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[Contribution of professor Wang Xuetai in development of acu-moxibustion science].

Wang Xuetai is a famous specialist of acupuncture-moxibustion science. Ever since 1948, he devoted himself to the studies of acupuncture literature, history, theory, clinical treatment and experimental work. He presided the International Standardization of Nomenclature of Acupoints, guided the International Standardization of Locations of Acupoints, and was invited to be the advisor of Studies on Meridians, one of the programs of State Climb Plans. Especially in the recent 20 years, he concentrated his efforts on the studies of development strategies and the advance of internationalization of acupuncture. His academic thinking produces a great impact in both China and abroad.

Acupuncture↗

[Effect of increase and decrease of measurement voltage on skin impedance].

The skin impedance has been used as an index to plot out the meridian courses. In most of this kind of methods during measurement voltage was necessary to deliver to the subject's skin. It is unknown whether increasing the measuring voltage can change non-low skin impedance points (non-LSIP) into low skin impedance points (LSIP). In order to clarify the problem, we made an investigation on the effect of increasing and decreasing the measuring voltage on skin impedance. Subjects under observation were 12 healthy volunteers. On the medial side of forearm two levels were selected for measurement. Four or twenty non-LISP were observed on each level. The measuring system worked on the basis of bioelectrode method. The measurement and data processing were controlled by microcomputer. During measurement impedance of LSIP decreased correspondingly with the increase of voltage and vice versa, but the value of impedance was not exceeded 100k omega in spite of increasing or decreasing the voltage. That is, low impedance is the inherent characteristics of LSIP. On the contrary, the impedance of non-LSIP remained in higher than 600k omega in most of cases during increasing voltage from 10 to 50v. As the voltage increased to 65v, the impedance in a part of non-LSIP decreased to such a low level as LSIP. However, their impedance increased rapidly to high level again once the measuring voltage decreased. The above results reveal that the response of non-LSIPs and LSIPs were different from each other in nature. Increasing the voltage could not change a non-LSIP into LSIP.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[The difference in the time for the appearance of acupuncture effects between the subjects with and without PSM during acupuncture of neiguan].

It has been reported that ECG of the patients of coronary heart disease with PSM got marked improvement when Neiguan (PC6) was punctured, in comparison with the patients without propagated sensation along meridians (PSM). The difference between the two was significant. However some others reported that the acupuncture effects between the two had no striking difference. Authors detected that during acupuncture of Neiguan the change of ECG of the patients showed dynamic character and some patients without PSM were also marked as the duration of acupuncture was prolonged. For this reason, this paper was aimed to observe whether any difference appeared in the development of acupuncture effects between the patients with and without PSM. One hundred and seventy cases of patients with coronary heart disease were observed, of which 86 were male and 84 female, aged 35-83 years. Varying degree of PSM appeared in 80 of them, but not in the remaining 90. ECG was recorded with polygraph (model SJ-42) before acupuncture. Then the Neiguan acupoint of the left forearm was punctured by slow twisting for 5 minutes and the feature of PSM was carefully observed. Another recording of ECG was taken after retaining needle for 10 minutes. Retaining needle lasted for 30 minutes in a part of the patients and the needle was manipulated every 16 minutes in order to keep the needling sensation.(ABSTRACT TRUNCATED AT 250 WORDS)

Acupuncture Therapy↗

[Basics of acupuncture in the oral cavity--oral acupuncture].

In accordance with Professor Gleditsch's chinese doctrines the mouth cavity and it's surrounding areas are ensnared with energetic channels. The appropriate knowledge of meridian points is a decisive factor in making diagnoses of mouth cavity processes. There is an increasing responsibility of persons working around mouth cavity in recognising and correctly interpreting the connections between the mucous membrane processes and other remote organs and organ systems.

Acupuncture Points↗

[Influence of changing Ca++ concentration in neiguan (PC 6) on the effect of acupuncture treating experimental arrhythmia of rabbits].

We have made two kinds of experimental arrhythmia of rabbits by injecting aconitine and stimulating hypothalamus. Acupuncture could improve arrhythmia, after Ca++ in Neiguan (PC6) was chelated with EDTA solution the effect of acupuncturing Neiguan (PC6) was abolished. It indicates that Ca++ may be the key factor of acupuncture effect and one of the important material bases of the functional activity of meridians and collaterals.

Aconitine↗

[The progress of morphological research on the parabrachial nucleus].

In this paper, the progress of morphological research on the PBN, the cytoarchitecture of the PBN, and the fiber connections between the PBN and the spinal, the brainstem, the forebrain and the other nucleus were summarized. Its function in the relationship between the meridian and the internal organ was also assumed.

Animals↗

Anterior choroidal artery-territory infarction. Report of cases and review.

