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At least 991 records · Page 55Linked to original sources
PubMed2005

Obesity in South Australian adults--prevalence, projections and generational assessment over 13 years.

OBJECTIVES: To examine the trend in obesity prevalence using annual representative cross-sectional samples of the South Australian population, to project the increase of obesity using current trends, and to examine the increase in prevalence by generational assessment. METHODS: Face-to-face interviews of representative population samples of people aged 18 years and over living in South Australia from 1991 to 1998 and again in 2001 and 2003. Information on height and weight was provided by participants, in order to calculate body mass index (BMI) as a measure of obesity. RESULTS: The proportion of respondents classified as obese according to their self-reported body mass index (BMI > or = 30 to <35) increased significantly from 8.7% in 1991 to 14.1% in 2003 (chi2 trend=79.4, p<0.001). Severe obesity (BMI > or = 35) increased significantly from 2.6% in 1991 to 5.3% in 2003 (chi2 trend=50.4, p<0.001). Current prevalence trends indicate that by 2013, the self-reported prevalence of obesity in South Australian adults will be 27.8%, with the prevalence in males being 26.4% and in females, 29.3%. Secular obesity trends indicate that younger birth cohorts had the greatest percentage increases. CONCLUSIONS: Obesity has increased significantly between 1991 and 2003, and is increasing fastest among younger adults. Multifactorial interventions at all levels of the population are required to prevent overweight and obesity and promote weight maintenance, weight loss and address the health burden of obesity.

Adolescent↗
PubMed2026

Haplotype Blocks Are Associated With Rapid Local Adaptation to Environmental Shifts in Wild Barley.

Genomic mechanisms of local adaptation must be highly responsive in geographic regions where climate is changing rapidly. The Levant region is a critical biodiversity hotspot and the distribution edge for many species, including the wild ancestor of domesticated barley. This region is under an accelerated desertification process, thus enforcing a rapid genomic response to the projected environmental changes. To elucidate the genomic basis of rapid local adaptation, we studied wild barley populations using an ecological-genetic sampling design that decouples environmental variation from demographic background. We collected and sequenced 300 wild barley individuals and evaluated the phenotypes of 3600 progeny plants over 3&#x2009;years. Our genomic analyses revealed that local adaptation is associated with clusters of candidate genes forming haplotype blocks. These clusters are enriched with environment and stress responsive genes, including flowering time regulators, drought and heat responsive genes. We identified six candidate adaptive haplotype blocks which span 1-8&#x2009;Mbp and are distributed across chromosomes 1H, 2H, 4H and 5H, each segregating as two major haplotypes. Additionally, we integrated over 2600 occurrence records into ecological and evolutionary modelling to assess the genomic vulnerability of populations to projected future climates. Our study identifies candidate genomic regions and environmental drivers of local adaptation in wild barley and highlights the advantage of haplotype blocks architecture in orchestrating an efficient response to rapid environmental change. We highlight the ecological factors most strongly associated with the observed evolutionary responses and provide insights and guidelines for biodiversity conservation and implementation of crop wild relatives in breeding.

Hordeum↗
PubMed2001

A population of large lamina I projection neurons with selective inhibitory input in rat spinal cord.

Lamina I of the spinal dorsal horn contains a diverse mixture of neurons. Among these, a group of giant neurons (Waldeyer cells) has long been recognized. In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine receptor-associated protein gephyrin on their cell bodies and proximal dendrites. Most of these cells (27/29) were retrogradely labelled after injection of cholera toxin B subunit into the parabrachial area, and the majority (26/30) expressed the protein product of immediate-early gene c-fos, Fos, following noxious stimulation. Unlike many lamina I projection neurons, these cells either lacked the neurokinin 1 receptor, or expressed it at a very low level. Most of the gephyrin puncta on the cells were adjacent to axons that contained glutamate decarboxylase (and were therefore presumably GABAergic), which suggests that the cells are under powerful inhibitory control. Only around 35% of the puncta were associated with axons that expressed the glycine transporter GLYT2 (a marker for glycinergic axons); however, the glycine receptor alpha1 subunit was present at all of the gephyrin puncta on these cells. The cells received synapses from axons that contained nitric oxide synthase, most of which were also GABAergic, and in some cases this input was so dense that it outlined the cell bodies and dendrites. The innervation by nitric oxide synthase-containing axons was selective for these cells, compared to other neurons in the dorsal horn. From the results of this study we suggest that the gephyrin-rich cells form a specific population of lamina I projection neurons which convey noxious information to the brain. These cells are under powerful inhibitory control, and the study provides further evidence that inhibitory circuits in the dorsal horn are organized in a specific manner.

