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Postbulbar peptic ulceration of the duodenum.

One hundred and twenty patients operated upon for peptic ulcer diathesis had intraluminal digital examination of the duodenum seeking post-bulbar ulcers. Twelve such ulcers were found, an incidence of 10 per cent. In six of these patients, the postbulbar ulcer was an unexpected finding, and in two patients, a second ulcer was present. A review of the patients with postbulbar ulcers revealed that these patients had severe ulcer symptoms that responded poorly to medical management. Our patients were treated by truncal vagotomy and an outlet procedure. In ten patients, the anterior duodenotomy was extended to include the stenotic area. A Jaboulay gastroduodenostomy was performed in one patient, and duodenoplasty with pyloroplasty in another patient. These 12 patients were observed from one to six years. There were no deaths. Two patients had temporary gastric atony and one patient had a dumping syndrome. Three patients have had possible recurrence of the ulcer, reoperation being required in one patient. It is possible that unrecognized postbulbar stenosis may be a cause of recurrent peptic ulcer following some surgical procedures. To recognize these ulcers, we believe that the duodenum should be inspected by intraluminal palpation in all patients operated upon for peptic ulcer disease.

Adult↗

[Primary adenocarcinoma of the duodenum].

The authors describe a case of 60-year-old man with primary adenocarcinoma of the distal duodenum. The first, ex post assumed symptom, was haemorrhage into the gastrointestinal tract almost two years before the final diagnostic conclusion. The diagnosis was not correctly established even during subsequent examinations during progression of the disease and not even during the first surgical revision. The reason is, no doubt, the rareness of the diagnosis and the adverse site of the tumour. An asset was was enteroscopy, although its conclusion was not accurate as regards the site. The tumour was radically removed only during the second operation by segmental resection of the distal duodenum with a duodenojejunal anastomosis in the region of D2. The patient was then referred to the care of an oncologist. The case shows the diagnostic difficulties and the unique operation that was performed. Possible success of treatment is always conditioned by coordinated gastroenterological, surgical and oncological care.

Adenocarcinoma↗

[The effect of duodenum-preserving pancreatic head resection on the endocrine pancreas function in patients with chronic head pancreatitis].

In a prospective clinical-experimental study, 15 patients with chronic pancreatitis operated consecutively due to severe pain were examined for the effects of a duodenum-preserving resection of the pancreas head on endocrine pancreas function. This was done by means of oral and intravenous glucose tolerance testing before the operation, on the 10th or 11th postoperative day, and three months after the operation. In addition to glucose levels in the peripheral venous blood, levels of insulin, C-peptide, glucagon, somatostatin, and pancreatic polypeptide were determined. As indicated by the k-value, glucose tolerance improved postoperatively in 11 patients; two patients showed no change, and one patient was worse. Only one patient developed evident diabetes mellitus immediately postoperatively. The pre- and postoperative levels of insulin and C-peptide showed no significant differences. The fasting levels of glucagon were significantly lower postoperatively than before the operation (2p less than 0.01). Duodenum-preserving pancreas head resection led to improvement of the glucose tolerance in the majority of patients; a deterioration was observed only in two cases.

Adult↗

Mucosa-associated lymphoid tissue lymphoma of the duodenum: report of a case resistant to Helicobacter pylori eradication.

We present a case of mucosa-associated lymphoid tissue (MALT) lymphoma of the duodenum treated with surgical resection. A 64-year-old woman underwent upper gastrointestinal endoscopy because of melena. Examinations revealed an ulcer-forming lesion at the second portion of the duodenum that was diagnosed histologically as low-grade MALT lymphoma. We attempted Helicobacter pylori eradication therapy, although all the tests revealed negative results for its infection. No sign of remission was observed and we performed surgical resection. The patient has shown no sign of recurrence at present, 39 months after the operation. Duodenal MALT lymphoma is a rare entity. Only 17 cases have been reported in the English literature. We summarized the characteristics of the disease and tried to figure out differences in comparison with those in the stomach, including the involvement of the Helicobacter pylori infection.

Drug Resistance, Microbial↗

An early case of the Zollinger-Ellison syndrome produced by a carcinoid tumor of the duodenum.

We have reported a case of Zollinger-Ellison Syndrome which proved to be due to a small carcinoid tumor of the wall of the duodenum. At the time that this was found, I could not find any such cases in the literature. In talking with Dr. Ellison personally, it was my impression that he was probably not aware of this syndrome. There are relatively few cases in the literature, and in a report by Dr. Van Heerden, et al from the Mayo Clinic, of 154 patients with carcinoid tumors of the GI tract, there were only two cases of the carcinoid tumor found the duodenum. One had a gastrin producing tumor 1 cm in diameter with positive nodes which was excised locally, and the patient was alive and well and not taking medication after 10 years. In this case, I think that serendipity played a great part, because I had no knowledge of the relation between the carcinoid tumor and the severe ulcer diathesis it produced.

