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[Ambulatory hemorrhoidectomy through rubber band ligation-review of the literature].

The value of rubber band ligation in the treatment of haemorrhoids is discussed and the literature on the case histories of 3244 patients who were treated by this technique is reviewed. 36% of the patients found this form of therapy to be painless, 41% suffered little and 14% severe pain. 80% of all patients finally were free of symptoms. Rubber band ligation therefore is an effective method treating internal haemorrhoids. Its advantages are simplicity, relatively little discomfort for the patient, applicability in ambulant patients, no general anaesthesia, low cost and good results with only minor complications. Thus it is an alternative to sclerotherapy and to surgical haemorrhoidectomy.

Adolescent↗

Local controlled release of 1-hydroxyethylidene diphosphonate using silicone-rubber matrices. Effects of sterilization on in vitro release and in vivo efficacy.

Calcification (CALC) is the most frequent cause of the clinical failure of bioprosthetic heart valves (BHVs). Controlled release of disodium ethanehydroxydiphosphonate (EHDP) has been demonstrated to inhibit subdermal BHV calcification at effective low local doses, avoiding adverse effects. However, the eventual circulatory use of controlled release EHDP necessitates addressing several critical issues that may affect efficacy. These include the effects of sterilization on EHDP release and the efficacy of sustained release matrices containing CaEHDP, which is less soluble than NaEHDP. The effects of CaEHDP-NaEHDP incorporation and steam sterilization on controlled release of EHDP from silicone-rubber matrices was studied both in vitro and in vivo using a rat subdermal model and sheep tricuspid valve replacements. Autoclaved EHDP matrices (20% wt/wt) released 88.9% +/- 7.84 of contained drug after 140 days in vitro, compared with control (87.6% +/- 10.3 cumulative release). Autoclaved EHDP matrices completely inhibited BHV CALC in 60 day rat subdermal implants (8.84 +/- 3.68 micrograms Ca++/mg tissue), comparable to nonsterilized EHDP-loaded matrices (7.06 +/- 2.00 micrograms Ca++/mg tissue). Nontreated CALC levels were 183 +/- 7.60 micrograms Ca++/mg tissue. Na-CaEHDP co-incorporation into silicone rubber matrices markedly prolonged controlled release with the 1:1 Na-CaEHDP mixture demonstrating an extrapolated release duration of approximately 20 years, assuming the total amount of dispersed drug was released. Data from tricuspid valve replacements in sheep demonstrate erratic control calcification (41.3 +/- 14.9 micrograms Ca++/mg tissue), but complete suppression of BHV calcification with Na2EHDP controlled release (5.74 +/- 1.35 micrograms Ca++/mg tissue) after 150 days.

Animals↗

Patient and operator attitudes toward rubber dam.

The increasing reliance of modern dentistry on adhesive materials, has acted as a renewed incentive for the use of rubber dam. A safe, dry field in a comfortable patient, with the teeth and colored rubber dam contrasting, are the major advantages to the operator. Few articles have assessed the reactions of either the patient or the operator; in this study, it is accepted well.

Adolescent↗

[Rubber-band ligation of hemorrhoids].

In the last few years there has been a considerable reduction in surgical treatment of piles; on the other hand a series of therapeutic outpatient treatments has developed aiming at a conservative management of piles. This new approach is mainly due to high costs in surgical treatment. In accordance also with the experience of the most important proctologic centres, nowadays only 26% of our patients suffering from piles undergo operation, since we regard rubber band ligation as a more rational and economical method for the treatment of hemorrhoids. The instruments and the technique related to band ligation have been described together with some modifications suggested by our personal experience. Indications and contraindications for rubber band ligation have been analyzed pointing out that, in our opinion, such an approach is advised also in the management of stage 3 and 4 hemorrhoids; on the other hand the surgical treatment has its role when band ligation is contraindicated. We have then reported about the good results obtained with 162 patients suffering from stage 2, 3 and 4 hemorrhoids, by using band ligation. Our experience, in accordance with international literature, enables us to emphasize the almost complete absence of complications and the satisfactory results of band ligation, even if compared to other methods.

Hemorrhoids↗

[Dural arteriovenous malformation in posterior fossa treated with artificial embolization using a liquid silicon rubber, phycon (author's transl)].

Many cases of dural arteriovenous malformation have been reported recently. However, the surgical treatment for these diseases has not been established yet. We propose a new method of treatment on this peculiar vascular diseases, that is one of the artificial embolizations; A catheter is inserted into feeding artery, from which liquid silicon rubber, Phycon, is injected. The rubber is hardened in the vascular net-work. It can not pass into drainer because of its viscosity. Therefore the malformation never develope again. We tried this new method on 46-year-old woman, who suffered from subarachnoidal bleeding, tinnitus and headache. The left common carotid and vertebral angiography revealed dural arteriovenous malformation in posterior fossa (Fig. 1); the feeding arteries of which were middle meningeal arteries, occipital artery, and tentorial artery, etc; the drainers were transverse and sigmoid sinuses. We treated for this case with above-mentioned method; The liquid plastic of 1 - 2 ml injected into each of the main feeding arteries, namely two middle meningeal arteries and occipital artery. Postoperative angiograms revealed this technic was convenient and sufficient for the treatment of dural arteriovenous malformations (Fig. 7).