Amino Acid Transport Systems, Neutral↗
PubMed1983

Forecasting metropolitan and urban subregional population changes and their resource use implications: methodology and example--Sydney, Australia.

This paper is concerned with the methodology of forecasting population change and structures of large cities and their major subregions. "The model isolates quantifiable base populations and their growth, and international, inter-state and city-hinterland migration streams and the national increase attributable to each, and intra-urban mobility, as components of growth and change." The model is applied to data for Sydney, Australia, and its applicability to other urban systems is considered.

Australia↗
PubMed2004

Human population density and extinction risk in the world's carnivores.

Understanding why some species are at high risk of extinction, while others remain relatively safe, is central to the development of a predictive conservation science. Recent studies have shown that a species' extinction risk may be determined by two types of factors: intrinsic biological traits and exposure to external anthropogenic threats. However, little is known about the relative and interacting effects of intrinsic and external variables on extinction risk. Using phylogenetic comparative methods, we show that extinction risk in the mammal order Carnivora is predicted more strongly by biology than exposure to high-density human populations. However, biology interacts with human population density to determine extinction risk: biological traits explain 80% of variation in risk for carnivore species with high levels of exposure to human populations, compared to 45% for carnivores generally. The results suggest that biology will become a more critical determinant of risk as human populations expand. We demonstrate how a model predicting extinction risk from biology can be combined with projected human population density to identify species likely to move most rapidly towards extinction by the year 2030. African viverrid species are particularly likely to become threatened, even though most are currently considered relatively safe. We suggest that a preemptive approach to species conservation is needed to identify and protect species that may not be threatened at present but may become so in the near future.

Animals↗
PubMed1999

Waist and hip circumferences, and waist-hip ratio in 19 populations of the WHO MONICA Project.

OBJECTIVE: To assess differences in waist and hip circumferences and waist-to-hip ratio (WHR) measured using a standard protocol among populations with different prevalences of overweight. In addition, to quantify the associations of these anthropometric measures with age and degree of overweight. DESIGN: Cross-sectional study of random population samples. SUBJECTS: More than 32000 men and women aged 25-64y from 19 (18 in women) populations participating in the second MONItoring trends and determinants in CArdiovascular disease (MONICA) survey from 1987-1992. RESULTS: Age standardized mean waist circumference range between populations from 83-98 cm in men and from 78-91cm in women. Mean hip circumference ranged from 94-105cm and from 97-108cm in men and women, respectively, and mean WHR from 0.87-0.99 and from 0.76-0.84, respectively. Together, height, body mass index (BMI), age group and population explained about 80% of the variance in waist circumference. BMI was the predominant determinant (77% in men, 75% women). Similar results were obtained for hip circumference. However, height, BMI, age group and population, accounted only for 49% (men) and 30% (women) the variation in WHR. CONCLUSION: Considerable variation in waist and hip circumferences and WHR were observed among the study populations. Waist circumference and WHR, both of which are used as indicators of abdominal obesity, seem to measure different aspects of the human body: waist circumference reflects mainly the degree of overweight whereas WHR does not.

Adult↗
PubMed1998

Diabetes and impaired glucose tolerance in three Alaskan Eskimo populations. The Alaska-Siberia Project.

