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At least 991 records · Page 55Linked to original sources

Pediatric ear, nose and throat services' demands and resources: a global perspective.

Global population trends, health care economics and disease patterns are reviewed. The world's population has doubled twice in the twentieth century, and will grow by at least a further 2 billion before stabilizing in the middle of the next century. There is gross maldistribution of wealth and health care expenditures: 20% of the population control 80% of the gross domestic product, the same 20% of the population spend 87% of the total global health care funds. Extreme poverty facilitates all manner of diseases. Globally, infections remain the most important causes of disease. Of these, upper respiratory infections are an important cause of hearing loss and learning handicap in children world-wide. Epidemic meningitis in Africa and parts of Asia is a preventable major cause of death and deafness. There are about 80,000 otolaryngologists in the world and they too are maldistributed, with most in Europe and the Americas. This is exacerbated when looked at from the standpoint of children, most children live where there are fewest otolaryngologists: the differences are greater than two orders of magnitude. This greatly affects the role and scope of paediatric otolaryngology. The discipline is small and rapidly evolving. Suggestions are made for sharing training.

Child↗

Fever or a soar throat after start of antithyroidal drugs? A medical emergency.

We describe two patients who developed granulocytopenia (granulocyte count < 1.0 x 10(9)/1) after treatment with antithyroid drugs. Although, perhaps, an already known side-effect of these drugs, we present these cases in order to stay alert for this serious complication. The first patient developed granulocytopenia upon reinstitution of propylthiouracil after an uncomplicated first course of ATD-treatment. In the second case we report the use of granulocyte colony-stimulating factor (G-CSF) for treatment of a patient with methimazole-induced granulocytopenia. Furthermore, we discuss current concepts concerning pathophysiology, prevention and therapy.

Adult↗

Detection of influenza virus from throat and pharyngeal swabs with a nested duplex light cycler RT-PCR.

A rapid duplex RT-PCR method was developed using the Roche LightCycler technology for detection of influenza type A and influenza type B viruses. Ninety-seven clinical specimens were analyzed using the Lightcycler method compared with conventional viral culture. Thirty-seven specimens (38.1%) were positive by RT-PCR using matrix protein (MP) primers for influenza A or B virus, compared to thirteen culture positive specimens (13.4%). All culture positive specimens were also positive by RT-PCR. A nested PCR reaction using hemagglutination (HA) gene primers confirmed all of the earlier positive PCR reactions. This LightCycler PCR technique was found to be more sensitive than viral culture for influenza virus detection.

Cohort Studies↗

Alcohol-related diseases of the mouth and throat.

Chronic consumption of alcoholic beverages is an accepted social custom worldwide. In the upper aerodigestive tract, local morphological, metabolic and functional alterations can be present as a result of alcohol consumption. A clinical link between the chronic consumption of alcohol and head and neck cancer has been observed for decades. While alcohol was described initially as a risk enhancer only in smokers, a number of epidemiological studies have now provided sufficient evidence that chronic alcohol consumption increases the risk of head and neck cancer independent of exposure to tobacco smoke. Systemic effects of alcohol interact with local changes in the morphology and function of the salivary glands. In addition, alcohol leads to the accumulation of pathological microbes within the mucosa, leading to chronic infection. Susceptibility to carcinogens and cell proliferation in the mucosa are increased, resulting in genetic changes with the development of dysplasia, leucoplakia and carcinoma. Chronic alcohol consumption has been correlated with an increased risk of cancer and increased mortality in a dose-effect relationship. A number of biologically plausible mechanisms exist by which alcohol may cause cancer. These mechanisms are discussed in this chapter.

Alcohol Drinking↗