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At least 991 records · Page 55Linked to original sources
PubMed1989

Calcium and GTP: essential components in vesicular trafficking between the endoplasmic reticulum and Golgi apparatus.

Ca2+ and GTP hydrolysis are shown to be required for the transport of protein between the ER and the cis-Golgi compartment in semiintact cells, an in vitro system that reconstitutes transport between intact organelles. Transport was inhibited rapidly and irreversibly in the presence of micromolar concentrations of the nonhydrolyzable GTP analogue, GTP gamma S. The transport block in the presence of GTP gamma S was found to be distal to a post-ER, pre-Golgi compartment where proteins accumulate during incubation at 15 degrees C. In addition, transport was completely inhibited in the absence of free Ca2+. A sharp peak defining optimal transport between the ER and the cis-Golgi was found to occur in the presence of 0.1 microM free Ca2+. Inhibition of transport in the absence of free Ca2+ was found to be fully reversible allowing the step inhibited by GTP gamma S to be assigned to a position intermediate between the ER and the Ca2+ requiring step. The results suggest that GTP hydrolysis may trigger a switch to insure vectorial transport of protein along the ER/Golgi pathway, and that a free Ca2+ level similar to the physiological levels found in interphase cells is essential for a terminal step in vesicle delivery to the cis-Golgi compartment.

Aluminum↗
PubMed1982

[The Golgi apparatus in hyperplastic conditions of the human endometrium].

In our investigations we have studied both normal human endometrium and pathological endometrial tissue. Golgi system was visualized according to Aoyama technique and observed in TEM. It has been concluded that Golgi system is different in size, location and morphological features. Those differences are connected with either physiological or pathological picture of human endometrium. In pathological hyperplastic conditions of endometrium one can observe the changes in circulatory system of the cell. Thus we could accept as probable the fact of marked decrease or exclusion of secretory process of the cells.

Endometrial Hyperplasia↗