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[Results of the bicycle ergometric test in stenocardia patients performing the load manually].

Comparative study was carried out of the results of the bicycle ergometry test in hand- and foot-pedalling conducted on 56 patients with stable angina pectoris. It is shown that in performing work by muscles of the shoulder girdle the chrono- and inotropic reserves of the heart are expended more rapidly, and an attack of angina develops in lesser physical exertion. It is recommended to conduct the bicycle ergometry test with hand pedalling for determining the working capacity of individuals with ischemic heart disease if their occupation is linked with physical exertion of the shoulder girdle muscles.

Aged↗

[Plasma myoglobin level as a course criterium in patients with acute myocardial infarct].

Myoglobin and the enzymatic activity of creatine phosphokinase CK), MB-isoenzyme of CK (CK-MB), aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and lactic acid dehydrogenase (LDH) were serially determined in 10 patients with acute myocardial infarction. Additionally the same parameters were assessed in 5 patients with angina pectoris for 24 hours after bicycle ergometry. 10 in-patients served as controls. Myoglobin was determined by radioimmunoassay and the other enzyme activities according to the current kinetic methods. Comparison of myoglobin with the enzymatic parameters showed that the myoglobin peak occurs 5.6 hours after the beginning of the sampling period, i.e. 7.3 hours earlier than CK and CK-MB and 11.6 hours earlier than GOT. In analogy to this finding the descending limb of the myoglobin curve was significantly earlier at a level of one third of the peak value, i.e. 8.2 hours earlier than CK-MB, 18.8 hours earlier than CK and 27.3 hours earlier than GOT. No signs of myocardial necrosis in terms of myoglobin or enzymatic activity could be detected after bicycle ergometry. It is concluded that myoglobin is a more sensitive parameter for assessment of the acute phase in patients with myocardial infarction than the usualy enzymatic parameters.

Acute Disease↗

[Comparative studies on influences of physical and psychological strain on the ECG in coronary disease patients].

In 7 patients suffering from heart infarction the electrocardiogram was telemetrically registered during telecast of the world championship in football 1974. The same patients were tested on a bicycle ergometer with standardized loads of 50, 75, 100 and 125 Watt for 3 minutes. Heart rate under psychial strain did not exceed the rate of 50 Watt on bicycle ergometer. Only 1 patient showed some extrasystoles during ergometry. Looking at television all patients developed extrasystoles, in one case 122. If the FRG took part in the game, ventricular extrasystoles were two times, auricular extrasystoles were four times more frequent than during games between foreign countries. It is concluded that psychical strain is able to produce dangerous arrhythmias in patients suffering from coronary heart disease. This danger cannot be proved by bicycle ergometry.

Cardiac Complexes, Premature↗

[Phenomenon of pyrophosphate accumulation in the prognosis of different forms of ischemic heart disease].

The results of pyrophosphate 99mTc scintigraphy of the myocardium during exercise were compared with the parameters of the tolerance and adaptation to the load and the frequency of manifestations of myocardial ischemia during bicycle ergometry in relation to the prognostic value with regard to coronary heart disease (CHD) development. The studies involved 21 patients with myocardial infarction at the early recovery period and 23 CHD patients without a history of myocardial infarction. Manifestations of myocardial ischemia and the pattern of pyrophosphate build-up in the myocardium during exercise are approximately equally informative with regard to the prognosis of a high risk of complications in CHD patients. As regards the capacity to detect patients with a low risk of CHD complications, the finding of pyrophosphate 99mTc scintigraphy of the myocardium are more reliable than the electrocardiographic manifestations of myocardial ischemia or chest pain during bicycle ergometry. The parameters of the tolerance and adaptation to the load were found to be of little use in predicting CHD complications.

Adaptation, Physiological↗

[Are coronary patients endangered through arrhythmias in diving?].

In 25 patients suffering from coronary heart disease with myocardial infarction electrocardiograms were registered continuously during diving and under water swimming. The results are compared to findings in the same patients during bicycle ergometry. Submersion under water produced a highly significant bradycardia and an increase of arrhythmias. During under water swimming heart rate increased less than during 50 Watt ergometry and premature beats were very frequent. It is discussed that the diving bradycardia combined with breath holding provokes the accumulation of arrhythmias. After myocardial infarction patients should not submerge the head under water.

Arrhythmias, Cardiac↗

[Changes in the blood pressure during an exercise test in children and adolescents. Results with reference to height].