Occlusion of the anterior choroidal artery (AChA) can cause infarction in the posterior limb of the internal capsule. Infarction is less frequent in the thalamus, midbrain, temporal lobe, and lateral geniculate body territories of the AChA. The most common clinical sign is hemiparesis. Hemisensory loss is usually transient but may be severe at onset. Homonymous upper-quadrant anopia, hemianopia, or upper- and lower-quadrant sector anopsia can be present. A homonymous defect in the upper and lower visual fields sparing the horizontal meridian is probably diagnostic of a lesion in the lateral geniculate body in the territory of the AChA. The most common stroke mechanism is small-vessel occlusive disease, predominantly found in hypertensive and diabetic patients, but cardiac-origin embolism also can affect the AChA territory. Two of our patients had infarction after temporal lobe resection for epilepsy. Occasionally patients have associated disabilities of higher cortical function that are usually transient. The lesion should be recognizable by computed tomography.

Adult↗

Iridolenticular contact decreases following laser iridotomy for pigment dispersion syndrome.

OBJECTIVE: To evaluate changes in anterior segment anatomy after laser iridotomy for pigment dispersion syndrome. METHODS: Ultrasound biomicroscopy was performed on 7 eyes of 7 untreated patients with reverse pupillary block and pigment dispersion syndrome. A radially oriented image with the probe perpendicular to the eye in the superior meridian was obtained before and at least 1 week after laser iridotomy in each eye. We assessed changes in angle recess area and iris-lens contact distance. RESULTS: Mean +/- SD patient age was 31.3 +/- 5.7 years and mean +/- SD refractive error was -5.0 +/- 3.9 diopters. Angle recess area (mean +/- SD, 0.78 +/- 0.28 vs 0.35 +/- 0.11 mm2; P=.001, paired t test) and iris-lens contact distance (2.05 +/- 0.28 vs 0.79 +/- 0.13 mm; P<.001) decreased following iridotomy. Central anterior chamber depth did not change. CONCLUSION: Flattening of the iris following laser iridotomy for pigment dispersion syndrome causes a decrease in iris-lens contact and angle width while lens position remains constant.

Adult↗

A comparison of manual kinetic and automated static perimetry in obtaining ptosis fields.

OBJECTIVE: To compare examination time and visual field loss for ptosis fields obtained with manual kinetic (Goldmann) perimetry and automated static (Humphrey) perimetry. METHODS: Both eyes of 12 patients with bilateral aponeurogenic ptosis were prospectively examined using Goldmann and Humphrey (ptosis protocol) perimetry with the eyelids ptotic and taped into a normal position. RESULTS: Bilateral examination time for Goldmann fields was 10 +/- 2 minutes and for Humphrey fields was 50 +/- 10 minutes (P<.001, n = 12). Superior fields at the 12:00 meridian were 46 degrees +/- 6 degrees taped, and 28 degrees +/- 12 degrees untaped for Goldmann perimetry (P<.001), and 38 degrees +/- 8 degrees taped, and 24 degrees +/- 12 degrees untaped for Humphrey perimetry P<.001). Goldmann field loss was 18 degrees +/- 9 degrees (taped minus untaped). Humphrey field loss was 14 degrees +/- 13 degrees (P<.04, n = 24). Mean Goldmann radial fields were 56 degrees +/- 6 degrees taped and 39 degrees +/- 13 degrees untaped (P<.001). Goldmann superior hemifield areas were 5,167 +/- 964 degrees2 taped and 2,830 +/- 1,466 degrees2 untaped (P<.001). Humphrey mean vertical superior hemifield was 37 degrees +/- 9 degrees taped and 21 degrees +/- 11 degrees untaped (P<.001). Mean sensitivity of Humphrey fields was 15 +/- 3 dB taped and 9 +/- 5 dB untaped (P<.001). Mean vertical center of gravity was 23 degrees +/- 3 degrees taped and 16 degrees +/- 5 degrees untaped (P <.001). CONCLUSION: Goldmann manual kinetic and Humphrey automated static visual field testing are both effective in documenting ptosis associated visual field loss. Humphrey automated ptosis fields, as performed in this study, require longer examination times than Goldmann manual fields and may be a less sensitive indicator of field loss.

Adult↗

Selective loss of S-cones in diabetic retinopathy.

