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Results for “Thyroid Function Tests”

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At least 991 records · Page 55Linked to original sources
PubMed1986

Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma).

A consecutive series of 77 ambulatory, clinically euthyroid patients with systemic sclerosis was evaluated for clinical, chemical and serologic evidence of thyroid disease. Measurements of baseline serum thyroid function tests and the thyroid stimulating hormone response to thyrotropin releasing hormone (TRH) were made. We classified 18 (23%) patients as abnormal, including 8 (10%) who were chemically hypothyroid and 10 (13%) with normal baseline studies but an exaggerated response to TRH injection. The remaining 59 (77%) patients were euthyroid by all measurements. Antithyroid antibodies were present in only 4 of 8 (50%) of the hypothyroid group. There were no differences between the 3 patient groups with regard to the extent of scleroderma, the presence of internal organ involvement, or the frequency of common signs or symptoms of hypothyroidism. Abnormal thyroid function in systemic sclerosis is frequent, often unsuspected clinically, and may occur without markers of autoimmune thyroid disease.

Adult↗
PubMedDate not supplied

Thyroid nodules in childhood and adolescence--thirty years of experience.

In the thirty year period between 1966 and 1996, fifty-two patients underwent surgery for thyroid nodules at the Royal Children's Hospital, Melbourne. We aimed to review their presentation, investigation, histology, treatment and to follow up those who had malignant neoplasms. Forty-one of the fifty-two patients presented with a single thyroid nodule. Investigations performed included thyroid function tests (N = 32), thyroid autoantibodies (N = 21), an ultrasound of the thyroid (N = 26) and 99mTechnetium scanning (N = 32). Thirty-five of the neoplasms were benign, the follicular adenoma (N = 16) being the most common. Seventeen patients had malignant neoplasms, seven of whom had papillary and seven of whom had follicular carcinoma. Three patients had medullary carcinoma of the thyroid. Nine of the seventeen patients with thyroid malignancy received post-operative 131I treatment. At the time of this review, all patients were living.

Adolescent↗
PubMed1999

[Late complications after treatment of Hodgkin's disease].

Treatment of Hodgkin's disease involves chemotherapy and radiation. Both modalities may cause cardiac, pulmonary and thyroid side-effects. In a cross-sectional study, we aimed to assess the occurrence and severity of such complications. From 1980 to 1989, 129 Norwegian patients (< 50 years old) had curative treatment for Hodgkin's disease 116 (90%) of them participated in the study (follow-up period 5-13 years). Methods included lung function tests, chest X-rays, bicycle exercise tests, echocardiography and thyroid function tests. Nearly 30% of the patients reported dyspnoea on exertion and had associated reductions in lung function. Evidence of fibrosis occurred in 68%, but was associated with reduced lung function in only 12%. Pathological left-sided heart valve regurgitations were detected in 24% of the patients, pericardial thickening in 15%, and coronary artery disease in 5%. Biochemical hypothyreosis was found in 67% of the patients. We conclude that cardiac, pulmonary and thyroid dysfunctions are frequent long-term side-effects after treatment for Hodgkin's disease. We recommend annual screening of thyroid function and echocardiographic examination in patients who have received standard mantle field radiotherapy without cardiac shielding. Lung function testing should be done in individuals who require further radiation, chemotherapy or thoracic surgery.

Adult↗
PubMed1996

A prospective analysis of subacute thyroid dysfunction after neck irradiation.

PURPOSE: Exposure of the thyroid to therapeutic doses of external irradiation has been demonstrated to induce thyroid dysfunction. This study was designed to assess the relationship between irradiation and early thyroid dysfunction, prospectively. METHODS AND MATERIALS: Twenty patients in whom the thyroid was incidentally exposed to therapeutic doses of irradiation were studied. The dose given to the thyroid was 40-54 Gy over 4-7 weeks. Thyroid function tests, including serum thyroid stimulating hormone (TSH), free thyroxine (free T4), free triiodothyronine (free T3), antithyroglobulin antibody, and antimicrosomal antibody, were performed prior to irradiation and at 3, 6, and 12 months after radiotherapy. RESULTS: Serum TSH levels did not change significantly at 3 months after irradiation (mean TSH level: 1.33 microU/ml before irradiation, 1.74 microU/ml at 3 months, p = 0.11). However, a significant elevation was noted at 6 months (mean TSH: 3.50 microU/ml at 6 months, p = 0.0001, vs. preirradiation), when TSH levels were higher than preirradiation levels in 19 of 20 patients. After irradiation, 13 patients remained in a euthyroid state (euthyroid group), while in the other 7 patients hypothyroidism occurred (hypothyroid group) and thyroid hormone-replacement therapy was performed. After 6 months, elevation of TSH was less significant in the euthyroid group, whereas elevation of TSH persisted continuously and exponentially in the hypothyroid group. Thyroid autoantibodies did not turn positive in any patient during follow-up. CONCLUSIONS: Damage of the thyroid develops in most patients when the organ is exposed to radiation. This radiation-induced damage is initially manifested within 6 months after irradiation.

