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Results for “STAPHYLOCOCCAL INFECTIONS”

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At least 991 records · Page 55Linked to original sources
PubMed1991

[The extracorporeal immunostimulating effect of terrilytin in staphylococcal infection].

The intravenous injection of terrilytin-treated lymphocytes into rats infected with staphylococci enhances the formation of staphylococcal alpha antitoxin in the animals and the development of immune response to T-dependent antigen, such as sheep red blood cells (SRBC), but produces no effect on the development of immune response induced by T-independent antigen (lipopolysaccharide). Terrilytin-treated lymphocytes induce the release of the factor promoting the development of immune response to staphylococcal antigens and SRBC by spleen cells, incapable of adherence to plastic, but have no influence on the development of immune response to lipopolysaccharide in rats infected with staphylococci. At the same time in such rats spleen cells adhering to plastic take part in the transfer of signals from terrilytin-treated lymphocytes to nonadhering spleen cells of recipients.

Adjuvants, Immunologic↗
PubMed1980

Experimental staphylococcal infections in newborn mice: inhibition of weight gain as an index of virulence.

We attempted to evaluate the neonatal mouse model as an indicator of the virulence of staphylococcal strains freshly isolated from human patients in hospital. In preliminary studies with two previously characterised clinical isolates of Staphylococcus aureus and one of S. epidermidis, three indices of infection were studied. These were: mortality rate, multiplication of organisms in the skin, and the effect on weight gain. Of these inhibition of normal weight grain by mice given subcutaneous injections when 3 days old was the most convenient and easily applied test. At a challenge dose of 10(6) c.f.u., the multiplication of organisms in the skin was correlated with the inhibition of normal weight gain. Weight gain was used to compare the virulence of a small series of clinical isolates from different types of staphylococcal infection. Strains isolated from severe infections caused a greater inhibition of weight gain than did strains from milder infections or environmental sources.

Animals↗
PubMed1983

Impact of methicillin-resistant Staphylococcus aureus on the incidence of nosocomial staphylococcal infections.

MRSA strains have become increasingly prevalent in the United States and are now an important cause of nosocomial infections in many large, medical school-affiliated hospitals. In affected institutions, from a few percent to 50% of all hospital-acquired S aureus infections are caused by MRSA strains. It has been suggested that the overall incidence of nosocomial S aureus infections may not increase in hospitals where MRSA strains have become epidemic or endemic and that MRSA strains merely replace methicillin-susceptible strains as a cause of hospital-acquired infections. Several recent studies lend support to this theory. Thompson et al [1] reported that the overall incidence of nosocomial S aureus-associated bacteremias and postoperative wound infections in a university hospital did not increase during a period when MRSA strains caused a significantly greater proportion of such infections. Similarly, Linnemann et al [2] found that the overall incidence of nosocomial S aureus-associated bacteremias did not change during a four-year period when the incidence of MRSA-associated bacteremias increased appreciably. At the University of Mississippi Medical Center, MRSA strains have been recovered from patients with increased frequency since an outbreak of MRSA infections occurred in the burn unit in June 1979 [3]. Continuing surveillance has revealed that the incidence of nosocomial MRSA infections was significantly higher in 1980-1982 than during 1979 (P = 0.002 by Mann-Whitney U test). MRSA strains accounted for 11% of nosocomial S aureus infections in 1979, 38% in 1980, 50% in 1981, 36% in 1982, and 32% in early 1983.(ABSTRACT TRUNCATED AT 250 WORDS)

Cross Infection↗