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PubMed2002

Thyrotropin screening for congenital hypothyroidism in Queen Sirikit National Institute of Child Health, Thailand (during year 1995-2000).

OBJECTIVES: To detect newborns with congenital hypothyroidism (CH) by TSH screening and to treat the affected infants as early as possible. To find the incidence of CH in neonates born at Rajavithi Hospital from 1995 to 2000. The effects of thyroid pathology, ages at the initiation of treatment, associated conditions, and severity of CH on the intellectual outcome of the patients were also analyzed. STUDY DESIGNS: Thyrotropin (TSH) screening for CH in Queen Sirikit National Institute of Child Health was done in neonates born at Rajavithi Hospital from 1995 to 2000. Infants with elevated TSH level of greater than 25 mU/L were recalled for tests including serum T4, TSH and roentgenogram of bone age. Infants with CH were treated with levothyroxine 10-12 Ug/Kg/day: growth and development, serum T4, TSH were followed-up every 3 months for at least 2 years to keep serum T4 between 10-14 Ug/dL and serum TSH below 6 mU/L. Levothyroxine was discontinued for 4 weeks when the infants were over 2 years old. Serum T4, TSH, thyroid scan, and uptake were then performed on these infants. The patients must be euthyroid at the time of the intelligence testing. The Stanford Binet or Vineland Social Maturity scale was used to evaluate the patient's intelligence between the ages of 2 and 5 years. RESULTS: From 1995 to 2000, 62,681 neonates were screened for CH. The incidence of CH was 1:4,178 live births. The sex ratio female: male 2:1. Fifteen infants with CH were started on levothyroxine 10-12 Ug/Kg/day orally once a day. The age of initiation of treatment was between 2-8 weeks. There were 4 patients with lingual thyroid, 4 patients with thyroid hypoplasia, 2 patients with thyroid aplasia and one patient with organification defect. The average intelligence score was 93.8. The factor that significantly affected the intellectual outcome of the patients was associated with adverse conditions such as prematurity with complications, epilepsy and family disruption (p<0.05).

Congenital Hypothyroidism↗
PubMed1980

Intelligence as an information-processing concept.

Attempts to relate information-processing capacities to intelligence test scores have had modest success when normal subjects are used but have been very successful in showing differences between extreme groups in information-processing capacity. This is illustrated by reviewing studies relating memory to verbal comprehension. The reason for these disparate results may be that in normal subjects individual competence may depend largely on differences in choice of a problem-solving strategy. Using sentence verification as an example, it is shown that information-processing and psychometric measures are in much closer correspondence when account is taken of one's problem-solving strategy. This, however, still leaves us with the problem of explaining positive manifold, i.e. the psychometric evidence for a concept of general intelligence. The relation between g and the idea of attentional resources is explored, by applying the dual task methodology to memory and reasoning tests. The results support the notion that g can be related to attentional resources.

Attention↗
PubMed2005

Persistent cognitive deficits in community-treated alcoholic men and women volunteering for research: limited contribution from psychiatric comorbidity.

OBJECTIVE: The contribution of psychiatric comorbidity to cognitive status was assessed in a sample of treatment-seeking alcoholics who met criteria to participate in studies of effects of chronic alcohol misuse on brain structure and cognition. METHOD: Alcoholic men (n = 43) and women (n = 21) who responded to notices about a research study were screened, clinically assessed and administered Wechsler Memory and Intelligence tests after 3 months of sobriety, on average. Cognitive performance was compared with that of an age-matched sample of healthy controls (n = 51). RESULTS: As a group, the alcoholics achieved significantly lower scores than controls on summary indices of the Wechsler Memory and Adult Intelligence Scales and showed greater decline from estimated premorbid intelligence levels than controls. Almost 60% of the alcoholics had at least one additional psychiatric (mood or anxiety) or past substance-dependence comorbidity. There were no marked sex differences in patterns of comorbidity. Comorbid alcoholics were younger, had consumed less alcohol over their lifetime and performed between noncomorbid alcoholics and controls on all tests. CONCLUSIONS: Mood and anxiety comorbidity did not necessarily compound poor cognitive test performance associated with chronic alcohol misuse. While unexpected, this finding suggests that, in this sample, poorer cognitive performance was more a function of alcoholism per se than nonalcoholic comorbidity.