OBJECTIVE: To determine whether selective cone loss could explain the acquired tritan-like color confusion found in diabetic retinopathy. METHODS: Terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick end labeling (TUNEL) was employed on paraffin sections of retinas from 5 donors with diabetic retinopathy. For quantitative analysis, postmortem retinas were obtained from 13 human donors; 7 from patients with various durations and stages of diabetic retinopathy (4 background, 3 proliferative) and 6 controls. Enzyme histochemical analysis for carbonic anhydrase (CA) was used to distinguish L/M-cones (positive for CA) from S-cones (negative for CA). Cone topography was determined by sampling 360 degrees from 0.1 to 1.5 mm of foveal eccentricity and along the horizontal meridians from 1.5 to 15.0 mm. RESULTS: Rare cells in both the inner and outer nuclear layers of the diabetic eyes were positively labeled with the TUNEL method. The CA staining revealed incomplete and patchy losses of S-cones that were limited to the diabetic retinas. Statistically significant reduction in the density of S-cones was found at nearly all foveal eccentricities from 0.1 mm to 15.0 mm. This was not the case for the L/M-cones. On average, for all locations, the percentage of S-cones compared with L/M-cones was decreased by 21.0% +/- 3.4% with respect to the controls. CONCLUSION: The S-cones selectively die in diabetic retinopathy. CLINICAL RELEVANCE: Selective loss of S-cones may contribute to the tritan-like color vision deficit seen in patients with diabetic retinopathy.

Adult↗

Nasotemporal asymmetry of retinopathy of prematurity.

OBJECTIVE: To quantify an apparent nasotemporal asymmetry in the location of retinopathy of prematurity with respect to the optic disc. METHODS: Twenty-four-bit color images were captured using a contact digital fundus camera during routine screening. Semiautomated measurements were undertaken to determine the distance between the optic disc and retinopathy located in the nasal and temporal regions of the retina. RESULTS: Forty-nine image pairs (17 right eye, 32 left eye) were captured from 10 infants during a period of 32 to 40 weeks postmenstrual age. For right eyes, averaged across age, the mean (SD) distance between the optic disc and temporal retinopathy was 426 (26) pixels and that between the optic disc and nasal retinopathy was 330 (26) pixels. Corresponding measurements for the left eye were 428 (30) and 332 (24) pixels. This observed asymmetry was found to be statistically significant in both left and right eyes (Mann-Whitney U test, P<.01). While the distance between the optic disc and retinopathy increased with age by 10 to 17 pixels per week, the extent of the asymmetry did not vary systematically with age. CONCLUSION: The location of retinopathy of prematurity is asymmetric along the horizontal meridian with respect to the optic disc-an observation germane to retinal vascular development, the pathogenesis of retinopathy of prematurity, and current disease classification by circular (symmetric) zones.

Gestational Age↗

A randomized trial of the effects of rigid contact lenses on myopia progression.

OBJECTIVE: To compare the effects of rigid gas-permeable contact lenses (RGPs) and soft contact lenses (SCLs) on myopia progression in children. METHODS: We randomly assigned 116 subjects to wear RGPs or SCLs. Subjects underwent cycloplegic autorefraction, keratometry, and A-scan ultrasonographic axial length measurements at each annual visit. All analyses were conducted according to the original randomization assignment. The primary outcome measure was the 3-year change in spherical equivalent cycloplegic autorefraction. RESULTS: The mean +/- SD spherical equivalent cycloplegic refractive error progressed -1.56 +/- 0.95 diopters (D) for RGP wearers and -2.19 +/- 0.89 D for the SCL wearers during the 3 years of the study (analysis of covariance [ANCOVA], P<.001). The axial growth of the eyes was not significantly different between treatment groups (ANCOVA, P = .57). The steep corneal meridian of the RGP wearers steepened 0.62 +/- 0.60 D, and that of the SCL wearers steepened 0.88 +/- 0.57 D during the 3 years (ANCOVA, P = .01). CONCLUSIONS: The RGP wearers' myopia progressed less than that of the SCL wearers. The corneal curvature of the SCL wearers steepened more than that of the RGP wearers, but the axial growth was not significantly different between the groups. Most refractive error treatment effect was limited to the first year of the trial. The results of the study provide information for eye care practitioners to share with their patients, but they do not indicate that RGPs should be prescribed primarily for myopia control.

Child↗

Ultrasound biomicroscopy in asymmetric pigment dispersion syndrome and pigmentary glaucoma.

OBJECTIVE: To identify differences in anterior chamber anatomy among patients with asymmetric pigment dispersion syndrome and no other discernible cause for the asymmetry. METHODS: Ultrasound biomicroscopy and A-scan biometry were performed on both eyes of 13 patients with asymmetric pigment dispersion syndrome without a known cause for asymmetric involvement. A radial perpendicular image in the horizontal temporal meridian detailing the scleral spur, angle anatomy, and iris configuration was obtained for each eye by 2 examiners. RESULTS: There were no differences in lens thickness (P = .33), refractive error (P = .84), or axial length (P = .99) between more and less affected eyes. However, the mean +/- SD iris concavity (P<.001), iris-lens contact distance (P = .02), and distance from the scleral spur to the iris insertion (0.42 +/- 0.11 vs 0.29 +/- 0.06 mm) (P = .002) were greater in the more affected eye of each patient. CONCLUSION: A more posterior iris insertion predisposes to the phenotypic expression of pigment dispersion syndrome.