The variations of blood pressure (BP) during exercise are important when there is a doubt about the normality of the values or a possibility of future abnormality. This is particularly true in children and adolescents with borderline or variable values, whose capacity of cardiovascular adaptation to sport is to be evaluated or who have a family history of hypertension. This study was undertaken to establish the profile of blood pressure on exercise during bicycle ergometry with reference to the height of the child or adolescent. BP and heart rate were measured in 651 healthy children aged 5 to 18 years during stress testing by bicycle ergometry. The sample was divided according to sex and height (120-139, 140-159, 160-180 cm), and according to resting BP values. During simple progressive exercise, the work required is increased by 10 watts every 2 minutes for children less than 140 cm tall, and by 20 watts when over 140 cm tall. BP and heart rate were measured during the last 30 seconds of each stage. Heart rate and systolic BP increased progressively with work load; on the other hand, the diastolic pressure did not change on exercise. The regression equation and the slope of systolic BP with respect to heart rate are reported, and allow comparison of different groups according to height, sex and resting systolic BP. The increase in systolic BP was the same in all groups except for boys taller than 160 cm in whom it was significantly greater (p less than 0,01). Sex and resting BP had no significant effect on the slope of systolic BP on exercise. The same applied to exercise lasting more than 6 minutes. The mean values and standard deviation of systolic BP at a heart rate of 150/min were, for each height group in ascending order: 121.5 +/- 19, 129 +/- 22 and 151 +/- 26 mmHg for boys, and 118.5 +/- 26, 126 +/- 21 and 137 +/- 26 mmHg for girls. In order to simplify the interpretation of the results obtained individually, charts in the form of an ellipse were plotted containing the usual values (95% of a healthy population) of systolic BP on exercise at the heart rate of 150/min, for each sex. They were established with reference to resting systolic BP and height. The diagnostic and prognostic value of this test will have to be evaluated by comparison with values obtained in hypertensive children.

Adolescent↗

[Role of left ventricle angioscintigraphy during exercise in the diagnosis of coronary disease. Comparison of static and dynamic exercise].

The aim of this study was to compare the diagnostic value of exercise stress testing, Thallium 201 myocardial scintigraphy or after administration of dipyridamole and left ventricular angioscintigraphy performed either during a static (handgrip) or dynamic exercise (bicycle ergometry) for the positive diagnosis of stenosing coronary artery disease. The exercise angioscintigraphy was performed at equilibrium with 99m Tc red blood cell labelling. The global ejection fraction and that of seven radial segments of the left ventricle were measured, the data being recorded within a period of 2 minutes. The handgrip consisted in compressing a dynamometric ball at 1/3 maximal force for 3 minutes, with both hands; the ergometric exercise was increased by 30 Watt 2 minute increments until a positive ECG or 85% of the theoretical maximal heart rate for age was obtained. Normal subjects (n = 29) increased their global (+ 8%) and regional ejection fractions in each of the seven segments (p less than 0.05) during ergometric exercise: there was no significant change of global (-3% NS) or segmental ejection fractions during the handgrip exercise. In the coronary group (at least one greater than 70% stenosis) (n = 61) the fall in global ejection fraction was the same (-14%) with both forms of exercise; a similar fall in the segmental ejection fraction in the territory distal to the stenosis was observed with the handgrip (-22%) and bicycle ergometry (-28% NS). Dynamic exercise testing seemed superior to handgrip exercise. Therefore, the finding of an abnormal global ejection fraction on exercise (i.e. either a global ejection fraction less than the lower limit of normal on exercise, or lower than the global ejection fraction at rest), or of an abnormal regional ejection fraction (i.e. either a regional ejection fraction less than the lower limit of normal over at least 3 segments, or a regional ejection fraction on exercise lower than the regional ejection fraction at rest over at least 3 segments) detected coronary artery disease with a sensitivity of 94% and a specificity of 72%. Dynamic exercise angiography seemed to be more sensitive than maximal ECG stress testing (94% compared to 64%) more rapidly positive (p less than 0.05), as sensitive (94% compared to 83% NS) than Thallium myocardial scintigraphy, but less specific (72% compared to 90%, p less than 0.05), and as unspecific as ECG stress testing.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

[Ergometrically determined work capacity in chronic hemodialysis treatment].

To evaluate the degree of physical activity in hemodialysis patients, working capacity was assessed by bicycle ergometry in 16 hemodialysis patients (mean age 47 +/- 12 [SD] years). The mean length of dialysis treatment was 21 +/- 17 months. The laboratory and clinical findings were as follows (mean values +/- SD): urea 34 +/- 6 mmol/l; creatinine 1127 +/- 169 mumol/l; potassium 5.7 +/- 0.63 mmol/l; calcium 2.25 +/- 0.22 mmol/l; phosphate 1.76 +/- 0.54 mmol/l; hemoglobin 8.54 +/- 1.02 g/dl; hematocrit 26.1 +/- 2.9%; blood pressure 140 +/- 18/86 +/- 9 mm Hg; nerve conduction velocity 39.5 +/- 6.5 m/sec. Mean working capacity was 58 +/- 31 W (41 +/- 24% of normal values) and the specific working capacity (watts/kg body weight) was 0.79 +/- 0.54. The duration of exercise testing was 4.9 +/- 2 min. The ergometry had to be discontinued because of the following reasons: leg fatigue (10 patients); general fatigue (3); dyspnea (1); attainment of maximal heart rate (2). The maximal blood pressure during exercise testing was 149 +/- 21/86 +/- 14 mm Hg and the maximal increase in heart rate 117 +/- 34 beats/min. In patients treated with a beta-blocker agent for hypertension, maximal increase in blood pressure was comparable to normotensive patients. There was a negative correlation between working capacity and the age of the patients (r = 0.77; p less than 0.01). A positive correlation was found between working capacity and the serum creatinine level (r = 0.52; p less than 0.05).

