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PubMedDate not supplied

Behavioral assessment of young nonhuman primates: perceptual-cognitive development.

The Infant Primate Research Laboratory at the University of Washington utilizes a range of test procedures to study perceptual-cognitive development in nonhuman primate infants at high and low risk for poor developmental outcome. These test procedures rely on the visual preferences of infants and are employed in research with both human and animal subjects. The forced-choice preferential looking technique is based on the primate infants' preference for patterned over plain stimuli and allows the early measurement of visual acuity. The novelty paradigm is based on the preference that infants show for novel over familiar stimuli and is used to study intramodal and cross-modal recognition memory. Tests of recognition memory have shown sensitivity in detecting subtle functional alterations associated with perinatal risk factors such as teratogen exposure. The use of measures which assess early patterns of visual attention should be considered in both human and nonhuman primate studies in behavioral teratology.

Animals↗
PubMedDate not supplied

Dynamic assessment of cognitive and cardiovascular performance in the elderly.

Dynamic measures of cardiovascular and cognitive performance have been used as a preliminary step toward developing predictors of decline in functional performance in older persons. Both batteries use multiple measures to examine the cooperativity of various aspects of performance, and both examine the subject's response to naturally occurring stresses. In these two senses, the measures are dynamic. For the cardiovascular measure we conducted ambulatory monitoring of blood pressure and pulse at 7.5-min intervals over a 24-h period. These parameters were analyzed simultaneously to examine changes in one relative to the others, using spectroscopy. After appropriate filtering, several dominant ultradian rhythms were noted, with periods of 47 min, 180 min and 6 to 8 h, the latter rhythm being present only in subjects aged greater than or equal to 60. A battery of computer-administered cognitive tests was developed to assess reaction time, visual recognition memory and word recognition memory. This testing allows for both a time and performance level grading. The results of the computer battery correspond well with those for standard neuropsychological tests. In general, performance declined with age, and reaction time increased. The computerized tests are faster, more consistently administered, and do not rely on a skilled professional for administration or analysis. They also provide a wide variety of measures that can be used in isolating components of performance. Once the acceptability and tolerance of older subjects toward such testing was established, attention shifted to questions of measurement stability and discriminant validity. Since the project's primary purpose is to predict subtle measures of decline in function, the battery's ultimate test is in its ability to correctly identify those about to change functional status. However, many different measures of status change are possible, and the predictive accuracy will depend on the outcome chosen. Subsequent work will focus on the predictors to refine measures and compare data collected at one point in time with the predictive power of change scores that reflect the individual subject's "signature." By-products of this work include a wealth of longitudinal physiologic and neuropsychologic data on older persons and tools that may be useful to the practicing physician.

Aged↗
PubMed2001

Semantic knowledge and episodic memory for faces in semantic dementia.

Previous studies have documented poor recognition memory for faces in patients with semantic dementia. Preserved face recognition memory was found in this study, however, so long as atrophy was confined predominantly to the left temporal lobe. Patients with structural damage to the right temporal lobe were typically impaired, with the status of the hippocampus and parahippocampal gyrus (including the perirhinal cortex) on the right being critical. Two single-case studies of patients with predominantly left temporal lobe pathology confirmed good recognition memory for famous faces, even if semantic knowledge about the celebrities depicted was severely degraded. An effect of semantic knowledge on recognition memory became apparent only when perceptually different photographs of the famous people were used at study and test. These results support the view that new episodic learning typically draws on information from both perceptual and semantic systems.

Aged↗
PubMed2003

Adult age differences in temporal and item memory.

Three experiments tested whether the relationship between age differences in temporal and item memory depends on the degree to which the item memory measure relies on memory for context. The authors predicted a stronger relationship of temporal memory to free recall than to recognition memory. Results showed that age differences in temporal memory could be eliminated after controlling for free recall but not recognition memory performance. Under some conditions recognition memory accounted for a significant portion of age-related variance in temporal memory. These results challenge past research that has interpreted age differences in temporal and item memory as independent and suggest that a generalized decline in context memory may underlie reduced performance in older adults on all types of memory tests.

Adolescent↗
PubMed1990

Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets.

In order to test the contribution of the target areas of the nucleus basalis magnocellularis to the mediation of item and order recognition memory for spatial locations, one set of rats received lesions of the dorsolateral frontal cortex, parietal cortex, or basolateral amygdala after training in an order recognition memory task, whereas another set of animals received lesions of the nucleus basalis magnocellularis or basolateral amygdala in an item recognition memory task. Animals with basolateral amygdala lesions displayed a deficit for order recognition memory, but no deficit for item recognition memory, a pattern equivalent to that found for animals with nucleus basalis magnocellularis lesions. In contrast, animals with dorsolateral frontal cortex displayed no deficit, and animals with parietal cortex lesions displayed only a partial deficit for order recognition memory, results that differ from those found for animals with nucleus basalis magnocellularis lesions. It appears that the nucleus basalis magnocellularis influences item and order recognition memory for lists of spatial locations primarily through projections to limbic but not neocortical targets.