Alcoholism↗
PubMed1981

Central nervous system involvement in childhood systemic lupus erythematosus.

The records of 37 patients with systemic lupus erythematosus (SLE) followed at The Children's Hospital of Philadelphia between 1968 and 1978 were reviewed for evidence of central nervous system (CNS) involvement. Criteria for CNS involvement included evidence of organic brain syndrome, electroencephalographic abnormalities with symptoms referable to CNS, or objective neurologic signs. Sixteen of 37 children had CNS involvement (43%). Thirteen patients had CNS involvement at the onset of SLE. Three patients had late onset CNS manifestations 1 to 2 years after the diagnosis of SLE. The most frequently observed symptoms were headache, behavior disorder, lethargy, diplopia, blurred vision, memory alteration, dizziness, and alteration of consciousness. The most frequently observed neurologic signs were seizures, cranial nerve palsy, ataxia, papilledema, nystagmus, meningitis, tremor, rigidity, cortical blindness, and coma. Neuropsychiatric manifestations included organic brain syndrome, functional psychosis, and personality disorder. Laboratory tests showed elevated cerebrospinal fluid opening pressure and protein, negative cultures, and abnormal electroencephalograms and computerized axial tomography scans. Fourteen of 16 children with CNS manifestations are alive. Thirteen had a mean IQ of 89 by the Wechsler Intelligence Tests. Twelve are in educational programs. One required long-term psychiatric care. A residual neurologic abnormality, a seizure disorder, was present in 3. CNS involvement with SLE in children carries a favorable prognosis.

Adolescent↗
PubMed1990

Intelligence and behaviour and motor vehicle accident mortality.

Risk factors for mortality from motor vehicle accidents (MVAs) were examined in all Australian former National Service conscripts of the Vietnam conflict era, by comparing all those who had died from MVAs since the end of their basic training up until 1982 with a random sample of survivors, using data available from service records. Decedents were in their third and fourth decades. Risk of mortality was higher for men with lower scores on the army intelligence test, with poorer education, with lower preenlistment occupational status, with a history of juvenile offenses before army enlistment, and who went absent without leave (AWOL) during National Service. These factors were modelled using logistic regression, which showed that intelligence plus either lower levels of education or a history of offenses before army service were the most important of these factors in predicting mortality in MVAs.

Accidents, Traffic↗
PubMed1982

On the self-serving function of an academic wooden leg: test anxiety as a self-handicapping strategy.

The present study investigated the hypothesis that psychological symptoms may serve a self-protective function by providing an alternative explanation for potential failure in evaluating situations. It was hypothesized that highly test-anxious subjects would report anxiety symptoms in a pattern that reflected strategic presentation of symptoms; more specifically, it was predicted that greater reported anxiety should result when anxiety was a viable explanation for poor performance on an intelligence test and that lower reported anxiety should result when anxiety was not a viable explanation for poor performance. Analysis of state measures of self-reported anxiety supported these predictions. Further analysis indicated that when anxiety was not a viable explanation for poor test performance, high test-anxiety subjects reported reduced effort as an alternative self-protective strategy. These results are discussed in terms of traditional models of symptoms as self-protective strategies, current social psychological models of symptoms, and in reference to recent theory and research about the nature and treatment of test anxiety.

Achievement↗
PubMed1991

Scatter variability in the WAIS-R profiles of mentally retarded adults.

One hundred and sixty mentally retarded adults were administered the WAIS-R, and the scatter variability of their test profiles was examined. Compared to the WAIS data of Coolidge et al. (1986), the WAIS-R was less variable in its intratest and intertest scatter. The data support Wechsler's original statements about the characteristics of intelligence test profiles among mentally retarded adults.