Cranial Fossa, Posterior↗

[Genetic aspects of blue rubber-bleb nevus syndrome and multiple generalized glomangiomatosis].

Morphology, clinical findings and histological examination allow to recognize the solitary glomus tumor from the multiple glomus tumors and the blue rubber-bleb nevus-syndrome; however, the latter are more difficult to identify separately. They are transmitted as autosomal dominant conditions with good penetrance. With the hypothesis of a dual mutation system and that of the putative induction of paramutations the authors try to account for the variable expression of these conditions. It may be suggested that the existence of a common histological pattern, the multiple systematic, the multiple generalized tumors and the blue rubber-bleb nevus syndrome being perhaps the different expression of the same basic pathologic process.

Diagnosis, Differential↗

Association of blue rubber bleb nevus syndrome with chronic lymphocytic leukemia and hypernephroma.

A male patient with clinical and pathologic features of blue rubber bleb nevus syndrome is described. Multiple hemangiomata were disseminated throughout the skin and gastrointestinal tract, and typical findings of B cell chronic lymphocytic leukemia and renal cell carcinoma were evident. This case demonstrates a unique instance of associated neoplasia in blue rubber bleb nevus syndrome.

Adenocarcinoma↗

Cystic osteolysis induced by silicone rubber prosthesis.

Synovitic symptoms and radiologically documented cystic lesions in several carpal bones and distal radius developed two years after the implantation of silicone rubber scaphoid prosthesis for pseudoarthrosis. Open biopsy revealed granulomatous synovitis and osteitis and foreign material in carpal tissues. Ultrastructurally dense material was found in the cytoplasm of histiocytic, often multinucleated cells. Electron-probe analysis of the material showed a definite peak for silicon, proving the causal relationship of symptoms and signs to the silicone rubber prosthesis.

Adult↗

Hysteroscopic tubal occlusion with silicone rubber.

A new method of sterilization for women is being investigated in several outpatient centers. The technique involves flowing liquid silicone rubber into the fallopian tubes. The silicone cures in place and forms a rubbery solid plug. The catalyzed liquid silicone is pumped through a special polysulfone guide assembly that fits through the operating channel of a standard hysteroscope. On the end of the guide is a hollow premolded silicone rubber tip that fits into the cornual ostium of the tube. When the silicone cures it also cross-links to this tip so that the tip becomes part of the plug. Results as of April 1, 1982, from 350 women in the Philadelphia center suggest that proper plug formation prevents pregnancy and that the method can be applied to about 85% of properly selected women.

Fallopian Tubes↗

[Combined rubber band ligation and cryosurgery of hemorrhoids (author's transl)].

By means of the combined rubber band ligation and cryosurgery of hemorrhoids a good therapy result was achieved on more than 200 patients. For the treatment of not too large hemorrhoid nodes and confluent hemorrhoids the aspiration ligation is quite sufficient. In third degree hemorrhoids, particularly in large prolapsing hemorrhoids, the rubber band ligation should include also the cryodestruction. In some cases two or three weeks later the cryodestruction has to be carried out again, depending on the finding and stage progredience. The advantage of this combined method is that the treatment can be performed on outpatients, and without much pains it is an effective therapy in any kind of hemorrhoid ailments. In addition, the postoperative complaints are less than by using the cryosond only. The application of cryotherapy shows also good results in the case of marriscae and anal fissures.

Cryosurgery↗

Oxygen exchange in silicone rubber capillaries.

Capillaries of 7 and 12.5 mu diameter have been fabricated in silicone rubber. Whole blood treated with heparin has been perfused through these capillaries. Under flowing conditions, no clotting or other clumping effects have been observed and red cells appear to maintain a constant velocity. Oxygen transfer data to and from saline perfusing the 12.5 mu diameter capillaries have been obtained in order to determine how rapidly O2 will permeate the silicone rubber film. The data indicate that the capillaries simulate lung tissue oxygen exchange and will allow for the first time the experimental determination of oxygen exchange kinetics in flowing whole blood.

Blood Flow Velocity↗

Use of a hand-carved silicone-rubber spacer for advanced Kienböck's disease.

We found that the use of a hand-carved silicone-rubber (Silastic) spacer was reasonably effective in relieving symptoms in thirty-six patients with advanced Kienböck's disease, even though there was still some residual postoperative loss of wrist motion and grip strength. Preoperatively all patients had pain and limited motion of the wrist as well as weakness of grip. Roentgenographically all had fragmentation and collapse of the lunate, and 92 per cent had measurable carpal collapse. Most had had symptoms for longer than one year. After removal of the deformed lunate through a dorsal incision, a silicone-rubber spacer was shaped to fit the defect. Patients were followed for an average of fifty-four months. Thirty-two patients were followed for at least two years; all but three were improved. This procedure is not recommended when the shape of the lunate is normal or not significantly altered, or when the lunate has not collapsed as measured by precise determinants.

