[SOFAN, a DMSO-containing dermatologic agent in small-animal practice].
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The author revealed an increase of dienic conjugates in 391 patients under the effect of drugs in patients with drug intolerance and a study is also presented in 46 patients with good tolerance to drugs. It is shown that the dienic test has an information value as to intolerance of penicillin, streptomycin, tetraolean, analgin, novocaine and vitamin B1.
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A total of 156 patients with early syphilis were treated with tetracyclin and oletetrin. The drugs were administered 4 times daily (every 6 hrs) in a dose of 0.5 g (daily dose 2.0 g). Patients with primary seropositive syphilis were treated for 20 days, the dose per course being 40 g, those with secondary fresh syphilis for 25 days, dose per course 50 g, those with secondary recurring syphilis for 40 days, dose per course 80 g. The treatment was well tolerated by all the patients. Early negative results of specific serologic tests after treatment confirm the efficacy of the suggested method.
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The results of rapid single-course oletetrine and tetracycline therapy of early syphilis are analyzed. The time of Treponema pallidum disappearance from syphilid discharge, of syphilid regression, and of the first negative results of the routine serologic tests, immunofluorescence 200/ABC and T. pallidum immobilization tests, as well as the blood serum tetracycline level indicate a high therapeutic efficacy of this method and recommend it for wide use.
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