Aged↗

[Primitive adenocarcinoma of the duodenum. Description of two clinical cases].

Two cases of a primitive adenocarcinoma of the duodenum are presented. Both cancers were localized near the papilla. Duodenocephalopancreatectomy was the surgical treatment for each patient. One patient died of myocardial infarction eight months after surgery, without any sign of recurrence of the cancer; the other is in good health three months after surgery. The rarity of such a tumor is underlined: in 44 papers published in various journals from 1971 to 1993, 88 cases of primitive adenocarcinoma of the duodenum were examined; the average number of cases per author was two. Between 1980 and 1993, an Italian multicenter study carried out in 36 hospital and university centers, showed only 89 cases of primitive duodenal adenocarcinoma.

English Abstract↗

Local recurrence of primary non-ampullary adenocarcinoma of duodenum after surgical treatment--a case report and a literature review.

Worldwide there is no general attitude on optimal surgical procedure in treatment of primary non-ampullary adenocarcinoma of duodenum, especially for early stage of duodenal cancer. Some authors prefer local excision and segmental resection while others rather perform duodenopancreatic resection, even in the case of early stage of duodenal cancer with aim to avoid tumor recurrence. In this paper we present a rare clinical course of a 60-year-old male patient with an endoscopically and pathohistologically proven early stage duodenal cancer that was treated by wide local excision. Three years after operation, control endoscopy showed "flat" polyp in the duodenum and radical duodenopancreatic resection was performed. Pathohistological examination of resected specimen showed cancer that had spread throughout the duodenal wall with metastases in the regional lymph nodes. According to our findings and literature review we gave some direction concerning the optimal diagnostic and surgical procedure for this rare tumor.

Duodenal Neoplasms↗

[Adenocarcinoma of the third part of the duodenum].

Adenocarcinoma of the third part of the duodenum is a rare tumour (34 cases reported in the literature). The clinical signs are polymorphic and non-specific and the stenotic form is the most frequent (57%). Complications are numerous and frequent. The difficult radiological diagnosis reveals either a short stenosis, a filling defect or, more rarely, and enlarged duodenal shadow or an ulcer. Duodenal fibroscopy allows the histological diagnosis and the differential diagnosis with other duodenal tumours. Adenocarcinoma of the third part of the duodenum requires cephalic duodenopancreatectomy (operative mortality of about 16%), which is the only treatment allowing a 3-year survival in 50% of cases and a 5-year survival in 30-40% of cases.

Adenocarcinoma↗

[One-stage segmental pylorus-preserving resection of the stomach and duodenum in stenosing duodenal ulcer].

The analysis of the results of surgical treatment of 32 patients with duodenal ulcer disease complicated by postpyloric stenosis of the duodenum, using the original technique--combination of selective proximal vagotomy with segmental pylorus-preserving resection of the stomach and duodenum was carried out. A good immediate and long-term result was noted, there were no ulcer recurrences. Such an operative intervention is expedient in stenosing duodenal ulcer, its combination with a gastric ulcer, and as well in postvagotomy ulcer recurrency developing against the background of high gastric acid production.

Constriction, Pathologic↗

Villous tumors of the duodenum. Presentation of five cases.

Five cases of villous tumors of the duodenum are reported. These tumors have a predilection for the periampullary region and tend to present with jaundice or obstruction of the duodenal lumen. In four of these patients, malignant transformation was seen. Endoscopy and biopsy play a major rôle in attempting to obtain an accurate preoperative diagnosis. Unfortunately, the diagnosis of malignant degeneration is frequently missed, even when multiple biopsies are taken. For this reason villous tumors should always be resected, and the strategy of treatment must depend on pre-, intra- and postoperative histological evaluation, location in the duodenum and intra-operative findings.

Adenocarcinoma↗

Carcinoma of the duodenum after trauma, radiotherapy and chemotherapy.

The case history is reported of a patient with a carcinoma of the duodenum 30 years after blunt abdominal trauma at the site of the 'scar' in the duodenum. Thirteen years after the trauma the patient was treated with chemotherapy and abdominal irradiation for a relapse of Hodgkin's disease. At follow-up, 25 months after the operation, he had no local recurrence of Hodgkin's disease or duodenal cancer. The possible relation between the cancer and the abdominal trauma, chemotherapy and abdominal irradiation is discussed.

Abdominal Injuries↗

Evaluation of atropine, glucagon, and metoclopramide for facilitation of endoscopic intubation of the duodenum in dogs.

