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At least 991 records · Page 55Linked to original sources
PubMed1985

Regional odontodysplasia in epidermal nevus syndrome.

Epidermal nevus syndrome is defined as a combination of nevoid skin alterations, epileptic seizures, and psychomotoric retardation. Involvement of other organs, especially the eyes, may also occur, but is not obligatory. The present report is concerned with a case that combined regional odontodysplasia with nevoid skin alterations in the overlying skin area of the face. This observation suggests that odontodysplasia may be the result of aberrations in the development and migration of cells of the neural crest occurring early in embryonic life.

Child↗
PubMed2006

The equine periodontium as a continuously remodeling system: morphometrical analysis of cell proliferation.

OBJECTIVE: The hypsodont equine cheek tooth erupts continuously throughout life. Tooth eruption is inevitably associated with a remodeling of the periodontium. One major process of remodeling in the PDL is cell proliferation. The aim of this study was to detect cell proliferation at different sites of the equine PDL in order to examine the dynamics of the periodontal cell population. DESIGN: Specimens from nine warm-blood horses were taken-- containing the PDL interposed between the cementum and the alveolar bone--at three designated levels: subgingival, middle, and apical. Cell proliferation was detected immunohistochemically by use of anti-Ki-67 in combination with an elaborate morphometrical procedure using an image-analysis program. Three zones of the PDL were distinguished in each specimen: a zone next to the dental cementum, a central zone, and a zone next to the alveolar bone. The PDL was divided into three levels and three zones, resulting in nine defined regions of interest. RESULTS: The proliferation index was high at the apical level and in the zone next to the alveolar bone. The opposite was true of cell density, which was high at the subgingival level and in a zone next to the dental cementum. CONCLUSIONS: Evaluation and statistical analysis of the parameters proliferation index and cell density in distinct, biologically appropriate sites of the equine PDL suggest the presence of dynamic processes like cell migration by which the cells of the PDL move from an area next to the alveolar bone towards the dental cementum, and in an apico-occlusal direction. Furthermore, our study confirms the close relationship between cell proliferation, cell migration, and eruption.

Animals↗
PubMed1998

Surgical management of impacted third molars.

Teeth may become impacted when they fail to erupt or develop into the proper functional location. As such, impacted teeth are considered nonfunctional, abnormal, and pathological. The mandibular third molar is the most common tooth to become impacted. The cause of impacted third molars is thought to be inadequate space. Several studies indicate that a change from a coarse, attritive diet to a modern, refined diet has lead to an increased incidence of impacted teeth. Interproximal attrition allows for greater mesial migration of teeth and space for third molar teeth. Teeth that fail to attain a functional position may be pathological and should be considered for removal. The indications for removing impacted teeth can be divided into those of acute or chronic pathology. Impacted third molars are often associated with pain, infection, cyst formation, benign tumors, root resorption, bone loss, periodontal disease, and caries. The decision to surgically remove impacted third molars is often unclear. There are no absolute treatment protocols established. The dentist must consider a variety of factors and make an informed decision with the patient. Most experienced clinicians combine objective data and common sense to arrive at a logical treatment plan. The purpose of this article is to discuss factors related to impacted teeth and help the orthodontist understand the general management of impacted third molars. The decision for surgery will be assisted by an understanding of all of the risk factors associated with impacted teeth and presenting the options to the patient.

Decision Trees↗
PubMed1994

Phylogenetic, paleodemographic, and taphonomic implications of Victoriapithecus deciduous teeth from Maboko, Kenya.