Adult↗
PubMed1970

Chlordiazepoxide (Librium) and tests of thyroid function.

The effect of chlordiazepoxide (Librium) on thyroid function was examined in 14 euthyroid patients who required the drug for psychiatric reasons and in six patients with clinically mild thyrotoxicosis. There was no significant difference in results from tests of thyroid iodide trapping (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) or of thyroid hormone release (protein-bound iodine, T3 resin uptake, and free thyroxine index) carried out before and during treatment with the drug over a four-week period. It is suggested that chlordiazepoxide need not be withdrawn before thyroid status and function are assessed in any patient taking the drug.

Adult↗
PubMed1986

Laboratory decision science applied to chemometrics: strategic testing of thyroid function.

Clinical decision analysis and cost-effectiveness analysis have begun to penetrate academic laboratory medicine. Decision science offers tools by which clinical chemical tests may be evaluated for their medical efficacy and economic feasibility. In the "treat, test, observe" paradigm it provides a framework for placing new laboratory tests in an appropriate clinical context. A general overview of the decision analysis method and the laboratory-oriented model is presented, with an application to the development of strategies for hospital-based testing of thyroid function.

Costs and Cost Analysis↗
PubMed2002

Thyroid dysfunction in chronic schizophrenia within a state psychiatric hospital.

OBJECTIVES: This study seeks to determine the prevalence and pattern of thyroid dysfunction in a group of adult psychiatric inpatients with chronic schizophrenia. We also hypothesize that raised thyroid hormones are associated with more severe psychopathology. METHODS: Thyroid function tests were performed on 189 patients and the Brief Psychiatric Rating Scale (BPRS) was administered by a single rater on all patients. RESULTS: There was a high prevalence of (36.4%) thyroid function test abnormalities but all patients except 1 were assessed to be clinically euthyroid. Free thyroxine (fT4) and triiodothyronine (fT3) were significantly higher in patients with mild (BPRS score, 10-20) and major syndrome (BPRS score, equal or above 21) compared to no syndrome (BPRS score, 0-9). No correlation was found between thyroid hormones and neuroleptic use. CONCLUSION: Although thyroid function test abnormalities are common in patients with chronic schizophrenia, clinical thyroid illness was absent. This calls for caution in the use and interpretation of thyroid function tests in patients with chronic schizophrenia.

Adult↗
PubMed1998

Transient cold nodule of the thyroid due to localized postpartum thyroiditis.

A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymphocytes, suggesting lymphocytic thyroiditis. Thyroid function tests were normal and thyroid autoantibodies were negative. After two months the thyroid nodule was not palpated and thyroid scintigraphy returned to normal. Thyroid function tests remained normal twelve months after delivery. These findings suggest that postpartum thyroiditis may present as a localized transient form and should be considered in the differential diagnosis of painless solitary nodule that appears postpartum.

Adult↗
PubMed2004

Effect of iodinated contrast media on thyroid function in adults.

Excess free iodide in the blood (ingested or injected) may cause thyrotoxicosis in patients at risk. Iodinated contrast medium solutions contain small amounts of free iodide and may be of significance for patients at risk. The free iodide may also interfere with nuclear medicine diagnostic studies and treatment. Therefore the Contrast Media Safety Committee of the European Society of Urogenital Radiology reviewed the literature on this subject in order to prepare guidelines. A report and guidelines were prepared based on an extensive Medline search. The report was discussed with the participants attending the Tenth European Symposium on Urogenital Radiology, Uppsala, Sweden, September 2003. Contrast medium induced thyrotoxicosis is rare. Contrast medium injection does not affect thyroid function tests (e.g., T3, T4, TSH) in patients with a normal thyroid. Routine monitoring of thyroid function tests before contrast medium injection in patients with a normal thyroid is not indicated even in areas where there is dietary iodine deficiency. Patients at risk of developing thyrotoxicosis after contrast medium injection are patients with Graves' disease and patients with multinodular goiter with thyroid autonomy, especially elderly patients and patients living in areas of iodine deficiency. Patients at high-risk should be carefully monitored by endocrinologists after contrast medium examinations. Prophylaxis in these groups is not generally recommended, although it may offer some protection in selected high-risk individuals. The free iodide load of contrast media injections interferes with iodide uptake in the thyroid and therefore compromises diagnostic thyroid scintigraphy and radio-iodine treatment of thyroid malignancies for 2 months after administration of contrast media. Simple guidelines on the subject are proposed.

Contrast Media↗
PubMed1976

Simple modifications of three routine in vitro tests of thyroid function.

Semi-automation of equipment and simple modifications of technique reduced the work load without loss of diagnostic accuracy for three commonly used in vitro tests of thyroid function (total thyroxine, thyrobinding index, and free thyroxine index). Major innovations were the use of serum standards for all tests and having each duplicate for tests performed by a different technician. Attention is drawn to the false-positive and false-negative errors that occur when the 95% euthyroid limits is the sole reference range used.

Evaluation Studies as Topic↗