Amygdala↗
PubMed1988

Memory deficits in psychiatric outpatients and affective ratings of positive and neutral lists of words.

The experimental findings on memory deficits from hospitalized psychiatric patients were applied to the recall and recognition memory of outpatients. Two positive and one list of 25 neutral words each were learned by the subjects for recognition and then rated as an orienting task during rehearsal for recall. On the first positive list, compared to 20 controls, the 7 patients showed substantial recall deficits, but recognition memory and affective ratings were relatively normal. On the subsequent positive list, outpatients' recall memory declined and did not recover after shifting to neutral words on the third list. There was little evidence for the build-up of interference, instead factors such as fatigue may affect patients' recall memory. Recognition memory showed signs of interference contributing to the patients' deficits. Psychiatric outpatients have significant recall deficits, less severe recognition deficits, and attitude problems that may contribute to the high rate of readmissions.

Adult↗
PubMed2004

"It's magic!" The effects of presentation modality on children's event memory, suggestibility, and confidence judgments.

The current study investigated the influence of presentation modality (live, video, and slide show) on children's memory, suggestibility, recognition, and metamemorial monitoring processes. A total of 270 children in three age groups (5- and 6-year-olds, 7- and 8-year-olds, and 9- and 10-year-olds) watched a magic show and were questioned about it 1 week later. The live show yielded more correct answers to nonleading questions, higher resistance to misleading questions, and better recognition memory than did the video condition, which in turn resulted in better performance than did the slide show. Although presentation modality raised the general level of memory performance, the effects were equally strong in all age groups and did not affect memory phenomena such as the size of the misinformation effect and confidence judgments.

Child↗
PubMed1979

Memory loss and response bias in senescence.

Recognition memory was studied in young and elderly women by assessing memory strength and response bias using Signal Detection Theory methodology. Young women (mean age 21 years; n = 8) had better recognition memory (d' and d'e) than did elderly women (mean age 71 years; n = 16) but the groups did not differ significantly on correct recognitions (hit rate) or incorrect recognitions (false affirmative rate). Evaluation of response bias indicated that the elderly women adopted a lax response strategy which resulted in an inflated correct recognition rate. The data indicate that, in aging research, evaluation of memory in terms of correct and incorrect recognitions can lead to erroneous interpretations, due to uncontrolled bias effects. Age does adversely influence recognition memory strength suggesting that acquisition and/or storage processes are not invariant with age.

Adult↗
PubMed2006

Neutral and emotional episodic memory: global impairment after lorazepam or scopolamine.

RATIONALE: Benzodiazepines and anticholinergic drugs have repeatedly been shown to impair episodic memory for emotionally neutral material in humans. However, their effect on memory for emotionally laden stimuli has been relatively neglected. OBJECTIVE: We sought to investigate the effects of the benzodiazepine, lorazepam, and the anticholinergic, scopolamine, on incidental episodic memory for neutral and emotional components of a narrative memory task in humans. MATERIALS AND METHODS: A double-blind, placebo-controlled independent group design was used with 48 healthy volunteers to examine the effects of these drugs on emotional and neutral episodic memory. RESULTS: As expected, the emotional memory advantage was retained for recall and recognition memory under placebo conditions. However, lorazepam and scopolamine produced anterograde recognition memory impairments on both the neutral and emotional components of the narrative, although floor effects were obtained for recall memory. Furthermore, compared with placebo, recognition memory for both central (gist) and peripheral (detail) aspects of neutral and emotional elements of the narrative was poorer after either drug. CONCLUSIONS: Benzodiazepine-induced GABAergic enhancement or scopolamine-induced cholinergic hypofunction results in a loss of the enhancing effect of emotional arousal on memory. Furthermore, lorazepam- and scopolamine-induced memory impairment for both gist (which is amygdala dependent) and detail raises the possibility that their effects on emotional memory do not depend only on the amygdala. We discuss the results with reference to potential clinical/forensic implications of processing emotional memories under conditions of globally impaired episodic memory.

Adolescent↗
PubMed1985

The molecule-group schema of memory: storage, recognition and retrieval.