More than 240 milk teeth of Victoriapithecus macinnesi, representing all elements of the deciduous dentition, are described. Their morphology is intermediate between that of hominoids and cercopithecids. Unlike colobine and cercopithecine milk teeth, Victoriapithecus dp3s, dp4s, and at least 7 (14%) dp4s lack transverse distal loph(id)s and are not bilophodont. Victoriapithecus also differs from cercopithecids in having less elongated deciduous premolars, a dp3 metacone set mesial to a very small hypocone, a dp4 crista obliqua, and a dp4 hypoconulid. The deciduous canines and incisors of Victoriapithecus are like those of other cercopithecids in having an uneven distribution of enamel around a compressed (rather than cylindrical) root, but differ from cercopithecids and resemble hominoids in being more elongated. Since Colobinae and Cercopithecinae share features of the deciduous dentition that are derived relative to Victoriapithecus and hominoids, extant Old World monkeys are interpreted as representing the sister-taxon of the middle Miocene cercopithecoids. Due to a dramatic increase in the number of deciduous teeth found at Maboko Island, juvenile individuals represent a much larger proportion of recently excavated Victoriapithecus collections than is true of pre-1987 assemblages which mainly derive from sediment first excavated during the 1930s and 1940s. Age distribution differences between pre- and post-1987 samples indicate that paleontological collection procedures were more important than taphonomic biases in determining the paleodemographic profile of the Maboko fossils. Since the Victoriapithecus assemblage from Maboko is strikingly similar to that of fossil Theropithecus oswaldi from Olorgesailie in terms of the large number of specimens and high representation of juvenile and infant individuals, the latter can no longer be viewed as unique among cercopithecoid fossil assemblages. Rather than being related to a specific cause of death, such as selective hunting of T. oswaldi by Homo (Shipman et al. [1981] Curr. Anthropol. 22:257-268), the large number of cercopithecoids at both sites is attributed to the fact that both assemblages represent excavated samples and that the preferred habitats of the extinct monkeys were probably at or near the site of deposition. The greater number of young adult male than female canines in the apparently attritional Maboko Bed 5 assemblage, indicate that the social organization of V. macinnesi may have been similar to that of modern macaques, with males migrating out of their natal group and suffering higher death rates than females at puberty.

Animals↗
PubMed1988

Numeric anomalies of teeth in concomitant hypodontia and hyperdontia.

Variations in tooth number in children, each of whom had supernumerary teeth and agenesis of teeth, is described. Among the 11, seven had cleft lip and palate, and two had clefting syndromes; two children had dental anomalies only. Only children who had both supernumerary teeth and congenitally missing teeth outside the area of the cleft alveolus were included. Concomitant hypodontia and hyperdontia were observed in the same dentition in nine subjects, in the same jaw in eight subjects, and in the same jaw quadrant in only three subjects. Supernumerary teeth and agenesis of teeth were observed simultaneously more often in the permanent dentitions than in the deciduous dentitions or in both dentitions simultaneously. The overall number of supernumeraries was 10 in the deciduous dentition and 14 in the permanent dentition of the 11 subjects. The number of congenitally absent teeth was 14 in the deciduous dentition and 40 in the permanent dentition. The etiology of concomitant hypodontia and hyperdontia is difficult to explain. It may result from disturbances in migration, proliferation, and differentiation of neural crest cells or interactions between the epithelial and mesenchymal cells during the initiation of odontogenesis.

Abnormalities, Multiple↗
PubMed2004

Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury.

The reparative mechanisms that operate following carious and traumatic dental injury are critical for pulp survival and involve a series of highly conserved processes. It appears that these processes share genetic programs-linked to cytoskeletal organization, cell movement, and differentiation-that occur throughout embryogenesis. Reactionary dentin is secreted by surviving odontoblasts in response to moderate stimuli, leading to an increase in metabolic activity. In severe injury, necrotic odontoblasts are replaced by other pulp cells, which are able to differentiate into odontoblast-like cells and produce a reparative dentin. This complex process requires the collaborative efforts of cells of different lineage. The behavior of each of the contributing cell types during the phases of proliferation, migration, and matrix synthesis as well as details of how growth factors control wound cell activities are beginning to emerge. In this review, we discuss what is known about the molecular mechanisms involved in dental repair.

Conserved Sequence↗
PubMed1988

Gingivitis in the human deciduous dentition. A correlative clinical and block surface light microscopic (BSLM) study.

This study examined the relationship between clinical and histomorphometric parameters in the human deciduous dentition. Clinical parameters including plaque index, gingival swelling, gingival color, tooth mobility and degree of root resorption were determined prior to the extraction of teeth. The teeth were extracted with their surrounding gingiva in order to preserve the in situ relationship between the hard and soft tissues. Histomorphometric analysis was carried out on 55 sites, using block surface light microscopy (BSLM). Apical migration of the junctional epithelium was found at 53% (29) of the sites. The gingival sulcus was shallow (0.3 +/- 0.19 mm) and coronal to the cemento-enamel junction at 84% (46) of the sites. Junctional epithelium with retepegs was present at 89% (49) of the sites, whilst an inflammatory cell infiltrate (ICI) was present at all sites examined. The ICI was located opposite to the junctional epithelium and cementum at 80% (44) of the sites. The extent of ICI correlated positively with the patients' age and was significantly increased when clinical evidence of gingival swelling or redness was present.

Adolescent↗
PubMed1994

Neural cell adhesion proteins and neurological diseases.

