Sequelae to cold injury in one hundred patients; follow-up study four years after occurrence of cold injury.
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Since 1973 we have performed over 1,000 free flap reconstructions mainly in head and neck, breast, and upper and lower limb surgery. In lower leg reconstructions, changing indications for flap selection were not only correlated to new anatomical developments, but mainly due to a better understanding of adaptability of known muscle or fascial free flaps. Reducing donor site morbidity and planning for saving donor sites for future reconstructions are important. Morbidity is reduced by selection of free flaps ideally adjusted to the shape of the defect. Innervated free flaps or functional muscle transplants are rarely indicated in the lower leg. In the early years of microsurgical free flaps, soft tissue reconstruction or bone coverage was the primary indication. Later improving the vascularity of the wound bed by free flap cover increased the indication to chronic infected leg ulcers, osteomyelitis, diabetes, or artheriosclerotic wound defects or pressure sores due to lack of sensibility. Reconstruction of the foot and restoring its weight-bearing capacity is one of the more challenging applications of free flap cover.
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We present a patient with diffuse and intense uptake in the soft tissues of both lower legs and feet seen on 99mTc-HMDP bone scintigraphy. This finding presumably resulted from compromised blood supply to the lower legs plus a cold environment. The extraosseous bone imaging agent localization was presumably related to an existing ischemic condition that was exacerbated by cold. Differential diagnosis of the scan pattern should be differentiated from the artifact of socks contaminated by radioactive urine.
The obvious hazard of a cold exposure under natural as well as artificial conditions is tissue cooling and the associated sequel of more or less harmful effects from cold injury to discomfort. The nature, risk and magnitude of effects depend largely on the cooling effect, which results from the interaction of climatic factors (air temperature, mean radiant temperature, humidity and wind), protection (clothing) and metabolic heat production (activity). Assessment of cold stress should be based on methods which measure or predict this cooling effect in a relevant and reliable way. The nature of cooling encompasses (1) whole-body cooling, (2) extremity cooling, (3) convective cooling (wind chill), (4) conductive cooling (contact) and (5) airway cooling. The review contains a description of methods for evaluation of the various types of cold stress, as well as a discussion of their capacity and limitations. On the basis of selected methods, recommendations related to lowest permissible temperatures and other measures are discussed and compared with published data. Apparently, local cooling in most cases produces discomfort and harmful effects, before more significant whole-body cooling develops. With strong wind or movement at very low temperature, frostnip of unprotected skin may quickly develop. For most other conditions extremity (digit) cooling determines duration of exposure. However, as digit cooling largely depends on whole-body heat balance, it is important to control body cooling by selection and use of appropriate protective clothing.
Carcinomas of the extremities are relatively rare neoplasms when compared to Sarcomas. After a review of the literature about carcinomas in chronic fistulae and other bone lesions, two cases are reported in which a carcinoma originated in scar-tissue, 31 years after a frost-bite lesion of the foot. The problems of etiology, pathogenesis and therapy are pointed out.
Seven cases of phalangeal microgeodic syndrome in childhood are reported. Reviewing the literature, we have found a total of thirty Japanese cases, including the cases of our own. On the other hand, only ten cases have been reported outside Japan. The mean age of onset of the Japanese was six and a half years, which is older than that in the initial description. Of further interest is the fact all the cases in Japan occurred sporadically and exclusively in winter, and regressed spontaneously and fairly rapidly within six months. Furthermore, most of the cases reported in Europe also occurred in the winter months. These facts imply an etiological relationship between the lowered temperature and the bone lesions.
The behavior of the complement and of its components C4 and C3 has been studied in serum and in blister fluid both in patients with pemphigus vulgaris and other bullous dermatoses and in healthy subjects with experimentally induced blisters. The results are suggestive of local activation of the complement, in the blister fluid of patients with pemphigus vulgaris, pemphigus erythematosus and bullous pemphigoid according to the classical enzymatic sequence.
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The review of 32 deaths resulting from hypothermia yielded mostly the common pathological findings as bright red livores, haemolytic frost marks of the skin and Wichnewski erosions of the gastric mucosa. In addition the muscle system of the body core (musc. ileopsoas) showed hemorrhages and histologically necrosis of its fibres in form of segmental and discoid sarcoplasmatic alteration. These changes are a quite specific sign of death due to hypothermia, as far as mechanical injury can be excluded. For best result however a special autopsy technique and an appropriate histological staining are advisable.