Adult↗

Localization of multifocal electroretinogram abnormalities to the lesion site: findings in a family with Best disease.

OBJECTIVE: To determine the association between multifocal electroretinogram (mfERG) abnormalities and macular lesions, as shown by retinal photography and optical coherence tomography (OCT), in a 3-generation family with vitelliform macular dystrophy. METHODS: Five family members were examined using OCT, mfERG, and retinal photography. To localize mfERG abnormalities in relation to retinal findings, we overlaid the mfERG trace arrays on the retinal images and aligned the mfERGs and OCT images in the 180 degrees meridian. RESULTS: Family members had typical macular lesions, normal full-field ERGs, and reduced electro-oculogram light-dark ratios. The OCT images demonstrated variable lesion severity. Some individuals with good vision and normal-appearing fundi showed OCT abnormalities of the choroid and retinal pigment epithelium. The overlay technique revealed that the depressed mfERGs corresponded with the lesions detected by OCT and retinal photography. The latencies of mfERG components in the 2 central stimulus rings in our patients were often prolonged. CONCLUSIONS: The mfERG abnormalities matched the localization of the macular lesions in our patients. The latencies of the mfERG N1 and P1 components in the first 2 concentric stimulus rings were often significantly (>2 SDs) delayed, an observation that has not been previously reported, to our knowledge.

Adult↗

Carcinoma metastatic to the eye and orbit II. A clinicopathological study of 26 patients with carcinoma metastatic to the anterior segment of the eye.

In 26 of 227 patients with carcinoma metastatic to the eye or orbit, metastasis to the anterior uveal tract was the predominating feature. There was a definite propensity for the tumor to involve the horizontal meridian of the iris or ciliary body, rather than the upper or lower portions. The site of the primary tumor in the 26 patients was as follows: lung 14; breast, 9; kidney, 2; and rectum, 1. Ocular symptoms and signs produced by the metastatic tumors at onset or during the course of the disease included decreased vision (80%), a visible mass (72%), redness of the eye (56%), pain (56%), glaucoma (56%), iridocylitis (44%), and hyphema (24%). The median survival of the 26 patients with metastasis to the anterior segment of the eye was only 5.4 months from the time of ocular surgery. This is poorer than the median survival (7.2 months) of the patients with metastasis confined to the posterior segment, and much worse than the median survival (15.6 months) of the 28 patients with orbital involvement.

Adenocarcinoma↗

The ocular tilt reaction. A paroxysmal dyskinesia associated with elliptical nystagmus.

The ocular tilt reaction, a synkinesis of ocular torsion, skew deviation, and head tilting, was a paroxysmal disorder in a patient with multiple sclerosis. In this distinctive pattern of eye and head motion, the 12 o'clock corneal meridians of both eyes are rotated conjugately in the direction of the lower skewed eye and the head is inclined laterally in the same direction. Paroxysmal activation of brain stem otolithic vestibular projections is proposed responsible for the dyskinesia. Coincident attacks of vertical and horizontal low amplitude pendular oscillation of the eyes produced elliptical nystagmus. This ocular motor disorder was treated effectively with carbamazepine.

Adult↗

Foveal sparing. New anatomical evidence for bilateral representation of the central retina.

The pattern of retinal ganglion cell projections to the dorsal lateral geniculate nuclei has been demonstrated with horseradish peroxidase neuronography. A 1 degree-wide strip centered on the vertical meridian has been found in which ipsilaterally and contralaterally projecting ganglion cells intermingle. This strip expands to a width of 3 degrees at the fovea, since mixing of horseradish peroxidase-labeled and unlabeled ganglion cells was found in a band approximately 0.5 degrees wide along both the nasal and temporal rims of the foveola. These labeled ganglion cells rimming the foveal pit in its entirety represent a possible anatomical basis for "foveal sparing".

Animals↗

The fishmouth phenomenon. II. Wedge scleral buckling.

Radial retinal folding, associated with equatorial scleral buckling, contributes to the difficulty in repairing a retinal detachment due to a fishmouth break. To minimize this effect, a wedge-shaped implant was designed to approximate more closely the same relative reduction in the circumference of the circles of the globe along the meridian of the break. The surgical details of use of the implant are described. In a consecutive series of 56 eyes in which the fishmouth phenomenon was expected, 49 (88%) were successfully managed at first encounter using a wedge buckling device. Revised scleral bucklings and open-sky vitrectomies, in early failures and delayed recurrences, salvaged additional eyes for final success in 52 (93%) of the eyes.

Adolescent↗