A new schema, the molecule-group schema, explains memory storage, recognition and retrieval. The schema consists of three postulates about molecular specificity, grouping, and diffusion. In the schema, the physical memory trace consists of a stable group of different kinds of highly specific molecules. The schema is intended to provide an alternative to the widely known synaptic-change schema, in which it is assumed that changes of synaptic efficacies constitute the memory trace. The new schema is used to develop a particular model of memory. In the model, recognition occurs when specific intracellular "endotransmitters" react with complementary "endoreceptors" in the same cell. Retrieval, modelled as the process whereby memory causes the recurrence of a previously experienced pattern of neural activity, occurs when a group of pools of endotransmitters, located within an intracellular memory organelle, is released, allowing the endotransmitters to diffuse to the periphery of the cell body. The model suffices to explain long-term and short-term memory of events as well as innate memory.

Animals↗
PubMed2000

Complementary neural mechanisms for tracking items in human working memory.

Recognition of a specific visual target among equally familiar distracters requires neural mechanisms for tracking items in working memory. Event-related functional magnetic resonance imaging revealed evidence for two such mechanisms: (i) Enhanced neural responses, primarily in the frontal cortex, were associated with the target and were maintained across repetitions of the target. (ii) Reduced responses, primarily in the extrastriate visual cortex, were associated with stimulus repetition, regardless of whether the stimulus was a target or a distracter. These complementary neural mechanisms track the status of familiar items in working memory, allowing for the efficient recognition of a currently relevant object and rejection of irrelevant distracters.

Cerebral Cortex↗
PubMed1993

[The influence of the type of conversation on its memory].

The present study investigated the effect of the type of conversation on the recognition memory of statements appeared in the conversation. The experiment used two types of conversation; goal-oriented conversation and desultory conversation. The examined items were as follows: (1) the recognition memory of the surface form of statements which appeared in both types of conversation, (2) the effect of whether the sex of speaker was the same as the subject's or not, (3) the effect of whether the subject joined the conversation or just listened to conversation. Subjects (40 male and female undergraduates) were randomly assigned either to the listening condition in which they read the scenario of a conversation silently while listening to the tape recorded version of the same conversation, or to the utterance condition in which they played the part given in the scenario as if they were conversing with a partner whose utterance was given by the tape. The following results were obtained. Recognition memory of both surface form and content of statements was high in the goal-oriented, listening, same-sex condition, in the goal-oriented, utterance, other-sex condition, and in the desultory, listening, other-sex condition; it was low in desultory, utterance, other-sex condition. These results suggested that the recognition memory of conversation was dependent on various factors such as the type of conversation, the identity of the speaker (self or non-self), and the part played in the conversation (joining or listening).

Adult↗
PubMed1981

A similarity between weak normal memory and amnesia with two and eight choice word recognition: a signal detection analysis.

Two and eight choice recognition memory was compared in a group of normal individuals shortly after learning a list of words and seven days later. In addition to selecting the correct response, subjects were required to indicate the confidence of their choices. The results showed that eight choice recognition performance was differentially worse than two choice recognition at delayed compared to immediate test. These results were similar to some reported by Miller (1977) in which he compared recognition in dementing amnesics and controls at immediate test. While Miller interpreted his data in terms of a selective retrieval deficit in amnesics, our data suggests that both sets of results arise because Signal Detection Theory is applicable to recognition memory data. An additional result was that subjects felt they guessed correctly selected words more frequently after a delay.

Adult↗
PubMed2005

Executive function in Tourette's syndrome and obsessive-compulsive disorder.

BACKGROUND: Cognitive performance was compared in the genetically and neurobiologically related disorders of Tourette's syndrome (TS) and obsessive-compulsive disorder (OCD), in three domains of executive function: planning, decision-making and inhibitory response control. METHOD: Twenty TS patients, twenty OCD patients and a group of age- and IQ-matched normal controls completed psychometric and computerized cognitive tests and psychiatric rating scales. The cognitive tests were well-characterized in terms of their sensitivity to other fronto-striatal disorders, and included pattern and spatial recognition memory, attentional set-shifting, and a Go/No-go set-shifting task, planning, and decision-making. RESULTS: Compared to controls, OCD patients showed selective deficits in pattern recognition memory and slower responding in both pattern and spatial recognition, impaired extra-dimensional shifting on the set-shifting test and impaired reversal of response set on the Go/No-go test. In contrast, TS patients were impaired in spatial recognition memory, extra-dimensional set-shifting, and decision-making. Neither group was impaired in planning. Direct comparisons between the TS and OCD groups revealed significantly different greater deficits for recognition memory latency and Go/No-go reversal for the OCD group, and quality of decision-making for the TS group. CONCLUSIONS: TS and OCD show both differences (recognition memory, decision-making) and similarities (set-shifting) in selective profiles of cognitive function. Specific set-shifting deficits in the OCD group contrasted with their intact performance on other tests of executive function, such as planning and decision-making, and suggested only limited involvement of frontal lobe dysfunction, possibly consistent with OCD symptomatology.