Adolescent↗
PubMed1977

Performance of criminals and neurotics on the Kahn test of symbol arrangement.

The diagnostic power of the Kahn Test of Symbol Arrangement (KTSA) in differentiating between criminals and neurotics was examined. Three groups of males--30 incarcerated criminal recidivists, 30 neurotics, and 30 trainees in a work-placement bureau--were given the KTSA and an intelligence test. The groups were equated for age and socioeconomic status. Qualitative differences between the symbol-patterns of the criminals and the neurotics were noted. The KTSA scores of the two groups differed from those of the control group but not from each other.

Adult↗
PubMed1991

Congenital muscular dystrophy: brain alterations in an unselected series of Western patients.

The typical form of congenital muscular dystrophy (CMD) described in Western countries is generally considered different from its Japanese variant because of the absence of CNS involvement. Evaluations from both a clinical and a neuroradiological point of view were made of the CNS functions of 12 unselected Western children affected by CMD. In five patients, clinical observation and intelligence tests showed a mild to severe mental retardation. One of these patients suffered also from a severe form of epilepsy. In the same five patients, various degrees of white matter hypodensity, ventricular enlargement and cerebral atrophy were also detected. Similar neuroradiological abnormalities were also found in five of the seven children who did not have clinical symptoms or signs of CNS involvement. In one of these cases, necropsy neuropathological examination showed the gyral anomalies characteristic of the Japanese type of CMD. This study clearly indicates the high frequency of subclinical CNS alterations in typical Western CMD, suggesting that it should be considered a type of myoencephalopathy like its Japanese counterpart.

Adolescent↗
PubMed1998

Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behcet's disease.

The most serious central nervous system (CNS) manifestation in Behcet's disease is a slowly progressive dementia (progressive NB), which may ultimately lead to the deterioration of the personality of patients. An open trial was designed to investigate the efficacy of low dose weekly methotrexate (MTX) therapy for progressive NB. Six patients with Behcet's disease, whose neuropsychiatric manifestations were judged to be progressive (4 females and 2 males, aged 55.0+/-8.2 years), were given oral MTX (7.5-12.5 mg/week) until the end of the 12-month trial. The clinical responses of the patients to MTX were judged by neuropsychiatric findings, intelligence test, brain MRI scans and cerebrospinal fluid (CSF) IL-6 levels. After the 12-month trial, CSF IL-6 levels were found to be significantly decreased. Accordingly, the neuropsychological manifestations as well as the findings on MRI scans and intelligence quotients were not significantly worsened after the trial. Three patients presented with mild liver dysfunction, which returned to normal by decreasing the dose of MTX. However, 6 months after discontinuation of MTX, all the six patients showed significant exacerbation of the manifestations as evidenced by a decrease in verbal intelligence quotients along with the marked elevation of CSF IL-6. These results suggest that low dose weekly MTX therapy might have a beneficial effect in the treatment of progressive NB, although a trial for a longer period would be necessary.

Aged↗
PubMed1999

[Social-emotional and cognitive markers in children of divorce and in children from 2-parent families--a cross sectional study].

Related to the research of the effects of separation and divorce on children there is a lack of empirical studies in Germany. The following cross-sectional field-study directly investigate 48 children from divorced and 32 children from two-parent-families regarding socio-emotional and some cognitive characteristics (nonclinical samples). Projective and semi-projective tests were the preferred instruments. One of the main questions was related to frustration behavior, measured by the Rosenzweig-Picture-Frustration Test (childrens form). This test was used for the first time by a population of German children of divorce. Children of divorce showed a special frustration behavior, a so called M-profile showing many impunitive reactions. They avoid direct conflicts or struggle and try to deny the frustration. Also the subtests of the Hamburg-Wechsler-Intelligence test for children (HAWIK) show clearly that children from divorced families obtain much poorer test values in contrast to children from two-parent homes.

