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At least 991 records · Page 55Linked to original sources
PubMed1995

Synthesis and biological activity of novel metal complexes of 2-acetylpyridine thiosemicarbazones.

2-Acetylpyridine-(2-methylthiosemicarbazone), 2-acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(4-phenylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. They were studied also for their antimalarial activity and for toxicity in vivo. The platinum metal chelates exhibited significant activity against a wide spectrum of microorganisms at different concentrations. The Ru (III) chelates derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the complexes in mice infected with Plasmodium berghei indicated that cures were attainable at dose levels of 20-160 mg/kg.

Animals↗
PubMed1994

Synthesis and anticonvulsant activity of some new thiosemicarbazone and 4-thiazolidone derivatives bearing an isatin moiety.

A series of 3-thiosemicarbazono-2-indolinones and 3-(4-thiazolidone-2-hydrazono)-2-indolinones was synthesized by condensation of various isatin derivatives with 4-substituted 3-thiosemicarbazides and cyclization of the products by monochloroacetic acid or ethyl alpha-bromoacetate. In the present work we report on the structure determination and anticonvulsant evaluation of the title compounds.

Animals↗
PubMed1993

Synthesis, antibacterial and antifungal activity of metal (II) complexes of 2-acetylpyridine thiosemicarbazones.

2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2- methylthiosemicarbazone) and their metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal (II) complexes exhibited significant activity against a wide spectrum of microorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most active compounds.

Amebicides↗
PubMed1996

Synthesis and biological activity of platinum group metal complexes of o-vanillin thiosemicarbazones.

o-Vanillin-(4-methylthiosemicarbazone), o-Vanillin-(4-phenylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. The platinum group metal chelates exibited significant activity against a wide spectrum of microorganisms at different concentrations. The Pt(II) and Ru(III) chelates derived from o-vanillin-(4-phenylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the compounds in mice infected with Plasmodium berghei indicated that cures were attainable at dose levels of 40-160 mg/kg but with toxic death prevalence at higher dose levels.

Animals↗