Adult↗
PubMed2004

Recollection-like memory retrieval in rats is dependent on the hippocampus.

Recognition memory may be supported by two independent types of retrieval, conscious recollection of a specific experience and a sense of familiarity gained from previous exposure to particular stimuli. In humans, signal detection techniques have been used to distinguish recollection and familiarity, respectively, in asymmetrical and curvilinear components of their receiver operating characteristic (ROC) curves, standard curves that represent item recognition across different levels of confidence or bias. To determine whether animals also employ multiple processes in recognition memory and to explore the anatomical basis of this distinction, we adapted these techniques to examine odour recognition memory in rats. Their ROC curve had asymmetrical and curvilinear components, indicating the existence of both recollection and familiarity in rats. Furthermore, following selective damage to the hippocampus the ROC curve became entirely symmetrical and remained curvilinear, supporting the view that the hippocampus specifically mediates the capacity for recollection.

Animals↗
PubMed2004

Comparison of blind and sighted participants' performance in a letter recognition working memory task.

The performance in letter recognition of 21 blind participants was compared with that of 16 age-matched sighted participants in an n-back working memory task. Blind participants were tested tactually with series of raised letters and Braille characters, and sighted participants tactually with series of raised letters and visually with series of letters presented on a computer screen. With this approach, we wanted to compare the tactual performances by trained (blind) and non-trained (sighted) participants, and tactual and visual performances by trained (blind and sighted, respectively) participants. Increments of mnemonic load increased the number of incorrect responses significantly in all n-back tasks. As expected, the blind participants outperformed the sighted ones statistically significantly in the tactile raised letters n-back task. The sighted participants produced significantly fewer incorrect responses in the visual task than the blind participants in the raised letters task, whereas there was no such difference between sighted subjects' visual performance and blind subjects' tactile performance in the Braille task. These results demonstrate the degree and limits to which everyday practice develops perceptual skills either in persons without sensory deficits (vision and visual environment), or persons with severe sensory loss (blindness and tactile environment). The performance level of blind persons relying on their tactile skills is just about the same as that of sighted subjects relying on their visual skills.

Adult↗
PubMed1996

The primate temporal pole: its putative role in object recognition and memory.

In this article, we consider both the ventral temporopolar cortex and the perirhinal cortex (areas 35 and 36) as the anterior ventromedial temporal (aVMT) cortex, and discuss its role based on recent data in monkeys and human subjects. In monkeys, the aVMT cortex receives its primary input from area TE, and only minor input from other cortical areas. Laminar patterns of connections suggest that the aVMT cortex is a hierarchically higher-order area than area TE. Lesions of this cortex produce deficits in the learning and performance of visual memory tasks. Neurons in the aVMT cortex respond selectively to complex stimuli and changes in activity related to visual memory tasks. In humans, damage of this cortex induces deficits in the recognition of familiar objects and faces. The aVMT cortex is activated during recognition of familiar faces. In addition, the aVMT cortex is one of the most vulnerable areas in Alzheimer's disease. All these data indicate that the aVMT cortex is a higher-order visual cortical area that is related to object recognition and memory. The anterior area TE has been implicated in both functions. We propose here that these areas and the anterior entorhinal cortex are designated as the temporal pole, a brain region which is specialized for both object recognition and memory.

Animals↗
PubMed2003

Modification of social memory, hypothalamic-pituitary-adrenal axis, and brain asymmetry by neonatal novelty exposure.

Although corticosterone (a stress hormone) is known to influence social behavior and memory processes, little has been explored concerning its modulatory role in social recognition. In rats, social recognition memory for conspecifics typically lasts <2 hr when evaluated using a habituation paradigm. Using neonatal novelty exposure, a brief and transient early life stimulation method known to produce long-lasting changes in the hypothalamic-pituitary-adrenal axis, we found that social recognition memory was prolonged to at least 24 hr during adulthood. This prolonged social memory was paralleled by a reduction in the basal blood concentration of corticosterone. The same neonatal stimulation also resulted in a functional asymmetry expressed as a greater right-turn preference in a novel environment. Rats that preferred to turn right showed better social recognition memory. These inter-related changes in basal blood corticosterone concentration, turning asymmetry, and social recognition memory suggest that stress hormones and brain asymmetry are likely candidates for modulating social memory. Furthermore, given that neonatal stimulation has been shown to improve learning and memory performance primarily under aversive learning situations, the neonatal novelty exposure-induced enhancement in social recognition broadens the impact of early life stimulation to include the social domain.

Animals↗