Age Factors↗

[The dipyridamole test in the diagnosis of ischemic heart disease in women].

Bicycle ergometry and the dipyridamol test were performed in 25 females with coronary artery stenosis and 42 with unchanged coronary arteries (according to the coronarography data). The sensitivity of the dipyridamol test was 80% at its specificity was 78% according to the electrocardiographic data that correlated well with those of bicycle ergometry. The dipyridamol test can be used for examining females with suspected coronary heart disease.

Adult↗

[Clinical evaluation of 2 new methods of non-invasive diagnosis of coronary insufficiency].

One-dimensional hyperplane was determined as capable of distinguishing between patients with coronary insufficiency and normal subjects by some parameters of bicycle ergometry. Twenty-four normal subjects and 159 anginal patients (males with normal blood pressure and normal body weight) were tested by bicycle ergometry. Test results were assessed individually with respect to changes in electrocardiographic repolarization complex, changes in R-wave amplitude, Robinson's index and the index of myocardial adaptation to exercise. All examined tests showed similar specificity. The myocardial adaptation index had significantly higher sensitivity as compared to other three indices.

Adaptation, Physiological↗

[Use of measured physical exercise testing in the early periods following acute myocardial infarction].

To assess cardiovascular status and response to rationed exercise in the early post-infarction period, 24 patients were subjected to bicycle ergometry within 14-19 days of the attack. It was demonstrated that early post-infarction bicycle ergometry is a safe and fairly informative method to assess cardiovascular function and identify patients with unfavourable cardiovascular response to exercise who require further management adjustment, provided it is modified to suit specific indications.

Acute Disease↗

[Physical exertion tolerance in patients with coronary insufficiency in relation to the presence of asynergic areas].

A comparative study of coronarographic, ventriculographic and bicycle ergometry results in 81 coronary patients demonstrated that myocardial contractility disorders (extensive asynergic areas, elevated ultimate diastolic pressure) combined with considerable coronary arterial lesion could result in reduced physical stress tolerance. In cases where one coronary artery is affected, asynergic areas may produce no basic influence on exercise tolerance. The predictive value of summary R amplitude increment at bicycle ergometry was estimated at 70.5% for the diagnosis of asynergia so that it can be used as a sign of possible left-ventricular dysfunction.

Adult↗

Ventilation and acid-base equilibrium for upper body and lower body exercise.

The purpose of this study was to compare pulmonary ventilation and blood acid-base responses for upper and lower body exercise at a variety of metabolic intensities. Nine male subjects completed a progressive intensity, discontinuous test for arm crank (AC) and cycle (CY) ergometry. During submaximal exercise, oxygen uptake (VO2), pulmonary ventilation (VE), VE/VO2, alveolar ventilation (VA) and blood lactate (LA) values were found to increase, whereas arterial carbon dioxide partial pressure (PCO2) and arterial pH values were found to decrease with increasing power output for both modes of ergometry. Generally, for a given submaximal power output level, VO2, VE, VE/VO2, VA. and LA values were higher, but, PCO2 and pH values were lower for AC compared to CY exercise. During maximal exercise, VO2, VE, VA, LA, and PCO2 values were lower for AC than CY exercise. When VE, VA, LA, PCO2 and pH were expressed in relation to percent of peak VO2 (ergometer specific), nearly identical response patterns were found for both modes of exercise. These results indicate that pulmonary ventilation and blood acid-base responses are dependent upon relative exercise intensity rather than the muscle groups employed.

Acid-Base Equilibrium↗

[Response of the heart rate and blood pressure to exertion - criterion for the differential therapy of hypertension].