Neural cell adhesion proteins play important roles in neural development and are involved in various neurological diseases. P0, a major protein in mammalian peripheral myelin, mediates not only homophilic cell adhesion but also neurite outgrowth. The P0 glycopeptide inhibits the cell adhesion, but not the neurite outgrowth. Several point mutations of the P0 gene in human chromosome 1q22-23 were found in Charcot-Marie-Tooth (CMT) disease type 1B and Dejerine-Sottas (DS) disease. PASII/PMP22 and connexin 32 were also reported as target proteins of similar hereditary neuropathies. L1 is a large multifunctional protein involved in cell adhesion, neurite outgrowth, fasciculation, and neuronal cell migration. A short isoform of L1 localizes in non-neuronal cells in contrast to the complete L1 exclusively expressed in neurons. Recently various L1 mutations have been reported in X-linked hydrocephalus, MASA syndrome with mental retardation and spastic paraplegia type 1. Further studies on the mutations and disease phenotypes are important and interesting.

Animals↗
PubMed2004

Are breeding teeth in Atlantic salmon a component of the drastic alterations of the oral facial skeleton?

Upriver spawning migration of starving Atlantic salmon (Salmo salar) involves drastic skeletal alterations, among which a toothless stage followed by the appearance of a new set of so-called breeding teeth has been described. To investigate this phenomenon, we examined the patterns of tooth replacement on the lower jaws in different life stages of wild animals before and after spawning. Prior to spawning, every position held either a functional or a replacement tooth, both in first-time (grilse) and repetitive (salmon) spawners. Teeth were in a similar developmental stage every three positions along the tooth row. A functional tooth occurred in every third position and intermediate positions were taken by developing teeth. Within the process of replacement, teeth were resorbed and not shed. Our observations on an uninterrupted tooth replacement pattern provided no evidence of an intermediate toothless stage nor of a specialized breeding-teeth generation. Only animals that survived spawning (kelts) showed a highly variable tooth pattern, but with the initial "every third position" pattern still recognizable in some animals. We hypothesise that previous accounts describing a complete tooth loss/replacement relate to proliferation of the oral mucosa that conceals the teeth prior to the breeding period and to the use of maceration techniques that could have removed all teeth with an incompletely mineralised base.

Animals↗
PubMed1975

Dental prophylaxis procedures in control of periodontal disease in Lucknow (rural) India.

Frequent professional scaling and regular tooth brushing are the main public health measures available for preventing and controlling periodontal disease but their frequency and efficacy are still incompletely understood. This investigation was carried out on 1,416 rural children and 189 factory workers in Lucknow area in the age groups 14 +/- 1, 17 +/- 1 and 28 +/- 2 years of age to evaluate the optimum requirement of these measures to the extent they will be economical and usable in the public health programs. The prevalence of gingivitis and periodontal disease in Lucknow children and adult samples was found to vary between 93 to 100%. Periodontal disease (including gingivitis and loss of attachment) and calculus accumulation showed considerable reduction (P less than 0.01) with any type of treatment. Scaling alone will not reduce the plaque formation for which regular tooth brushing is essential. Yearly and half-yearly scaling along with tooth brushing instructions will considerably improve and maintain the oral hygiene thereby reducing the prevalence and severity of periodontal disease, plaque, and calculus accumulations. However, more intensive measures (quarterly prophylaxis) will further improve the periodontal health and reduce calculus accumulation. The apical migration of the epithelial attachment can practically be stopped by rendering scaling half yearly, without any instructions in oral hygiene and elimination of dental plaque.

Adolescent↗
PubMed1988

Growth and migration of gingival epithelial cells on mineralized and partially demineralized root surfaces in an in vitro system.

The capacity of epithelial cells to migrate and grow from gingival explants cultured on mineralized and partially demineralized root surfaces in an in vitro system was assessed. Explants of attached gingiva were obtained from mongrel dogs, cut into rectangular pieces (1 x 2 mm) and cultured either on mineralized or partially demineralized cementum in a defined culture medium containing transferrin, insulin, epidermal growth factor, cortisone, high density lipoprotein and selenium. After seven days of culture, the specimens were prepared for scanning electron microscopic examination. The amount of epithelial outgrowth from each explant was assessed by measuring the distances between the four aspects of the rectangular explant and the furthest epithelial cell located opposite to each of these aspects. The mean value obtained for epithelial outgrowth of explants grown on mineralized cementum was six times higher than that for explants cultured on partially demineralized cementum. These results indicate that partially demineralized cementum does not support epithelial growth and migration in vitro.

Animals↗