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At least 991 records · Page 55Linked to original sources
PubMed1976

[Rhesus-erythroblastosis. Diagnosis, therapy, prevention].

In consequence of feto-maternal disagreement within the rhesus-system the antibody production by the mother's immunogenic system can be initiated. Those rhesus-antibodies penetrate through the placental barrier and -- due to a massive heamolysis of the fetal erythrocytes -- they cause the principal symptoms such as anaemia, jaundice of the new born and hydrops congenitus universalis. Consequently adhered to screening examinations during pregnancy along with routine examinations of blood-group and antibody-titers help to determine a predisposition to as well as manifest incompatibilities. If antibody levels are suspiciously high, amniocentesis must be performed repeatedly. A possible severe damage to the child can be prevented by intrauterine blood-transfusion and by induced termination of labour or termination of pregnancy before date. The rhesus-injured newborn must be transferred immediately to an intensive-care-unit. In case of pronounced augmentation of the bilirubin-titer photo-therapy should be tried along with one or more blood-exchange transfusions. The formation of rhesus-antibodies can be prevented by prophylaxis with immunoglobulin-G-anti-D. The principle of this method is the suppression of maternal immune-response by application of 250-300 mug anti-D to the rhesus-negative mother after the birth of a rhesus-positive child.

Amniocentesis↗
PubMed1976

[Improved diagnosis fetal erythroblastosis due to Rh factors by combination of spectrophotometry (delta E 450) and a modified amniotic fluid ratio].

154 tests of amniotic fluid of 70 rh-sensitized women, won by transabdominal amniocentesis in the time between the 28th and 39th week of gestation were analysed. Besides experiential carried out spectrophotometric after Liley (estimation of delta E 450) liquor ratio were scrutinized concerning its value of statement for antenatal diagnosis in 2 variations (original liquor ratio and liquor ratio II). An equivalent pertinent judgment of delta E450 and Original liquor ratio was won. The best results were obtained with liquor ratio II and the combination of this method with delta E450. For further improvement of diagnostic reliability 2 methods of amniotic fluid analysis should be combined.

Amniocentesis↗