OBJECTIVE: The objectives of this study were to determine the prevalence of diabetes and impaired glucose tolerance (IGT) in three Alaskan Eskimo populations, using standardized diagnostic criteria, and to evaluate family history and obesity as risk factors. RESEARCH DESIGN AND METHODS: This cross-sectional study involved men and women > or = 25 years of age from three Eskimo ethnic groups (Siberian Yupik, Central Yupik, and Inupiat) residing in northwestern Alaska. Glucose tolerance status was defined by World Health Organization criteria and was based on a 75-g oral glucose tolerance test. Data on age, family history of diabetes, and degree of Eskimo ancestry were obtained from a personal interview. Obesity was assessed using BMI. RESULTS: A total of 454 of 899 (50.5%) eligible participants were examined for diabetic status (239 Siberian Yupik, 106 Central Yupik, and 109 Inupiat participants). The prevalence of diabetes was more than twice as high among the Siberian Yupik (9.6%) as among the Central Yupik (2.8%) and Inupiat participants (3.7%). Diabetes was more prevalent in women than men (8.8 vs. 4.2%). IGT was found in an additional 11.7% of the women and 4.7% of the men. The combined prevalence of diabetes and IGT in the population > or = 55 years of age was 30.4% (diabetes 12.0%, IGT 18.4%). Of the people identified with diabetes, 47% had not been previously diagnosed. Age-specific prevalences were similar to those found in U.S. whites in the National Health and Nutrition Examination Survey II. After adjustment for age, family history of diabetes was associated with diabetes in study participants with an odds ratio of 4.4, while obesity was associated with diabetes with an odds ratio of 2.6. CONCLUSIONS: These prevalences of diabetes are the highest yet reported among Eskimo populations. Obesity and family history of diabetes are associated with increased odds of developing diabetes. These data underscore the need to further examine risk factors and to design effective interventions.

Adult↗
PubMed1995

Afferent projections to the cingulate cortex in albino rats: a study with a retrograde labeling method using fluoro-gold.

We studied the neuronal populations that project their axons to the cingulate cortex in albino rats using the retrograde fluorescent dye of 4% Fluoro-Gold injected into the anterior, middle and posterior portions of the cingulate cortex. The result showed that the following ipsilateral structures are sending fibers to these three portions: the prefrontal cortex, frontoparietal motor cortex, indusium griseum, dorsal endopiriform nucleus, lateral part of medial mammillary nucleus, nuclei of diagonal band of Broca, anterior pretectum, anterior part of caudate-putamen, hippocampal formation, anteroventral, anteromedial, lateroposterior, ventroposterior and dorsomedial thalamic nuclei. The anterior portion of the cingulate cortex receives inputs from the following ipsi- and contralateral structures: the accessory olfactory bulbs, anterior olfactory nuclei, middle and posterior portions of the cingulate cortex. The middle cingulate cortex receives fibers only from the ipsilateral dorsal part of the lateral septal nucleus in addition from the ipsi- and contralateral anterior and posterior portions of the cingulate cortex. While the posterior portion of the cingulate cortex receives separate inputs from the following ipsilateral structures: anterodorsal thalamic nucleus, temporal cortex, entorhinal cortex, areas 17 and 18, as well as from the ipsi- and contralateral anterior and middle portions of the cingulate cortex. The present study shows that the cingulate cortex receives various kinds of inputs from the other parts of the brain which are involved in emotion, memory, vision and motion, and also suggests that there are differences in afferent projections among the anterior, middle and posterior portions of the cingulate cortex.

Afferent Pathways↗
PubMed1993

The TAPS Project. 10: The long-stay populations of Friern and Claybury hospitals. The baseline survey.

As part of the TAPS project, the baseline long-stay populations of Friern and Claybury Hospitals were compared using the TAPS assessment schedules. Each hospital has reduced bed numbers by two-thirds, and although the two have been subjected to different influences, their remaining long-stay patients were similar, and characterised by severe problems with hygiene, florid psychotic symptoms, a high prevalence of negative symptoms, and impoverished social networks.

Adult↗