Tracheostomy in the management of laryngotracheobronchitis. Red Cross War Memorial Children's Hospital experience, 1980-1985.

In the 6-year period 1980-1985 162 children required tracheostomy during treatment of laryngotracheobronchitis at Red Cross War Memorial Children's Hospital, Cape Town. This represents 4.6% of 3,500 children with this disorder and 28% of those requiring airway intervention. Fifty-eight percent of the children were decannulated within 4 weeks and 75% within 10 weeks. Fifty-four per cent of the children required one or more further procedures before decannulation, including 7 children who required a laryngotracheoplasty. Obstructing stomal granulation tissue had to be removed from 24 children and suprastomal collapse was a cause of decannulation failure in 29 children. Use of an expiratory valve as an aid to decannulation is discussed. Three children died of tracheostomy airway complications and 6 of a medical disorder. Another complication, laryngeal incompetence, was particularly associated with herpetic laryngeal ulceration.

Age Factors↗

[Epidemics of laryngitis (8983 cases of laryngotracheitis and croup). I. Epidemiologic aspects].

They are retrospectively reviewed 893 croup cases, occurred in epidemic bout during September-October 1987, all of them were attended at our hospital's emergency room. Incidence was more frequent among males, aged 6 months to 3 years; the asked for medical attendance mostly by night. It was also investigated the stational distribution of 7,439 croup cases, occurred since June 1981 to December 1987. It was observed an epidemic bout pattern of biannual frequency, occurring in autumn and winter months, highest incidence observed in October.

Adolescent↗

[Four cases of airway infections caused by MRSA (methicillin resistant Staphylococcus aureus)].

Currently, infections caused by MRSA (methicillin-resistant Staphylococcus aureus) pose a great problem clinically. We present 4 patients with MRSA infections experienced by us. In these patients the infection was localized in the trachea and main bronchus. The first patient was a 62-year-old man. After undergoing operation for early gastric cancer, he had septic shock and was admitted to our center. The second was a 60-year-old man. After he underwent operation for advanced gastric carcinoma at another hospital septicemia developed due to suture failure and he was admitted to our center. The third was a 38-year-old woman who was admitted to our center because of grades II degrees-III degrees burns on 75 to 80% of her body surface area. The fourth was a 60-year-old man who was admitted to our center because of rupture of an aneurysm of the abdominal aorta. It is assumed that MRSA has quite different characteristics from the usual MSSA (methicillin-sensitive Staphylococcus aureus) in that it produces a new penicillin-bound protein (PBP-2') within cells. Thus, from the fiberoptic bronchoscopy findings of our own cases it is considered that there may be cases in which the observed lesion is localized in the central airway alone, without involvement of the segmental bronchi. We believe it necessary to take some prompt measures under a suspicion of airway infection caused by MRSA in the following cases: (1) compromised hosts under tracheal intubation, (2) patients who are under treatment with second or third generation cephalosporins, and (3) patients with production of bloody sputum, and (4) endotoxin-positive patients.

Adult↗

[Surgery of inflammatory and neoplastic tracheal stenosis. Apropos of 38 cases].

This is a retrospective study of 38 patients who were operated on for inflammatory (31) or tumoral tracheal stenosis. A cervical approach was possible in 20 cases; a sternotomy was required in 8 cases and a thoracotomy in 5 cases. Per-operative ventilation was satisfactory for all patients. There were 2 deaths in patients suffering from chronic airflow obstruction. There were 2 immediate and 13 late post-operative stenosis; 9 of these were symptomatic and required treatment which was successful in 7 cases. 25 of the 30 patients (among 33 survivors) who were followed-up were symptomless; 4 patients who had operations for a tumour had a larger than 3 years survival.

Adolescent↗

[Enoxacin in the treatment of bacterial infections of the respiratory system].

The above study was carried out in 30 patients, 22 males, 8 females, aged between 30 and 66 years, average age 57.17 +/- 1.43 years, 19 of whom with flare-ups of chronic or asthmatic bronchitis, 6 suffering from flare-ups of chronic bronchoectasic bronchitis, and 5 with acute tracheobronchitis. Treatment with two 300 mg tablets of enoxacin daily lasted from 10 to 15 days. The clinical result was good in 95% of the cases, and microbiological results were also satisfactory in that the micro-organisms isolated were sensitive to the antibiotic. Tolerance was good both locally and generally, only two patients complained of slight stomach discomfort. Both symptoms and laboratory findings improved progressively, and the result was considered excellent in four cases, good in 25 and only fair in one.