Affective Symptoms↗
PubMed2004

Sensory ERPs predict differences in working memory span and fluid intelligence.

The way our brain reacts to sensory stimulation may provide important clues about higher-level cognitive function and its operation. Here we show that short-latency (< 200 ms) sensory cortical responses elicited by visual and auditory stimuli differ dramatically between subjects with high and low working-memory span, as well as between subjects scoring high and low on a fluid intelligence test. Our findings also suggest that this link between sensory responses and complex cognitive tasks is modality specific (visual sensory measures correlate with visuo-spatial tasks whereas auditory sensory measures correlate with verbal tasks). We interpret these findings as indicating that people's effectiveness in controlling attention and gating sensory information is a critical determinant of individual differences in complex cognitive abilities.

Acoustic Stimulation↗
PubMed1992

Evaluation of the speech intelligibility rating (SIR) test for hearing aid comparisons.

The SIR test was created for use in hearing aid comparisons. The test protocol obtains listener judgments of the intelligibility of connected speech passages. This study was conducted to evaluate the effectiveness of the SIR test in differentiating among hearing aids. Specific research questions were (a) Is the sensitivity of the SIR test sufficient for differentiating among very similar and slightly dissimilar hearing aids? (b) Does the SIR test result in reliable hearing aid rankings? and (c) What are the effects of using shortened connected speech passages? Ten listeners with hearing impairments rated the intelligibility of both full-length and shortened SIR test passages while wearing each of four individually selected hearing aids representing three different frequency/gain prescriptions. Results suggested that the SIR test is capable of differentiating among slightly dissimilar hearing aids and that hearing aid rankings resulting from speech intelligibility ratings were reliable. The decision to use full-length or shortened SIR test passages depends on the outcome the user wishes to maximize. Under the conditions used in this study, maximum sensitivity was achieved with ratings from five shortened passages, whereas maximum reliability was obtained with three full-length passages.

Adult↗
PubMed1994

Prediction of psychosocial recovery after head injury with cognitive tests and neurobehavioral ratings.

A series of 53 patients was studied using a battery of tests and a neurobehavioral rating scale on average 4 months after closed-head injury (CHI). Social outcome was assessed 1 year after injury by interviewing a family member. The results supported the hypothesis that tests of flexibility and programming rather than tests of cognitive skills predict psychosocial recovery after CHI. Spatial Learning with Self-Set Goals and Sorting were measures of flexibility and programming. Contrary to expectation, word fluency performance was unrelated to these measures, but was associated with conventional intelligence tests, which did not predict psychosocial recovery. Cognition/Energy deficit on the Neurobehavioral Rating Scale and increased age were useful predictors of poor psychosocial outcome, whereas computed tomography findings or the Glasgow Coma Score were weakly related to the outcome indices. Evidently, cognitive flexibility and mental programming are very important psychological prerequisites of social recovery after CHI.

Adolescent↗
PubMed2006

Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testing.

BACKGROUND: Horizontal gaze palsy and progressive scoliosis (HGPPS) is caused by mutations of the ROBO3 gene, which encodes a receptor associated with axonal guidance during development. Although there is evidence for uncrossed cuneatal and corticospinal tracts in HGPPS, it is unclear whether other central nervous system pathways are involved. OBJECTIVE: To study two patients with HGPPS homozygotic for the ROBO3 E319K mutation using a variety of neurophysiological and neuropsychological tests. METHODS: A battery of neuropsychological tests was applied to assess various cognitive and perceptual functions. The corticospinal, somatosensory and auditory pathways were evaluated using appropriate neurophysiological tests. To access motor pathways to the neck muscles, electromyographic recordings were obtained from the sternocleidomastoideus and splenius capitis muscle during active head rotation. RESULTS: Both patients performed normally on manual dexterity, complex sensory and visuospatial functions, reading and general intelligence tests. Motor evoked potentials in both patients showed uncrossed corticospinal tracts for the extremities, although in one patient, electromyography indicated pyramidal tract crossing for the neck muscles. Although somatosensory evoked potentials showed uncrossed somatosensory fibres subserving proprioception and light touch, right median nerve somatosensory evoked potential in one patient indicated a partial lemniscal crossing. Sympathetic skin response and blink reflex showed a midline crossing of the spinothalamic and quintothalamic tracts. Brain stem auditory evoked potentials indicated a lack of crossing in the level of the trapezoid body. CONCLUSIONS: Our patients with the ROBO3 E319Kappa mutation show normal perceptual and cognitive functions and have both crossed and uncrossed motor, sensory and auditory pathways.

