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Results for “TOXEMIA”

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At least 991 records · Page 55Linked to original sources
PubMed1989

[The main pathogenetic mechanisms of disorders of the detoxication function of the liver in endogenous toxemia of various etiologies].

The mechanisms of cell proliferative activity regulation under the effect of growth factors, mitogens, virus transformation, etc. were analyzed. Changes in the location of cAMP-dependent protein kinase caused by these factors, the effect of the nerve growth factor on the activities of protein kinase and high-affinity ATPase, and the mechanism of antiproliferative action of staphylococcal enterotoxin A were specified. Data on receptor-independent intracellular penetration of protein factors hydrophobized by fatty acid residues are overviewed.

Animals↗
PubMed1989

[Effects of dalargin, a synthetic analog of endogenous opioids, on functional indices of isolated rat heart in experimental toxemia in vitro].

The authors studied direct effect of alpha-toxin of Staphylococcus aureus on the main functional indices of isolated perfused heart of intact Wistar rats with the working left ventricle and the ways of pharmacological correction of cardiotoxic lesion of the myocardium in vitro. It was established that alpha-toxin produced a dose-dependent effect on the functional indices of the isolated rat heart, causing in low concentrations positive inotropic effect and with more high concentrations--inhibition of cardiac activity.

Animals↗
PubMed1989

[The reaction to heparin in patients with burn toxemia during extracorporeal detoxification].

The comparison of sensitivity to heparin before hemosorption in burn patients with high level of the blood middle molecular peptides before the operation on the heart in patients with rheumatic cardiac defect without changes in the blood peptide level was carried out. In the model experiments, the influence of a fraction of the middle molecular peptides obtained from the blood of healthy and burned dogs on the effects of heparin and protamine sulfate, and as well on thrombocytic aggregation was studied. The role of the middle molecular peptides in the alteration of response to heparin in burn disease is discussed.

Blood Coagulation↗
PubMed1989

[Syndrome of endogenous toxemia in complications of pancreonecrosis].

The authors have performed an investigation of the syndrome of endogenous intoxication in the following complications of pancreatonecrosis: pancreatogenous shock, fermentative and fibrinous-purulent peritonitis, parapancreatic infiltrate, abscesses of the pancreas and phlegmons of the retroperitoneal fat. The most pronounced toxicosis was observed in purulent processes in the pancreas, parapancreatic fat and abdominal cavity.

Adult↗
PubMedDate not supplied

[Evaluation of the functional state of the liver using the blood enzyme spectrum after hemosorption for burn toxemia].

A rate of blood serum toxicity was markedly increased beginning from the second day after thermic burns of dogs. At the same time, statistically distinct alterations were found in liver tissue specific enzymes activity demonstrating the necrotic impairments of liver tissue and cytolysis of hepatocytes. After hemosorption the rate of blood serum toxicity was steadily decreased, the enzymatic spectrum and leukocyte index of intoxication were normalized in blood serum, which appears to relate to lowering of destructive processes in liver tissue and to maintaining of hepatocytes functional activity.

Alanine Transaminase↗
PubMed1988

[Early toxemia in patients with severe mechanical injuries].

The examination of 2033 patients with severe mechanical injuries has shown that early intoxication takes place in 30.3% of the patients. Patients with blood loss of 35-40% and more, receiving more than 1 l of preserved blood make a group of high risk. Intoxication was more frequent in patients with one localization of injury when it is an injury of extremities or abdomen. In associated injuries the development of intoxication is determined by localization and kind of the main injury and is dependent on association with severe traumas of the extremities and abdomen.

Blood Group Incompatibility↗
PubMed1987

[Indicators of general toxemia in diffuse peritonitis].

Methods of determination of general toxicity are thought to be necessary to obtain higher efficiency of treatment of patients with peritonitis. They facilitate the establishment of indications for choice of methods of the complex detoxicating therapy. Using the method of determination of the concentration of toxic middle mass metabolites gives an objective assessment of the degree of the endogenic intoxication syndrome.

Hemoperfusion↗