Adult↗

Epidemiologic survey of bovine diseases in Suriname.

A seroepidemiologic survey of cattle diseases was undertaken in Suriname in 1985 to help assess the livestock disease situation in that country. The six diseases covered by the survey were bovine coronavirus infection, bovine rhinotracheitis, bovine virus diarrhea, brucellosis, parainfluenza-3 infection, and respiratory syncytial virus infection. The results indicated relatively low prevalences of these diseases compared to the prevalences found in most developed countries. The reasons for this are uncertain, but the finding suggests that the cattle population in Suriname could lack extensive exposure to these diseases and so could be highly susceptible to them. In addition, the evident need for more thoroughgoing survey data points up the need to establish a continuous animal data health monitoring system in Suriname--as well as in other developing countries where there is a need to objectively assess the livestock disease picture.

Animals↗

Necrotizing tracheobronchitis following mechanical ventilation of the newborn.

Mechanical ventilation of newborn infants with respiratory distress is associated with diverse pathology of the lung. Recent reports have focused on a distinct lesion pattern of the tracheobronchial system--necrotizing tracheobronchitis. While many advanced cases of the disease proved fatal secondary to airway obstruction, others were successfully treated by removal of the occlusion. We describe two neonates with necrotizing tracheobronchitis, one of whom had a complete occlusion of the right main stem bronchus that was relieved by curettage during bronchoscopic examination.

Bronchi↗

[Treatment of children with acute stenosing laryngotracheitis during prolonged tracheal intubation].

Therapy of acute decompensated forms of laryngotracheitis in children has not been well developed. The mortality rate as a result of asphyxia reaches 10 to 52%. The present authors were able to reduce significantly the number of hazardous complications and lethal outcomes when treating 32 children with acute decompensated forms of laryngotracheitis (only one patient died). This was achieved by using prolonged (from 6 hrs to 19 days) intubation of the trachea, intensive medicine and physical therapy methods. Special attention was given to intubation tubes and drugs used. The postintubation course was smooth and no complications in the trachea were seen after treatment.

Acute Disease↗

The isolation and attenuation of a virus causing rhinotracheitis in turkeys in South Africa.

In March 1978, a number of turkeys with severe respiratory symptoms affecting over 80% of the flock were investigated for a possible causative agent. With the standard techniques used for the isolation of bacteriae, mycoplasmae and viruses, only Mycoplasma gallisepticum, Mycoplasma meleagridis and Newcastle disease virus were isolated. Tracheal organ cultures were subsequently prepared from 27-day-old turkey embryos and inoculated with sinus exudate from affected turkeys. After an incubation period of 4 days a virus was isolated with which the typical symptoms, as observed in the field, could be reproduced in susceptible turkeys after 3-5 days. Following primary isolation in tracheal organ cultures, the virus grew readily in embryonated eggs and Vero cells. With the electron microscope, virus-like particles, varying in size from 40 nm-500 nm, were observed, having a pleomorphic shape and studded with fine surface projections. The virus seems to fall into the family Paramyxoviridae. A vaccine produced from attenuated virus in embryonated eggs afforded good protection against mortalities due to airsacculitis that normally follows on to turkey rhinotracheitis infection. The serological and clinical effects of the virus on chickens are also reported on.

Animals↗

Respiratory disease (rhinotracheitis) of turkeys in Brittany, France. III. Interaction of multiple infecting agents.

A candidate breeder flock of turkeys was studied during and after an outbreak of rhinotracheitis. Laboratory studies revealed the presence of three pathogens during the acute phase of the disease. These agents were hemorrhagic enteritis virus (HEV), paramyxovirus type 2 (PMV2), and chlamydia. Twenty-five turkeys in the flock were individually identified, and blood samples from these birds were collected for serological studies each week for 21 weeks. The serological results revealed high titers for HEV and chlamydia but very low titers for PMV2.

Animals↗