Cognition↗
PubMed1976

Length of male and female friendship and perceived intelligence in self and friend.

The Self-Rating Scale of Intelligence (SRSI) and the Otis intelligence test were administered to -20 pairs each of same-sex long-acquaintance males and females and 12 pairs each of same-sex short-acquaintance males and females. The SRSI provided subjects with the opportunity to make intelligence attributions to self, friend, and ideal friend and to provide the expected rating of self by the friend and people-in-general. Significant positive correlations were obtained from relating the within-person perceptions, while nonsignificant correlations were obtained from the relation of perceptions and objectively measured intelligence between friends. Self-concept support from the friend and from people-in-general were the more significant relationships identified across groups.

Female↗
PubMed2005

Helminth infection and cognitive impairment among Filipino children.

The objective of this study was to examine the independent effect of infection with each of four helminths (Ascaris lumbricoides, Schistosoma japonicum, Necator americanus, and Trichuris trichiura) on cognitive function after adjusting for the potential confounders nutritional status, socioeconomic status (SES), hemoglobin, sex, and the presence of other helminthes. This cross-sectional study was carried out in a rural village in Leyte, The Philippines in 319 children 7-18 years old. Three stools were collected and read in duplicate by the Kato Katz method. Infection intensity was defined by World Health Organization criteria. Cognitive tests were culturally adapted and translated. Learning and memory cognitive domains were each defined by three subscales of the Wide Range Assessment of Memory and Learning, which had an inter-rater reliability >/= 0.92 and test-retest reliabilities ranging from 0.61 to 0.89. A household SES questionnaire was administered. A logistic regression model was used to quantify the association between performance in different cognitive domains (learning, memory, verbal fluency, and the Philippine Non-Verbal Intelligence Test) and helminth infections. After adjusting for age, sex, nutritional status, hemoglobin, and SES, S. japonicum infection was associated with poor performance on tests of learning (odds ratio [OR] = 3.04, 95% confidence interval [CI] = 1.1-6.9), A. lumbricoides infection was associated with poor performance on tests of memory (OR = 2.2, 95% CI = 1.04-4.7), and T. trichiura infection was associated with poor performance on tests of verbal fluency (OR = 4.5, 95% CI = 1.04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates.

Adolescent↗
PubMed1984

Males with low birthweight examined at 18 years of age.

An 18 years follow-up study of 105 males born in 1962/63 with birthweight less than or equal to 2 500 g was made at the military draft board examinations in 1981. The medical and psychological tests were compared to the tests of the total cohort of 35 728 Norwegian conscripts. The early neonatal mortality in the study was 15.2%, and of those examined at 18 years of age was 6.7% unfit for military service, compared to 6.2% in the total cohort. Ten organ systems were analyzed, significantly increased frequency of unfitness being found only for the vision. Intelligence testing was done on 71 of the studied subjects, and the mean was the same as the national average. Children with weight-for-date centile less than 10 at birth had the same general intelligence at 18 years as the national average. However, the weight and height at adult age were significantly correlated to the weight-for-date at birth. The study indicates that those low birthweight children who survived the neonatal period in the beginning of the nineteen-sixties, were except for stature and minor defects of vision, indistinguishable from those of normal birthweight at the age of eighteen.

Adolescent↗