Adolescent↗

Rubber band ligation of hemorrhoids.

A retrospective review of 384 patients who had undergone rubber band ligation for hemorrhoidal disease by one surgeon from 1988 to 1993 is presented. The primary indications for treatment were rectal bleeding and prolapse. Eighty-nine percent of the patients were improved following treatment. In selected patients, rubber band ligation is an acceptable alternative to surgical hemorrhoidectomy.

Hemorrhoids↗

[Inspection of surgical rubber gloves used during dental procedures].

The resistance and durability of operating rubber gloves (PALMA) during different types of dental treatment were investigated. Six percent of the rubber gloves were found to be defective. One pair of gloves could be used 2.15 times on average. The vulnerability of the gloves increased after repeated sterilizations. The results suggest that the use of disposable gloves should be preferred in the daily dental practice.

Acquired Immunodeficiency Syndrome↗

Blue rubber bleb nevus syndrome in the foot.

Blue rubber bleb nevi are histologically benign vascular neoplasms of the skin and gastrointestinal tract, which may cause pain and limb-threatening deformities, as well as potentially fatal visceral hemorrhage. Treatment of cutaneous and soft tissue lesions includes local excision, aimed at symptomatic relief, with appropriate referral for evaluation of gastrointestinal lesions and secondary anemia. A case of blue rubber bleb nevus syndrome with lesions of the foot is reported.

Adult↗

Silicone-rubber catheter fracture and embolization in a very low birth weight infant.

A 28-week preterm infant had a percutaneous silicone-rubber central venous catheter placed for parenteral nutritional support. The catheter was later found to have fractured, and a 5.5 cm piece of catheter was lodged in the patient's right atrium. It was retrieved percutaneously by fluoroscopically guided cardiac catheterization without complications. Fracture and embolization of a catheter is a rare but serious complication of central venous catheters, and we report our experience as the only known case of a silicone-rubber catheter fracture and embolization in a premature infant, in which the catheter fragment was retrieved via a percutaneous endovascular approach.

Catheterization↗

[Treatment of intraarticular finger fractures with the help of the traction system of "pins and rubbers" according to Y. Suzuki].

The results of treatment of intraarticular finger fractures by means of Y. Suzuki's pins and rubbers traction system are presented. The system consists of 2-3 thin K-wires and 2 rubber bands, is easy to assemble, effective, and less clumsy then the ones applied previously. It also allows for the reduction of palmar displacement of bony fragments. Sixteen intraarticular fractures have been treated. The average total range of motion of the injured PIP joint was 82 degrees at the average follow-up of 8.5 months.

Adolescent↗

Pharmaceutical container/closure integrity. II: The relationship between microbial ingress and helium leak rates in rubber-stoppered glass vials.

Helium leak rate measurements were quantitatively correlated to the probability of microbial ingress for rubber-stoppered glass vials subjected to immersion challenge. Standard 10-mL tubing glass vials were modified by inserting micropipettes of various sizes (0.1 to 10 microns nominal diameter) into a side wall hole and securing them with epoxy. Butyl rubber closures and aluminum crimps were used to seal the vials. The test units were sealed in a helium-filled glove bag, then the absolute helium leak rates were determined. The test units were disassembled, filled with media, resealed, and autoclaved. The test units were thermally treated to eliminate airlocks within the micropipette lumen and establish a liquid path between microbial challenge media and the test units' contents. Microbial challenge was performed by immersing the test units in a 35 degrees C bath containing magnesium ion and 8 to 10 logs of viable P. diminuta and E. coli for 24 hours. The test units were then incubated at 35 degrees C for an additional 13 days. Microbial ingress was detected by turbidity and plating on blood agar. The elimination of airlocks was confirmed by the presence of magnesium ions in the vial contents by atomic absorption spectrometry. A total of 288 vials were subjected to microbial challenge testing. Those test units whose contents failed to show detectable magnesium ions were eliminated from further analysis. At large leak rates, the probability of microbial ingress approached 100% and at very low leak rates microbial ingress rates were 0%. A dramatic increase in microbial failure occurred in the leak rate region 10(-4.5) to 10(-3) std cc/sec, which roughly corresponded to leak diameters ranging from 0.4 to 2 microns. Below a leak rate of 10(-4.5) std cc/sec the microbial failure rate was < 10%. The critical leak rate in our studies, i.e. the value below which microbial ingress cannot occur because the leak is too small, was observed to be between 10(-5) and 10(-5.8) std cc/sec, which corresponds to an approximate leak diameter of 0.2-0.3 micron.

Drug Contamination↗