In 37 patients with essential hypertension (WHO-stage I and II) ergometric examinations with submaximum stress were performed in sitting position for the judgement of the behaviour of heart rate and blood pressure (control group 20 clinically healthy persons). On account of the different behaviour of the heart rate the patients could be subdivided into 4 groups: A: normal heart rate in rest and under stress. B: heart rate increased only under stress. C: heart rate increased already in rest. Group D consisted of patients with hypertensive disturbance of the regulation (normal blood pressure immediately before ergometry). In 12 of the patients were also performed ergometric examinations under therapy: in group A the combined use of beta-receptor blocker and saluretic was necessary, in the groups B, C and D monotherapy with beta-receptor blocker was sufficient. The opinion is uttered that an abundant increase of blood pressure under stress in anamnestically known increased values of blood pressure in rest is also an indication to therapy as the appearance of very varying and on an average occasionally increased blood pressure values. In group A (normal regulation of frequency) by the beta-receptor blocker alone as a rule no sufficient effect is expected, the combination with a saluretic is necessary. In the other groups apart from the regulation of the blood pressure also the regulation of the heart rate is disturbed (among others reduction of the vagal inhibition of the heart, lack of training) and apart from the medicamentous therapy with beta-receptor blockers also a physical training is to be recommended. The different patterns of reaction which were to be proved by means of ergometry in patients with hypertension may in most cases be supposed already by the observation of the course and thus be included in the consideration concerning the differential therapy.

Adult↗

Adaptation to peripheral muscle training.

Ten healthy subjects underwent a 6-week dynamic exercise program designed to put a high relative load on individual muscle groups while maintaining low central circulatory stress levels. This was done to test the hypothesis that such "peripheral" training could produce skeletal muscle adaptation at low levels of myocardial work. Such a program may be useful in rehabilitating patients whose myocardial disease prevents adequate levels of participation in the traditional types of large muscle training. Strength testing, muscle biopsies and both submaximal and maximal bicycle ergometry were done to assess the effects of "peripheral" training. Heart rate during the training sessions decreased progressively over the 6 weeks (p less than 0.001). Quadriceps strength increased (p less than 0.02) with training as did both quadriceps (p less than 0.03) and gastrocnemius (p less than 0.008) fiber areas. Fiber composition was unchanged. Succinic dehydrogenase concentrations were unchanged while phosphorylase activity decreased in both muscle groups (p less than 0.03). Submaximum and maximum bicycle ergometry results were unchanged with training. The data show that dynamic training of small groups of muscles sequentially can produce significant skeletal muscle adaptation with little central circulatory stress. The effects of "peripheral" training in cardiac patients remain to be determined.

Adaptation, Physiological↗

[Exercise-induced asthma (EIA) and radioallergosorbenttest (RAST) (author's transl)].

38 children with bronchial asthma were investigated for allergy (RAST), non-specific bronchial hyperreactivity (acetylcholine challenge) and reaction to physical exercise (free running and bicycle ergometry). 17 patients showed EIA caused by free running and 11 by cycloergometry. Patients with clear-cut allergy (n = 27, high RAST values, class 3 and 4) showed exercise-induced bronchoconstriction in a high percentage of cases (16 of 27 following running, 10 of 27 after bicycle ergometry). Such patients also had non-specific bronchial hyperreactivity. This would explain treatment failures after correctly performed specific immunotherapy.

Acetylcholine↗

[Effect of a bicycle ergometer load on the state of the sympathetic-adrenal system and hemodynamic indices in highly trained athletes].

The effect of the bicycle-ergometry load on the condition of the sympatheticoadrenal system, the values of cardio- and hemodynamics, and some biochemical indices of metabolism was studied in 36 athletes. Study of the activity of the sympatheticoadrenal system in a complex with the functional and biochemical values during bicyle-ergometry load made it possible to appraise the condition of the adaptive reactions of the athlete's organism during muscular activity and to diagnose in time and prevent a state of physical overstrain.

Adolescent↗

Catecholamine response to exercise and training in individuals with spinal cord injury.

It is unknown whether the catecholamine (CAT) response to acute exercise and prolonged training in humans with spinal cord injury (SCI) is similar to that of neurologically intact man. Plasma samples were collected from seven subjects with chronic SCI (level of injury C5-T7) at rest and during voluntary arm-crank ergometry (ACE) before and after 6 months of training with functional electrical stimulation cycle ergometry (FES-CE). Similar plasma collections were made during one FES-CE exercise training session after 6 months of training. Norepinephrine (NE) and epinephrine (EPI) were measured by HPLC. After FES-CE training, resting NE decreased 37% (950 +/- 150 vs 1510 +/- 350 pmol.l-1 pretraining); resting EPI decreased 80% (54 +/- 10 vs 163 +/- 32 pmol.l-1 pretraining) (P < 0.05 by paired t-tests). No significant changes were observed in group means after training for the CAT response to submaximal ACE; however, five of seven subjects exhibited greater increments in plasma NE with ACE after FES-CE training. Acute FES-CE exercise elicited a 55-844% increase in NE, and a 35-350% increase in EPI above resting values with power outputs eliciting heart rates of 90-146 bpm. These data provide evidence for a systemic CAT response in subjects with SCI during acute FES-CE and reduced resting CAT following 6 months of training with FES-CE.

Adult↗