Modification of gastroduodenal motility has been proposed to aid endoscopic examination of the duodenum in dogs. The objective of this study was to evaluate the use of the following pharmacologic agents for facilitation of endoscopic intubation of the duodenum in 6 clinically normal dogs: metoclopramide HCl (0.2 mg/kg of body weight), atropine sulfate (0.045 mg/kg), glucagon (0.06 mg/kg), and isotonic saline solution. In a randomized, blinded, crossover design, the ease of endoscopic duodenal intubation was qualitatively scored by 3 endoscopists (in random order), using the following scale: 1 - immediate entry; 2 - rapid entry--moderate manipulation; 3 - difficult entry--multiple attempts; and 4 - no entry after 2 minutes [corrected]. Anesthesia was induced with thiopental and maintained with halothane. The 4 agents were diluted to a fixed volume and randomly administered. Duodenal intubation was attempted 2 minutes after IV injection of 1 of the agents. Four endoscopic procedures (1 for each agent) were performed on each dog with a minimum of 5 days between each procedure. In this study, no agent facilitated endoscopic duodenal intubation at the dose used. Instead, atropine and metoclopramide made duodenal intubation significantly more difficult, compared with use of saline solution. Difference between intubation after administration of glucagon and saline solution was not seen. On the basis of our findings, the use of these agents for facilitating endoscopic duodenal intubation is not recommended. In addition, in this study, we found that experience in endoscopic intubation is an important factor in determining the ease of duodenal intubation.

Animals↗

Simultaneous adenocarcinoma of the stomach and fourth portion of the duodenum: case report and review of the literature.

We treated a woman with simultaneous adenocarcinoma of the stomach and fourth portion of the duodenum. She complained of symptoms of obstruction in the duodenum, and both lesions were correctly diagnosed, preoperatively. Noncurative resection was done because of distant lymph node metastasis. The new adjuvant chemotherapy using THP-adriamycin and UFT was prescribed, and one year after surgery she remains in recession.

Adenocarcinoma↗

Upper gastrointestinal bleeding due to superior mesenteric artery to duodenum fistula: rare complication of metastatic lung carcinoma.

Although metastases from primary carcinoma of the lung to the small intestine appear to be more common than previously suspected, they rarely produce symptoms. Such metastases may present as bowel perforations. Overt gastrointestinal bleeding has been described only as a prelude to perforation. We describe the case of a 55-yr-old man with carcinoma of the lung that had metastasized to the brain and to the third part of the duodenum. The duodenal metastasis presented with massive upper gastrointestinal hemorrhage. The metastasis was seen to be actively bleeding at endoscopy, and a direct fistula from a branch of the superior mesenteric artery to the third part of the duodenum was shown angiographically. Arterial invasion and destruction by tumor was confirmed at postmortem examination. This complication of metastatic carcinoma of the lung has not been previously described in the English literature.

Carcinoma↗

[Early diagnosis and treatment of concomitant pathology of the gallbladder and duodenum in ambulatory care].

Analysis was made of the clinical manifestations of concomitant pathology of the gallbladder and duodenum in 138 patients as well as of the main causes of diagnostic errors made during their examination under outpatient conditions. In concomitant pathology of the gallbladder and duodenum, the classical picture characteristic for their isolated injury was lacking. The main causes of diagnostic errors made during those patients' examination by the district physicians were low quality of differential diagnosis, non-performance of the available research methods, and changes in the disease course.

Adult↗

Lymphosarcoma of the duodenum associated with carcinoma of the lung. Five-year survival.

The case presented describes a patient with lymphosarcoma of the duodenum associated with carcinoma of the lung. This emphasizes the basic problems which lymphosarcoma of the duodenum presents. They are vague symptoms until late in the course of the disease, the absence of early physical findings, the difficulty in interpretation of radiological studies and the frequent association with other primary malignancies elsewhere.

Adenocarcinoma, Bronchiolo-Alveolar↗

[Intramural hematoma of the duodenum. Diagnosis and therapy].

Two cases of intramural haematoma of the duodenum caused by injury are examined. The clinical signs were non-specific: vomiting and epigastric pain. The salient features of laboratory tests were leucocytosis and hyperamylasaemia. Radiography of the digestive tract revealed classic bunching of the mucous plicae in the second section of the duodenum in one case and a mark on the gastric antrum together with a clear stretch in the third duodenal section in the other. Surgical examination and drainage of the haematoma was performed in one case while the other was given conservative treatment. Both patients were clinically cured on release from hospital.

Adolescent↗

[A case of a carcinoid of the duodenum (somatostatin-, serotonin- and ACTH-producing) with carcinoma of the stomach].

A case of a duodenal carcinoid which was producing somatostatin, serotonin and ACTH in a 65-year-old man is reported. The patient was found to have a submucosal protruded mass of the duodenal bulb and a tumor mass-like IIa + IIc in the antral portion of the stomach. Subtotal gastrectomy was performed and the histological diagnosis of the tumors were found to be a classical carcinoid of the duodenum and a well-differentiated tubular adenocarcinoma of the stomach. The carcinoid cells of the duodenum had numerous cyto-plasmic granules which were positive by Grimelius staining and negative by Hellerström-Hellmann staining, and 200-300 nm in size, electronmicroscopically. These cells were shown to contain somatostatin, serotonin or ACTH-positive cells by means of monoclonal immunohistochemistry, however, results were negative for gastrin, insulin, glucagon, calcitonin, VIP or PP.

Adenocarcinoma↗